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Palamut (Sarda sarda) balığında paraoksonaz (PON) enzim aktivitesi üzerine cıva, bakır ve çinkonun etkisi

Yıl 2021, Cilt 38, Sayı 4, 479 - 486, 15.12.2021
https://doi.org/10.12714/egejfas.38.4.09

Öz



Çevre kirliliğinde sık rastlanan ağır metal kirlilikleri, biyokimyasal enzim reaksiyonları üzerinden organizmada zararlı etkiler meydana getirdiği için bu çalışmada çevre kirliliğinde sık rastlanan cıva (Hg+2), bakır (Cu+2) ve çinko (Zn+2) ağır metal iyonlarının palamut (Sarda sarda) balığı kas dokusunda bulunan PON (paraoksonaz) aktivitesi üzerine etkileri araştırılmıştır. Çalışmada Samsun bölgesi denizinden taze olarak temin edilen 25 adet palamut balığının kas dokuları kullanıldı. Ağır metal çözeltilerinden farklı hacimlerde eklenerek PON enzim aktivitesindeki değişiklikler tayin edildi. Farklı hacimlerde kullanılan Hg+2 ağır metal iyonunun PON enzim aktiviteleri 30,9383 U/mLdak, 29,0598 U/mLdak, 26,3799 U/mLdak, 23,9443 U/mLdak, 20,6725 U/mLdak olarak hesaplandı, farklı hacimlerde kullanılan Cu+2 ağır metal iyonunun PON enzim aktiviteleri 19,7949 U/mLdak, 19,4807 U/mLdak 19,1864 U/mLdak, 19,1200 U/mLdak, 18,9037 U/mLdak olarak hesaplandı ve farklı hacimlerde kullanılan Zn+2 ağır metal iyonunun PON enzim aktiviteleri 23,8305 U/mLdak, 23,0781 U/mLdak, 22,9073 U/mLdak, 22,4324 U/mLdak, 21,8159 U/mLdak olarak hesaplandı. Elde edilen bu veriler sonucunda % aktivite değerleri hesaplanarak % aktivite grafikleri çizildi. Çalışma sonucunda Cu+2 ve Zn+2 ağır metal iyonlarının artan derişimlerinin enzim aktivitesinde azalmaya neden olduğu fakat kullanılan farklı derişimler arasında istatistiksel olarak anlamlı bir fark olmadığı belirlendi. Hg+2 ağır metal iyonun artan derişimlerinin PON enzim aktivitesini inhibe ettiği, kullanılan farklı derişimlere bağlı olarak aktiviteler arasında istatistiksel olarak anlamlı bir azalmaya neden olduğu belirlendi (p < 0.05).



Kaynakça

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  • Ashraf, W. (2005). Accumulation of heavy metals in kidney and heart tissues of Epinephelus microdon fish from the Arabian Gulf. Environmental Monitoring and Assessment, 101(1-3), 311-316. DOI: 10.1007/s10661-005-0298-4
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  • Beyaztaş, S., Türker, D., Sinan, S. & Arslan, O. (2007). Cyprinus carpio paraoksonaz enziminin bazı ağır metallerle inhibisyon etkisinin incelenmesi. 21. Ulusal Kimya Kongresi (pp. 23-27). Malatya, Türkiye.
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  • Costa, L.G., Li, W.F., Richter, R.J., Shih, D.M., Lusis, A. & Furlong, C.E. (1999). The role of paraoxonase (PON1) in the detoxification of organophosphates and its human polymorphism. Chemico-Biological İnteractions, 119-120, 429-438. DOI: 10.1016/s0009-2797(99)00055-1
  • Çoğun, H.Y. & Kargın, F. (2020). Copper accumulation and Na/K ion levels in gill tissue of Cyprinus carpio (in Turkish with English abstract). Journal of Anatolian Environmental and Animal Sciences, 5(3), 313-317. DOI: 10.35229/jaes.749347
  • Deakin, S. & James, R.W. (2004). Genetic and environmental factors modulating serum concentrations and activities of the antioxidant enzyme paraoxonase-I. Clinical Science, 107(5), 435-447. DOI: 10.1042/CS20040187
  • Dedeoğlu, N., Arslan, M. & Erzengin, M. (2014). Purification of holstein bull semen paraoxonase 1 (PON1) by hydrophobic ınteraction chromatography and ınvestigation of ıts ınhibition kinetics by heavy metals. Biological Trace Element Research, 158(1), 29-35. DOI: 10.1007/s12011-014-9916-8
  • Deveci, H.A., Kaya, İ., Yılmaz, M. & Karapehlivan, M. (2015). Effect of zinc sulphate on the levels of plasma paraoxonase activity, total oxidant and high density lipoprotein of transcaucasian barb (Capoeta capoeta Guldenstaedt, 1773). Fresenius Environmental Bulletin, 24(9), 2732-2735.
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  • Elana, T., Elana, M., Magdalena, G., Isabel, L. & Ana, M.P. (2006). Effects of caloric restriction and gender on rat serum paraoxonase 1 activity. The Journal of Nutritional Biochemistry, 17(3), 197-203. DOI: 10.1016/j.jnutbio.2005.07.004
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The effect of mercury, copper, and zinc on paraoxonase (PON) enzyme activity in Bonito (Sarda sarda) fish

Yıl 2021, Cilt 38, Sayı 4, 479 - 486, 15.12.2021
https://doi.org/10.12714/egejfas.38.4.09

Öz



Since heavy metal dirtiness, which we frequently encounter in environmental pollution causes harmful effects on the organism through biochemical enzyme reactions, in this study, the effects of mercury (Hg+2), copper (Cu+2), and zinc (Zn+2) heavy metal ions, which are common in environmental pollution, on PON (paraoxonase) enzyme activity in muscle tissue of bonito (Sarda sarda) were investigated. In the study, 25 bonito (S. sarda) fish muscle tissues freshly obtained from the Samsun region sea were used. The changes in PON enzyme activity were determined by adding different volumes of heavy metal solutions. PON enzyme activities of Hg+2 heavy metal ion used in different volumes were calculated as 30.9383 U/mLdak, 29.0598 U/mLdak, 26.3799 U/mLdak, 23.9443 U/mLdak, 20.6725 U/mLdak, PON enzyme activities of Cu+2 heavy metal ion used in different volumes were calculated as 19.7949 U/mLdak, 19.4807 U/mLdak 19.1864 U/mLdak, 19.1200 U/mLdak, 18.9037 U/mLdak and PON enzyme activities of Zn+2 heavy metal ion used in different volumes were calculated as 23.8305 U/mLdak, 23.0781 U/mLdak, 22.9073 U/mLdak, 22.4324 U/mLdak, 21.8159 U/mLdak. As a result of these obtained data, activity (%) values were calculated and activity (%) graphs were drawn. As a result of the study, it was determined that increasing concentrations of Cu+2 and Zn+2 heavy metal ions caused a decrease in PON enzyme activity, but there was no statistically significant difference between the different concentrations used. It was determined that increasing concentrations of Hg+2 heavy metal ion inhibited the PON enzyme activity, caused a statistically significant decrease between the activities depending on the different concentrations used (p < 0.05).


Kaynakça

  • Ağcasulu, Ö. (2007). Investigation of accumulation of heavy metals in tissues of Capoeta tinca (Heckel, 1843) living in çeltikçe stream of sakarya rıver. Gazi University Institute of Science, MS Thesis, Ankara, Turkey. (In Turkish).
  • Ashraf, W. (2005). Accumulation of heavy metals in kidney and heart tissues of Epinephelus microdon fish from the Arabian Gulf. Environmental Monitoring and Assessment, 101(1-3), 311-316. DOI: 10.1007/s10661-005-0298-4
  • Aviram, M. (1999). Does paraoxonase play a role in susceptibility to cardiovascular disease? Moleculer Medicine Today, 5(9), 381-386. DOI: 10.1016/S1357-4310(99)01546-4
  • Aytekin, T. & Kargın, F. (2019). Effect of copper on G6PD activity in the liver, gill, kidney and muscle tissues of Oreochromis niloticus. Journal of Anatolian Environmental and Animal Sciences, 4(2), 60-63. DOI: 10.35229/jaes.537019
  • Babacan, F., Isık, B. & Bıngol, B. (2011). Changes in serum paraoxonase activity, calcium and lipid profiles in pre-eclampsia, a preliminary study. Journal of Turkish Society of Obstetrics and Gynecology, 8(3), 169-174. DOI: 10.5505/tjod.2011.24540
  • Baillie, T.A., Moldeus, P., Mason, R.P. & Younes, M. (1993). Enzymes interacting with organophosphorus compounds. Shannon: Elsevier Scientific Publishers Ireland Ltd.
  • Beyaztaş, S., Türker, D., Sinan, S. & Arslan, O. (2007). Cyprinus carpio paraoksonaz enziminin bazı ağır metallerle inhibisyon etkisinin incelenmesi. 21. Ulusal Kimya Kongresi (pp. 23-27). Malatya, Türkiye.
  • Broomfield, CA. & Ford, K.W. (1991). Hydrolysis of nerve gasses by plasma enzymes. Proceedings of the 3rd International Meeting on Cholinesterases (pp. 167). La Grande-Motte, France.
  • Bury, N.R., Walker, P.A. & Glover, C.N. (2003). Nutritive metal uptake in teleost fish. Journal of Experimental Biology, 206, 11-23. DOI: 10.1242/jeb.00068
  • Carey, J.N.G., Shih, D.M., Hama, S.Y., Villa, N., Navab, M. & Reddy, T.S. (2005). The paraoxonase gene family and atherosclerosis. Free Radical Biology and Medicine, 38(2), 153-163. DOI: 10.1016/j.freeradbiomed.2004.09.035
  • Cicik, B. (2003). The effects of copper-zinc interaction on the accumulation of metals in liver, gill and muscle tissues of common carp (Cyprinus carpio L.) (in Turkish with English abstract). Ekoloji Çevre Dergisi, 12(48), 32-36
  • Coppock, R.W. & Nation, P.N. (2007). Aquatic toxicology. In C. Ramsh, (Ed.), Veterinary toxicology: Basic and Critical Principles. Elsevier Inc (pp. 709-713). Amsterdam, Netherlands.
  • Costa, L.G., Li, W.F., Richter, R.J., Shih, D.M., Lusis, A. & Furlong, C.E. (1999). The role of paraoxonase (PON1) in the detoxification of organophosphates and its human polymorphism. Chemico-Biological İnteractions, 119-120, 429-438. DOI: 10.1016/s0009-2797(99)00055-1
  • Çoğun, H.Y. & Kargın, F. (2020). Copper accumulation and Na/K ion levels in gill tissue of Cyprinus carpio (in Turkish with English abstract). Journal of Anatolian Environmental and Animal Sciences, 5(3), 313-317. DOI: 10.35229/jaes.749347
  • Deakin, S. & James, R.W. (2004). Genetic and environmental factors modulating serum concentrations and activities of the antioxidant enzyme paraoxonase-I. Clinical Science, 107(5), 435-447. DOI: 10.1042/CS20040187
  • Dedeoğlu, N., Arslan, M. & Erzengin, M. (2014). Purification of holstein bull semen paraoxonase 1 (PON1) by hydrophobic ınteraction chromatography and ınvestigation of ıts ınhibition kinetics by heavy metals. Biological Trace Element Research, 158(1), 29-35. DOI: 10.1007/s12011-014-9916-8
  • Deveci, H.A., Kaya, İ., Yılmaz, M. & Karapehlivan, M. (2015). Effect of zinc sulphate on the levels of plasma paraoxonase activity, total oxidant and high density lipoprotein of transcaucasian barb (Capoeta capoeta Guldenstaedt, 1773). Fresenius Environmental Bulletin, 24(9), 2732-2735.
  • Dökmeci, İ. (2001). Zehirler ve zehirlenmeler. Toksikoloji. 3. Baskı, Nobel Tıp Kitabevi (pp. 249-692). İstanbul, Türkiye.
  • Eckerson, H.W., Wyte, C.M. & La Du, B.N. (1983). The human serum paraoxonase/arylesterase polymorphism. American Journal of Human Genetics, 35(6), 1126-1138.
  • Ekinci, D., Beydemir, S. & Küfrevioglu, O.I. (2007). In vitro inhibitory effects of some heavy metals on human erythrocyte carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry, 22(6), 745-750. DOI: 10.1080/14756360601176048
  • Elana, T., Elana, M., Magdalena, G., Isabel, L. & Ana, M.P. (2006). Effects of caloric restriction and gender on rat serum paraoxonase 1 activity. The Journal of Nutritional Biochemistry, 17(3), 197-203. DOI: 10.1016/j.jnutbio.2005.07.004
  • Erdös, E.G., Debay, C.R. & Westerman, M.P. (1960). Arylesterases in blood: Effect of calcium and inhibitors. Biochemical Pharmacology, 5(3), 173-186. DOI: 10.1016/0006-2952(60)90061-7
  • Erel, O. (2005). A new automated colorimetric method for measuring total oxidant status. Clinical Biochemistry, 38(12), 1103-1111. DOI: 10.1016/j.clinbiochem.2005.08.008
  • Erel, O. (2004). A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable abts radical cation. Clinical Biochemistry, 37(4), 277-285. DOI: 10.1016/j.clinbiochem.2003.11.015
  • Erol K., Gençer, N., Arslan, M. & Arslan, O. (2013). Purification, characterization, and investigation of in vitro inhibition by metals of paraoxonase from different sheep breeds. Artifical Cells, Nanomedic, and Biotechnology, 41(2), 125-130. DOI: 10.3109/10731199.2012.696065
  • Gülcü, F. & Gürsu, M.F. (2003). The standardization of paraoxonase and arylesterase activity measurements (in Turkish with English abstract). Turkish Journal of Biochemistry, 28(2), 45-49.
  • Güller, U., Taşer, P., Çiftci, M. & Küfrevioğlu, Ö.İ. (2014). Purification of glutathione s-transferase from bonito (Sarda sarda) liver and investigation of metal ions effects on enzyme activity. Hacettepe Journal of Biology and Chemistry, 42(3), 435-442.
  • Henry, F., Amara, R., Courcot, L., Lacouture, D. & Bertho, M.L. (2004). Heavy metals in four fish species from the French coast of the Eastern English Channel and Southern Bight of North Sea. Environment International 30(5), 675-683. DOI: 10.1016/j.envint.2003.12.007
  • Hu, H. (2002). Human health and heavy metals exposure. In McCally M (ed.), Life support: The environment and human health. MIT press (pp. 65). Cambridge, Massachusetts Londan, England.
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Ayrıntılar

Birincil Dil İngilizce
Konular Balıkçılık, Biyoloji
Bölüm Makaleler
Yazarlar

Büşra ŞAHİN (Sorumlu Yazar)
ONDOKUZ MAYIS UNIVERSITY
0000-0002-5245-478X
Türkiye


Sena ÇENESİZ
ONDOKUZ MAYIS ÜNİVERSİTESİ
0000-0002-3544-503X
Türkiye

Destekleyen Kurum Ondokuz Mayıs Üniversitesi Bilimsel Araştırma Projeleri Komisyonu Başkanlığı
Proje Numarası PYO.VET.1904.19.011
Teşekkür Ondokuz Mayıs Üniversitesi Bilimsel Araştırma Projeleri Komisyonu Başkanlığı'nın PYO.VET.1904.19.011 proje numarasıyla verdiği desteğe teşekkür ederiz.
Yayımlanma Tarihi 15 Aralık 2021
Başvuru Tarihi 21 Nisan 2021
Kabul Tarihi 14 Ekim 2021
Yayınlandığı Sayı Yıl 2021, Cilt 38, Sayı 4

Kaynak Göster

APA Şahin, B. & Çenesiz, S. (2021). The effect of mercury, copper, and zinc on paraoxonase (PON) enzyme activity in Bonito (Sarda sarda) fish . Ege Journal of Fisheries and Aquatic Sciences , 38 (4) , 479-486 . DOI: 10.12714/egejfas.38.4.09