BibTex RIS Kaynak Göster

Marine bioactive compounds.

Yıl 2013, Cilt: 30 Sayı: 2, 85 - 92, 01.06.2013

Öz

Kaynakça

  • Arthaud, I.D.B., Rodrigues, F.A.R., Jimenez, P.C., Montenegro, R.C., Angelim, A.L., Maciel, V.M.M., Silveira, E.R., Freitas, H.P.S., Sousa, T.S., Pessoa, O.D.L., Lotufo, T.M.C., Costa-Lotufo, L.V., 2012. Studies on the Secondary Metabolites of a Pseudoalteromonas sp. Isolated from
  • Sediments Collected at the Northeastern Coast of Brazil, Chemistry & Biodiversity, 9: 418–427. doi: 10.1002/cbdv.201100092
  • Ausubel, J., Crist, D.T., Waggoner, P.E., 2010. First Census of Marine Life : Highlights of a decade of discovery, Washington DC: Census of Marine Life, 68p.
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  • Bérdy, J., 2005. Bioactive microbial metabolites, Journal of Antibiotics, 58: 1– p. doi: 10.1038/ja.2005.1
  • Bernan, V.S., Greenstein, M., Maise, W.M., 1997. Marine microorganisms as a source of new natural products, Advences in Applied Microbiology, 43: –89p. doi: 10.1016/S0065-2164(08)70223-5
  • Blunt, J.W., Copp, B.R., Munro, M.H.G., Northcote, P.T., Prinsep, M.R., Marine natural products, Natural Product Reports, 27:165–237p. doi: 10.1039/B906091J
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  • Marine natural products, Natural Product Reports, 29:144–222p. doi: 10.1039/C2NP00090C
  • Bugni, T.S., Ireland, C.M., 2004. Marine-derived fungi: a chemically and biologically diverse group of microorganisms, Natural Products Reports, : 143–163p. doi:10.1039/b301926h
  • Burgess, J.G., 2012. New and emerging analytical techniques for marine biotechnology, Current Opinion in Biotechnology, 23: 29–33 doi: 10.1039/B301926H
  • Cabrita, M.T., Vale, C., Rauter, A.P., 2010. Halogenated Compounds from
  • Marine Algae, Marine Drugs, 8: 2301-2317p. doi: 10.3390/md8082301
  • Chu, D.T., Plattner, J.J., Katz, L., 1996. New directions in antibacterial research, Journal of Medicinal Chemistry, 39, 3853–3874p. doi: 10.1021/jm960294s
  • Clark, A.M., 1996. Natural products as a resource for new drugs,
  • Pharmaceutical Research, 8, 1133-1144p. doi: 10.1023/A:1016091631721
  • Colegate, S.M., Molyneux, R.J., 2008. An Introduction and Overview,
  • Bioactıve Natural Products Detection, Isolation, and Structural Determination, Taylor & Francis Group, p. 1-9. Cragg, G.M., Newman, D.J., Snader,K.M., 1997. Natural products in drug discovery and development, Journal of Natural Products, 60: 52–60p. doi: 10.1021/np9604893
  • Cragg, G.M., Grothaus, P.G., Newman, D.J., 2009. Impact of Natural
  • Products on Developing New Anti-Cancer Agents, Chemical Reviews, : 3012-3043p. doi: 10.1021/cr900019j
  • Cragg, G.M., Newman, D.J., 2013. Natural products: A continuing source of novel drug leads, Biochimica et Biophysica Acta (BBA), 1830: 3670–3695. doi: 10.1016/j.bbagen.2013.02.008
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  • Microbiology, 5: 755–757p. doi: 10.1038/nrmicro1762
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Denizel biyoaktif bileşikler.

Yıl 2013, Cilt: 30 Sayı: 2, 85 - 92, 01.06.2013

Öz

Yüzlerce yıl boyunca yeni ilaçların temelini doğal ürünler ve bunlardan elde edilmiş bileşikler oluşturmuştur. Sekonder metabolitler olarak adlandırılan bu bileşikler doğada organizmalar tarafından düşmanlarından korunma amacıyla üretilmektedir. Son yıllarda benzer metabolitlerin izole edilmesi ve ayrıca sentetik üretimin yüksek tarama olanakları sunmasının da etkisiyle doğal ürünlere yönelik ilaç araştırmaları oldukça azalmıştır. Bununla birlikte çeşitli patojenlerin hastanelerde ve toplumda dirençli suşlar geliştirmesi giderek daha yaygınlaşmaktadır. Yeni hastalıklar yeni ilaçların keşfini zorunlu hale getirirken, bütün bunlarla mücadele için gerekli olan yeni antimikrobiyallerin geliştirilmesinde ilerleme yavaş olmaktadır. Bu nedenle özellikle sağlık alanındaki bu ve benzeri problemler cytarabine (Ara-c), vidarabine (Vira-A1) ve salinosporamide A gibi yeni küçük molekül yapılı bileşiklerinin keşfinde öncelik olması gerektiğini göstermektedir. Yeni teknolojiler henüz araştırılmamış biyolojik kaynakların doğal ilaç keşiflerinde kullanılmasını sağlayan oldukça etkili akıllı tarama yöntemleri sunmaktadır. Özellikle hızlı genetik sekanslama ile birlikte biyosentetik yolakların manipulasyonundaki ilerlemeler yeni ilaçların keşfi için büyük bir kaynak sunabilecek potansiyele sahiptir. Teknolojideki bu ilerlemeler yeni ilaç keşfine ve doğal ürünlere olan ilginin tekrar artmasını da sağlamıştır. Bu derlemede, yeni bileşikler için son derece zengin bir kaynak sunarken aynı zamanda tedavi edici potansiyeli olabilecek denizel kimyasal çeşitliliği bir araya getiren denizel metabolitler üzerinde durulmuştur

Kaynakça

  • Arthaud, I.D.B., Rodrigues, F.A.R., Jimenez, P.C., Montenegro, R.C., Angelim, A.L., Maciel, V.M.M., Silveira, E.R., Freitas, H.P.S., Sousa, T.S., Pessoa, O.D.L., Lotufo, T.M.C., Costa-Lotufo, L.V., 2012. Studies on the Secondary Metabolites of a Pseudoalteromonas sp. Isolated from
  • Sediments Collected at the Northeastern Coast of Brazil, Chemistry & Biodiversity, 9: 418–427. doi: 10.1002/cbdv.201100092
  • Ausubel, J., Crist, D.T., Waggoner, P.E., 2010. First Census of Marine Life : Highlights of a decade of discovery, Washington DC: Census of Marine Life, 68p.
  • Baker, D.D., Alvi, A.A., 2004. Small-molecule natural products: new structures, new activities, Current Opinion in Biotechnology,15: 576– p. doi: 10.1016/j.copbio.2004.09.003
  • Bérdy, J., 2005. Bioactive microbial metabolites, Journal of Antibiotics, 58: 1– p. doi: 10.1038/ja.2005.1
  • Bernan, V.S., Greenstein, M., Maise, W.M., 1997. Marine microorganisms as a source of new natural products, Advences in Applied Microbiology, 43: –89p. doi: 10.1016/S0065-2164(08)70223-5
  • Blunt, J.W., Copp, B.R., Munro, M.H.G., Northcote, P.T., Prinsep, M.R., Marine natural products, Natural Product Reports, 27:165–237p. doi: 10.1039/B906091J
  • Blunt, J.W., Copp, B.R., Keyzers, R.A., Munro, M.H.G., Prinsep, M.R., 2012.
  • Marine natural products, Natural Product Reports, 29:144–222p. doi: 10.1039/C2NP00090C
  • Bugni, T.S., Ireland, C.M., 2004. Marine-derived fungi: a chemically and biologically diverse group of microorganisms, Natural Products Reports, : 143–163p. doi:10.1039/b301926h
  • Burgess, J.G., 2012. New and emerging analytical techniques for marine biotechnology, Current Opinion in Biotechnology, 23: 29–33 doi: 10.1039/B301926H
  • Cabrita, M.T., Vale, C., Rauter, A.P., 2010. Halogenated Compounds from
  • Marine Algae, Marine Drugs, 8: 2301-2317p. doi: 10.3390/md8082301
  • Chu, D.T., Plattner, J.J., Katz, L., 1996. New directions in antibacterial research, Journal of Medicinal Chemistry, 39, 3853–3874p. doi: 10.1021/jm960294s
  • Clark, A.M., 1996. Natural products as a resource for new drugs,
  • Pharmaceutical Research, 8, 1133-1144p. doi: 10.1023/A:1016091631721
  • Colegate, S.M., Molyneux, R.J., 2008. An Introduction and Overview,
  • Bioactıve Natural Products Detection, Isolation, and Structural Determination, Taylor & Francis Group, p. 1-9. Cragg, G.M., Newman, D.J., Snader,K.M., 1997. Natural products in drug discovery and development, Journal of Natural Products, 60: 52–60p. doi: 10.1021/np9604893
  • Cragg, G.M., Grothaus, P.G., Newman, D.J., 2009. Impact of Natural
  • Products on Developing New Anti-Cancer Agents, Chemical Reviews, : 3012-3043p. doi: 10.1021/cr900019j
  • Cragg, G.M., Newman, D.J., 2013. Natural products: A continuing source of novel drug leads, Biochimica et Biophysica Acta (BBA), 1830: 3670–3695. doi: 10.1016/j.bbagen.2013.02.008
  • DaSilva, E., Iaccarino, M., 1999. Emerging diseases: a global threat, Biotechnology doi: 10.1016/S0734-9750(99)00024-5 : –384p.
  • DeLong, E.F., 2007. Modern microbial seascapes. Forward Nature Reviews
  • Microbiology, 5: 755–757p. doi: 10.1038/nrmicro1762
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Toplam 111 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Ferhat Can Özkaya

Cem Erdoğan

Muhammet Altunok

Yayımlanma Tarihi 1 Haziran 2013
Gönderilme Tarihi 7 Aralık 2015
Yayımlandığı Sayı Yıl 2013Cilt: 30 Sayı: 2

Kaynak Göster

APA Özkaya, F. C. ., Erdoğan, C. ., & Altunok, M. . (2013). Denizel biyoaktif bileşikler. Ege Journal of Fisheries and Aquatic Sciences, 30(2), 85-92.