Denizel biyoaktif bileşikler.

Ferhat Can Özkaya; Cem Erdoğan; Muhammet Altunok

EN TR

Marine bioactive compounds.

Abstract

Keywords

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Denizel biyoaktif bileşikler.

Öz

Yüzlerce yıl boyunca yeni ilaçların temelini doğal ürünler ve bunlardan elde edilmiş bileşikler oluşturmuştur. Sekonder metabolitler olarak adlandırılan bu bileşikler doğada organizmalar tarafından düşmanlarından korunma amacıyla üretilmektedir. Son yıllarda benzer metabolitlerin izole edilmesi ve ayrıca sentetik üretimin yüksek tarama olanakları sunmasının da etkisiyle doğal ürünlere yönelik ilaç araştırmaları oldukça azalmıştır. Bununla birlikte çeşitli patojenlerin hastanelerde ve toplumda dirençli suşlar geliştirmesi giderek daha yaygınlaşmaktadır. Yeni hastalıklar yeni ilaçların keşfini zorunlu hale getirirken, bütün bunlarla mücadele için gerekli olan yeni antimikrobiyallerin geliştirilmesinde ilerleme yavaş olmaktadır. Bu nedenle özellikle sağlık alanındaki bu ve benzeri problemler cytarabine (Ara-c), vidarabine (Vira-A1) ve salinosporamide A gibi yeni küçük molekül yapılı bileşiklerinin keşfinde öncelik olması gerektiğini göstermektedir. Yeni teknolojiler henüz araştırılmamış biyolojik kaynakların doğal ilaç keşiflerinde kullanılmasını sağlayan oldukça etkili akıllı tarama yöntemleri sunmaktadır. Özellikle hızlı genetik sekanslama ile birlikte biyosentetik yolakların manipulasyonundaki ilerlemeler yeni ilaçların keşfi için büyük bir kaynak sunabilecek potansiyele sahiptir. Teknolojideki bu ilerlemeler yeni ilaç keşfine ve doğal ürünlere olan ilginin tekrar artmasını da sağlamıştır. Bu derlemede, yeni bileşikler için son derece zengin bir kaynak sunarken aynı zamanda tedavi edici potansiyeli olabilecek denizel kimyasal çeşitliliği bir araya getiren denizel metabolitler üzerinde durulmuştur

Anahtar Kelimeler

Doğal ürünler, biyoaktif sekonder metabolitler, denizel çevreler, denizel canlılar

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

Ferhat Can Özkaya

Cem Erdoğan

Muhammet Altunok

Yayımlanma Tarihi

1 Haziran 2013

Gönderilme Tarihi

7 Aralık 2015

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 1970 Cilt: 30 Sayı: 2

IZ

https://izlik.org/JA87BZ29XL

Kaynak Göster

RIS / Bibtex

APA

Özkaya, F. C., Erdoğan, C., & Altunok, M. (2013). Denizel biyoaktif bileşikler. Ege Journal of Fisheries and Aquatic Sciences, 30(2), 85-92. https://izlik.org/JA87BZ29XL