Denizel biyoaktif bileşikler.

Ferhat Can Özkaya; Cem Erdoğan; Muhammet Altunok

EN TR

Denizel biyoaktif bileşikler.

Abstract

Yüzlerce yıl boyunca yeni ilaçların temelini doğal ürünler ve bunlardan elde edilmiş bileşikler oluşturmuştur. Sekonder metabolitler olarak adlandırılan bu bileşikler doğada organizmalar tarafından düşmanlarından korunma amacıyla üretilmektedir. Son yıllarda benzer metabolitlerin izole edilmesi ve ayrıca sentetik üretimin yüksek tarama olanakları sunmasının da etkisiyle doğal ürünlere yönelik ilaç araştırmaları oldukça azalmıştır. Bununla birlikte çeşitli patojenlerin hastanelerde ve toplumda dirençli suşlar geliştirmesi giderek daha yaygınlaşmaktadır. Yeni hastalıklar yeni ilaçların keşfini zorunlu hale getirirken, bütün bunlarla mücadele için gerekli olan yeni antimikrobiyallerin geliştirilmesinde ilerleme yavaş olmaktadır. Bu nedenle özellikle sağlık alanındaki bu ve benzeri problemler cytarabine (Ara-c), vidarabine (Vira-A1) ve salinosporamide A gibi yeni küçük molekül yapılı bileşiklerinin keşfinde öncelik olması gerektiğini göstermektedir. Yeni teknolojiler henüz araştırılmamış biyolojik kaynakların doğal ilaç keşiflerinde kullanılmasını sağlayan oldukça etkili akıllı tarama yöntemleri sunmaktadır. Özellikle hızlı genetik sekanslama ile birlikte biyosentetik yolakların manipulasyonundaki ilerlemeler yeni ilaçların keşfi için büyük bir kaynak sunabilecek potansiyele sahiptir. Teknolojideki bu ilerlemeler yeni ilaç keşfine ve doğal ürünlere olan ilginin tekrar artmasını da sağlamıştır. Bu derlemede, yeni bileşikler için son derece zengin bir kaynak sunarken aynı zamanda tedavi edici potansiyeli olabilecek denizel kimyasal çeşitliliği bir araya getiren denizel metabolitler üzerinde durulmuştur

Keywords

Doğal ürünler, biyoaktif sekonder metabolitler, denizel çevreler, denizel canlılar

References

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Ferhat Can Özkaya

Cem Erdoğan

Muhammet Altunok

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June 1, 2013

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December 7, 2015

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Year 2013 Volume: 30 Number: 2

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APA

Özkaya, F. C., Erdoğan, C., & Altunok, M. (2013). Denizel biyoaktif bileşikler. Ege Journal of Fisheries and Aquatic Sciences, 30(2), 85-92. https://izlik.org/JA87BZ29XL

AMA

1.Özkaya FC, Erdoğan C, Altunok M. Denizel biyoaktif bileşikler. EgeJFAS. 2013;30(2):85-92. https://izlik.org/JA87BZ29XL

Chicago

Özkaya, Ferhat Can, Cem Erdoğan, and Muhammet Altunok. 2013. “Denizel Biyoaktif Bileşikler”. Ege Journal of Fisheries and Aquatic Sciences 30 (2): 85-92. https://izlik.org/JA87BZ29XL.

EndNote

Özkaya FC, Erdoğan C, Altunok M (June 1, 2013) Denizel biyoaktif bileşikler. Ege Journal of Fisheries and Aquatic Sciences 30 2 85–92.

IEEE

[1]F. C. Özkaya, C. Erdoğan, and M. Altunok, “Denizel biyoaktif bileşikler”., EgeJFAS, vol. 30, no. 2, pp. 85–92, June 2013, [Online]. Available: https://izlik.org/JA87BZ29XL

ISNAD

Özkaya, Ferhat Can - Erdoğan, Cem - Altunok, Muhammet. “Denizel Biyoaktif Bileşikler”. Ege Journal of Fisheries and Aquatic Sciences 30/2 (June 1, 2013): 85-92. https://izlik.org/JA87BZ29XL.

JAMA

1.Özkaya FC, Erdoğan C, Altunok M. Denizel biyoaktif bileşikler. EgeJFAS. 2013;30:85–92.

MLA

Özkaya, Ferhat Can, et al. “Denizel Biyoaktif Bileşikler”. Ege Journal of Fisheries and Aquatic Sciences, vol. 30, no. 2, June 2013, pp. 85-92, https://izlik.org/JA87BZ29XL.

Vancouver

1.Ferhat Can Özkaya, Cem Erdoğan, Muhammet Altunok. Denizel biyoaktif bileşikler. EgeJFAS [Internet]. 2013 Jun. 1;30(2):85-92. Available from: https://izlik.org/JA87BZ29XL

Marine bioactive compounds.

Abstract

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Denizel biyoaktif bileşikler.

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