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Trends in a natural product fucoxanthin

Yıl 2021, Cilt: 38 Sayı: 1, 117 - 124, 15.03.2021

Bahar Aslanbay , Esra İmamoğlu

https://doi.org/10.12714/egejfas.38.1.15

Öz


Fucoxanthin is a xanthophyll pigment which occurs in marine brown seaweeds (macroalgae), diatoms and several microalgae species. It forms with chlorophyll a-c and several proteins, a major fucoxanthin-chlorophyll a/c complex, which transfers light energy to the photosynthesis center and plays a major role in light harvesting. Recent studies have reported that fucoxanthin has many physiological functions and biological effects, such as anti-obesity, antidiabetic, anti-inflammatory, anticancer and cardiovascular system protection. Therefore, this pigment is highly preferred for the prevention and treatment of various chronic diseases. In addition, potential applications of high value fucoxanthin can be found in cosmetic, food and feed industries. In this review paper, the historical development, characteristic properties and possible sources of fucoxanthin are extensively described. The potential biological activities of fucoxanthin are also discussed. Finally, brief overview of common applications and market analysis of commercial fucoxanthin are also reported.

Anahtar Kelimeler

Fucoxanthin Xanthophyll Carotenoid Algal biotechnology Natural product

Proje Numarası

115M014

Kaynakça

  • Abu-Ghannam, N. & Shannon, E. (2017). Seaweed Carotenoid, Fucoxanthin, as Functional Food, in V. K. Gupta, H. Treichel, V. Shapaval, L. Antonio de Oliveira and M. G. Tuohy (Eds.), Microbial Functional Foods and Nutraceuticals, John Wiley & Sons, Ltd, Chichester, UK.
  • Airanthi, M.K.W., Hosokawa, M. & Miyashita, K. (2011). Comparative antioxidant activity of edible japanese brown seaweeds. Journal of Food Science, 76(1), 104-111. DOI: 10.1111/j.1750-3841.2010.01915.x
  • Buschmann, A.H., Camus, C., Infante, J., Neori, A., Israel, A., Hernández-González, M.C., Pereda, S.V., Gomez-Pinchetti, J.L., Golberg, A., Tadmor-Shalev, N. & Critchley, A.T. (2017). Seaweed production: overview of the global state of exploitation, farming and emerging research activity. European Journal of Phycology, 52(4): 391-406. DOI: 10.1080/09670262.2017.1365175
  • Conceição, D., Lopes, R.G., Derner, R.B., Cella, H., Barbosa do Carmo, A.P., D’Oca, M.G.M., Petersen, R., Passos, M.F., Vargas, V.J.C., Galli-Terasawa, L.V. & Kava, V. (2020). The effect of light intensity on the production and accumulation of pigments and fatty acids in Phaeodactylum tricornutum. Journal of Applied Phycology, 1-9 p. DOI: 10.1007/s10811-019-02001-6
  • Crupi, P., Toci, A.T., Mangini, S., Wrubl, F., Rodolfi, L., Tredici, M.R., Coletta, A. & Antonacci, D. (2013). Determination of fucoxanthin isomers in microalgae (Isochrysis sp.) by high-performance liquid chromatography coupled with diode-array detector multistage mass spectrometry coupled with positive electrospray ionization, Rapid Communications in Mass Spectrometry, 27(9), 1027-1035. DOI: 10.1002/rcm.6531
  • D’Orazio, N., Gemello, E., Gammone, M.A., Girolamo, M., Ficoneri, C. & Riccioni, G. (2012). Fucoxantin: A treasure from the sea. Marine Drugs, 10, 604-616. DOI: 10.3390/md10030604
  • Demirel, Z., Tok, R., İlter, I., Akyıl, S., Erdoğan, A., Koç, M., Kaymak Ertekin, F. & Conk Dalay, M. (2018). Biyokütle için mikroalg ve siyanobakteri’nin büyük ölçekli üretimi. Aquatic Research, 1(2): 64-76. DOI: 10.3153/AR18008
  • Dittami, S.M., Michel, G., Collen, J., Boyen, C. & Tonon, T. (2010). Chlorophyll-binding proteins revisited - a multigenic family of light-harvesting and stress proteins from a brown algal perspective. BMC Evolutionary Biology, 10: 365. DOI: 10.1186/1471-2148-10-365
  • Englert, G., Bjornland, T. & Liaaen-Jensen, S. (1990). 1D and 2D NMR study of some allenic carotenoids of the fucoxanthin series. Magnetic Resonance in Chemistry, 28: 519-528.
  • Gammone, M.A. & D’Orazio, N. (2015). Anti-obesity activity of the marine carotenoid fucoxanthin. Marine Drugs, 13, 2196-2214. DOI: 10.3390/md13042196
  • Gammone, M.A., Riccioni, G. & D’Orazio, N. (2015). Marine carotenoids against oxidative stress: Effects on human health. Marine Drugs, 13, 6226-6246. DOI: 10.3390/md13106226
  • Garama, D., Bremer, P. & Carne, A. (2012). Extraction and analysis of carotenoids from the New Zealand sea urchin Evechinus chloroticus gonads. Acta Biochimica Polonica, 59(1): 83-85.
  • Heo, S.J., Yoon, W.J., Kim, K.N., Ahn, G.N., Kang, S.M., Kang, D.H., Affan, A., Oh, C., Jung, W.K. & Jeon, Y.J. (2010) Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages. Food and Chemical Toxicology, 48: 2045–2051. DOI: 10.1016/j.fct.2010.05.003
  • Irvani, N., Hajiaghaee, R. & Zarekarizi, A.R. (2018). A review on biosynthesis, health benefits and extraction methods of fucoxanthin, particular marine carotenoids in algae. Journal of Medicinal Plants, 17(67).
  • Jaswir, I., Noviendri, D., Salleh, H.M., Taher, M., Miyashita, K. & Ramli, N. (2012). Analysis of fucoxanthin content and purification of all-trans-fucoxanthin from Turbinaria turbinata and Sargassum plagyophyllum by SiO2 open column chromatography and reversed phase-HPLC. Journal of Liqiud Chromatography & Related Technology, 36: 1340–1354. DOI: 10.1080/10826076.2012.691435
  • Joel, J. (2016). Global fucoxanthin market 2016 industry trends, sales, supply, demand, analysis and forecast to 2021, Analysis and Forecast. New York.
  • Joshi, S., Kumari, R. & Upasani, V.N. (2018). Applications of algae in cosmetics: An overview, International Journal of Innovvative Research in Science, Engineering and Technology, 7(2), 1269-1278. DOI: 10.15680/IJIRSET.2018.0702038
  • Kang, S.I., Shin, H.S., Kim, H.M., Yoon, S.A., Kang, S.W., Kim, J.H., Ko, H.C. & Kim SJ. (2012). Petalonia binghamiae extract and its constituent fucoxanthin ameliorate high-fat diet-induced obesity by activating AMP-activated protein kinase. Journal of Agricultural Food and Chemistry, 60: 3389−3395. DOI: 10.1021/jf2047652
  • Kim, S.M., Jung, Y.J., Kwon, O.H., Cha, K.H., Um, B.H., Chung, D. & Pan, C.H. (2012). A potential commercial source of fucoxanthin extracted from the microalga Phaeodactylum tricornutum. Applied Biochemistry and Biotechnology, 166: 1843–1855. DOI: 10.1007/s12010-012-9602-2
  • Kumar, S.R., Hosokawa, M. & Miyashita, K. (2013). Fucoxanthin: A marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms. Marine Drugs, 11(12): 5130-5147. DOI: 10.3390/md11125130
  • Lu, X., Liu, B., He, Y., Guo, B., Sun, H. & Chen, F. (2019). Novel insights into mixotrophic cultivation of Nitzschia laevis for co-production of fucoxanthin and eicosapentaenoic acid. Bioresource Technology, 294, 122145. DOI: 10.1016/j.biortech.2019.122145
  • Maeda, H. (2015). Nutraceutical effects of fucoxanthin for obesity and diabetes therapy: A review, Journal of Oleo Sciences, 64(2), 125-132. DOI: 10.5650/jos.ess14226
  • Martin, L.J. (2015). Fucoxanthin and its metabolite fucoxanthinol in cancer prevention and treatment. Marine Drugs, 13(8): 4784-4798. DOI: 10.3390/md13084784
  • Matos, J., Cardoso, C., Gomes, A., Campos, A.M., Fale, P., Afonso, C. & Bandarra, N.M. (2019). Bioprospection of Isochrysis galbana and its potential as a nutraceutical. Food & Function, 10, 7333. DOI: 10.1039/c9fo01364d
  • Mise, T., Ueda, M. & Yasumoto, T. (2011) Production of fucoxanthin-rich powder from Cladosiphon okamuranus. Advance Journal of Food Science and Technology, 3(1): 73-76.
  • Mohamadnia, S., Tavakoli, O., Faramrzi M.A. & Shamsollahi, Z. (2020). Production of fucoxanthin by the microalga Tisochrysis lutea: A review of recent developments. Aquaculture, 516, 734637. DOI: 10.1016/j.aquaculture.2019.734637
  • Nahar, M., Hasan, W., Rajak, R. & Jat, D. (2017). Oxidative Stress And Antioxidants: An Overview, International Journal of Advanced Research and Review, 2(9), 110-119.
  • Oryza Oil & Fat Chemical Co., Ltd. (2008). Fucoxanthin dietary ingredient for prevention of metabolic syndrome, antioxidation and cosmetics, Product Cataloug. Alıntılanma adresi: http://www.oryza.co.jp/pdf/english/Fucoxanthin_1.0.pdf (02.12.2019)
  • Páduaa, D., Rochaa, E., Gargiuloa, D. & Ramosa, A.A. (2015). Bioactive compounds from brown seaweeds: Phloroglucinol, fucoxanthin and fucoidan as promising therapeutic agents against breast cancer. Phytochemistry Letters, 14, 91–98. DOI: 10.1016/j.phytol.2015.09.007
  • Peng, J., Yuan, J.P., Wu, C.F. & Wang, J.H. (2011). Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: Metabolism and bioactivities relevant to human health. Marine Drugs, 9(10): 1806-1828. DOI: 10.3390/md9101806
  • Perez-Lopez, P., Balboa, E.M., Gonzalez-Garcia, S., Dominguez, H., Feijoo, G. & Moreira, T. (2014). Comparative environmental assessment of valorization strategies of the invasive macroalgae Sargassum muticum. Bioresource Technology, 161, 137–148. DOI: 10.1016/j.biortech.2014.03.013
  • Prabhasankar, P., Bhaskar, N., Hirose, A., Stephen, N., Growda, L.R., Hosokawa, M. & Miyashita, K. (2009). Edible Japanese seaweed, wakame (Undaria pinnatifida) as an ingredient in pasta: Chemical, functional and structural evaluation. Food Chemistry, 115, 501–508 p. DOI: 10.1016/j.foodchem.2008.12.047
  • Quitain, A.T., Kai, T., Sasaki, M. & Goto, M. (2013). Supercritical Carbon dioxide extraction of fucoxanthin from Undaria pinnatifida. Journal of Agricultural Food and Chemistry, 61, 5792−5797. DOI: 10.1021/jf400740p
  • Rajauria, G., Foley, B. & Abu-Ghannama, N. (2017). Characterization of dietary fucoxanthin from Himanthalia elongata brown seaweed. Food Research International, 99(3): 995-1001. DOI: 10.1016/j.foodres.2016.09.023
  • Raposo, M.F.J., Morais, A.M.M.B. & Morais, R.M.S.C. (2015). Carotenoids from marine microalgae: A valuable natural source for the prevention of chronic diseases. Marine Drugs, 13, 5128-5155. DOI: 10.3390/md13085128
  • Sahin, M.S., Khazi, M.I., Demirel, Z. & Conk Dalay, M. (2019). Variation in growth, fucoxanthin, fatty acids profile and lipid content of marine diatoms Nitzschia sp. and Nanofrustulum shiloi in response to nitrogen and iron. Biocatalysis and Agricultural Biotechnology, 19, 390-398. DOI: 10.1016/j.bcab.2018.12.023
  • Sakai, S., Sugawara, T. & Hirata, T. (2011). Inhibitory effect of dietary carotenoids on dinitrofluorobenzene-induced contact hypersensitivity in mice. Bioscience, Biotechnology and Biochemistry, 75, 1013 – 1015. DOI: 10.1271/bbb.110104
  • Sangeetha, R.K., Bhaskar, N., Divakar, S. & Baskaran, V. (2010). Bioavailability and metabolism of fucoxanthin in rats: structural characterization of metabolites by LC-MS (APCI). Molecular and Cellular Biochemistry, 333: 299–310. DOI: 10.1007/s11010-009-0231-1
  • Susanto, E., Fahmi, A.S., Abeb, M., Hosokawa, M. & Miyashita, K. (2016). Lipids, fatty acids, and fucoxanthin content from temperate and tropical brown seaweeds. Aquatic Procedia, 7, 66 – 75. DOI: 10.1016/j.aqpro.2016.07.009
  • Takahashi, K., Hosokawa, M., Kasajima, H., Hatanaka, K., Kudo, K., Shimoyama, N. & Miyashita, K. (2015). Anticancer effects of fucoxanthin and fucoxanthinol on colorectal cancer cell lines and colorectal cancer tissues. Oncology Letters, 10, 1463-1467. DOI: 10.3892/ol.2015.3380
  • Urikura, I., Sugawara, T. & Hirata, T. (2011). Protective effect of fucoxanthin against UVB induced skin photoaging in hairless mice. Bioscience, Biotechnology and Biochemistry, 75(4), 757-760. DOI: 10.1271/bbb.110040
  • Wang, H., Zhang, Y., Chen, L., Cheng, W. & Liu, T. (2018). Combined production of fucoxanthin and EPA from two diatom strains Phaeodactylum tricornutum and Cylindrotheca fusiformis cultures. Bioprocess and Biosystem Engineering, 41: 1061. DOI: 10.1007/s00449-018-1935-y
  • Xia, S., Wang, K., Wan, L., Li, A., Hu, Q. & Zhang, C. (2013). Production, Characterization, and Antioxidant Activity of Fucoxanthin from the Marine Diatom Odontella aurita. Marine Drugs, 11, 2667-2681. DOI: 10.3390/md11072667
  • Zarekarizi, A., Hoffmann, L. & Burritt, D. (2019). Approaches for the sustainable production of fucoxanthin, a xanthophyll with potential health benefits. Journal of Applied Phycology, 31(1), 281-299. DOI: https://doi.org/10.1007/s10811-018-1558-3
  • Zhang, H., Tang, Y., Zhang, Y., Zhang, S., Qu, J., Wang, X., Kong, R., Han, C. & Liu, Z. (2015). Fucoxanthin: A promising medicinal and nutritional ingredient. Evidence-Based Complementary Alternative Medicine, 2015, 723515. DOI: 10.1155/2015/723515
  • Zhao, D., Kim, S., Pan, C. & Chung, D. (2014). Effects of heating, aerial exposure and illumination on stability of fucoxanthin in canola oil. Food Chemistry, 145, 505–513. DOI: 10.1016/j.foodchem.2013.08.045

Doğal ürün fukoksantin trendleri

Yıl 2021, Cilt: 38 Sayı: 1, 117 - 124, 15.03.2021

Bahar Aslanbay , Esra İmamoğlu

https://doi.org/10.12714/egejfas.38.1.15

Öz


Fukoksantin, ksantofil grubuna ait karotenoidlerden biri olup yaygın olarak kahverengi deniz yosunlarında (makroalgler), diatomlarda ve birkaç mikroalg türünde bulunmaktadır. Fukoksantin pigmenti, alglerde klorofil ve protein ile birlikte kompleks bir yapı oluşturarak ışığın toplanmasında ve fotosentez merkezine gönderilmesinde önemli bir rol almaktadır. Son yıllarda yapılan araştırmalar sonucunda fukoksantinin hayvanlar üzerinde antiobezite, antidiyabet, antienflamatuvar, antikanser ve kardiyovasküler sistemi koruma gibi olumlu etkilere sahip olduğu görülmüştür. Bu nedenle kronik hastalıkların önlenmesinde ve tedavisinde fukoksantinin etken madde olarak kullanımına dair çalışmalar sürdürülmektedir. Ayrıca kozmetik, gıda ve yem sektörlerinde de fukoksantin bileşiğinin kullanım potansiyeli değerlendirilmektedir. Bu makalede fukoksantin karotenoidinin genel özelliklerinden, tarihsel gelişiminden ve mevcut kaynaklarından bahsedilmiş, hayvanlar üzerindeki potansiyel biyolojik aktiviteleri incelenmiş ve kullanım alanları ile birlikte piyasadaki durumu ortaya konmuştur.

Anahtar Kelimeler

Fukoksantin Ksantofil Karotenoid Algal biyoteknoloji Doğal ürün

Destekleyen Kurum

TUBİTAK

Proje Numarası

115M014

Teşekkür

Bu çalışma, ES1408 COST aksiyonu kapsamında olup Türkiye Bilimsel ve Teknolojik Araştırma Kurumu (TUBİTAK) 115M014 proje kapsamında finansal olarak desteklenmiştir.

Kaynakça

  • Abu-Ghannam, N. & Shannon, E. (2017). Seaweed Carotenoid, Fucoxanthin, as Functional Food, in V. K. Gupta, H. Treichel, V. Shapaval, L. Antonio de Oliveira and M. G. Tuohy (Eds.), Microbial Functional Foods and Nutraceuticals, John Wiley & Sons, Ltd, Chichester, UK.
  • Airanthi, M.K.W., Hosokawa, M. & Miyashita, K. (2011). Comparative antioxidant activity of edible japanese brown seaweeds. Journal of Food Science, 76(1), 104-111. DOI: 10.1111/j.1750-3841.2010.01915.x
  • Buschmann, A.H., Camus, C., Infante, J., Neori, A., Israel, A., Hernández-González, M.C., Pereda, S.V., Gomez-Pinchetti, J.L., Golberg, A., Tadmor-Shalev, N. & Critchley, A.T. (2017). Seaweed production: overview of the global state of exploitation, farming and emerging research activity. European Journal of Phycology, 52(4): 391-406. DOI: 10.1080/09670262.2017.1365175
  • Conceição, D., Lopes, R.G., Derner, R.B., Cella, H., Barbosa do Carmo, A.P., D’Oca, M.G.M., Petersen, R., Passos, M.F., Vargas, V.J.C., Galli-Terasawa, L.V. & Kava, V. (2020). The effect of light intensity on the production and accumulation of pigments and fatty acids in Phaeodactylum tricornutum. Journal of Applied Phycology, 1-9 p. DOI: 10.1007/s10811-019-02001-6
  • Crupi, P., Toci, A.T., Mangini, S., Wrubl, F., Rodolfi, L., Tredici, M.R., Coletta, A. & Antonacci, D. (2013). Determination of fucoxanthin isomers in microalgae (Isochrysis sp.) by high-performance liquid chromatography coupled with diode-array detector multistage mass spectrometry coupled with positive electrospray ionization, Rapid Communications in Mass Spectrometry, 27(9), 1027-1035. DOI: 10.1002/rcm.6531
  • D’Orazio, N., Gemello, E., Gammone, M.A., Girolamo, M., Ficoneri, C. & Riccioni, G. (2012). Fucoxantin: A treasure from the sea. Marine Drugs, 10, 604-616. DOI: 10.3390/md10030604
  • Demirel, Z., Tok, R., İlter, I., Akyıl, S., Erdoğan, A., Koç, M., Kaymak Ertekin, F. & Conk Dalay, M. (2018). Biyokütle için mikroalg ve siyanobakteri’nin büyük ölçekli üretimi. Aquatic Research, 1(2): 64-76. DOI: 10.3153/AR18008
  • Dittami, S.M., Michel, G., Collen, J., Boyen, C. & Tonon, T. (2010). Chlorophyll-binding proteins revisited - a multigenic family of light-harvesting and stress proteins from a brown algal perspective. BMC Evolutionary Biology, 10: 365. DOI: 10.1186/1471-2148-10-365
  • Englert, G., Bjornland, T. & Liaaen-Jensen, S. (1990). 1D and 2D NMR study of some allenic carotenoids of the fucoxanthin series. Magnetic Resonance in Chemistry, 28: 519-528.
  • Gammone, M.A. & D’Orazio, N. (2015). Anti-obesity activity of the marine carotenoid fucoxanthin. Marine Drugs, 13, 2196-2214. DOI: 10.3390/md13042196
  • Gammone, M.A., Riccioni, G. & D’Orazio, N. (2015). Marine carotenoids against oxidative stress: Effects on human health. Marine Drugs, 13, 6226-6246. DOI: 10.3390/md13106226
  • Garama, D., Bremer, P. & Carne, A. (2012). Extraction and analysis of carotenoids from the New Zealand sea urchin Evechinus chloroticus gonads. Acta Biochimica Polonica, 59(1): 83-85.
  • Heo, S.J., Yoon, W.J., Kim, K.N., Ahn, G.N., Kang, S.M., Kang, D.H., Affan, A., Oh, C., Jung, W.K. & Jeon, Y.J. (2010) Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages. Food and Chemical Toxicology, 48: 2045–2051. DOI: 10.1016/j.fct.2010.05.003
  • Irvani, N., Hajiaghaee, R. & Zarekarizi, A.R. (2018). A review on biosynthesis, health benefits and extraction methods of fucoxanthin, particular marine carotenoids in algae. Journal of Medicinal Plants, 17(67).
  • Jaswir, I., Noviendri, D., Salleh, H.M., Taher, M., Miyashita, K. & Ramli, N. (2012). Analysis of fucoxanthin content and purification of all-trans-fucoxanthin from Turbinaria turbinata and Sargassum plagyophyllum by SiO2 open column chromatography and reversed phase-HPLC. Journal of Liqiud Chromatography & Related Technology, 36: 1340–1354. DOI: 10.1080/10826076.2012.691435
  • Joel, J. (2016). Global fucoxanthin market 2016 industry trends, sales, supply, demand, analysis and forecast to 2021, Analysis and Forecast. New York.
  • Joshi, S., Kumari, R. & Upasani, V.N. (2018). Applications of algae in cosmetics: An overview, International Journal of Innovvative Research in Science, Engineering and Technology, 7(2), 1269-1278. DOI: 10.15680/IJIRSET.2018.0702038
  • Kang, S.I., Shin, H.S., Kim, H.M., Yoon, S.A., Kang, S.W., Kim, J.H., Ko, H.C. & Kim SJ. (2012). Petalonia binghamiae extract and its constituent fucoxanthin ameliorate high-fat diet-induced obesity by activating AMP-activated protein kinase. Journal of Agricultural Food and Chemistry, 60: 3389−3395. DOI: 10.1021/jf2047652
  • Kim, S.M., Jung, Y.J., Kwon, O.H., Cha, K.H., Um, B.H., Chung, D. & Pan, C.H. (2012). A potential commercial source of fucoxanthin extracted from the microalga Phaeodactylum tricornutum. Applied Biochemistry and Biotechnology, 166: 1843–1855. DOI: 10.1007/s12010-012-9602-2
  • Kumar, S.R., Hosokawa, M. & Miyashita, K. (2013). Fucoxanthin: A marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms. Marine Drugs, 11(12): 5130-5147. DOI: 10.3390/md11125130
  • Lu, X., Liu, B., He, Y., Guo, B., Sun, H. & Chen, F. (2019). Novel insights into mixotrophic cultivation of Nitzschia laevis for co-production of fucoxanthin and eicosapentaenoic acid. Bioresource Technology, 294, 122145. DOI: 10.1016/j.biortech.2019.122145
  • Maeda, H. (2015). Nutraceutical effects of fucoxanthin for obesity and diabetes therapy: A review, Journal of Oleo Sciences, 64(2), 125-132. DOI: 10.5650/jos.ess14226
  • Martin, L.J. (2015). Fucoxanthin and its metabolite fucoxanthinol in cancer prevention and treatment. Marine Drugs, 13(8): 4784-4798. DOI: 10.3390/md13084784
  • Matos, J., Cardoso, C., Gomes, A., Campos, A.M., Fale, P., Afonso, C. & Bandarra, N.M. (2019). Bioprospection of Isochrysis galbana and its potential as a nutraceutical. Food & Function, 10, 7333. DOI: 10.1039/c9fo01364d
  • Mise, T., Ueda, M. & Yasumoto, T. (2011) Production of fucoxanthin-rich powder from Cladosiphon okamuranus. Advance Journal of Food Science and Technology, 3(1): 73-76.
  • Mohamadnia, S., Tavakoli, O., Faramrzi M.A. & Shamsollahi, Z. (2020). Production of fucoxanthin by the microalga Tisochrysis lutea: A review of recent developments. Aquaculture, 516, 734637. DOI: 10.1016/j.aquaculture.2019.734637
  • Nahar, M., Hasan, W., Rajak, R. & Jat, D. (2017). Oxidative Stress And Antioxidants: An Overview, International Journal of Advanced Research and Review, 2(9), 110-119.
  • Oryza Oil & Fat Chemical Co., Ltd. (2008). Fucoxanthin dietary ingredient for prevention of metabolic syndrome, antioxidation and cosmetics, Product Cataloug. Alıntılanma adresi: http://www.oryza.co.jp/pdf/english/Fucoxanthin_1.0.pdf (02.12.2019)
  • Páduaa, D., Rochaa, E., Gargiuloa, D. & Ramosa, A.A. (2015). Bioactive compounds from brown seaweeds: Phloroglucinol, fucoxanthin and fucoidan as promising therapeutic agents against breast cancer. Phytochemistry Letters, 14, 91–98. DOI: 10.1016/j.phytol.2015.09.007
  • Peng, J., Yuan, J.P., Wu, C.F. & Wang, J.H. (2011). Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: Metabolism and bioactivities relevant to human health. Marine Drugs, 9(10): 1806-1828. DOI: 10.3390/md9101806
  • Perez-Lopez, P., Balboa, E.M., Gonzalez-Garcia, S., Dominguez, H., Feijoo, G. & Moreira, T. (2014). Comparative environmental assessment of valorization strategies of the invasive macroalgae Sargassum muticum. Bioresource Technology, 161, 137–148. DOI: 10.1016/j.biortech.2014.03.013
  • Prabhasankar, P., Bhaskar, N., Hirose, A., Stephen, N., Growda, L.R., Hosokawa, M. & Miyashita, K. (2009). Edible Japanese seaweed, wakame (Undaria pinnatifida) as an ingredient in pasta: Chemical, functional and structural evaluation. Food Chemistry, 115, 501–508 p. DOI: 10.1016/j.foodchem.2008.12.047
  • Quitain, A.T., Kai, T., Sasaki, M. & Goto, M. (2013). Supercritical Carbon dioxide extraction of fucoxanthin from Undaria pinnatifida. Journal of Agricultural Food and Chemistry, 61, 5792−5797. DOI: 10.1021/jf400740p
  • Rajauria, G., Foley, B. & Abu-Ghannama, N. (2017). Characterization of dietary fucoxanthin from Himanthalia elongata brown seaweed. Food Research International, 99(3): 995-1001. DOI: 10.1016/j.foodres.2016.09.023
  • Raposo, M.F.J., Morais, A.M.M.B. & Morais, R.M.S.C. (2015). Carotenoids from marine microalgae: A valuable natural source for the prevention of chronic diseases. Marine Drugs, 13, 5128-5155. DOI: 10.3390/md13085128
  • Sahin, M.S., Khazi, M.I., Demirel, Z. & Conk Dalay, M. (2019). Variation in growth, fucoxanthin, fatty acids profile and lipid content of marine diatoms Nitzschia sp. and Nanofrustulum shiloi in response to nitrogen and iron. Biocatalysis and Agricultural Biotechnology, 19, 390-398. DOI: 10.1016/j.bcab.2018.12.023
  • Sakai, S., Sugawara, T. & Hirata, T. (2011). Inhibitory effect of dietary carotenoids on dinitrofluorobenzene-induced contact hypersensitivity in mice. Bioscience, Biotechnology and Biochemistry, 75, 1013 – 1015. DOI: 10.1271/bbb.110104
  • Sangeetha, R.K., Bhaskar, N., Divakar, S. & Baskaran, V. (2010). Bioavailability and metabolism of fucoxanthin in rats: structural characterization of metabolites by LC-MS (APCI). Molecular and Cellular Biochemistry, 333: 299–310. DOI: 10.1007/s11010-009-0231-1
  • Susanto, E., Fahmi, A.S., Abeb, M., Hosokawa, M. & Miyashita, K. (2016). Lipids, fatty acids, and fucoxanthin content from temperate and tropical brown seaweeds. Aquatic Procedia, 7, 66 – 75. DOI: 10.1016/j.aqpro.2016.07.009
  • Takahashi, K., Hosokawa, M., Kasajima, H., Hatanaka, K., Kudo, K., Shimoyama, N. & Miyashita, K. (2015). Anticancer effects of fucoxanthin and fucoxanthinol on colorectal cancer cell lines and colorectal cancer tissues. Oncology Letters, 10, 1463-1467. DOI: 10.3892/ol.2015.3380
  • Urikura, I., Sugawara, T. & Hirata, T. (2011). Protective effect of fucoxanthin against UVB induced skin photoaging in hairless mice. Bioscience, Biotechnology and Biochemistry, 75(4), 757-760. DOI: 10.1271/bbb.110040
  • Wang, H., Zhang, Y., Chen, L., Cheng, W. & Liu, T. (2018). Combined production of fucoxanthin and EPA from two diatom strains Phaeodactylum tricornutum and Cylindrotheca fusiformis cultures. Bioprocess and Biosystem Engineering, 41: 1061. DOI: 10.1007/s00449-018-1935-y
  • Xia, S., Wang, K., Wan, L., Li, A., Hu, Q. & Zhang, C. (2013). Production, Characterization, and Antioxidant Activity of Fucoxanthin from the Marine Diatom Odontella aurita. Marine Drugs, 11, 2667-2681. DOI: 10.3390/md11072667
  • Zarekarizi, A., Hoffmann, L. & Burritt, D. (2019). Approaches for the sustainable production of fucoxanthin, a xanthophyll with potential health benefits. Journal of Applied Phycology, 31(1), 281-299. DOI: https://doi.org/10.1007/s10811-018-1558-3
  • Zhang, H., Tang, Y., Zhang, Y., Zhang, S., Qu, J., Wang, X., Kong, R., Han, C. & Liu, Z. (2015). Fucoxanthin: A promising medicinal and nutritional ingredient. Evidence-Based Complementary Alternative Medicine, 2015, 723515. DOI: 10.1155/2015/723515
  • Zhao, D., Kim, S., Pan, C. & Chung, D. (2014). Effects of heating, aerial exposure and illumination on stability of fucoxanthin in canola oil. Food Chemistry, 145, 505–513. DOI: 10.1016/j.foodchem.2013.08.045
Toplam 46 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Yapısal Biyoloji , Kimya Mühendisliği
Bölüm Derleme
Yazarlar

Bahar Aslanbay

Esra İmamoğlu 0000-0001-8759-7388

Proje Numarası 115M014
Gönderilme Tarihi 18 Şubat 2020
Yayımlanma Tarihi 15 Mart 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 38 Sayı: 1

Kaynak Göster

APA Aslanbay, B., & İmamoğlu, E. (2021). Doğal ürün fukoksantin trendleri. Ege Journal of Fisheries and Aquatic Sciences, 38(1), 117-124. https://doi.org/10.12714/egejfas.38.1.15