Research Article
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Effect of pollution on enzymes playing role in ion homeostasis and osmoregulation of carps (Cyprinus carpio L.) in Atatürk Dam Lake

Year 2025, Volume: 42 Issue: 2, 183 - 190, 15.06.2025

Özge Fırat , Özge Temiz , Özgür Fırat

Abstract

The Atatürk Dam Lake has recently become the focus of toxicological research due to the fact that it is the largest dam in Türkiye (i); that it is affected by pollutants originating from the intensive activities in the residential areas around the dam (ii); that it contains aquatic products with high economic, commercial and nutritional value (iii); and that undesirable changes in water quality and/or fish have the potential to affect humans (iv). In the current work, changes in the Na+/K+-ATPase (EC 3.6.3.9), Ca2+-ATPase (EC 3.6.3.8) and Mg2+-ATPase (EC 3.6.3.2) activities in the tissues of carps (Cyprinus carpio) caught in Samsat (relatively clean area) and Sitilce (area affected by urban activities) in the Adıyaman province borders and Bozova (area affected by agricultural activities) in the Şanlıurfa province borders of the dam lake in september 2021 were determined. When the Samsat region was compared, significant decreases were observed in all ATPase enzyme activities examined in gill, liver, intestine and kidney tissues of fish from Sitilce and Bozova regions, while enzyme activities in muscle tissue did not show any significant change. Our study clearly demonstrated that the pollutants in the Atatürk Dam Lake have toxic effects on ion balance, ion homeostasis and osmoregulation mechanisms in fish and that ATPases can be used as useful biomarkers in determining pollution in aquatic ecosystems.

Keywords

Atatürk Dam Lake Cyprinus carpio fish ATPaz water pollution

Project Number

KMYOMAP/2021-0001

References

  • Abdallah, S.M., Muhammed, R.E., Mohamed, R.E., Daous, H.E., Saleh, D.M., Ghorab, M.A., Chen, S., & El-Sayyad, G.S. (2024). Assessment of biochemical biomarkers and environmental stress indicators in some freshwater fish. Environmental Geochemistry and Health, 46, 464. https://doi.org/10.1007/s10653-024-02226-6
  • Apiamu, A., Osawaru, S.U., Asagba, S.O., Evuen, U.F., & Achuba, F.I. (2022). Exposure of African catfish (Clarias gariepinus) to lead and zinc modulates membrane-bound transport protein: A plausible effect on Na+/K+-ATPase activity. Biological Trace Element Research, 200, 4160–4170. https://doi.org/10.1007/s12011-021-03005-5
  • Atkinson, A., Gatemby, A.O., & Lowe, A.G. (1973). The determination of inorganic ortophosphate in biological systems. Biochimica et Biophysica Acta, 320, 195-204. https://doi.org/10.1016/0304-4165(73)90178-5
  • Atlı, G., & Canlı, M. (2008). Characterization of branchial Na, K-ATPase from three freshwater fish species (Oreochromis niloticus, Cyprinus carpio, and Oncorhynchus mykiss). Turkish Journal of Zoology, 32, 299-304.
  • Balaji, G., Nachiyappan, M., & Venugopal, R. (2015). Sub-lethal effect of cypermethrin on Ca+, Mg+ and Na+/K+ - ATPase activity in fresh water teleost, Cyprinus carpio. World Journal of Zoology, 10(3), 168-174. https://doi.org/10.5829/idosi.wjz.2015.10.3.9581
  • Bayhan, Y.K. (2021). The fish fauna of the Atatürk Dam Lake (Adıyaman/Turkey). Natural and Engineering Sciences, 6, 237-255. https://doi.org/10.28978/nesciences.1036854
  • Dane, H., & Sisman, T. (2020). A morpho-histopathological study in the digestive tract of three fish species influenced with heavy metal pollution. Chemosphere, 242, 125212. https://doi.org/10.1016/j.chemosphere.2019.125212
  • Deenathayalan, U., Nandita, R., Kavithaa, K., Kavitha, V.S., Govindasamy, C., Al‑Numair, K.S., Alsaif, M.A., Cheon, Y.P., Arul, N., & Brindha, D. (2024). Evaluation of developmental toxicity and oxidative stress caused by zinc oxide nanoparticles in zebra fish embryos/larvae. Biotechnology and Applied Biochemistry, 196, 4954 4973. https://doi.org/10.1007/s12010-023-04791-5
  • de la Torre, F.R., Salibian, A., & Ferrari, L. (2007). Assessment of the pollution impact on biomarkers of effect of a freshwater fish. Chemosphere, 68, 1582 1590. https://doi:10.1016/j.chemosphere.2007.02.033
  • Dogan, Z., Eroglu, A., Kanak, E.G., Atli, G., & Canli, M. (2014). Response of antioxidant system of tilapia (Oreochromis niloticus) following exposure to chromium and copper in differing hardness. Bulletin of Environmental Contamination and Toxicology, 92, 680 686. https://doi.org/10.1007/s00128-014-1245-2
  • Fırat, O., & Alıcı, M.F. (2012). Assessment of pollution in Ataturk Dam Lake (Adıyaman, Turkey) using several biochemical parameters in common carp, Cyprinus carpio. Bulletin of Environmental Contamination and Toxicology, 89, 474-478. https://doi.org/10.1007/s00128-012-0728-2
  • Fırat, Ö., & Kaya, Ö. (2019). Evaluation of protective role of selenium on mercury toxicity by superoxide dismutase, catalase and malondialdehyde parameters in Oreochromis niloticus (Linnaeus, 1758). Ege Journal of Fisheries and Aquatic Sciences, 36(3), 245-253. https://doi.org/10.12714/egejfas.2019.36.3.05
  • Fırat, Ö., & Kılınç, Ü. (2022). Assessment of lead, cadmium, chrome, iron, zinc and copper levels in tissues of Cyprinus carpio from Atatürk Dam Lake (Adıyaman). Commagene Journal of Biology, 6(1), 20-25. https://doi.org/10.31594/commagene.1079557
  • Firat, O. (2016). Evaluation of metal concentrations in fish species from Ataturk Dam Lake (Adiyaman, Turkey) in relation to human health. Fresenius Environmental Bulletin, 25, 3629-3634.
  • Firidin, G. (2018). Oxidative stress parameters, induction of lipid peroxidation, and ATPase activity in the liver and kidney of Oreochromis niloticus exposed to lead and mixtures of lead and zinc. Bulletin of Environmental Contamination and Toxicology, 100, 477 484. https://doi.org/10.1007/s00128-018-2281-0
  • Gupta, P., Mahapatra, A., Suman, A., & Singh, R.K. (2023). In silico and in vivo assessment of developmental toxicity, oxidative stress response and Na+/K+-ATPase activity in zebrafish embryos exposed to cypermethrin. Ecotoxicology and Environmental Safety, 251, 114547. https://doi.org/10.1016/j.ecoenv.2023.114547
  • Gündoğdu, S. (2023). Microplastic intake of Unio mancus Lamarck 1819 collected from Ataturk Dam Lake, Türkiye. Turkish Journal of Zoology, 47(5), 268-278. https://doi.org/10.55730/1300-0179.3140
  • Hegazi, M.M., Mostafa, A.H., Assem, E.H., Mourad, H.M., & Hasanein, S.S. (2015). The effect of seasonal metals pollution in two Hotspots (El-Mex, Abu-Qir) Bays on ATPases in gills of Siganus rivulatus. International Journal of Environmental Monitoring and Analysis, 3, 51-58. https://doi: 10.11648/j.ijema.s.2015030501.17
  • Ji, P., Liu, G., Xu, J., Wang, X., Li, J., Zhao, Z., Zhang, X., Zhang, Y., Xu, P., & Sun, X. (2012). Characterization of common carp transcriptome: Sequencing, De Novo assembly, annotation and comparative genomics. PLoS One, 7(4), 35152. https://doi.org/10.1371/journal.pone.0035152
  • Karadag, H., Fırat, Ö., & Fırat, Ö. (2014). Use of oxidative stress biomarkers in Cyprinus carpio L. for the evaluation of water pollution in Ataturk Dam Lake (Adiyaman, Turkey). Bulletin of Environmental Contamination and Toxicology, 92, 289-293. https://doi.org/10.1007/s00128-013-1187-0
  • Khoshnood, Z. (2024). A review on toxic effects of pesticides in zebrafish, Danio rerio and common carp, Cyprinus carpio, emphasising atrazine herbicide. Toxicology Reports, 13, 101694. https://doi.org/10.1016/j.toxrep.2024.101694
  • Langeswaran, K., Jagadeesan, A.J., & Balasubramanian, M.P. (2012). Modulation of membrane bound ATPases and metabolizing enzymes against n-nitosodiethylamine (DEN) induced primary liver cancer in wistar albino rats. International Journal of Pharma and Bio Sciences, 3(2), 156–165.
  • Lopez-Lopez, E., Sedeno-Díaz, J.E., Soto, C., & Favari, L. (2011). Responses of antioxidant enzymes, lipid peroxidation, and Na+/K+-ATPase in liver of the fish Goodea atripinnis exposed to Lake Yuriria water. Fish Physiology and Biochemistry, 37, 511–522. https://doi.org/10.1007/s10695-010-9453-0
  • Lowry, O.H., Rosebrough, N.J., Farr, A.L., & Randall, R.J. (1951). Protein measurements with the folin phenol reagent. Journal of Biological Chemistry, 193, 265-275. https://doi.org/10.1016/S0021-9258(19)52451-6
  • Metz, J.R., van den Burg, E.H., Wendelaar Bonga, S.E., & Flik, G. (2003). Regulation of branchial Na+/K+-ATPase in common carp Cyprinus carpio L. acclimated to different temperatures. The Journal of Experimental Biology, 206, 2273-2280. https://doi.org/10.1242/jeb.00421
  • Sancho, E., Fernandez-Vega, C., Ferrando, M.D., & Andreu-Moliner, E. (2003). Eel ATPase activity as biomarker of thiobencarb exposure. Ecotoxicology and Environmental Safety, 56, 434–441. https://doi.org/10.1016/S0147-6513(03)00077-0
  • Sun, Y., Fu, Z., & Ma, Z. (2024). The effects of acute ammonia stress on liver antioxidant, immune and metabolic responses of juvenile yellowfin tuna (Thunnus albacares). Comparative Biochemistry and Physiology, 297(A), 111707. https://doi.org/10.1016/j.cbpa.2024.111707
  • Suvetha, L., Ramesh, M., & Saravanan, M. (2010). Influence of cypermethrin toxicity on ionic regulation and gill Na+/K+-ATPase activity of a freshwater teleost fish Cyprinus carpio. Environmental Toxicology and Pharmacology, 29, 44–49. https://doi:10.1016/j.etap.2009.09.005
  • Temiz, O., Cogun, H., & Kargin, F. (2018). Influence of chlorantraniliprole toxicity on ionic regulation of gill and muscle ATPase activity of nile fish (Oreochromis niloticus). Fresenius Environmental Bulletin, 27, 5027–5032.
  • Temiz, Ö., Kargın, D. (2024). Physiological responses of oxidative damage, genotoxicity and hematological parameters of the toxic effect of neonicotinoid-thiamethoxam in Oreochromis niloticus. Environmental Toxicology and Pharmacology, 106, 104377. https://doi.org/10.1016/j.etap.2024.104377
  • Temiz, Ö., Kargın, D., & Çoğun, H.Y. (2021). In vivo effects on stress protein, genotoxicity, and oxidative toxicity parameters in Oreochromis niloticus tissues exposed to thiamethoxam. Water Air Soil Pollution, 232, 221. https://doi.org/10.1007/s11270-021-05101-7
  • Uçkun, A.A. (2017). Ecotoxicological evaluation of pesticide pollution in Ataturk Dam Lake (Euphrates River), Turkey. Turkish Journal of Fisheries and Aquatic Sciences, 17(2), 313 321. https://doi.org/10.4194/1303-2712-v17_2_10
  • Uçkun, A.A., Yologlu, E., & Uçkun, M. (2017). Seasonal monitoring of metals in water, sediment and mussel (Unio mancus) from Atatürk Dam Lake (Euphrates River). Van Veterinary Journal, 28(2), 75-83.
  • Uçkun, A.A., & Uçkun, M. (2021a). Evaluation of some biomarkers in carp (Cyprinus carpio Linnaeus, 1758) depending on water and sediment pollution of Atatürk Dam Lake. BEU Journal of Science, 10(3), 744-753. https://doi.org/10.17798/bitlisfen.898021
  • Uçkun, M., & Uçkun, A.A. (2021b). Effect of imidacloprid application to freshwater mussels (Unio mancus) on gill ATPase activities. Erciyes University Journal of Institue of Science and Technology, 37(1), 91-98.
  • Veedu, S.K., Ayyasamy, G., Tamilselvan, H., & Ramesh, M. (2022). Single and joint toxicity assessment of acetamiprid and thiamethoxam neonicotinoids pesticides on biochemical indices and antioxidant enzyme activities of a freshwater fish Catla catla. Comparative Biochemistry and Physiology, 257(C), 109336. https://doi.org/10.1016/J.CBPC.2022.109336
  • Wang, L., Wu, D., Robinson, C.V., Wu, H., & Fu, T.-M. (2020). Structures of a complete human V-ATPase reveal mechanisms of its assembly. Molecular Cell, 80, 501 511. https://doi.org/10.1016/j.molcel.2020.09.029
  • Wong, C., & Wong, M. (2000). Morphological and biochemical changes in the gills of tilapia (Oreochromis mossambicus) to ambient cadmium exposure. Aquatic Toxicology, 48(4), 517 527. https://doi.org/10.1016/S0166-445X(99)00060-0

Atatürk Barajı Gölü'ndeki sazanların (Cyprinus carpio L.) iyon homeostazisi ve ozmoregülasyonunda rol oynayan enzimler üzerine kirliliğin etkisi

Year 2025, Volume: 42 Issue: 2, 183 - 190, 15.06.2025

Özge Fırat , Özge Temiz , Özgür Fırat

Abstract

Atatürk Barajı Gölü Türkiye’deki en büyük baraj olması (i); çevresindeki yerleşim bölgelerindeki yoğun faaliyetlerden kaynaklı kirleticilerden etkilenmesi (ii); ekonomik, ticari ve besin değeri yüksek su ürünleri içermesi (iii); su kalitesinde ve/veya balıklarda istenmeyen değişimlerin insanları da etkileme potansiyeli (iv) nedeniyle son yıllarda toksikolojik araştırmaların odağı halindedir. Sunulan çalışmada baraj gölünün Adıyaman il sınırlarındaki göreceli olarak temiz olan Samsat ve kentsel aktivitelerden etkilenen Sitilce bölgeleri ile Şanlıurfa il sınırlarındaki tarımsal aktivitelerden etkilenen Bozova bölgesinde 2021 yılının Eylül ayında yakalanan sazanların (Cyprinus carpio) dokularındaki Na+/K+-ATPaz (EC 3.6.3.9), Ca+2-ATPaz (EC 3.6.3.8) ve Mg+2-ATPaz (EC 3.6.3.2) aktivitelerindeki değişimler araştırılmıştır. Samsat bölgesi ile karşılaştırıldığında Sitilce ve Bozova bölgesi balıklarının solungaç, karaciğer, bağırsak ve böbrek dokularında incelenen tüm ATPaz enzim aktivitelerinde anlamlı azalışlar gözlemlenirken, kas dokusu enzim aktivitelerinde bir değişim gözlenmemiştir. Çalışmamız Atatürk Baraj Gölü'ndeki kirleticilerin balıklarda iyon dengesi, iyon homeostazisi ve ozmoregülasyon mekanizmaları üzerinde toksik etkilere sahip olduğunu ve ATPazların sucul ekosistemlerde kirliliğin belirlenmesinde yararlı biyobelirteçler olarak kullanılabileceğini açıkça ortaya koymuştur.

Keywords

Atatürk Barajı Gölü Cyprinus carpio balık ATPaz su kirliliği

Ethical Statement

Adıyaman Üniversitesi Hayvan Deneyleri Yerel Etik Kurulu’ndan onay alındı (Tarih: 24/12/2020, Karar No:4, Protokol No: 2020/067)

Supporting Institution

Adıyaman Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi

Project Number

KMYOMAP/2021-0001

Thanks

Adıyaman Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi'nin yöneticilerine ve çalışanlarına teşekkür ederiz.

References

  • Abdallah, S.M., Muhammed, R.E., Mohamed, R.E., Daous, H.E., Saleh, D.M., Ghorab, M.A., Chen, S., & El-Sayyad, G.S. (2024). Assessment of biochemical biomarkers and environmental stress indicators in some freshwater fish. Environmental Geochemistry and Health, 46, 464. https://doi.org/10.1007/s10653-024-02226-6
  • Apiamu, A., Osawaru, S.U., Asagba, S.O., Evuen, U.F., & Achuba, F.I. (2022). Exposure of African catfish (Clarias gariepinus) to lead and zinc modulates membrane-bound transport protein: A plausible effect on Na+/K+-ATPase activity. Biological Trace Element Research, 200, 4160–4170. https://doi.org/10.1007/s12011-021-03005-5
  • Atkinson, A., Gatemby, A.O., & Lowe, A.G. (1973). The determination of inorganic ortophosphate in biological systems. Biochimica et Biophysica Acta, 320, 195-204. https://doi.org/10.1016/0304-4165(73)90178-5
  • Atlı, G., & Canlı, M. (2008). Characterization of branchial Na, K-ATPase from three freshwater fish species (Oreochromis niloticus, Cyprinus carpio, and Oncorhynchus mykiss). Turkish Journal of Zoology, 32, 299-304.
  • Balaji, G., Nachiyappan, M., & Venugopal, R. (2015). Sub-lethal effect of cypermethrin on Ca+, Mg+ and Na+/K+ - ATPase activity in fresh water teleost, Cyprinus carpio. World Journal of Zoology, 10(3), 168-174. https://doi.org/10.5829/idosi.wjz.2015.10.3.9581
  • Bayhan, Y.K. (2021). The fish fauna of the Atatürk Dam Lake (Adıyaman/Turkey). Natural and Engineering Sciences, 6, 237-255. https://doi.org/10.28978/nesciences.1036854
  • Dane, H., & Sisman, T. (2020). A morpho-histopathological study in the digestive tract of three fish species influenced with heavy metal pollution. Chemosphere, 242, 125212. https://doi.org/10.1016/j.chemosphere.2019.125212
  • Deenathayalan, U., Nandita, R., Kavithaa, K., Kavitha, V.S., Govindasamy, C., Al‑Numair, K.S., Alsaif, M.A., Cheon, Y.P., Arul, N., & Brindha, D. (2024). Evaluation of developmental toxicity and oxidative stress caused by zinc oxide nanoparticles in zebra fish embryos/larvae. Biotechnology and Applied Biochemistry, 196, 4954 4973. https://doi.org/10.1007/s12010-023-04791-5
  • de la Torre, F.R., Salibian, A., & Ferrari, L. (2007). Assessment of the pollution impact on biomarkers of effect of a freshwater fish. Chemosphere, 68, 1582 1590. https://doi:10.1016/j.chemosphere.2007.02.033
  • Dogan, Z., Eroglu, A., Kanak, E.G., Atli, G., & Canli, M. (2014). Response of antioxidant system of tilapia (Oreochromis niloticus) following exposure to chromium and copper in differing hardness. Bulletin of Environmental Contamination and Toxicology, 92, 680 686. https://doi.org/10.1007/s00128-014-1245-2
  • Fırat, O., & Alıcı, M.F. (2012). Assessment of pollution in Ataturk Dam Lake (Adıyaman, Turkey) using several biochemical parameters in common carp, Cyprinus carpio. Bulletin of Environmental Contamination and Toxicology, 89, 474-478. https://doi.org/10.1007/s00128-012-0728-2
  • Fırat, Ö., & Kaya, Ö. (2019). Evaluation of protective role of selenium on mercury toxicity by superoxide dismutase, catalase and malondialdehyde parameters in Oreochromis niloticus (Linnaeus, 1758). Ege Journal of Fisheries and Aquatic Sciences, 36(3), 245-253. https://doi.org/10.12714/egejfas.2019.36.3.05
  • Fırat, Ö., & Kılınç, Ü. (2022). Assessment of lead, cadmium, chrome, iron, zinc and copper levels in tissues of Cyprinus carpio from Atatürk Dam Lake (Adıyaman). Commagene Journal of Biology, 6(1), 20-25. https://doi.org/10.31594/commagene.1079557
  • Firat, O. (2016). Evaluation of metal concentrations in fish species from Ataturk Dam Lake (Adiyaman, Turkey) in relation to human health. Fresenius Environmental Bulletin, 25, 3629-3634.
  • Firidin, G. (2018). Oxidative stress parameters, induction of lipid peroxidation, and ATPase activity in the liver and kidney of Oreochromis niloticus exposed to lead and mixtures of lead and zinc. Bulletin of Environmental Contamination and Toxicology, 100, 477 484. https://doi.org/10.1007/s00128-018-2281-0
  • Gupta, P., Mahapatra, A., Suman, A., & Singh, R.K. (2023). In silico and in vivo assessment of developmental toxicity, oxidative stress response and Na+/K+-ATPase activity in zebrafish embryos exposed to cypermethrin. Ecotoxicology and Environmental Safety, 251, 114547. https://doi.org/10.1016/j.ecoenv.2023.114547
  • Gündoğdu, S. (2023). Microplastic intake of Unio mancus Lamarck 1819 collected from Ataturk Dam Lake, Türkiye. Turkish Journal of Zoology, 47(5), 268-278. https://doi.org/10.55730/1300-0179.3140
  • Hegazi, M.M., Mostafa, A.H., Assem, E.H., Mourad, H.M., & Hasanein, S.S. (2015). The effect of seasonal metals pollution in two Hotspots (El-Mex, Abu-Qir) Bays on ATPases in gills of Siganus rivulatus. International Journal of Environmental Monitoring and Analysis, 3, 51-58. https://doi: 10.11648/j.ijema.s.2015030501.17
  • Ji, P., Liu, G., Xu, J., Wang, X., Li, J., Zhao, Z., Zhang, X., Zhang, Y., Xu, P., & Sun, X. (2012). Characterization of common carp transcriptome: Sequencing, De Novo assembly, annotation and comparative genomics. PLoS One, 7(4), 35152. https://doi.org/10.1371/journal.pone.0035152
  • Karadag, H., Fırat, Ö., & Fırat, Ö. (2014). Use of oxidative stress biomarkers in Cyprinus carpio L. for the evaluation of water pollution in Ataturk Dam Lake (Adiyaman, Turkey). Bulletin of Environmental Contamination and Toxicology, 92, 289-293. https://doi.org/10.1007/s00128-013-1187-0
  • Khoshnood, Z. (2024). A review on toxic effects of pesticides in zebrafish, Danio rerio and common carp, Cyprinus carpio, emphasising atrazine herbicide. Toxicology Reports, 13, 101694. https://doi.org/10.1016/j.toxrep.2024.101694
  • Langeswaran, K., Jagadeesan, A.J., & Balasubramanian, M.P. (2012). Modulation of membrane bound ATPases and metabolizing enzymes against n-nitosodiethylamine (DEN) induced primary liver cancer in wistar albino rats. International Journal of Pharma and Bio Sciences, 3(2), 156–165.
  • Lopez-Lopez, E., Sedeno-Díaz, J.E., Soto, C., & Favari, L. (2011). Responses of antioxidant enzymes, lipid peroxidation, and Na+/K+-ATPase in liver of the fish Goodea atripinnis exposed to Lake Yuriria water. Fish Physiology and Biochemistry, 37, 511–522. https://doi.org/10.1007/s10695-010-9453-0
  • Lowry, O.H., Rosebrough, N.J., Farr, A.L., & Randall, R.J. (1951). Protein measurements with the folin phenol reagent. Journal of Biological Chemistry, 193, 265-275. https://doi.org/10.1016/S0021-9258(19)52451-6
  • Metz, J.R., van den Burg, E.H., Wendelaar Bonga, S.E., & Flik, G. (2003). Regulation of branchial Na+/K+-ATPase in common carp Cyprinus carpio L. acclimated to different temperatures. The Journal of Experimental Biology, 206, 2273-2280. https://doi.org/10.1242/jeb.00421
  • Sancho, E., Fernandez-Vega, C., Ferrando, M.D., & Andreu-Moliner, E. (2003). Eel ATPase activity as biomarker of thiobencarb exposure. Ecotoxicology and Environmental Safety, 56, 434–441. https://doi.org/10.1016/S0147-6513(03)00077-0
  • Sun, Y., Fu, Z., & Ma, Z. (2024). The effects of acute ammonia stress on liver antioxidant, immune and metabolic responses of juvenile yellowfin tuna (Thunnus albacares). Comparative Biochemistry and Physiology, 297(A), 111707. https://doi.org/10.1016/j.cbpa.2024.111707
  • Suvetha, L., Ramesh, M., & Saravanan, M. (2010). Influence of cypermethrin toxicity on ionic regulation and gill Na+/K+-ATPase activity of a freshwater teleost fish Cyprinus carpio. Environmental Toxicology and Pharmacology, 29, 44–49. https://doi:10.1016/j.etap.2009.09.005
  • Temiz, O., Cogun, H., & Kargin, F. (2018). Influence of chlorantraniliprole toxicity on ionic regulation of gill and muscle ATPase activity of nile fish (Oreochromis niloticus). Fresenius Environmental Bulletin, 27, 5027–5032.
  • Temiz, Ö., Kargın, D. (2024). Physiological responses of oxidative damage, genotoxicity and hematological parameters of the toxic effect of neonicotinoid-thiamethoxam in Oreochromis niloticus. Environmental Toxicology and Pharmacology, 106, 104377. https://doi.org/10.1016/j.etap.2024.104377
  • Temiz, Ö., Kargın, D., & Çoğun, H.Y. (2021). In vivo effects on stress protein, genotoxicity, and oxidative toxicity parameters in Oreochromis niloticus tissues exposed to thiamethoxam. Water Air Soil Pollution, 232, 221. https://doi.org/10.1007/s11270-021-05101-7
  • Uçkun, A.A. (2017). Ecotoxicological evaluation of pesticide pollution in Ataturk Dam Lake (Euphrates River), Turkey. Turkish Journal of Fisheries and Aquatic Sciences, 17(2), 313 321. https://doi.org/10.4194/1303-2712-v17_2_10
  • Uçkun, A.A., Yologlu, E., & Uçkun, M. (2017). Seasonal monitoring of metals in water, sediment and mussel (Unio mancus) from Atatürk Dam Lake (Euphrates River). Van Veterinary Journal, 28(2), 75-83.
  • Uçkun, A.A., & Uçkun, M. (2021a). Evaluation of some biomarkers in carp (Cyprinus carpio Linnaeus, 1758) depending on water and sediment pollution of Atatürk Dam Lake. BEU Journal of Science, 10(3), 744-753. https://doi.org/10.17798/bitlisfen.898021
  • Uçkun, M., & Uçkun, A.A. (2021b). Effect of imidacloprid application to freshwater mussels (Unio mancus) on gill ATPase activities. Erciyes University Journal of Institue of Science and Technology, 37(1), 91-98.
  • Veedu, S.K., Ayyasamy, G., Tamilselvan, H., & Ramesh, M. (2022). Single and joint toxicity assessment of acetamiprid and thiamethoxam neonicotinoids pesticides on biochemical indices and antioxidant enzyme activities of a freshwater fish Catla catla. Comparative Biochemistry and Physiology, 257(C), 109336. https://doi.org/10.1016/J.CBPC.2022.109336
  • Wang, L., Wu, D., Robinson, C.V., Wu, H., & Fu, T.-M. (2020). Structures of a complete human V-ATPase reveal mechanisms of its assembly. Molecular Cell, 80, 501 511. https://doi.org/10.1016/j.molcel.2020.09.029
  • Wong, C., & Wong, M. (2000). Morphological and biochemical changes in the gills of tilapia (Oreochromis mossambicus) to ambient cadmium exposure. Aquatic Toxicology, 48(4), 517 527. https://doi.org/10.1016/S0166-445X(99)00060-0
There are 38 citations in total.

Details

Primary Language Turkish
Subjects Structural Biology, Aquaculture and Fisheries (Other)
Journal Section Articles
Authors

Özge Fırat 0000-0001-9010-955X

Özge Temiz 0000-0003-0668-5744

Özgür Fırat 0000-0002-9683-8945

Project Number KMYOMAP/2021-0001
Early Pub Date June 14, 2025
Publication Date June 15, 2025
Submission Date December 30, 2024
Acceptance Date March 3, 2025
Published in Issue Year 2025Volume: 42 Issue: 2

Cite

APA Fırat, Ö., Temiz, Ö., & Fırat, Ö. (2025). Atatürk Barajı Gölü’ndeki sazanların (Cyprinus carpio L.) iyon homeostazisi ve ozmoregülasyonunda rol oynayan enzimler üzerine kirliliğin etkisi. Ege Journal of Fisheries and Aquatic Sciences, 42(2), 183-190.