Ege Journal of Fisheries and Aquatic Sciences
Review
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Doğal ürün fukoksantin trendleri

Year 2021, Volume: 38 Issue: 1, 117 - 124, 15.03.2021

Bahar ASLANBAY Esra İMAMOĞLU

https://doi.org/10.12714/egejfas.38.1.15

Abstract


Fukoksantin, ksantofil grubuna ait karotenoidlerden biri olup yaygın olarak kahverengi deniz yosunlarında (makroalgler), diatomlarda ve birkaç mikroalg türünde bulunmaktadır. Fukoksantin pigmenti, alglerde klorofil ve protein ile birlikte kompleks bir yapı oluşturarak ışığın toplanmasında ve fotosentez merkezine gönderilmesinde önemli bir rol almaktadır. Son yıllarda yapılan araştırmalar sonucunda fukoksantinin hayvanlar üzerinde antiobezite, antidiyabet, antienflamatuvar, antikanser ve kardiyovasküler sistemi koruma gibi olumlu etkilere sahip olduğu görülmüştür. Bu nedenle kronik hastalıkların önlenmesinde ve tedavisinde fukoksantinin etken madde olarak kullanımına dair çalışmalar sürdürülmektedir. Ayrıca kozmetik, gıda ve yem sektörlerinde de fukoksantin bileşiğinin kullanım potansiyeli değerlendirilmektedir. Bu makalede fukoksantin karotenoidinin genel özelliklerinden, tarihsel gelişiminden ve mevcut kaynaklarından bahsedilmiş, hayvanlar üzerindeki potansiyel biyolojik aktiviteleri incelenmiş ve kullanım alanları ile birlikte piyasadaki durumu ortaya konmuştur.

Keywords

Fukoksantin, Ksantofil, Karotenoid, Algal biyoteknoloji, Doğal ürün

Supporting Institution

TUBİTAK

Thanks

Bu çalışma, ES1408 COST aksiyonu kapsamında olup Türkiye Bilimsel ve Teknolojik Araştırma Kurumu (TUBİTAK) 115M014 proje kapsamında finansal olarak desteklenmiştir.

References

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  • Airanthi, M.K.W., Hosokawa, M. & Miyashita, K. (2011). Comparative antioxidant activity of edible japanese brown seaweeds. Journal of Food Science, 76(1), 104-111. DOI: 10.1111/j.1750-3841.2010.01915.x
  • Buschmann, A.H., Camus, C., Infante, J., Neori, A., Israel, A., Hernández-González, M.C., Pereda, S.V., Gomez-Pinchetti, J.L., Golberg, A., Tadmor-Shalev, N. & Critchley, A.T. (2017). Seaweed production: overview of the global state of exploitation, farming and emerging research activity. European Journal of Phycology, 52(4): 391-406. DOI: 10.1080/09670262.2017.1365175
  • Conceição, D., Lopes, R.G., Derner, R.B., Cella, H., Barbosa do Carmo, A.P., D’Oca, M.G.M., Petersen, R., Passos, M.F., Vargas, V.J.C., Galli-Terasawa, L.V. & Kava, V. (2020). The effect of light intensity on the production and accumulation of pigments and fatty acids in Phaeodactylum tricornutum. Journal of Applied Phycology, 1-9 p. DOI: 10.1007/s10811-019-02001-6
  • Crupi, P., Toci, A.T., Mangini, S., Wrubl, F., Rodolfi, L., Tredici, M.R., Coletta, A. & Antonacci, D. (2013). Determination of fucoxanthin isomers in microalgae (Isochrysis sp.) by high-performance liquid chromatography coupled with diode-array detector multistage mass spectrometry coupled with positive electrospray ionization, Rapid Communications in Mass Spectrometry, 27(9), 1027-1035. DOI: 10.1002/rcm.6531
  • D’Orazio, N., Gemello, E., Gammone, M.A., Girolamo, M., Ficoneri, C. & Riccioni, G. (2012). Fucoxantin: A treasure from the sea. Marine Drugs, 10, 604-616. DOI: 10.3390/md10030604
  • Demirel, Z., Tok, R., İlter, I., Akyıl, S., Erdoğan, A., Koç, M., Kaymak Ertekin, F. & Conk Dalay, M. (2018). Biyokütle için mikroalg ve siyanobakteri’nin büyük ölçekli üretimi. Aquatic Research, 1(2): 64-76. DOI: 10.3153/AR18008
  • Dittami, S.M., Michel, G., Collen, J., Boyen, C. & Tonon, T. (2010). Chlorophyll-binding proteins revisited - a multigenic family of light-harvesting and stress proteins from a brown algal perspective. BMC Evolutionary Biology, 10: 365. DOI: 10.1186/1471-2148-10-365
  • Englert, G., Bjornland, T. & Liaaen-Jensen, S. (1990). 1D and 2D NMR study of some allenic carotenoids of the fucoxanthin series. Magnetic Resonance in Chemistry, 28: 519-528.
  • Gammone, M.A. & D’Orazio, N. (2015). Anti-obesity activity of the marine carotenoid fucoxanthin. Marine Drugs, 13, 2196-2214. DOI: 10.3390/md13042196
  • Gammone, M.A., Riccioni, G. & D’Orazio, N. (2015). Marine carotenoids against oxidative stress: Effects on human health. Marine Drugs, 13, 6226-6246. DOI: 10.3390/md13106226
  • Garama, D., Bremer, P. & Carne, A. (2012). Extraction and analysis of carotenoids from the New Zealand sea urchin Evechinus chloroticus gonads. Acta Biochimica Polonica, 59(1): 83-85.
  • Heo, S.J., Yoon, W.J., Kim, K.N., Ahn, G.N., Kang, S.M., Kang, D.H., Affan, A., Oh, C., Jung, W.K. & Jeon, Y.J. (2010) Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages. Food and Chemical Toxicology, 48: 2045–2051. DOI: 10.1016/j.fct.2010.05.003
  • Irvani, N., Hajiaghaee, R. & Zarekarizi, A.R. (2018). A review on biosynthesis, health benefits and extraction methods of fucoxanthin, particular marine carotenoids in algae. Journal of Medicinal Plants, 17(67).
  • Jaswir, I., Noviendri, D., Salleh, H.M., Taher, M., Miyashita, K. & Ramli, N. (2012). Analysis of fucoxanthin content and purification of all-trans-fucoxanthin from Turbinaria turbinata and Sargassum plagyophyllum by SiO2 open column chromatography and reversed phase-HPLC. Journal of Liqiud Chromatography & Related Technology, 36: 1340–1354. DOI: 10.1080/10826076.2012.691435
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  • Joshi, S., Kumari, R. & Upasani, V.N. (2018). Applications of algae in cosmetics: An overview, International Journal of Innovvative Research in Science, Engineering and Technology, 7(2), 1269-1278. DOI: 10.15680/IJIRSET.2018.0702038
  • Kang, S.I., Shin, H.S., Kim, H.M., Yoon, S.A., Kang, S.W., Kim, J.H., Ko, H.C. & Kim SJ. (2012). Petalonia binghamiae extract and its constituent fucoxanthin ameliorate high-fat diet-induced obesity by activating AMP-activated protein kinase. Journal of Agricultural Food and Chemistry, 60: 3389−3395. DOI: 10.1021/jf2047652
  • Kim, S.M., Jung, Y.J., Kwon, O.H., Cha, K.H., Um, B.H., Chung, D. & Pan, C.H. (2012). A potential commercial source of fucoxanthin extracted from the microalga Phaeodactylum tricornutum. Applied Biochemistry and Biotechnology, 166: 1843–1855. DOI: 10.1007/s12010-012-9602-2
  • Kumar, S.R., Hosokawa, M. & Miyashita, K. (2013). Fucoxanthin: A marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms. Marine Drugs, 11(12): 5130-5147. DOI: 10.3390/md11125130
  • Lu, X., Liu, B., He, Y., Guo, B., Sun, H. & Chen, F. (2019). Novel insights into mixotrophic cultivation of Nitzschia laevis for co-production of fucoxanthin and eicosapentaenoic acid. Bioresource Technology, 294, 122145. DOI: 10.1016/j.biortech.2019.122145
  • Maeda, H. (2015). Nutraceutical effects of fucoxanthin for obesity and diabetes therapy: A review, Journal of Oleo Sciences, 64(2), 125-132. DOI: 10.5650/jos.ess14226
  • Martin, L.J. (2015). Fucoxanthin and its metabolite fucoxanthinol in cancer prevention and treatment. Marine Drugs, 13(8): 4784-4798. DOI: 10.3390/md13084784
  • Matos, J., Cardoso, C., Gomes, A., Campos, A.M., Fale, P., Afonso, C. & Bandarra, N.M. (2019). Bioprospection of Isochrysis galbana and its potential as a nutraceutical. Food & Function, 10, 7333. DOI: 10.1039/c9fo01364d
  • Mise, T., Ueda, M. & Yasumoto, T. (2011) Production of fucoxanthin-rich powder from Cladosiphon okamuranus. Advance Journal of Food Science and Technology, 3(1): 73-76.
  • Mohamadnia, S., Tavakoli, O., Faramrzi M.A. & Shamsollahi, Z. (2020). Production of fucoxanthin by the microalga Tisochrysis lutea: A review of recent developments. Aquaculture, 516, 734637. DOI: 10.1016/j.aquaculture.2019.734637
  • Nahar, M., Hasan, W., Rajak, R. & Jat, D. (2017). Oxidative Stress And Antioxidants: An Overview, International Journal of Advanced Research and Review, 2(9), 110-119.
  • Oryza Oil & Fat Chemical Co., Ltd. (2008). Fucoxanthin dietary ingredient for prevention of metabolic syndrome, antioxidation and cosmetics, Product Cataloug. Alıntılanma adresi: http://www.oryza.co.jp/pdf/english/Fucoxanthin_1.0.pdf (02.12.2019)
  • Páduaa, D., Rochaa, E., Gargiuloa, D. & Ramosa, A.A. (2015). Bioactive compounds from brown seaweeds: Phloroglucinol, fucoxanthin and fucoidan as promising therapeutic agents against breast cancer. Phytochemistry Letters, 14, 91–98. DOI: 10.1016/j.phytol.2015.09.007
  • Peng, J., Yuan, J.P., Wu, C.F. & Wang, J.H. (2011). Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: Metabolism and bioactivities relevant to human health. Marine Drugs, 9(10): 1806-1828. DOI: 10.3390/md9101806
  • Perez-Lopez, P., Balboa, E.M., Gonzalez-Garcia, S., Dominguez, H., Feijoo, G. & Moreira, T. (2014). Comparative environmental assessment of valorization strategies of the invasive macroalgae Sargassum muticum. Bioresource Technology, 161, 137–148. DOI: 10.1016/j.biortech.2014.03.013
  • Prabhasankar, P., Bhaskar, N., Hirose, A., Stephen, N., Growda, L.R., Hosokawa, M. & Miyashita, K. (2009). Edible Japanese seaweed, wakame (Undaria pinnatifida) as an ingredient in pasta: Chemical, functional and structural evaluation. Food Chemistry, 115, 501–508 p. DOI: 10.1016/j.foodchem.2008.12.047
  • Quitain, A.T., Kai, T., Sasaki, M. & Goto, M. (2013). Supercritical Carbon dioxide extraction of fucoxanthin from Undaria pinnatifida. Journal of Agricultural Food and Chemistry, 61, 5792−5797. DOI: 10.1021/jf400740p
  • Rajauria, G., Foley, B. & Abu-Ghannama, N. (2017). Characterization of dietary fucoxanthin from Himanthalia elongata brown seaweed. Food Research International, 99(3): 995-1001. DOI: 10.1016/j.foodres.2016.09.023
  • Raposo, M.F.J., Morais, A.M.M.B. & Morais, R.M.S.C. (2015). Carotenoids from marine microalgae: A valuable natural source for the prevention of chronic diseases. Marine Drugs, 13, 5128-5155. DOI: 10.3390/md13085128
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Trends in a natural product fucoxanthin

Year 2021, Volume: 38 Issue: 1, 117 - 124, 15.03.2021

Bahar ASLANBAY Esra İMAMOĞLU

https://doi.org/10.12714/egejfas.38.1.15

Abstract


Fucoxanthin is a xanthophyll pigment which occurs in marine brown seaweeds (macroalgae), diatoms and several microalgae species. It forms with chlorophyll a-c and several proteins, a major fucoxanthin-chlorophyll a/c complex, which transfers light energy to the photosynthesis center and plays a major role in light harvesting. Recent studies have reported that fucoxanthin has many physiological functions and biological effects, such as anti-obesity, antidiabetic, anti-inflammatory, anticancer and cardiovascular system protection. Therefore, this pigment is highly preferred for the prevention and treatment of various chronic diseases. In addition, potential applications of high value fucoxanthin can be found in cosmetic, food and feed industries. In this review paper, the historical development, characteristic properties and possible sources of fucoxanthin are extensively described. The potential biological activities of fucoxanthin are also discussed. Finally, brief overview of common applications and market analysis of commercial fucoxanthin are also reported.

Keywords

Fucoxanthin, Xanthophyll, Carotenoid, Algal biotechnology, Natural product

References

  • Abu-Ghannam, N. & Shannon, E. (2017). Seaweed Carotenoid, Fucoxanthin, as Functional Food, in V. K. Gupta, H. Treichel, V. Shapaval, L. Antonio de Oliveira and M. G. Tuohy (Eds.), Microbial Functional Foods and Nutraceuticals, John Wiley & Sons, Ltd, Chichester, UK.
  • Airanthi, M.K.W., Hosokawa, M. & Miyashita, K. (2011). Comparative antioxidant activity of edible japanese brown seaweeds. Journal of Food Science, 76(1), 104-111. DOI: 10.1111/j.1750-3841.2010.01915.x
  • Buschmann, A.H., Camus, C., Infante, J., Neori, A., Israel, A., Hernández-González, M.C., Pereda, S.V., Gomez-Pinchetti, J.L., Golberg, A., Tadmor-Shalev, N. & Critchley, A.T. (2017). Seaweed production: overview of the global state of exploitation, farming and emerging research activity. European Journal of Phycology, 52(4): 391-406. DOI: 10.1080/09670262.2017.1365175
  • Conceição, D., Lopes, R.G., Derner, R.B., Cella, H., Barbosa do Carmo, A.P., D’Oca, M.G.M., Petersen, R., Passos, M.F., Vargas, V.J.C., Galli-Terasawa, L.V. & Kava, V. (2020). The effect of light intensity on the production and accumulation of pigments and fatty acids in Phaeodactylum tricornutum. Journal of Applied Phycology, 1-9 p. DOI: 10.1007/s10811-019-02001-6
  • Crupi, P., Toci, A.T., Mangini, S., Wrubl, F., Rodolfi, L., Tredici, M.R., Coletta, A. & Antonacci, D. (2013). Determination of fucoxanthin isomers in microalgae (Isochrysis sp.) by high-performance liquid chromatography coupled with diode-array detector multistage mass spectrometry coupled with positive electrospray ionization, Rapid Communications in Mass Spectrometry, 27(9), 1027-1035. DOI: 10.1002/rcm.6531
  • D’Orazio, N., Gemello, E., Gammone, M.A., Girolamo, M., Ficoneri, C. & Riccioni, G. (2012). Fucoxantin: A treasure from the sea. Marine Drugs, 10, 604-616. DOI: 10.3390/md10030604
  • Demirel, Z., Tok, R., İlter, I., Akyıl, S., Erdoğan, A., Koç, M., Kaymak Ertekin, F. & Conk Dalay, M. (2018). Biyokütle için mikroalg ve siyanobakteri’nin büyük ölçekli üretimi. Aquatic Research, 1(2): 64-76. DOI: 10.3153/AR18008
  • Dittami, S.M., Michel, G., Collen, J., Boyen, C. & Tonon, T. (2010). Chlorophyll-binding proteins revisited - a multigenic family of light-harvesting and stress proteins from a brown algal perspective. BMC Evolutionary Biology, 10: 365. DOI: 10.1186/1471-2148-10-365
  • Englert, G., Bjornland, T. & Liaaen-Jensen, S. (1990). 1D and 2D NMR study of some allenic carotenoids of the fucoxanthin series. Magnetic Resonance in Chemistry, 28: 519-528.
  • Gammone, M.A. & D’Orazio, N. (2015). Anti-obesity activity of the marine carotenoid fucoxanthin. Marine Drugs, 13, 2196-2214. DOI: 10.3390/md13042196
  • Gammone, M.A., Riccioni, G. & D’Orazio, N. (2015). Marine carotenoids against oxidative stress: Effects on human health. Marine Drugs, 13, 6226-6246. DOI: 10.3390/md13106226
  • Garama, D., Bremer, P. & Carne, A. (2012). Extraction and analysis of carotenoids from the New Zealand sea urchin Evechinus chloroticus gonads. Acta Biochimica Polonica, 59(1): 83-85.
  • Heo, S.J., Yoon, W.J., Kim, K.N., Ahn, G.N., Kang, S.M., Kang, D.H., Affan, A., Oh, C., Jung, W.K. & Jeon, Y.J. (2010) Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages. Food and Chemical Toxicology, 48: 2045–2051. DOI: 10.1016/j.fct.2010.05.003
  • Irvani, N., Hajiaghaee, R. & Zarekarizi, A.R. (2018). A review on biosynthesis, health benefits and extraction methods of fucoxanthin, particular marine carotenoids in algae. Journal of Medicinal Plants, 17(67).
  • Jaswir, I., Noviendri, D., Salleh, H.M., Taher, M., Miyashita, K. & Ramli, N. (2012). Analysis of fucoxanthin content and purification of all-trans-fucoxanthin from Turbinaria turbinata and Sargassum plagyophyllum by SiO2 open column chromatography and reversed phase-HPLC. Journal of Liqiud Chromatography & Related Technology, 36: 1340–1354. DOI: 10.1080/10826076.2012.691435
  • Joel, J. (2016). Global fucoxanthin market 2016 industry trends, sales, supply, demand, analysis and forecast to 2021, Analysis and Forecast. New York.
  • Joshi, S., Kumari, R. & Upasani, V.N. (2018). Applications of algae in cosmetics: An overview, International Journal of Innovvative Research in Science, Engineering and Technology, 7(2), 1269-1278. DOI: 10.15680/IJIRSET.2018.0702038
  • Kang, S.I., Shin, H.S., Kim, H.M., Yoon, S.A., Kang, S.W., Kim, J.H., Ko, H.C. & Kim SJ. (2012). Petalonia binghamiae extract and its constituent fucoxanthin ameliorate high-fat diet-induced obesity by activating AMP-activated protein kinase. Journal of Agricultural Food and Chemistry, 60: 3389−3395. DOI: 10.1021/jf2047652
  • Kim, S.M., Jung, Y.J., Kwon, O.H., Cha, K.H., Um, B.H., Chung, D. & Pan, C.H. (2012). A potential commercial source of fucoxanthin extracted from the microalga Phaeodactylum tricornutum. Applied Biochemistry and Biotechnology, 166: 1843–1855. DOI: 10.1007/s12010-012-9602-2
  • Kumar, S.R., Hosokawa, M. & Miyashita, K. (2013). Fucoxanthin: A marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms. Marine Drugs, 11(12): 5130-5147. DOI: 10.3390/md11125130
  • Lu, X., Liu, B., He, Y., Guo, B., Sun, H. & Chen, F. (2019). Novel insights into mixotrophic cultivation of Nitzschia laevis for co-production of fucoxanthin and eicosapentaenoic acid. Bioresource Technology, 294, 122145. DOI: 10.1016/j.biortech.2019.122145
  • Maeda, H. (2015). Nutraceutical effects of fucoxanthin for obesity and diabetes therapy: A review, Journal of Oleo Sciences, 64(2), 125-132. DOI: 10.5650/jos.ess14226
  • Martin, L.J. (2015). Fucoxanthin and its metabolite fucoxanthinol in cancer prevention and treatment. Marine Drugs, 13(8): 4784-4798. DOI: 10.3390/md13084784
  • Matos, J., Cardoso, C., Gomes, A., Campos, A.M., Fale, P., Afonso, C. & Bandarra, N.M. (2019). Bioprospection of Isochrysis galbana and its potential as a nutraceutical. Food & Function, 10, 7333. DOI: 10.1039/c9fo01364d
  • Mise, T., Ueda, M. & Yasumoto, T. (2011) Production of fucoxanthin-rich powder from Cladosiphon okamuranus. Advance Journal of Food Science and Technology, 3(1): 73-76.
  • Mohamadnia, S., Tavakoli, O., Faramrzi M.A. & Shamsollahi, Z. (2020). Production of fucoxanthin by the microalga Tisochrysis lutea: A review of recent developments. Aquaculture, 516, 734637. DOI: 10.1016/j.aquaculture.2019.734637
  • Nahar, M., Hasan, W., Rajak, R. & Jat, D. (2017). Oxidative Stress And Antioxidants: An Overview, International Journal of Advanced Research and Review, 2(9), 110-119.
  • Oryza Oil & Fat Chemical Co., Ltd. (2008). Fucoxanthin dietary ingredient for prevention of metabolic syndrome, antioxidation and cosmetics, Product Cataloug. Alıntılanma adresi: http://www.oryza.co.jp/pdf/english/Fucoxanthin_1.0.pdf (02.12.2019)
  • Páduaa, D., Rochaa, E., Gargiuloa, D. & Ramosa, A.A. (2015). Bioactive compounds from brown seaweeds: Phloroglucinol, fucoxanthin and fucoidan as promising therapeutic agents against breast cancer. Phytochemistry Letters, 14, 91–98. DOI: 10.1016/j.phytol.2015.09.007
  • Peng, J., Yuan, J.P., Wu, C.F. & Wang, J.H. (2011). Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: Metabolism and bioactivities relevant to human health. Marine Drugs, 9(10): 1806-1828. DOI: 10.3390/md9101806
  • Perez-Lopez, P., Balboa, E.M., Gonzalez-Garcia, S., Dominguez, H., Feijoo, G. & Moreira, T. (2014). Comparative environmental assessment of valorization strategies of the invasive macroalgae Sargassum muticum. Bioresource Technology, 161, 137–148. DOI: 10.1016/j.biortech.2014.03.013
  • Prabhasankar, P., Bhaskar, N., Hirose, A., Stephen, N., Growda, L.R., Hosokawa, M. & Miyashita, K. (2009). Edible Japanese seaweed, wakame (Undaria pinnatifida) as an ingredient in pasta: Chemical, functional and structural evaluation. Food Chemistry, 115, 501–508 p. DOI: 10.1016/j.foodchem.2008.12.047
  • Quitain, A.T., Kai, T., Sasaki, M. & Goto, M. (2013). Supercritical Carbon dioxide extraction of fucoxanthin from Undaria pinnatifida. Journal of Agricultural Food and Chemistry, 61, 5792−5797. DOI: 10.1021/jf400740p
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Details

Primary Language Turkish
Subjects Structural Biology, Chemical Engineering
Journal Section Review
Authors

Bahar ASLANBAY
EGE ÜNİVERSİTESİ, MÜHENDİSLİK FAKÜLTESİ, BİYOMÜHENDİSLİK BÖLÜMÜ
Türkiye

Esra İMAMOĞLU
EGE ÜNİVERSİTESİ, MÜHENDİSLİK FAKÜLTESİ, BİYOMÜHENDİSLİK BÖLÜMÜ
0000-0001-8759-7388
Türkiye

Project Number 115M014
Publication Date March 15, 2021
Submission Date February 18, 2020
Acceptance Date June 17, 2020
Published in Issue Year 2021Volume: 38 Issue: 1

Cite

APA Aslanbay, B. & İmamoğlu, E. (2021). Doğal ürün fukoksantin trendleri . Ege Journal of Fisheries and Aquatic Sciences , 38 (1) , 117-124 . DOI: 10.12714/egejfas.38.1.15