Balıklarda bağışıklık sistemi, mukozal bağışıklıklık ve IL-1β, IL-18 ve TNF-α proenflamatuvar sitokinlerinin işlevleri

Serdar Kilercioğlu

doi:10.12714/egejfas.38.1.16

TR EN

Balıklarda bağışıklık sistemi, mukozal bağışıklıklık ve IL-1β, IL-18 ve TNF-α proenflamatuvar sitokinlerinin işlevleri

Öz

Balık, sucul ortamda türlü tehditler ile karşılaşmakta ve bu tehditlere karşı evrimsel süreçte geliştirdiği bağışıklık yanıtları ile karşılık vermektedir. Balıklarda bağışıklık sistemi doğal ve kazanılmış bağışıklığın sıvısal ve hücresel elemanlarından oluşur. Mukoza ile ilişkili dokular da savunma sisteminin bir parçası olup doğal ve kazanılmış bağışıklığın hücreleri ile donatılmıştır. Bağışıklık sisteminin hücre ve moleküllerinin oluştuğu, olgunlaştığı ve sisteme dahil edildiği organlar lenfoid organlar olarak adlandırılmaktadır. Sitokinler, canlıda büyüme, farklılaşma ve bağışıklık yanıtı gibi birçok görev üstlenen küçük glikoproteinlerdir. Sitokinlerin, bağışıklık sistemindeki ana rolleri bağışıklık yanıtlarını düzenlemeleri ve hücreler arası iletişimi sağlamalarıdır. Bu derlemede balık bağışıklık sisteminin ana sıvısal ve hücresel bileşenleri, mukozal bağışıklık sistemi, birincil lenfoid organların işlevleri ve proenflamatuvar etki gösteren IL-1β, IL-18 ve TNF-α sitokinleri hakkında literatürde yer alan bilgiler ana hatları ile bir araya getirilmiş, bahsi geçen sitokinlerin bağışıklık sistemindeki görevlerinin anlaşılması amaçlanmıştır.

Anahtar Kelimeler

References

Altınterim, B. (2011). Balık immünolojisi, bitkisel ve kimyasal immünostimulantlar. Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 1(4), 69–76.
Ángeles Esteban, M. (2012). An Overview of the Immunological Defenses in Fish Skin. ISRN Immunology, 2012, 1–29. DOI:10.5402/2012/853470
Arasu, A., Kumaresan, V., Sathyamoorthi, A., Palanisamy, R., Prabha, N., Bhatt, P., … Arockiaraj, J. (2013). Fish lily type lectin-1 contains β-prism architecture: Immunological characterization. Molecular Immunology, 56(4), 497–506. DOI:10.1016/j.molimm.2013.06.020
Ayhancı, T., & Altındiş, M. (2020). COVID-19 İmmünopatogenezi ve Sitokin Fırtınası. Journal Of Bıotechnology And Strategıc Health Research, 65–69. DOI:10.34084/bshr.726976
Beck, B. H., & Peatman, E. (2015). Mucosal Health in Aquaculture. Mucosal Health in Aquaculture. Elsevier. DOI:10.1016/C2013-0-06826-0
Boehm, T. (2011). Design principles of adaptive immune systems. Nature Reviews Immunology, 11(5), 307–317. DOI:10.1038/nri2944
Boschi, I., Randelli, E., Buonocore, F., Casani, D., Bernini, C., Fausto, A. M., & Scapigliati, G. (2011). Transcription of T cell-related genes in teleost fish, and the European sea bass (Dicentrarchus labrax) as a model. Fish & Shellfish Immunology, 31(5), 655–662. DOI:10.1016/j.fsi.2010.10.001
Boshra, H., Li, J., & Sunyer, J. O. (2006). Recent advances on the complement system of teleost fish. Fish & Shellfish Immunology, 20(2), 239–262. DOI:10.1016/j.fsi.2005.04.004

Bowden, T., Cook, P., & Rombout, J. (2005). Development and function of the thymus in teleosts. Fish & Shellfish Immunology, 19(5), 413–427. DOI:10.1016/j.fsi.2005.02.003
Bozkurt, M., & Eren, U. (2009). Balıklarda lenfoid organlar. Veteriner Hekimler Derneği Dergisi, 80(2), 13–18.
Brattgjerd, S., & Evensen, Ø. (1996). A Sequential Light Microscopic and Ultrastructural Study on the Uptake and Handling of Vibrio salmonicida in Phagocytes of the Head Kidney in Experimentally Infected Atlantic Salmon ( Salmo salar L.). Veterinary Pathology, 33(1), 55–65. DOI:10.1177/030098589603300106
Buchmann, K. (1999). Immune mechanisms in fish skin against monogeneans--a model. Folia Parasitologica, 46(1), 1–9. DOI:10.3147/jsfp.36.21
Castro, R., Bernard, D., Lefranc, M. P., Six, A., Benmansour, A., & Boudinot, P. (2011). T cell diversity and TcR repertoires in teleost fish. Fish & Shellfish Immunology, 31(5), 644–654. DOI:10.1016/j.fsi.2010.08.016
Castro, Rosario, & Tafalla, C. (2015). Overview of fish immunity. In Mucosal Health in Aquaculture (pp. 3–54). Elsevier. DOI:10.1016/B978-0-12-417186-2.00002-9
Chen, J., Wu, H. Q., Niu, H., Shi, Y. H., & Li, M. Y. (2009). Increased liver protein and mRNA expression of natural killer cell-enhancing factor B (NKEF-B) in ayu (Plecoglossus altivelis) after Aeromonas hydrophila infection. Fish & Shellfish Immunology, 26(3), 567–571. DOI:10.1016/j.fsi.2009.02.004
Dönmez, A. E. (2016). Balıklarda melanomakrofaj merkezleri. Ege Journal of Fisheries and Aquatic Sciences, 33(1), 81. DOI:10.12714/egejfas.2016.33.1.12
Durmaz, Y. (2016). Balıklarda Viral Enfeksiyonlara Karşı İmmun Sistemin İşleyişi. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 11(3), 355–355. DOI:10.17094/ataunivbd.282995
Duzguner, V., & Erdogan, S. (2012). Chronic exposure to imidacloprid induces inflammation and oxidative stress in the liver & central nervous system of rats. Pesticide Biochemistry and Physiology, 104(1), 58–64. DOI:10.1016/j.pestbp.2012.06.011
Eder, C. (2009). Mechanisms of interleukin-1β release. Immunobiology, 214(7), 543–553. DOI:10.1016/j.imbio.2008.11.007
Ellis, A. E. (1999). Immunity to bacteria in fish. Fish & Shellfish Immunology, 9(4), 291–308. DOI:10.1006/fsim.1998.0192
Engelsma, M.Y., Stet, R. J. M., Schipper, H., & Verburg-van Kemenade, B. M. L. (2001). Regulation of interleukin 1 beta RNA expression in the common carp, Cyprinus carpio L. Developmental & Comparative Immunology, 25(3), 195–203. DOI:10.1016/S0145-305X(00)00059-8
Engelsma, Marc Y., Huising, M. O., van Muiswinkel, W. B., Flik, G., Kwang, J., Savelkoul, H. F. J., & Verburg-van Kemenade, B. M. L. (2002). Neuroendocrine–immune interactions in fish: a role for interleukin-1. Veterinary Immunology and Immunopathology, 87(3–4), 467–479. DOI:10.1016/S0165-2427(02)00077-6
Fänge, R., & Nilsson, S. (1985). The fish spleen: structure and function. Experientia, 41(2), 152–158.
Fischer, U., Koppang, E. O., & Nakanishi, T. (2013). Teleost T and NK cell immunity. Fish & Shellfish Immunology, 35(2), 197–206. DOI:10.1016/j.fsi.2013.04.018
Franklin, C. E., Davison, W., & McKenzie, J. C. (1993). the Role of the Spleen During Exercise in the Antarctic Teleost, Pagothenia Borchgrevinki. Journal of Experimental Biology, 174(1), 381–386.
Goetz, F. (2004). Tumor necrosis factors. Developmental & Comparative Immunology, 28(5), 487–497. DOI:10.1016/j.dci.2003.09.008
Guardiola, F. A., Cuesta, A., Abellán, E., Meseguer, J., & Esteban, M. A. (2014). Comparative analysis of the humoral immunity of skin mucus from several marine teleost fish. Fish & Shellfish Immunology, 40(1), 24–31. DOI:10.1016/j.fsi.2014.06.018
Hod, E. A., Cadwell, C. M., Liepkalns, J. S., Zimring, J. C., Sokol, S. A., Schirmer, D. A., … Spitalnik, S. L. (2008). Cytokine storm in a mouse model of IgG-mediated hemolytic transfusion reactions. Blood, 112(3), 891–894. DOI:10.1182/blood-2008-01-132092
Holland, M. C. H., & Lambris, J. D. (2002). The complement system in teleosts. Fish & Shellfish Immunology, 12(5), 399–420. DOI:10.1006/fsim.2001.0408
Hong, S., Li, R., Xu, Q., Secombes, C. J., & Wang, T. (2013). Two Types of TNF-α Exist in Teleost Fish: Phylogeny, Expression, and Bioactivity Analysis of Type-II TNF-α3 in Rainbow Trout Oncorhynchus mykiss. The Journal of Immunology, 191(12), 5959–5972. DOI:10.4049/jimmunol.1301584
Huising, M. (2004). The molecular evolution of the interleukin-1 family of cytokines; IL-18 in teleost fish. Developmental & Comparative Immunology, 28(5), 395–413. DOI:10.1016/j.dci.2003.09.005
Jang, S. I., Hardie, L. J., & Secombes, C. J. (1995). Elevation of rainbow trout Oncorhynchus mykiss macrophage respiratory burst activity with macrophage-derived supernatants. Journal of Leukocyte Biology, 57(6), 943–947. DOI:10.1002/jlb.57.6.943
Karaman, Z., & Dorucu, M. (2017). Balıklarda Bağışıklık Sistemi Organları ve Histolojisi. International Journal of Pure and Applied Sciences, 3(1), 65–74.
Kav, K., & Erganis, O. (2008). Balıklarda Bağışıklık Sistemi. Veteriner Bilimleri Dergisi, 24(1), 97–106.
Kilercioglu, S., Ay, O., Oksuz, H., & Yilmaz, M. B. (2020). The effects of the neurotoxic agent emamectin benzoate on the expression of immune and stress-related genes and blood serum profiles in the Rainbow trout. Molecular Biology Reports. DOI:10.1007/s11033-020-05599-w
Kinoshita, S., Biswas, G., Kono, T., Hikima, J., & Sakai, M. (2014). Presence of two tumor necrosis factor (tnf)-α homologs on different chromosomes of zebrafish (Danio rerio) and medaka (Oryzias latipes). Marine Genomics, 13, 1–9. DOI:10.1016/j.margen.2013.10.004
Kono, T., Takayama, H., Nagamine, R., Korenaga, H., & Sakai, M. (2013). Establishment of a multiplex RT-PCR assay for the rapid detection of fish cytokines. Veterinary Immunology and Immunopathology, 151(1–2), 90–101. DOI:10.1016/j.vetimm.2012.10.012
Koppang, E. O., Fischer, U., Moore, L., Tranulis, M. A., Dijkstra, J. M., Köllner, B., … Hordvik, I. (2010). Salmonid T cells assemble in the thymus, spleen and in novel interbranchial lymphoid tissue. Journal of Anatomy, 217(6), 728–739. DOI:10.1111/j.1469-7580.2010.01305.x
Kranz, H., & Peters, N. (1984). Melano-macrophage centres in liver and spleen of ruffe(Gymnocephalus cernua) from the Elbe Estuary. Helgoländer Meeresuntersuchungen, 37(1–4), 415–424. DOI:10.1007/BF01989320
Larrick, J. W., & Wright, S. C. (1990). Cytotoxic mechanism of tumor necrosis factor‐α. The FASEB Journal, 4(14), 3215–3223. DOI:10.1096/fasebj.4.14.2172061
Lazado, C. C., & Caipang, C. M. A. (2014). Mucosal immunity and probiotics in fish. Fish & Shellfish Immunology, 39(1), 78–89. DOI:10.1016/j.fsi.2014.04.015
Lieschke, G. J., & Trede, N. S. (2009). Fish immunology. Current Biology, 19(16), R678–R682. DOI:10.1016/j.cub.2009.06.068
Liu, B., Li, M., Zhou, Z., Guan, X., & Xiang, Y. (2020). Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)? Journal of Autoimmunity, 111, 2–8.
Liu, Y., Iwasaki, T., Watarai, S., & Kodama, H. (2004). Effect of turpentine oil on C-reactive protein (CRP) production in rainbow trout (Oncorhynchus mykiss). Fish & Shellfish Immunology, 17(3), 203–210. DOI:10.1016/j.fsi.2004.03.003
Locksley, R. M., Killeen, N., & Lenardo, M. J. (2001). The TNF and TNF Receptor Superfamilies. Cell, 104(4), 487–501. DOI:10.1016/S0092-8674(01)00237-9
Lopez-Castejon, G., & Brough, D. (2011). Understanding the mechanism of IL-1β secretion. Cytokine & Growth Factor Reviews, 22(4), 189–195. DOI:10.1016/j.cytogfr.2011.10.001
Magadan, S., Sunyer, O. J., & Boudinot, P. (2015). Unique Features of Fish Immune Repertoires: Particularities of Adaptive Immunity Within the Largest Group of Vertebrates. In Results and Problems in Cell Differentiation (pp. 235–264). DOI:10.1007/978-3-319-20819-0_10
Magnadóttir, B. (2006). Innate immunity of fish (overview). Fish & Shellfish Immunology, 20(2), 137–151. DOI:10.1016/j.fsi.2004.09.006
Mashoof, S., & Criscitiello, M. (2016). Fish Immunoglobulins. Biology, 5(4), 45. DOI:10.3390/biology5040045
Mumford, S., Heidel, J., Smith, C., Morrison, J., Macconnell, B., & Blazer, V. (2007). Chapter 2: Normal Histology. In Fish Histology and Histopathology (p. 357).
Mustak, H. K., & Esendal, O. M. (2007). Toll benzeri reseptörler. Etlik Veteriner Mikroıbiyoloji Dergisi, 18, 33–37.
Mutoloki, S., Jørgensen, J. B., & Evensen, Ø. (2014). The Adaptive Immune Response in Fish. In Fish Vaccination (pp. 104–115). Chichester, UK: John Wiley & Sons, Ltd. DOI:10.1002/9781118806913.ch9
Nakanishi, T., Shibasaki, Y., & Matsuura, Y. (2015). T Cells in Fish. Biology, 4(4), 640–663. DOI:10.3390/biology4040640
Neves, J. V., Wilson, J. M., & Rodrigues, P. N. S. (2009). Transferrin and ferritin response to bacterial infection: The role of the liver and brain in fish. Developmental & Comparative Immunology, 33(7), 848–857. DOI:10.1016/j.dci.2009.02.001
Ottová, E., Šımková, A., & Morand, S. (2007). The role of major histocompatibility complex diversity in vigour of fish males (Abramis brama L.) and parasite selection. Biological Journal of the Linnean Society, 90(3), 525–538. DOI:10.1111/j.1095-8312.2007.00743.x
Özdemir, S., Altun, S., & Arslan, H. (2018). Imidacloprid exposure cause the histopathological changes, activation of TNF-α, iNOS, 8-OHdG biomarkers, and alteration of caspase 3, iNOS, CYP1A, MT1 gene expression levels in common carp (Cyprinus carpio L.). Toxicology Reports, 5, 125–133. DOI:10.1016/j.toxrep.2017.12.019
Palti, Y. (2011). Toll-like receptors in bony fish: From genomics to function. Developmental & Comparative Immunology, 35(12), 1263–1272. DOI:10.1016/j.dci.2011.03.006
Parra, D., Korytář, T., Takizawa, F., & Sunyer, J. O. (2016). B cells and their role in the teleost gut. Developmental & Comparative Immunology, 64, 150–166. DOI:10.1016/j.dci.2016.03.013
Pepys, M. B., Dash, A. C., Fletcher, T. C., Rıchardson, N., Munn, E. A., & Feınsteın, A. (1978). Analogues in other mammals and in fish of human plasma proteins, C-reactive protein and amyloid P component. Nature, 273(5658), 168–170. DOI:10.1038/273168a0
Pérez-Cordón, G., Estensoro, I., Benedito-Palos, L., Calduch-Giner, J. A., Sitjà-Bobadilla, A., & Pérez-Sánchez, J. (2014). Interleukin gene expression is strongly modulated at the local level in a fish–parasite model. Fish & Shellfish Immunology, 37(2), 201–208. DOI:10.1016/j.fsi.2014.01.022
Petrie-Hanson, L., & Ainsworth, A. J. (2000). Differential cytochemical staining characteristics of channel catfish leukocytes identify cell populations in lymphoid organs. Veterinary Immunology and Immunopathology, 73(2), 129–144. DOI:10.1016/S0165-2427(99)00155-5
Plouffe, D. A., Hanington, P. C., Walsh, J. G., Wilson, E. C., & Belosevic, M. (2005). Comparison of select innate immune mechanisms of fish and mammals. Xenotransplantation, 12(4), 266–277. DOI:10.1111/j.1399-3089.2005.00227.x
Press, C. M., & Evensen, Ø. (1999). The morphology of the immune system in teleost fishes. Fish & Shellfish Immunology, 9(4), 309–318. DOI:10.1006/fsim.1998.0181
Qiu, W., Hu, J., Magnuson, J. T., Greer, J., Yang, M., Chen, Q., Schlenk, D. (2020). Evidence linking exposure of fish primary macrophages to antibiotics activates the NF-kB pathway. Environment International, 138, 1–10.
Rakers, S., Niklasson, L., Steinhagen, D., Kruse, C., Schauber, J., Sundell, K., & Paus, R. (2013). Antimicrobial Peptides (AMPs) from Fish Epidermis: Perspectives for Investigative Dermatology. Journal of Investigative Dermatology, 133(5), 1140–1149. DOI:10.1038/jid.2012.503
Randelli, E., Buonocore, F., & Scapigliati, G. (2008). Cell markers and determinants in fish immunology. Fish & Shellfish Immunology, 25(4), 326–340. DOI:10.1016/j.fsi.2008.03.019
Rasmussen, S. B., Reınert, L. S., & Paludan, S. R. (2009). Innate recognition of intracellular pathogens: detection and activation of the first line of defense. APMIS, 117(5–6), 323–337. DOI:10.1111/j.1600-0463.2009.02456.x
Rauta, P. R., Samanta, M., Dash, H. R., Nayak, B., & Das, S. (2014). Toll-like receptors (TLRs) in aquatic animals: Signaling pathways, expressions and immune responses. Immunology Letters, 158(1–2), 14–24. DOI:10.1016/j.imlet.2013.11.013
Rebl, A., Goldammer, T., & Seyfert, H.-M. (2010). Toll-like receptor signaling in bony fish. Veterinary Immunology and Immunopathology, 134(3–4), 139–150. DOI:10.1016/j.vetimm.2009.09.021
Reis, M. I. R., do Vale, A., Pereira, P. J. B., Azevedo, J. E., & dos Santos, N. M. S. (2012). Caspase-1 and IL-1β Processing in a Teleost Fish. PLoS ONE, 7(11), e50450. DOI:10.1371/journal.pone.0050450
Reyes-Cerpa, S., Maisey, K., Reyes-Lpez, F., Toro-Ascuy, D., Mara, A., & Imarai, M. (2012). Fish Cytokines and Immune Response. In New Advances and Contributions to Fish Biology (pp. 3–57). InTech. DOI:10.5772/53504
Roca, F. J., Mulero, I., López-Muñoz, A., Sepulcre, M. P., Renshaw, S. A., Meseguer, J., & Mulero, V. (2008). Evolution of the Inflammatory Response in Vertebrates: Fish TNF-α Is a Powerful Activator of Endothelial Cells but Hardly Activates Phagocytes. The Journal of Immunology, 181(7), 5071–5081. DOI:10.4049/jimmunol.181.7.5071
Rombout, J. H. W. M., Abelli, L., Picchietti, S., Scapigliati, G., & Kiron, V. (2011). Teleost intestinal immunology. Fish & Shellfish Immunology, 31(5), 616–626. DOI:10.1016/j.fsi.2010.09.001
Rosinsk, S. L., Storb, R., Strong, R. K., Sale, G. E., Stone, D. M., Gewe, M. M., … Graves, S. S. (2015). Anti-CD28 Antibody-Initiated Cytokine Storm in Canines. Transplantation Direct, 1, 1–11.
Saeıj, J. P. J., Van Muıswınkel, W. B., Groeneveld, A., & Wıegertjes, G. F. (2002). Immune modulation by fish kinetoplastid parasites: a role for nitric oxide. Parasitology, 124(1), 77–86. DOI:10.1017/S0031182001008915
Salinas, I., Zhang, Y.-A., & Sunyer, J. O. (2011). Mucosal immunoglobulins and B cells of teleost fish. Developmental & Comparative Immunology, 35(12), 1346–1365. DOI:10.1016/j.dci.2011.11.009
Saurabh, S., & Sahoo, P. K. (2008). Lysozyme: an important defence molecule of fish innate immune system. Aquaculture Research, 39(3), 223–239. DOI:10.1111/j.1365-2109.2007.01883.x
Savan, R., Kono, T., Igawa, D., & Sakai, M. (2005). A novel tumor necrosis factor (TNF) gene present in tandem with theTNF-? gene on the same chromosome in teleosts. Immunogenetics, 57(1–2), 140–150. DOI:10.1007/s00251-005-0768-4
Savan, R., & Sakai, M. (2006). Genomics of fish cytokines. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 1(1), 89–101. DOI:10.1016/j.cbd.2005.08.005
Scapigliati, G., Buonocore, F., & Mazzini, M. (2006). Biological Activity of Cytokines: An Evolutionary Perspective. Current Pharmaceutical Design, 12(24), 3071–3081. DOI:10.2174/138161206777947489
Scapigliati, Giuseppe. (2004). Modelling of fish interleukin-1 and its receptor. Developmental & Comparative Immunology, 28(5), 429–441. DOI:10.1016/j.dci.2003.09.014
Secombes, C. J., & Wang, T. (2012). The innate and adaptive immune system of fish. In Infectious Disease in Aquaculture (pp. 3–68). Elsevier. DOI:10.1533/9780857095732.1.3
Secombes, C. J., Wang, T., & Bird, S. (2011). The interleukins of fish. Developmental & Comparative Immunology, 35(12), 1336–1345. DOI:10.1016/j.dci.2011.05.001
Secombes, C. J., Wang, T., Hong, S., Peddie, S., Crampe, M., Laing, K. J., Zou, J. (2001). Cytokines and innate immunity of fish. Developmental & Comparative Immunology, 25(8–9), 713–723. DOI:10.1016/S0145-305X(01)00032-5
Sekaran, K. P., Parasuraman, A. S., & Rajamani, D. M. (2017). Modulation of the innate immune responses in the striped snakehead murrel, Channa striata upon experimental infection with live and heat killed Aeromonas hydrophila. Open Veterinary Journal, 7(2), 157. DOI:10.4314/ovj.v7i2.13
Stafford, J. L., & Belosevic, M. (2003). Transferrin and the innate immune response of fish: identification of a novel mechanism of macrophage activation. Developmental & Comparative Immunology, 27(6–7), 539–554. DOI:10.1016/S0145-305X(02)00138-6
Taghon, T., & Rothenberg, E. V. (2008). Molecular mechanisms that control mouse and human TCR-αβ and TCR-γδ T cell development. Seminars in Immunopathology, 30(4), 383–398. DOI:10.1007/s00281-008-0134-3
Tanekhy, M., & Sakai, M. (2019). Inflammatory cytokines responses of common carp, Cyprinus carpio, leucocytes in vitro treated by immunostimulants. Iranian Journal of Fisheries Sciences, 18(4), 847–861.
Toledo-Ibarra, G. A., Rojas-Mayorquín, A. E., & Girón-Pérez, M. I. (2013). Influence of the Cholinergic System on the Immune Response of Teleost Fishes: Potential Model in Biomedical Research. Clinical and Developmental Immunology, 2013, 1–9. DOI:10.1155/2013/536534
Tort, L, Balasch, J. C., & Mackenzie, S. (2004). Fish health challenge after stress. Indicators of immunocompetence. Contributions to Science, 2(4), 443–454.
Tort, Lluis, Balasch, J. C., & Mackenzie, S. (2003). Fish immune system. A crossroads between innate and adaptive responses. Inmunologia.
Tung, J.-P., Fraser, J. F., Wood, P., & Fung, Y. (2009). Respiratory burst function of ovine neutrophils. BMC Immunology, 10(1), 25. DOI:10.1186/1471-2172-10-25
Uribe, C., Folch, H., Enriquez, R., & Moran, G. (2011).  Innate and adaptive immunity in teleost fish: a review. Veterinární Medicína, 56(10), 486–503. DOI:10.17221/3294-VETMED
Us, D. (2008). Cytokıne Storm In Avıan Influenza. Mikrobiyol Bül, 42, 365–380.
Vasta, G. R., Nita-Lazar, M., Giomarelli, B., Ahmed, H., Du, S., Cammarata, M., … Amzel, L. M. (2011). Structural and functional diversity of the lectin repertoire in teleost fish: Relevance to innate and adaptive immunity. Developmental & Comparative Immunology, 35(12), 1388–1399. DOI:10.1016/j.dci.2011.08.011
Vera-Jimenez, N. I., & Nielsen, M. E. (2013). Carp head kidney leukocytes display different patterns of oxygen radical production after stimulation with PAMPs and DAMPs. Molecular Immunology, 55(3–4), 231–236. DOI:10.1016/j.molimm.2013.01.016
Verburg‐Van Kemenade, B. M. L., Stolte, E. H., Metz, J. R., & Chadzinska, M. (2009). Chapter 7 Neuroendocrine–Immune Interactions in Teleost Fish. In Fish Physiology (pp. 313–364). DOI:10.1016/S1546-5098(09)28007-1
Wang, T., & Secombes, C. J. (2013). The cytokine networks of adaptive immunity in fish. Fish & Shellfish Immunology, 35(6), 1703–1718. DOI:10.1016/j.fsi.2013.08.030
Watts, M., Munday, B., & Burke, C. (2001). Immune responses of teleost fish. Australian Veterinary Journal, 79(8), 570–574. DOI:10.1111/j.1751-0813.2001.tb10753.x
Workenhe, S. T., Rise, M. L., Kibenge, M. J. T., & Kibenge, F. S. B. (2010). The fight between the teleost fish immune response and aquatic viruses. Molecular Immunology, 47(16), 2525–2536. DOI:10.1016/j.molimm.2010.06.009
Wu, L., Qin, Z., Liu, H., Lin, L., Ye, J., & Li, J. (2020). Recent Advances on Phagocytic B Cells in Teleost Fish. Frontiers in Immunology, 11. DOI:10.3389/fimmu.2020.00824 Yalçın, B. (2013). Major doku uygunluk kompleksi (MHC) molekülleri: genel özellikleri ve hastalıklarla ilişkisi. TURKDERM, 47(1), 12–17. DOI:10.4274/turkderm.47.s2
Yildirim, N. C., & Danabas, S. (2014). Assessment of immunomodulator biomarkers (Tnf-α, Il-1β and Il-6) in liver of Capoeta umbla for biomonitoring of pollution in Uzuncayir Dam Lake (Tunceli, Turkey). Iranian Journal of Fisheries Sciences, 13(3), 653–666.
Zapata, A., Diez, B., Cejalvo, T., Gutiérrez-de Frías, C., & Cortés, A. (2006). Ontogeny of the immune system of fish. Fish & Shellfish Immunology, 20(2), 126–136. DOI:10.1016/j.fsi.2004.09.005
Zhang, J.-M., & An, J. (2007). Cytokines, Inflammation, and Pain. International Anesthesiology Clinics, 45(2), 27–37. DOI:10.1097/AIA.0b013e318034194e Zou, J., & Secombes, C. (2016). The Function of Fish Cytokines. Biology, 5(2), 23. DOI:10.3390/biology5020023

Details

Primary Language

Turkish

Subjects

Structural Biology

Journal Section

Review

Authors

Serdar Kilercioğlu ^*
0000-0001-5288-0781
Türkiye

Publication Date

March 15, 2021

Submission Date

April 22, 2020

Acceptance Date

August 4, 2020

Published in Issue

Year 1970 Volume: 38 Number: 1

DOI

https://doi.org/10.12714/egejfas.38.1.16

IZ

https://izlik.org/JA75XK53DS

Cite

RIS / Bibtex

APA

Kilercioğlu, S. (2021). Balıklarda bağışıklık sistemi, mukozal bağışıklıklık ve IL-1β, IL-18 ve TNF-α proenflamatuvar sitokinlerinin işlevleri. Ege Journal of Fisheries and Aquatic Sciences, 38(1), 125-134. https://doi.org/10.12714/egejfas.38.1.16

Cited By

Utilization of Fish Byproduct in Edible Films: A Sustainable Approach to Improving Fillet Shelf Life

Food Science & Nutrition

https://doi.org/10.1002/fsn3.70731

Dietary Betaine Improves Immune Function, Antioxidant Status, Immune‐Related Signaling Molecules, and Disease Resistance in Fish Species

Aquaculture Nutrition

https://doi.org/10.1155/anu/4596572

Fish immune system, mucosal immunity and functions of IL-1β, TNF-α and IL-18 proinflammatory cytokines

Balıklarda bağışıklık sistemi, mukozal bağışıklıklık ve IL-1β, IL-18 ve TNF-α proenflamatuvar sitokinlerinin işlevleri

Öz

Anahtar Kelimeler

Fish immune system, mucosal immunity and functions of IL-1β, TNF-α and IL-18 proinflammatory cytokines

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

Utilization of Fish Byproduct in Edible Films: A Sustainable Approach to Improving Fillet Shelf Life

Dietary Betaine Improves Immune Function, Antioxidant Status, Immune‐Related Signaling Molecules, and Disease Resistance in Fish Species