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Deniz süngerlerinden antikanser metabolitler

Yıl 2021, Cilt: 38 Sayı: 1, 101 - 106, 15.03.2021

Belma Konuklugil İbrahim Seyda Uras

https://doi.org/10.12714/egejfas.38.1.12

Öz


Okyanuslar dünya yüzeyinin 70%'ini kaplamaktadır. Deniz ortamı, yüksek biyolojik çeşitlilik sunan, önemli bir sekonder metabolit kaynağıdır. Diğer deniz türlerinin yanı sıra, çok çeşitli sekonder metabolitlere sahip olan süngerler, ilaç keşfi için önemli bir potansiyel taşımaktadır. Kanser, yüksek morbidite ve mortalite ile önde gelen ölüm nedenlerinden biridir. Kanser tedavisinde yeni terapötik ajanların bulunması çok önemlidir. Son yıllarda, yeni antikanser bileşiklerini keşfetmeye yönelik çalışmalar deniz kaynaklarına odaklanmıştır. Bu derlemede hedefimiz antikanser etkisi olan, deniz süngerinden izole edilen sekonder metabolitler ile ilgili çalışmaları toplamaktır. Süngerlerden elde edilen bileşikler ve bu bileşiklerin yarısentetik türevleri arasından 3 adet bileşik FDA (Amerika Gıda ve İlaç Dairesi) tarafından onaylanmış ve 3 bileşik klinik faz çalışmalarındadır. Ayrıca, deniz süngerlerinden izole edilmiş 40'tan fazla bileşik, son 10 yılda antikanser aktivitesi açısından test edilmiştir. Sonuç olarak deniz süngerlerinden elde edilen sekonder metabolitler önemli ve gelecek vaat eden bir antikanser bileşik kaynağıdır.



Kaynakça

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Anticancer secondary metabolites from marine sponges

Yıl 2021, Cilt: 38 Sayı: 1, 101 - 106, 15.03.2021

Belma Konuklugil İbrahim Seyda Uras

https://doi.org/10.12714/egejfas.38.1.12

Öz


The oceans cover 70% of the Earth’s surface. The marine environment is an important source of secondary metabolites with high biodiversity. Besides other marine species, sponges with a wide range of secondary metabolites are an important potential for drug discovery. Cancer is one of the leading causes of death with high morbidity and mortality. It is very important to discover new therapeutic agents in the treatment of cancer. In recent years, studies on exploring new anticancer compounds are focused on the marine source. In this review, our target is collecting the studies about marine sponges secondary metabolites which have an anticancer effect. Among most of the isolated compounds from sponges and their semisynthetic derivatives, there are three FDA (US Food and Drug Administration) approved compounds and three compounds in clinical phase. Moreover, more than 40 compounds isolated from marine sponges have been tested for anticancer activity in recent 10 years. In conclusion marine sponges secondary metabolites are a promising and important source of the anticancer compounds.

Anahtar Kelimeler

natural products marine sponge secondary metabolites cancer treatment

Kaynakça

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  • Roel, M., Rubiolo, J.A., Guerra-Varela, J., Silva, S.B., Thomas, O.P., Cabezas-Sainz, P.,Sánchez, L., López, R. & Botana, L.M. (2016). Marine guanidine alkaloids crambescidins inhibit tumor growth and activate intrinsic apoptotic signaling inducing tumor regression in a colorectal carcinoma zebrafish xenograft model. Oncotarget, 7(50), 83071-83087. DOI: 10.18632/oncotarget.13068
  • Rothmeier, A. S., Schneiders, U.M., Wiedmann, R.M., Ischenko, I., Bruns, C. J., Rudy, A., Zahler, S. & Vollmar, A.M. (2010). The marine compound spongistatin 1 targets Vollmar, A.M. (2010). The marine compound spongistatin 1 targets pancreatic tumor progression and metastasis. International Journal of Cancer, 127(5), 1096-1105. DOI: 10.1002/ijc.25241
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  • Schneiders, U.M., Schyschka, L., Rudy, A. & Vollmar, A.M. (2009). BH3-only proteins Mcl-1 and Bim as well as endonuclease G are targeted in spongistatin 1-induced apoptosis in breast cancer cells. Molecular Cancer Therapeutics, 8(10), 2914-2925. DOI: 10.1158/1535-7163.Mct-08-1179
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Toplam 72 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Hidrobiyoloji
Bölüm Kısa Araştırmalar
Yazarlar

Belma Konuklugil 0000-0002-4753-0450

İbrahim Seyda Uras 0000-0001-5945-8743

Yayımlanma Tarihi 15 Mart 2021
Gönderilme Tarihi 25 Ocak 2020
Yayımlandığı Sayı Yıl 2021Cilt: 38 Sayı: 1

Kaynak Göster

APA Konuklugil, B., & Uras, İ. S. (2021). Anticancer secondary metabolites from marine sponges. Ege Journal of Fisheries and Aquatic Sciences, 38(1), 101-106. https://doi.org/10.12714/egejfas.38.1.12