Anticancer secondary metabolites from marine sponges

Belma Konuklugil; İbrahim Seyda Uras

doi:10.12714/egejfas.38.1.12

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Deniz süngerlerinden antikanser metabolitler

Öz

Okyanuslar dünya yüzeyinin 70%'ini kaplamaktadır. Deniz ortamı, yüksek biyolojik çeşitlilik sunan, önemli bir sekonder metabolit kaynağıdır. Diğer deniz türlerinin yanı sıra, çok çeşitli sekonder metabolitlere sahip olan süngerler, ilaç keşfi için önemli bir potansiyel taşımaktadır. Kanser, yüksek morbidite ve mortalite ile önde gelen ölüm nedenlerinden biridir. Kanser tedavisinde yeni terapötik ajanların bulunması çok önemlidir. Son yıllarda, yeni antikanser bileşiklerini keşfetmeye yönelik çalışmalar deniz kaynaklarına odaklanmıştır. Bu derlemede hedefimiz antikanser etkisi olan, deniz süngerinden izole edilen sekonder metabolitler ile ilgili çalışmaları toplamaktır. Süngerlerden elde edilen bileşikler ve bu bileşiklerin yarısentetik türevleri arasından 3 adet bileşik FDA (Amerika Gıda ve İlaç Dairesi) tarafından onaylanmış ve 3 bileşik klinik faz çalışmalarındadır. Ayrıca, deniz süngerlerinden izole edilmiş 40'tan fazla bileşik, son 10 yılda antikanser aktivitesi açısından test edilmiştir. Sonuç olarak deniz süngerlerinden elde edilen sekonder metabolitler önemli ve gelecek vaat eden bir antikanser bileşik kaynağıdır.

References

Abdel-Lateff, A., Al-Abd, A. M., Alahdal, A. M., Alarif, W. M., Ayyad, S. E., Al-Lihaibi, S.S. & Azhar, A. S. (2016). Antiproliferative effects of triterpenoidal derivatives, obtained from the marine sponge Siphonochalina sp., on human hepatic and colorectal cancer cells. Zeitschrift für Naturforschung C, 71(1-2), 29-35. DOI: 10.1515/znc-2015-0160
Bae, S.Y., Kim, G.D., Jeon, J.E., Shin, J. & Lee, S.K. (2013). Anti-proliferative effect of (19Z)-halichondramide, a novel marine macrolide isolated from the sponge Chondrosia corticata, is associated with G2/M cell cycle arrest and suppression of mTOR signaling in human lung cancer cells. Toxicology In Vitro, 27(2), 694-699. DOI: 10.1016/j.tiv.2012.11.001
Ben-Califa, N., Bishara, A., Kashman, Y. & Neumann, D. (2012). Salarin C, a member of the salarin superfamily of marine compounds, is a potent inducer of apoptosis. Investigational New Drugs, 30(1), 98-104. DOI: 10.1007/s10637-010-9521-4
Bérdy, J. (2005). Bioactive Microbial Metabolites. The Journal of Antibiotics, 58(1), 1-26. doi:10.1038/ja.2005.1
Berry, E., Hardt, J.L., Clardy, J., Lurain, J.R. & Kim, J.J. (2009). Induction of apoptosis in endometrial cancer cells by psammaplysene A involves FOXO1. Gynecologic Oncology, 112(2), 331-336. DOI: 10.1016/j.ygyno.2008.10.017
Bhatnagar, I. & Kim, S.K. (2010). Immense essence of excellence: marine microbial bioactive compounds. Marine Drugs, 8(10), 2673-2701. DOI: 10.3390/md8102673
Chan, A., Andreae, P.M., Northcote, P.T. & Miller, J.H. (2011). Peloruside A inhibits microtubule dynamics in a breast cancer cell line MCF7. Investigational New Drugs, 29(4), 615-626. DOI: 10.1007/s10637-010-9398-2
Chen, Y., Zhou, Q., Zhang, L., Zhong, Y., Fan, G., Zhang, Z. & Kong, D. (2017). Stellettin B induces apoptosis in human chronic myeloid leukemia cells via targeting PI3K and Stat5. Oncotarget, 8(17), 28906-28921. DOI: 10.18632/oncotarget.15957

Cheng, X., Li, J., Tanaka, K., Majumder, U., Milinichik, A.Z., Verdi, A.C. & Albone, E. F. (2018). MORAb-202, an Antibody-Drug Conjugate Utilizing Humanized Anti-human FRalpha Farletuzumab and the Microtubule-targeting Agent Eribulin, has Potent Antitumor Activity. Molecular Cancer Therapeutics, 17(12), 2665-2675. DOI: 10.1158/1535-7163.MCT-17-1215
Cheung, F. W., Li, C., Che, C. T., Liu, B. P., Wang, L., & Liu, W. K. (2010). Geoditin A induces oxidative stress and apoptosis on human colon HT29 cells. Marine Drugs, 8(1), 80-90. DOI: 10.3390/md8010080
Chinen, T., Nagumo, Y., Watanabe, T., Imaizumi, T., Shibuya, M., Kataoka, T. & Usui, T. (2010). Irciniastatin A induces JNK activation that is involved in caspase-8-dependent apoptosis via the mitochondrial pathway. Toxicology Letters, 199(3), 341-346. DOI: 10.1016/j.toxlet.2010.09.017
De Stefano, D., Tommonaro, G., Malik, S.A., Iodice, C., De Rosa, S., Maiuri, M.C. & Carnuccio, R. (2012). Cacospongionolide and scalaradial, two marine sesterterpenoids as potent apoptosis-inducing factors in human carcinoma cell lines. PLoS One, 7(4), e33031. DOI: 10.1371/journal.pone.0033031
Dias, D.A., Urban, S. & Roessner, U. (2012). A historical overview of natural products in drug discovery. Metabolites, 2(2), 303-336. DOI: 10.3390/metabo2020303
Dyshlovoy, S.A., Fedorov, S.N., Shubina, L.K., Kuzmich, A.S., Bokemeyer, C., Keller-von Amsberg, G. & Honecker, F. (2014). Aaptamines from the marine sponge Aaptos sp. display anticancer activities in human cancer cell lines and modulate AP-1-, NF-kappaB-, and p53-dependent transcriptional activity in mouse JB6 Cl41 cells. BioMed Research International, 2014, 469309. DOI: 10.1155/2014/469309
Dyshlovoy, S.A., Tabakmakher, K.M., Hauschild, J., Shchekaleva, R.K., Otte, K., Guzii, A.G. & von Amsberg, G. (2016a). Guanidine Alkaloids from the Marine Sponge Monanchora pulchra Show Cytotoxic Properties and Prevent EGF-Induced Neoplastic Transformation in Vitro. Marine Drugs, 14(7). DOI: 10.3390/md14070133
Dyshlovoy, S.A., Otte, K., Alsdorf, W.H., Hauschild, J., Lange, T., Venz, S. & von Amsberg, G. (2016b). Marine compound rhizochalinin shows high in vitro and in vivo efficacy in castration resistant prostate cancer. Oncotarget, 7(43), 69703-69717. DOI: 10.18632/oncotarget.11941
Ebada, S.S., Wray, V., De Voogd, N.J., Deng, Z., Lin, W. & Proksch, P. (2009). Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens. Marine Drugs, 7(3), 435-444. DOI: 10.3390/md7030435
Edelson, J.R., & Brautigan, D.L. (2011). The Discodermia calyx toxin calyculin a enhances cyclin D1 phosphorylation and degradation, and arrests cell cycle progression in human breast cancer cells. Toxins (Basel), 3(1), 105-119. DOI: 10.3390/toxins3010105
Fedorov, S.N., Makarieva, T.N., Guzii, A.G., Shubina, L.K., Kwak, J.Y. & Stonik, V.A. (2009). Marine two-headed sphingolipid-like compound rhizochalin inhibits EGF-induced transformation of JB6 P+ Cl41 cells. Lipids, 44(9), 777-785. DOI: 10.1007/s11745-009-3322-6
Florean, C., Schnekenburger, M., Lee, J.Y., Kim, K.R., Mazumder, A., Song, S. & Diederich, M. (2016). Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells. Oncotarget, 7(17), 24027-24049. DOI: 10.18632/oncotarget.8210
Gesto, D.S., Cerqueira, M.F.S.A., Fernandes, P.A. & Ramos, M. J. (2012). Gemcitabine: A Critical Nucleoside for Cancer Therapy. Current Medicinal Chemistry, 19(7), 1076-1087. DOI: 10.2174/092986712799320682
Guzman, E.A., Johnson, J.D., Carrier, M.K., Meyer, C.I., Pitts, T. P., Gunasekera, S.P. & Wright, A. E. (2009). Selective cytotoxic activity of the marine-derived batzelline compounds against pancreatic cancer cell lines. Anticancer Drugs, 20(2), 149-155. DOI: 10.1097/CAD.0b013e32831fa39e
Guzman, E., Maher, M., Temkin, A., Pitts, T. & Wright, A. (2013). Spongiatriol inhibits nuclear factor kappa B activation and induces apoptosis in pancreatic cancer cells. Marine Drugs, 11(4), 1140-1151. DOI: 10.3390/md11041140 Guzman, E.A., Maers, K., Roberts, J., Kemami-Wangun, H.V., Harmody, D. & Wright, A.E. (2015). The marine natural product microsclerodermin A is a novel inhibitor of the nuclear factor kappa B and induces apoptosis in pancreatic cancer cells. Investigational New Drugs, 33(1), 86-94. DOI: 10.1007/s10637-014-0185-3
Guzman, E.A., Xu, Q., Pitts, T.P., Mitsuhashi, K.O., Baker, C., Linley, P.A. & Wright, A.E. (2016). Leiodermatolide, a novel marine natural product, has potent cytotoxic and antimitotic activity against cancer cells, appears to affect microtubule dynamics, and exhibits antitumor activity. International Journal of Cancer, 139(9), 2116-2126. DOI: 10.1002/ijc.30253
Halim, H., Chunhacha, P., Suwanborirux, K. & Chanvorachote, P. (2011). Anticancer and antimetastatic activities of Renieramycin M, a marine tetrahydroisoquinoline alkaloid, in human non-small cell lung cancer cells. Anticancer Research, 31(1), 193-201.
Huang, H.H., Kuo, S.M., Wu, Y.J. & Su, J.H. (2016). Improvement and enhancement of antibladder carcinoma cell effects of heteronemin by the nanosized hyaluronan aggregation. International Journal of Nanomedicine, 11, 1237-1251. DOI: 10.2147/ijn.S99911
Jin, J.O., Shastina, V., Park, J.I., Han, J.Y., Makarieva, T., Fedorov, S. & Kwak, J.Y. (2009). Differential induction of apoptosis of leukemic cells by rhizochalin, two headed sphingolipids from sponge and its derivatives. Biological and Pharmaceutical Bulletin, 32(6), 955-962.
Khanal, P., Kang, B.S., Yun, H.J., Cho, H.G., Makarieva, T.N. & Choi, H.S. (2011). Aglycon of rhizochalin from the Rhizochalina incrustata induces apoptosis via activation of AMP-activated protein kinase in HT-29 colon cancer cells. Biological and Pharmaceutical Bulletin, 34(10), 1553-1558.
Kong, D., Aoki, S., Sowa, Y., Sakai, T. & Kobayashi, M. (2008). Smenospongine, a sesquiterpene aminoquinone from a marine sponge, induces G1 arrest or apoptosis in different leukemia cells. Marine Drugs, 6(3), 480-488. DOI: 10.3390/md20080023
Konishi, H., Kikuchi, S., Ochiai, T., Ikoma, H., Kubota, T., Ichikawa, D. & Otsuji, E. (2009). Latrunculin a has a strong anticancer effect in a peritoneal dissemination model of human gastric cancer in mice. Anticancer Research, 29(6), 2091-2097.
Krauss, A.C., Gao, X., Li, L., Manning, M.L., Patel, P., Fu, W. & Pazdur, R. (2018). FDA Approval Summary: (Daunorubicin and Cytarabine) Liposome for Injection for the Treatment of Adults with High-Risk Acute Myeloid Leukemia. Clinical Cancer Research., 25(9), 2685-2690, DOI: 10.1158/1078-0432.Ccr-18-2990
Leal, M.C., Madeira, C., Brandao, C. A., Puga, J. & Calado, R. (2012). Bioprospecting of marine invertebrates for new natural products - a chemical and zoogeographical perspective. Molecules, 17(8), 9842-9854. DOI:10.3390/molecules17089842
Lee, H.Y., Chung, K.J., Hwang, I. H., Gwak, J., Park, S., Ju, B.G. & Oh, S. (2015). Activation of p53 with ilimaquinone and ethylsmenoquinone, marine sponge metabolites, induces apoptosis and autophagy in colon cancer cells. Marine Drugs, 13(1), 543-557. DOI: 10.3390/md13010543
Liu, W.K., Ho, J.C. & Che, C.T. (2005). Apoptotic activity of isomalabaricane triterpenes on human promyelocytic leukemia HL60 cells. Cancer Letters, 230(1), 102-110. DOI: 10.1016/j.canlet.2004.12.034
Livett, B.G., Gayler, K.R. & Khalil, Z. (2004). Drugs from the Sea: Conopeptides as Potential Therapeutics. Current Medicinal Chemistry, 11(13), 1715-1723. DOI:
Mailhol, D., Willwacher, J., Kausch-Busies, N., Rubitski, E.E., Sobol, Z., Schuler, M., Lam, M.-H., Musto, S., Loganzo,F., Maderna, A. & Furstner, A. (2014). Synthesis, molecular editing, and biological assessment of the potent cytotoxin leiodermatolide. Journal of the American Chemical Society, 136(44), 15719-15729. DOI: 10.1021/ja508846g
Malve, H. (2016). Exploring the ocean for new drug developments: Marine pharmacology. Journal of Pharmacy And Bioallied Sciences, 8(2), 83-91. DOI: 10.4103/0975-7406.171700
Mann, J. (1994). Natural products: their chemistry and biological significance. Harlow, Essex, England; New York: Longman Scientific & Technical ; Wiley.
Martins, A., Vieira, H., Gaspar, H. & Santos, S. (2014). Marketed marine natural products in the pharmaceutical and cosmeceutical industries: tips for success. Marine Drugs, 12(2), 1066-1101. DOI: 10.3390/md12021066
Menis, J. & Twelves, C. (2011). Eribulin (Halaven): a new, effective treatment for women with heavily pretreated metastatic breast cancer. Breast Cancer (Dove Med Press), 3, 101-111. DOI: 10.2147/BCTT.S21741
Mishra, B.B., & Tiwari, V.K. (2011). Natural products: an evolving role in future drug discovery. European Journal of Medicinal Chemistry, 46(10), 4769-4807. DOI: 10.1016/j.ejmech.2011.07.057
Molinski, T.F., Dalisay, D.S., Lievens, S.L. & Saludes, J.P. (2009). Drug development from marine natural products. Nature Reviews Drug Discovery, 8(1), 69-85. DOI: 10.1038/nrd2487
Nguyen, H.T., Minh, C.V., Ha, T.T., Kiem, P., V., Huong, T.H., Dat, N.T., Nhiem, N.X., Tai, B.H., Hyun, J.-H.,Kang, H.-K. & Kim, Y.H. (2009). C29 sterols with a cyclopropane ring at C-25 and 26 from the Vietnamese marine sponge Ianthella sp. and their anticancer properties. Bioorganic & Medicinal Chemistry Letters, 19(16), 4584-4588. DOI: 10.1016/j.bmcl.2009.06.097
Pantazopoulou, A., Galmarini, C.M. & Peñalva, M.A. (2018). Molecular basis of resistance to the microtubule-depolymerizing antitumor compound plocabulin. Scientific Reports, 8(1), 8616. DOI: 10.1038/s41598-018-26736-3
Paterson, I., Dalby, S.M., Roberts, J.C., Naylor, G.J., Guzman, E.A., Isbrucker, R., Pitts, T.P., Linley, P.,
Divlianska, D., Reed, J.K. & Wright, A.E. (2011). Leiodermatolide, a potent antimitotic macrolide from the marine sponge Leiodermatium sp. Angewandte Chemie International Edition, 50(14), 3219-3223. DOI: 10.1002/anie.201007719
Pettit, G.R., Fujii, Y., Hasler, J.A., & Schmidt, J.M. (1982). Isolation and Characterization of Palystatins A-D. Journal of Natural Products, 45(3), 272-276. DOI:10.1021/np50021a007
Pihlanto-Leppälä, A. (2000). Bioactive peptides derived from bovine whey proteins: opioid and ace-inhibitory peptides. Trends in Food Science & Technology, 11(9), 347-356. DOI: 10.1016/S0924-2244(01)00003-6
Radwan, M., Hanora, A., Khalifa, S. & Abou-El-Ela, S.H. (2012). Manzamines: a potential for novel cures. Cell Cycle, 11(9), 1765-1772. DOI: 10.4161/cc.20135
Rasmussen, R.S., & Morrissey, M.T. (2007). Marine Biotechnology for Production of Food Ingredients. In Advances in Food and Nutrition Research (Vol. 52, pp. 237-292): Academic Press.
Rath, B., Hochmair, M., Plangger, A. & Hamilton, G. (2018). Anticancer Activity of Fascaplysin against Lung Cancer Cell and Small Cell Lung Cancer Circulating Tumor Cell Lines. Marine Drugs, 16(10), 383. DOI: 10.3390/md16100383
Roel, M., Rubiolo, J.A., Guerra-Varela, J., Silva, S.B., Thomas, O.P., Cabezas-Sainz, P.,Sánchez, L., López, R. & Botana, L.M. (2016). Marine guanidine alkaloids crambescidins inhibit tumor growth and activate intrinsic apoptotic signaling inducing tumor regression in a colorectal carcinoma zebrafish xenograft model. Oncotarget, 7(50), 83071-83087. DOI: 10.18632/oncotarget.13068
Rothmeier, A. S., Schneiders, U.M., Wiedmann, R.M., Ischenko, I., Bruns, C. J., Rudy, A., Zahler, S. & Vollmar, A.M. (2010). The marine compound spongistatin 1 targets Vollmar, A.M. (2010). The marine compound spongistatin 1 targets pancreatic tumor progression and metastasis. International Journal of Cancer, 127(5), 1096-1105. DOI: 10.1002/ijc.25241
Salma, Y., Lafont, E., Therville, N., Carpentier, S., Bonnafe, M.J., Levade, T., Génisson, Y. & Andrieu-Abadie, N. (2009). The natural marine anhydrophytosphingosine, Jaspine B, induces apoptosis in melanoma cells by interfering with ceramide metabolism. Biochemical Pharmacology, 78(5), 477-485. DOI: 10.1016/j.bcp.2009.05.002
Schneiders, U.M., Schyschka, L., Rudy, A. & Vollmar, A.M. (2009). BH3-only proteins Mcl-1 and Bim as well as endonuclease G are targeted in spongistatin 1-induced apoptosis in breast cancer cells. Molecular Cancer Therapeutics, 8(10), 2914-2925. DOI: 10.1158/1535-7163.Mct-08-1179
Schumacher, M., Cerella, C., Eifes, S., Chateauvieux, S., Morceau, F., Jaspars, M., Dicato, M. & Diederich, M. (2010). Heteronemin, a spongean sesterterpene, inhibits TNF alpha-induced NF-kappa B activation through proteasome inhibition and induces apoptotic cell death. Biochemical Pharmacology, 79(4), 610-622. DOI: 10.1016/j.bcp.2009.09.027
Schumacher, M., Kelkel, M., Dicato, M. & Diederich, M. (2011). Gold from the sea: marine compounds as inhibitors of the hallmarks of cancer. Biotechnology Advances, 29(5), 531-547. DOI: 10.1016/j.biotechadv.2011.02.002
Sobahi, T.R.A., Ayyad, S.N., Abdel-Lateff, A., Algandaby, M.M., Alorfi, H.S. & Abdel-Naim, A.B. (2017). Cytotoxic Metabolites from Callyspongia siphonella Display Antiproliferative Activity by Inducing Apoptosis in HCT-116 Cells. Pharmacognosy Magazine, 13(Suppl 1), S37-s40. DOI: 10.4103/0973-1296.203970
Su, J.-H., Chang, W.-B., Chen, H.-M., El-Shazly, M., Du, Y.-C., Kung, T.-H., Chen, Y._C., Sung, P.-J., Ho, Y.-S., Kuo, F.-W. & Lu, M.-C. (2012). 10-Acetylirciformonin B, A Sponge Furanoterpenoid, Induces DNA Damage and Apoptosis in Leukemia Cells. Molecules, 17(10), 11839-11848. DOI:10.3390/molecules171011839
Sudek, S., Lopanik, N.B., Waggoner, L.E., Hildebrand, M., Anderson, C., Liu, H. & Haygood, M.G. (2007). Identification of the Putative Bryostatin Polyketide Synthase Gene Cluster from “Candidatus Endobugula sertula”, the Uncultivated Microbial Symbiont of the Marine Bryozoan Bugula neritina. Journal of Natural Products, 70(1), 67-74. DOI:10.1021/np060361d
Tang, S.A., Zhou, Q., Guo, W.Z., Qiu, Y., Wang, R., Jin, M. & Kong, D. (2014). In vitro antitumor activity of stellettin B, a triterpene from marine sponge Jaspis stellifera, on human glioblastoma cancer SF295 cells. Marine Drugs, 12(7), 4200-4213. DOI: 10.3390/md12074200
Teta, R., Irollo, E., Della Sala, G., Pirozzi, G., Mangoni, A. & Costantino, V. (2013). Smenamides A and B, chlorinated peptide/polyketide hybrids containing a dolapyrrolidinone unit from the Caribbean sponge Smenospongia aurea. Evaluation of their role as leads in antitumor drug research. Marine Drugs, 11(11), 4451-4463. DOI: 10.3390/md11114451
Thomas, T.R., Kavlekar, D.P. & LokaBharathi, P.A. (2010). Marine drugs from sponge-microbe association--a review. Marine Drugs, 8(4), 1417-1468. DOI:10.3390/md8041417
Torre, L.A., Bray, F., Siegel, R.L., Ferlay, J., Lortet-Tieulent, J. & Jemal, A. (2015). Global cancer statistics, 2012. A Cancer Journal for Clinicians, 65(2), 87-108. DOI:10.3322/caac.21262
Umeyama, A., Matsuoka, N., Mine, R., Nakata, A., Arimoto, E., Matsui, M. &. Hashimoto, T. (2010). Polyacetylene diols with antiproliferative and driving Th1 polarization effects from the marine sponge Callyspongia sp. Journal of Natural Medicines, 64(1), 93-97. DOI: 10.1007/s11418-009-0363-3
Wang, W., Rayburn, E.R., Velu, S.E., Nadkarni, D.H., Murugesan, S. & Zhang, R. (2009). In vitro and in vivo anticancer activity of novel synthetic makaluvamine analogues. Clinical Cancer Research, 15(10), 3511-3518. DOI: 10.1158/1078-0432.Ccr-08-2689
Wang, L., Li, D., Xu, S., Cai, H., Yao, H., Zhang, Y., Jiang, J. & Xu, J. (2012). The conversion of oridonin to spirolactone-type or enmein-type diterpenoid: synthesis and biological evaluation of ent-6,7-seco-oridonin derivatives as novel potential anticancer agents. European Journal of Medicinal Chemistry, 52, 242-250. DOI: 10.1016/j.ejmech.2012.03.024
Wang, R., Zhang, Q., Peng, X., Zhou, C., Zhong, Y., Chen, X., Qiu, Y., Jin, M., Gong, M. & Kong, D. (2016). Stellettin B Induces G1 Arrest, Apoptosis and Autophagy in Human Non-small Cell Lung Cancer A549 Cells via Blocking PI3K/Akt/mTOR Pathway. Scientific Reports, 6, 27071. DOI: 10.1038/srep27071
Whitson, E.L., Pluchino, K.M., Hall, M.D., McMahon, J.B. & McKee, T.C. (2011). New candidaspongiolides, tedanolide analogues that selectively inhibit melanoma cell growth. Organic Letters, 13(13), 3518-3521. DOI: 10.1021/ol201329p
Wu, J.C., Wang, C.T., Hung, H.C., Wu, W.J., Wu, D.C., Chang, M.C. & Tai, M. H. (2016). Heteronemin Is a Novel c-Met/STAT3 Inhibitor Against Advanced Prostate Cancer Cells. The Prostate, 76(16), 1469-1483. DOI: 10.1002/pros.23230
Yoo, H., Lee, Y.S., Lee, S., Kim, S. & Kim, T.Y. (2012). Pachastrissamine from Pachastrissa sp. inhibits melanoma cell growth by dual inhibition of Cdk2 and ERK-mediated FOXO3 downregulation. Phytotherapy Research, 26(12), 1927-1933. DOI: 10.1002/ptr.4673
Zhang, Y.W., Ghosh, A.K. & Pommier, Y. (2012). Lasonolide A, a potent and reversible inducer of chromosome condensation. Cell Cycle, 11(23), 4424-4435. DOI: 10.4161/cc.22768

Details

Primary Language

English

Subjects

Hydrobiology

Journal Section

Short Communication

Authors

Belma Konuklugil
0000-0002-4753-0450
Türkiye

İbrahim Seyda Uras ^*
0000-0001-5945-8743
Türkiye

Publication Date

March 15, 2021

Submission Date

January 25, 2020

Acceptance Date

January 31, 2020

Published in Issue

Year 1970 Volume: 38 Number: 1

DOI

https://doi.org/10.12714/egejfas.38.1.12

IZ

https://izlik.org/JA29ZE62RW

Cite

RIS / Bibtex

APA

Konuklugil, B., & Uras, İ. S. (2021). Anticancer secondary metabolites from marine sponges. Ege Journal of Fisheries and Aquatic Sciences, 38(1), 101-106. https://doi.org/10.12714/egejfas.38.1.12

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Anticancer secondary metabolites from marine sponges

Deniz süngerlerinden antikanser metabolitler

Öz