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Balıklarda bağışıklık sistemi, mukozal bağışıklıklık ve IL-1β, IL-18 ve TNF-α proenflamatuvar sitokinlerinin işlevleri

Yıl 2021, Cilt: 38 Sayı: 1, 125 - 134, 15.03.2021

Serdar Kilercioğlu

https://doi.org/10.12714/egejfas.38.1.16

Öz

Balık, sucul ortamda türlü tehditler ile karşılaşmakta ve bu tehditlere karşı evrimsel süreçte geliştirdiği bağışıklık yanıtları ile karşılık vermektedir. Balıklarda bağışıklık sistemi doğal ve kazanılmış bağışıklığın sıvısal ve hücresel elemanlarından oluşur. Mukoza ile ilişkili dokular da savunma sisteminin bir parçası olup doğal ve kazanılmış bağışıklığın hücreleri ile donatılmıştır. Bağışıklık sisteminin hücre ve moleküllerinin oluştuğu, olgunlaştığı ve sisteme dahil edildiği organlar lenfoid organlar olarak adlandırılmaktadır. Sitokinler, canlıda büyüme, farklılaşma ve bağışıklık yanıtı gibi birçok görev üstlenen küçük glikoproteinlerdir. Sitokinlerin, bağışıklık sistemindeki ana rolleri bağışıklık yanıtlarını düzenlemeleri ve hücreler arası iletişimi sağlamalarıdır. Bu derlemede balık bağışıklık sisteminin ana sıvısal ve hücresel bileşenleri, mukozal bağışıklık sistemi, birincil lenfoid organların işlevleri ve proenflamatuvar etki gösteren IL-1β, IL-18 ve TNF-α sitokinleri hakkında literatürde yer alan bilgiler ana hatları ile bir araya getirilmiş, bahsi geçen sitokinlerin bağışıklık sistemindeki görevlerinin anlaşılması amaçlanmıştır.

Anahtar Kelimeler

Doğal bağışıklık kazanılmış bağışıklık mukozal bağışıklık lenfoid organlar balık sitokinleri IL-1β IL-18 TNF-α

Kaynakça

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Fish immune system, mucosal immunity and functions of IL-1β, TNF-α and IL-18 proinflammatory cytokines

Yıl 2021, Cilt: 38 Sayı: 1, 125 - 134, 15.03.2021

Serdar Kilercioğlu

https://doi.org/10.12714/egejfas.38.1.16

Öz

Fish exposed to various threats in the aquatic environment and respond to these with the immune responses which has developed in the evolutionary process. The immune system of teleost fish consists of the fluid and cellular factors of both natural and acquired immunity. Mucosa associated lymphoid tissues are a part of fish immune system and equipped with cells of natural and adaptive immunity. The organs in which all these cells and molecules are formed, matured and included in the system are called lymphoid organs. Cytokines, which are small glycoproteins, play critical roles in immunity. Their main roles in the immune system are to regulate immune responses and to enable communication between cells. In this review, the literature on the main factors of the fish immune system, mucosal immunity, the functions of the primary lymphoid organs, and proinflamatory cytokines IL-1β, TNF-α and IL-18 were collected. Furthermore, the functions of specified cytokines were aimed to clarify.

Anahtar Kelimeler

Innate immunity adaptive immunity lymphoid organs mucosal immunity fish cytokines IL-1β IL-18 TNF-α

Kaynakça

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  • Vasta, G. R., Nita-Lazar, M., Giomarelli, B., Ahmed, H., Du, S., Cammarata, M., … Amzel, L. M. (2011). Structural and functional diversity of the lectin repertoire in teleost fish: Relevance to innate and adaptive immunity. Developmental & Comparative Immunology, 35(12), 1388–1399. DOI:10.1016/j.dci.2011.08.011
  • Vera-Jimenez, N. I., & Nielsen, M. E. (2013). Carp head kidney leukocytes display different patterns of oxygen radical production after stimulation with PAMPs and DAMPs. Molecular Immunology, 55(3–4), 231–236. DOI:10.1016/j.molimm.2013.01.016
  • Verburg‐Van Kemenade, B. M. L., Stolte, E. H., Metz, J. R., & Chadzinska, M. (2009). Chapter 7 Neuroendocrine–Immune Interactions in Teleost Fish. In Fish Physiology (pp. 313–364). DOI:10.1016/S1546-5098(09)28007-1
  • Wang, T., & Secombes, C. J. (2013). The cytokine networks of adaptive immunity in fish. Fish & Shellfish Immunology, 35(6), 1703–1718. DOI:10.1016/j.fsi.2013.08.030
  • Watts, M., Munday, B., & Burke, C. (2001). Immune responses of teleost fish. Australian Veterinary Journal, 79(8), 570–574. DOI:10.1111/j.1751-0813.2001.tb10753.x
  • Workenhe, S. T., Rise, M. L., Kibenge, M. J. T., & Kibenge, F. S. B. (2010). The fight between the teleost fish immune response and aquatic viruses. Molecular Immunology, 47(16), 2525–2536. DOI:10.1016/j.molimm.2010.06.009
  • Wu, L., Qin, Z., Liu, H., Lin, L., Ye, J., & Li, J. (2020). Recent Advances on Phagocytic B Cells in Teleost Fish. Frontiers in Immunology, 11. DOI:10.3389/fimmu.2020.00824 Yalçın, B. (2013). Major doku uygunluk kompleksi (MHC) molekülleri: genel özellikleri ve hastalıklarla ilişkisi. TURKDERM, 47(1), 12–17. DOI:10.4274/turkderm.47.s2
  • Yildirim, N. C., & Danabas, S. (2014). Assessment of immunomodulator biomarkers (Tnf-α, Il-1β and Il-6) in liver of Capoeta umbla for biomonitoring of pollution in Uzuncayir Dam Lake (Tunceli, Turkey). Iranian Journal of Fisheries Sciences, 13(3), 653–666.
  • Zapata, A., Diez, B., Cejalvo, T., Gutiérrez-de Frías, C., & Cortés, A. (2006). Ontogeny of the immune system of fish. Fish & Shellfish Immunology, 20(2), 126–136. DOI:10.1016/j.fsi.2004.09.005
  • Zhang, J.-M., & An, J. (2007). Cytokines, Inflammation, and Pain. International Anesthesiology Clinics, 45(2), 27–37. DOI:10.1097/AIA.0b013e318034194e Zou, J., & Secombes, C. (2016). The Function of Fish Cytokines. Biology, 5(2), 23. DOI:10.3390/biology5020023
Toplam 104 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Yapısal Biyoloji
Bölüm Derleme
Yazarlar

Serdar Kilercioğlu 0000-0001-5288-0781

Yayımlanma Tarihi 15 Mart 2021
Gönderilme Tarihi 22 Nisan 2020
Yayımlandığı Sayı Yıl 2021 Cilt: 38 Sayı: 1

Kaynak Göster

APA Kilercioğlu, S. (2021). Balıklarda bağışıklık sistemi, mukozal bağışıklıklık ve IL-1β, IL-18 ve TNF-α proenflamatuvar sitokinlerinin işlevleri. Ege Journal of Fisheries and Aquatic Sciences, 38(1), 125-134. https://doi.org/10.12714/egejfas.38.1.16