The effect of mercury, copper, and zinc on paraoxonase (PON) enzyme activity in Bonito (Sarda sarda) fish

Büşra Şahin; Sena Çenesiz

doi:10.12714/egejfas.38.4.09

Research Article

Palamut (Sarda sarda) balığında paraoksonaz (PON) enzim aktivitesi üzerine cıva, bakır ve çinkonun etkisi

Year 2021, Volume: 38 Issue: 4, 479 - 486, 15.12.2021

Büşra Şahin , Sena Çenesiz

https://doi.org/10.12714/egejfas.38.4.09

Abstract

Çevre kirliliğinde sık rastlanan ağır metal kirlilikleri, biyokimyasal enzim reaksiyonları üzerinden organizmada zararlı etkiler meydana getirdiği için bu çalışmada çevre kirliliğinde sık rastlanan cıva (Hg⁺²), bakır (Cu⁺²) ve çinko (Zn⁺²) ağır metal iyonlarının palamut (Sarda sarda) balığı kas dokusunda bulunan PON (paraoksonaz) aktivitesi üzerine etkileri araştırılmıştır. Çalışmada Samsun bölgesi denizinden taze olarak temin edilen 25 adet palamut balığının kas dokuları kullanıldı. Ağır metal çözeltilerinden farklı hacimlerde eklenerek PON enzim aktivitesindeki değişiklikler tayin edildi. Farklı hacimlerde kullanılan Hg⁺² ağır metal iyonunun PON enzim aktiviteleri 30,9383 U/mLdak, 29,0598 U/mLdak, 26,3799 U/mLdak, 23,9443 U/mLdak, 20,6725 U/mLdak olarak hesaplandı, farklı hacimlerde kullanılan Cu⁺² ağır metal iyonunun PON enzim aktiviteleri 19,7949 U/mLdak, 19,4807 U/mLdak 19,1864 U/mLdak, 19,1200 U/mLdak, 18,9037 U/mLdak olarak hesaplandı ve farklı hacimlerde kullanılan Zn⁺² ağır metal iyonunun PON enzim aktiviteleri 23,8305 U/mLdak, 23,0781 U/mLdak, 22,9073 U/mLdak, 22,4324 U/mLdak, 21,8159 U/mLdak olarak hesaplandı. Elde edilen bu veriler sonucunda % aktivite değerleri hesaplanarak % aktivite grafikleri çizildi. Çalışma sonucunda Cu⁺² ve Zn⁺² ağır metal iyonlarının artan derişimlerinin enzim aktivitesinde azalmaya neden olduğu fakat kullanılan farklı derişimler arasında istatistiksel olarak anlamlı bir fark olmadığı belirlendi. Hg⁺² ağır metal iyonun artan derişimlerinin PON enzim aktivitesini inhibe ettiği, kullanılan farklı derişimlere bağlı olarak aktiviteler arasında istatistiksel olarak anlamlı bir azalmaya neden olduğu belirlendi (p < 0.05).

Keywords

Palamut (Sarda sarda), ağır metal, bakır (Cu), cıva (Hg), çinko (Zn), paraoksonaz (PON)

Supporting Institution

Ondokuz Mayıs Üniversitesi Bilimsel Araştırma Projeleri Komisyonu Başkanlığı

Project Number

PYO.VET.1904.19.011

Thanks

Ondokuz Mayıs Üniversitesi Bilimsel Araştırma Projeleri Komisyonu Başkanlığı'nın PYO.VET.1904.19.011 proje numarasıyla verdiği desteğe teşekkür ederiz.

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The effect of mercury, copper, and zinc on paraoxonase (PON) enzyme activity in Bonito (Sarda sarda) fish

Year 2021, Volume: 38 Issue: 4, 479 - 486, 15.12.2021

Büşra Şahin , Sena Çenesiz

https://doi.org/10.12714/egejfas.38.4.09

Abstract

Since heavy metal dirtiness, which we frequently encounter in environmental pollution causes harmful effects on the organism through biochemical enzyme reactions, in this study, the effects of mercury (Hg⁺²), copper (Cu⁺²), and zinc (Zn⁺²) heavy metal ions, which are common in environmental pollution, on PON (paraoxonase) enzyme activity in muscle tissue of bonito (Sarda sarda) were investigated. In the study, 25 bonito (S. sarda) fish muscle tissues freshly obtained from the Samsun region sea were used. The changes in PON enzyme activity were determined by adding different volumes of heavy metal solutions. PON enzyme activities of Hg+2 heavy metal ion used in different volumes were calculated as 30.9383 U/mLdak, 29.0598 U/mLdak, 26.3799 U/mLdak, 23.9443 U/mLdak, 20.6725 U/mLdak, PON enzyme activities of Cu⁺² heavy metal ion used in different volumes were calculated as 19.7949 U/mLdak, 19.4807 U/mLdak 19.1864 U/mLdak, 19.1200 U/mLdak, 18.9037 U/mLdak and PON enzyme activities of Zn⁺² heavy metal ion used in different volumes were calculated as 23.8305 U/mLdak, 23.0781 U/mLdak, 22.9073 U/mLdak, 22.4324 U/mLdak, 21.8159 U/mLdak. As a result of these obtained data, activity (%) values were calculated and activity (%) graphs were drawn. As a result of the study, it was determined that increasing concentrations of Cu⁺² and Zn⁺² heavy metal ions caused a decrease in PON enzyme activity, but there was no statistically significant difference between the different concentrations used. It was determined that increasing concentrations of Hg⁺² heavy metal ion inhibited the PON enzyme activity, caused a statistically significant decrease between the activities depending on the different concentrations used (p < 0.05).

Keywords

Bonito (Sarda sarda), heavy metals, copper (Cu), mercury (Hg), zinc (Zn), paraoxonase (PON)

Project Number

PYO.VET.1904.19.011

References

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Erol K., Gençer, N., Arslan, M. & Arslan, O. (2013). Purification, characterization, and investigation of in vitro inhibition by metals of paraoxonase from different sheep breeds. Artifical Cells, Nanomedic, and Biotechnology, 41(2), 125-130. DOI: 10.3109/10731199.2012.696065
Gülcü, F. & Gürsu, M.F. (2003). The standardization of paraoxonase and arylesterase activity measurements (in Turkish with English abstract). Turkish Journal of Biochemistry, 28(2), 45-49.
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Details

Primary Language	English
Subjects	Structural Biology, Fisheries Management
Journal Section	Articles
Authors	Büşra Şahin 0000-0002-5245-478X Sena Çenesiz 0000-0002-3544-503X
Project Number	PYO.VET.1904.19.011
Publication Date	December 15, 2021
Submission Date	April 21, 2021
Published in Issue	Year 2021Volume: 38 Issue: 4

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APA	Şahin, B., & Çenesiz, S. (2021). The effect of mercury, copper, and zinc on paraoxonase (PON) enzyme activity in Bonito (Sarda sarda) fish. Ege Journal of Fisheries and Aquatic Sciences, 38(4), 479-486. https://doi.org/10.12714/egejfas.38.4.09

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