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Balıklarda bağışıklık sistemi, mukozal bağışıklıklık ve IL-1β, IL-18 ve TNF-α proenflamatuvar sitokinlerinin işlevleri

Year 2021, Volume: 38 Issue: 1, 125 - 134, 15.03.2021

Serdar Kilercioğlu

https://doi.org/10.12714/egejfas.38.1.16

Abstract

Balık, sucul ortamda türlü tehditler ile karşılaşmakta ve bu tehditlere karşı evrimsel süreçte geliştirdiği bağışıklık yanıtları ile karşılık vermektedir. Balıklarda bağışıklık sistemi doğal ve kazanılmış bağışıklığın sıvısal ve hücresel elemanlarından oluşur. Mukoza ile ilişkili dokular da savunma sisteminin bir parçası olup doğal ve kazanılmış bağışıklığın hücreleri ile donatılmıştır. Bağışıklık sisteminin hücre ve moleküllerinin oluştuğu, olgunlaştığı ve sisteme dahil edildiği organlar lenfoid organlar olarak adlandırılmaktadır. Sitokinler, canlıda büyüme, farklılaşma ve bağışıklık yanıtı gibi birçok görev üstlenen küçük glikoproteinlerdir. Sitokinlerin, bağışıklık sistemindeki ana rolleri bağışıklık yanıtlarını düzenlemeleri ve hücreler arası iletişimi sağlamalarıdır. Bu derlemede balık bağışıklık sisteminin ana sıvısal ve hücresel bileşenleri, mukozal bağışıklık sistemi, birincil lenfoid organların işlevleri ve proenflamatuvar etki gösteren IL-1β, IL-18 ve TNF-α sitokinleri hakkında literatürde yer alan bilgiler ana hatları ile bir araya getirilmiş, bahsi geçen sitokinlerin bağışıklık sistemindeki görevlerinin anlaşılması amaçlanmıştır.

Keywords

Doğal bağışıklık kazanılmış bağışıklık mukozal bağışıklık lenfoid organlar balık sitokinleri IL-1β IL-18 TNF-α

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Fish immune system, mucosal immunity and functions of IL-1β, TNF-α and IL-18 proinflammatory cytokines

Year 2021, Volume: 38 Issue: 1, 125 - 134, 15.03.2021

Serdar Kilercioğlu

https://doi.org/10.12714/egejfas.38.1.16

Abstract

Fish exposed to various threats in the aquatic environment and respond to these with the immune responses which has developed in the evolutionary process. The immune system of teleost fish consists of the fluid and cellular factors of both natural and acquired immunity. Mucosa associated lymphoid tissues are a part of fish immune system and equipped with cells of natural and adaptive immunity. The organs in which all these cells and molecules are formed, matured and included in the system are called lymphoid organs. Cytokines, which are small glycoproteins, play critical roles in immunity. Their main roles in the immune system are to regulate immune responses and to enable communication between cells. In this review, the literature on the main factors of the fish immune system, mucosal immunity, the functions of the primary lymphoid organs, and proinflamatory cytokines IL-1β, TNF-α and IL-18 were collected. Furthermore, the functions of specified cytokines were aimed to clarify.

Keywords

Innate immunity adaptive immunity lymphoid organs mucosal immunity fish cytokines IL-1β IL-18 TNF-α

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There are 104 citations in total.

Details

Primary Language Turkish
Subjects Structural Biology
Journal Section Review
Authors

Serdar Kilercioğlu 0000-0001-5288-0781

Publication Date March 15, 2021
Submission Date April 22, 2020
Published in Issue Year 2021Volume: 38 Issue: 1

Cite

APA Kilercioğlu, S. (2021). Balıklarda bağışıklık sistemi, mukozal bağışıklıklık ve IL-1β, IL-18 ve TNF-α proenflamatuvar sitokinlerinin işlevleri. Ege Journal of Fisheries and Aquatic Sciences, 38(1), 125-134. https://doi.org/10.12714/egejfas.38.1.16