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Deniz süngerlerinden antikanser metabolitler

Year 2021, Volume: 38 Issue: 1, 101 - 106, 15.03.2021

Belma Konuklugil , İbrahim Seyda Uras

https://doi.org/10.12714/egejfas.38.1.12

Abstract


Okyanuslar dünya yüzeyinin 70%'ini kaplamaktadır. Deniz ortamı, yüksek biyolojik çeşitlilik sunan, önemli bir sekonder metabolit kaynağıdır. Diğer deniz türlerinin yanı sıra, çok çeşitli sekonder metabolitlere sahip olan süngerler, ilaç keşfi için önemli bir potansiyel taşımaktadır. Kanser, yüksek morbidite ve mortalite ile önde gelen ölüm nedenlerinden biridir. Kanser tedavisinde yeni terapötik ajanların bulunması çok önemlidir. Son yıllarda, yeni antikanser bileşiklerini keşfetmeye yönelik çalışmalar deniz kaynaklarına odaklanmıştır. Bu derlemede hedefimiz antikanser etkisi olan, deniz süngerinden izole edilen sekonder metabolitler ile ilgili çalışmaları toplamaktır. Süngerlerden elde edilen bileşikler ve bu bileşiklerin yarısentetik türevleri arasından 3 adet bileşik FDA (Amerika Gıda ve İlaç Dairesi) tarafından onaylanmış ve 3 bileşik klinik faz çalışmalarındadır. Ayrıca, deniz süngerlerinden izole edilmiş 40'tan fazla bileşik, son 10 yılda antikanser aktivitesi açısından test edilmiştir. Sonuç olarak deniz süngerlerinden elde edilen sekonder metabolitler önemli ve gelecek vaat eden bir antikanser bileşik kaynağıdır.



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Anticancer secondary metabolites from marine sponges

Year 2021, Volume: 38 Issue: 1, 101 - 106, 15.03.2021

Belma Konuklugil , İbrahim Seyda Uras

https://doi.org/10.12714/egejfas.38.1.12

Abstract


The oceans cover 70% of the Earth’s surface. The marine environment is an important source of secondary metabolites with high biodiversity. Besides other marine species, sponges with a wide range of secondary metabolites are an important potential for drug discovery. Cancer is one of the leading causes of death with high morbidity and mortality. It is very important to discover new therapeutic agents in the treatment of cancer. In recent years, studies on exploring new anticancer compounds are focused on the marine source. In this review, our target is collecting the studies about marine sponges secondary metabolites which have an anticancer effect. Among most of the isolated compounds from sponges and their semisynthetic derivatives, there are three FDA (US Food and Drug Administration) approved compounds and three compounds in clinical phase. Moreover, more than 40 compounds isolated from marine sponges have been tested for anticancer activity in recent 10 years. In conclusion marine sponges secondary metabolites are a promising and important source of the anticancer compounds.

Keywords

natural products marine sponge secondary metabolites cancer treatment

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There are 72 citations in total.

Details

Primary Language English
Subjects Hydrobiology
Journal Section Short Communications
Authors

Belma Konuklugil 0000-0002-4753-0450

İbrahim Seyda Uras 0000-0001-5945-8743

Publication Date March 15, 2021
Submission Date January 25, 2020
Published in Issue Year 2021Volume: 38 Issue: 1

Cite

APA Konuklugil, B., & Uras, İ. S. (2021). Anticancer secondary metabolites from marine sponges. Ege Journal of Fisheries and Aquatic Sciences, 38(1), 101-106. https://doi.org/10.12714/egejfas.38.1.12