This study investigated the use of cooked sunflower seed meal as soybean meal replacer in Clarias gariepinus diet in a 56-day feeding trial using growth performance, nutrient utilization, body composition, digestibility, hematology and liver histology as indices of assessment. Sunflower seed meal was cooked for 10, 20 and 30 minutes. Each of the differently cooked sunflower seed meal replaced soybean meal portion of control diet at 15, 30 and 45% to produce nine 40% crude protein, 18kJ/g test diets. A diet without sunflower meal served as the control. Triplicate groups of fish in 70-litre capacity aerated rectangular plastic tanks were alloted to each dietary treatment at a stocking rate of 15 fingerlings (3.72±0.22g average weight) per tank in a completely randomized design. Fish were fed to satiation. Data obtained from the experiment were subjected to statistical analysis. The results of the experiment revealed that up to 30% replacement level of 10- and 20-minutes cooked sunflower produced a statistically similar results with soybean-based control diets.