Mutagenicity of Nonylphenol and Octylphenol Using Salmonella Mutation Assay.

Meltem Boyacıoğlu; Özlem Çakal Arslan; Hatice Parlak; Muhammet Ali Karaaslan

EN TR

Mutagenicity of Nonylphenol and Octylphenol Using Salmonella Mutation Assay.

Öz

Nonilfenol ve Oktifenol’ün Salmonella mutasyon testi ile mutajenitesinin belirlenmesi. Bu çalışmada, yüzey suyunda, denizde, yeraltı sularında ve sucul sedimentte yüksek seviyelerde bulunan, endüstri ve bazı evsel ürünlerde yoğun olarak kullanılan Nonilfenol (NP) ve Oktilfenol (OP)’ ün mutajenik aktivitesi test edilmiştir. NP ve OP’nin toksisite ve östrojenik etkisine ait çok sayıda veri bulunmasına rağmen, bu kimyasalların mutajenik etkisi ile ilgi literatür az sayıdadır. Mutajenik etkinin belirlenmesi amacı ile NP 0.937- 4.685 µg/L aralığın da 6 farklı konsantrasyonda, OP ise 10- 160 µg/L aralığında 5 farklı konsantrasyonda test sistemi olarak seçilen Salmonella thyphimirium TA98 ve TA 100 suşları üzerinde (metabolik aktivasyonsuz) test edilmiştir. Sonuçlar revertant koloni sayılarına göre değerlendirildiğinde, tüm NP konsantrasyonlarının toksik olduğu buna rağmen mutajenik etkisinin olmadığı gözlenmiştir. Buna ek olarak OP’ün Salmonella thyphimirium TA98 suşu ile yapılan testlerde 40 μg /L ve Salmonella thyphimirium TA100 suşu ile yapılan testlerde ise 20 μg/L konsantrasyonları mutajenik bulunmuştur. Bu bulgular ışığında yapmış olduğumuz çalışma çevresel konsantrasyonlarda ki NP’ nin toksik, OP’ nin ise mutajenik etkiye sahip olması ile çevresel etkilerinin önemini vurgulamaktadır

Anahtar Kelimeler

Alkilfenol ethoksilat, nonyilfenol, oktilfenol, Salmonella thyphimirium, mutajenisite

References

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Primary Language

Turkish

Subjects

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Authors

Meltem Boyacıoğlu

Özlem Çakal Arslan

Hatice Parlak

Muhammet Ali Karaaslan

Publication Date

September 1, 2007

Submission Date

December 7, 2015

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-

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Year 2007 Volume: 24 Number: 3

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https://izlik.org/JA45LP92BU

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APA

Boyacıoğlu, M., Arslan, Ö. Ç., Parlak, H., & Karaaslan, M. A. (2007). Mutagenicity of Nonylphenol and Octylphenol Using Salmonella Mutation Assay. Ege Journal of Fisheries and Aquatic Sciences, 24(3), 299-302. https://izlik.org/JA45LP92BU

Mutagenicity of Nonylphenol and Octylphenol Using Salmonella Mutation Assay.

Nonilfenol ve Oktifenol'ün Salmonella mutasyon testi ile mutajenitesinin belirlenmesi.

Abstract

Keywords

Mutagenicity of Nonylphenol and Octylphenol Using Salmonella Mutation Assay.

Öz

Anahtar Kelimeler

References

Details

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Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

IZ

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