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Nonilfenol ve Oktifenol'ün Salmonella mutasyon testi ile mutajenitesinin belirlenmesi.

Year 2007, Volume: 24 Issue: 3, 299 - 302, 01.09.2007

Meltem Boyacıoğlu Özlem Çakal Arslan Hatice Parlak Muhammet Ali Karaaslan

Abstract

Keywords

-

References

  • Ahel, M., W. Giger and M. Koch. 1994. Behavior of alkylphenol polyethoxylate surfactants in the aquatic environment-I. Occurrence and transformation in sewage treatment. Water Res., 28: 1131-1142
  • Ahel, M., J. McEvoy and W. Giger. 1993. Bioaccumulation of the lipophilic metabolites of nonionic surfactants in freshwater organisms. Environ. Pollut., 79: 243-248.
  • Alexander, M. 1981. Biodegradation of chemicals of environmental concern. Sci., 211: 132-138
  • Ames, B.N., J. McCann and E. Yamasaki. 1975. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat. Res., 31: 347 -364
  • APERC. 2004. APE Research Council, Product information. 09.11.2007. http://www.aperc.org/productinfo.htm
  • Arslan Cakal, O. and H. Parlak. 2007. Embryotoxic effects of nonylphenol and octylphenol in sea urchin Arbacia lixula. Ecotox. 16: 439-444.
  • Arslan Cakal, O., H. Parlak, R. Oral and S. Katalay. 2007. The Effects of Nonylphenol and Octylphenol on Embryonic Development of Sea Urchin (Paracentrotus lividus). Arch Environ Contam And Tox. 53: 214-219
  • Bennie, D.T., C.A. Sullivan, H.B. Lee, T.E. Peart and R.J. Maguire. 1997. Occurrence of Alkylphenols and Alkylphenol mono- and di ethoxylates in natural waters of Laurentian Great Lakes basin and the upper St Lawrence River. Sci. Tot. Environ., 193: 263- 275
  • Cerna, N., V. Hajek, E. Stejskalova, L. Dobias, Z. Zudova and P. Rossner. 1991. Environmental genotoxicity monitoring using Salmonella typhimurium strains as indicator system. Sci. Total Environ.1(101): 1-2.
  • Colborn, T., F. Saal and A. Soto. 1993. Developmental effects of endocrine- disrupting chemicals in wildlife and humans. Environ. H. Persp., 101:378- 384
  • Comber, M.H.I., T.D. Williams and K.M. Stewart. 1993. The effects of Nonylphenol on Daphnia magna. Wat. Res. 27: 273-276
  • Cox, C. 1996. Nonyl Phenol And Related Chemicals. J. of Pesticide Ref./ Spring, 16 (1): 15-20. (Corrected 4/2003)
  • Czyż, A., H. Szpilewska, R. Dutkiewiez, W. Kowalska, A. Biniewska- Godlewska and G. Wegrzyn. 2002. Comparison of the Ames test and a enwly developed assay for detection of mutagenic pollution of marine environments. Mutat Res. 519: 67-74.
  • EA. 2005. Environmental Risk Evaluation Report: 4-tert-Octylphenol, April 2005. Environment Agency UK, Published by: Environment Agency, Rio House, Waterside Drive, Aztec West, Almondsbury, Bristol, BS32 4UD. http://www.environment-agency.gov.uk
  • ECB. 2002. 4-nonylphenol (branched) and nonylphenol (CAS Nos: 84852-15- 3 and 25154-52-3 EINECS Nos: 284-325-5 and 246-672-0), European Chemicals Bureau, Summary Risk Assessment Report, UK. http://ecb.jrc.it/DOCUMENTS/Existing- Chemicals/RISK_ASSESSMENT/SUMMARY/4- nonylphenol_nonylphenolsum017.pdf
  • Ekelund, R., A. Bergman, A. Granmo and M. Berggren. 1990. Bioaccumulation of 4- nonylphenol in marine animals-A reevaluation. Environ. Pollut., 64: 107-120.
  • Jobling, S. and Sumpter, J.P. 1993. Detergent components in sewage effluent are weakly estrogenic to fish: an in vitro study using rainbow trout (Oncorhynchus mykiss) hepatocytes. Aqua. Toxicol., 27: 361–372
  • Kataoka, H., T. Hayatsu, G. Hietsch, H. Steinkellner, S. Nishioka, S. Narimatsu, S. Knasmüller and H. Hayatsu. 2000. Identification of mutagenic heterocylic amines(IQ.Trp-P-1 and Aα C) in the water of the Danube River. Mutat. Res., 466: 27-35.
  • Kim, S.K., B. K. Kim, J.H. Shim, J.E. Gil, Y.D. Yoon and J.H. Kim. 2006. Nonylphenol and Octylphenol- Induced Apoptosis in Human Embryonic Stem Cells are related to Fas-Fas Ligand Pathway. Tox. Sci., 94(2): 310- 321.
  • Kotelevtsev, S. V. and I. Ludmilla (1995). Biochemical and Genotoxicological Monitoring of Ecosystems with Special Reference to Lake Baikal and Northern Black Sea. Nato Advanced Study Institute on Molecular Aspects of Oxidative Drug Metabolizing Enzymes: Their Significance in Environmental Toxicology, Chemical Carcinogenesis and Health. 99- 102.
  • Kubo, T., K. Urano and H. Utsumi. 2002. Mutagenicity Characteristics of 255 Environmental Chemicals, J. of H. Sci., 48 (6): 545-554.
  • Kutlu, M., G. Aydogan, F. Susuz and A. Özata. 2004. The Salmonella mutagenicity of water and sediments from the Porsuk River in Turkey. Environ. Tox. and Pharma., 17: 111-116.
  • Maguire, R.J. 1999. Review of Persistence of Nonylphenol and Nonylphenol Ethoxylates in Aquatic Environments. Water Qual. Res. J. Canada., 3437-78
  • Marcomoni, A., B. Pavoni, A. Sfriso and A.A. Orio. 1990. Persistent metabolites of Alkylphenol polyethoxylates in the marine environment. Mar. Chem., 29: 307-323
  • Maron, D.M. and B.N. Ames. 1983. Revised Methods for the Salmonella Mutagenicity Test. Mutat. Res., 113: 173- 215.
  • McCann, J. and B.N. Ames. 1976. Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion. Proc. Natl. Acad. Sci., USA 73: 950- 954.
  • McCann, J., E. Choi, E. Yamasaki and B.N. Ames 1975. Proc. Natl. Acad. Sci., USA 72 5135- 5139.
  • McLeese, D.W., V Zitko, D.B. Sergeant, L. Burridge and C.D. Metcalfe. 1981. Lethality and accumulation of Alkylphenols in aquatic fauna. Chemos., 10: 723-730
  • Mortelmans, K. and E. Zeiger. 2000. The Ames Salmonella/microsome mutagenicity assay. Mutat. Res., 455: 29-60.
  • Naylor, C.G., J.P. Mieure, W.J. Adams, J.A. Weeks, F.J. Castaldi, L.G. Ogle and R.R. Romano. 1992. Alkylphenol ethoxylates in the environment. J. Am. Oil Chem. Soc. 69: 695-703
  • Nimrod, A.C. and W.H. Benson. 1996. Environmental estrogenic effects of alkylphenol ethoxylates. Crit. Rev. Toxicol., 26: 335-364
  • OSPAR. 2006a. Hazardous substance series Number 136, Background document on Nonylphenol. OSPAR Commission (Protection for the Marine Environment of the North-East Atlantic).25.12.2008. http://www.ospar.org/documents/dbase/publications/p00136nonylphenol. pdf>
  • OSPAR. 2006b. Hazardous substance series Number 273, Background document on Octylphenol. OSPAR Commission (Protection for the Marine Environment of the North–east Atlantic). http://www.ospar.org/documents/dbase/publications/p00173_octylphenol .pdf> 25.12.2008.
  • Rasmussen, T.H., T.K. Andreassen, S.N. Pedersen, L.T.M. Van der Ven, P. Bjerregaard and B. Korsgaard. 2002. Effects of waterborne exposure of octylphenol and estrogen on pregnant viviparous eelpout (Zoarces viviparous) and her embryos in ovario. J. Exp. Biol., 205: 3857–3876
  • Schrenk-Bergt, C. and C. Steinberg. 1998. Endokrine Substanzen in der aquatischen Umwelt. In: Steinberg C, Bernhardt H, and Klappner H (Eds), Handbuch Angewandte Limnologie Teil Aquatische Ökotoxikologie. Ecomed, Landsberg, pp 1–55.
  • Snyder, S.A., T.L. Keith, D.A. Verbrugge, E.M. Snyder, T.S. Gross, K. Kanan and J.P. Giesy. 1999. Analytical methods for detection of selected estrogenic compounds in aqueous mixtures. Environ. Sci. and Tec., 33: 2814-2820
  • Soto, A.M., H. Justica, J.W. Wray and C. Sonneschein. 1991. p- Nonylphenol an estrogenic xenobiotic released from “modified” polystyrene. Environ. H. Persp., 92: 167-173
  • TemaNord. 1996. Chemicals with estrogen-like effects. Publication of Nordic Council of ministers. 580 pp
  • Trudeau, V.L., S. Chiu, S.W. Kennedy and R.J. Brooks. 2002. Octylphenol (OP) Alters the Expression of Members of the Amyloid Protein Family in the Hypothalamus of the Snapping Turtle, Chelydra serpentina serpentina Environ. H. Persp., 110 (3): 269-275
  • Vargas, V.M.F., S.B. Migliavacca, A.C. Melo, R.C. Horn, R.H. Guidobono, I.C.F. Sá Fereira and M.H.D. Pestana. 2001. Genotoxicity assessment in aquatic environments under the influence of heavy metals and organic contaminants. Mutat. Res., 490: 141-158.
  • White, R., S. Jobling, S.A. Hoare, J.P. Sumpter and M.G. Parker. 1994. Environmentally persistent Alkylphenolic compounds are estrogenic. Endoc., 135: 175-182
  • Zeytinoglu, H., E. Ergene and B. Tüylü. 2000. Mutagenicity assay in Salmonella for thirteen 2-substitued-1-H-phenanthro imidazoles. Drug Chem. Toxicol., 26: 245-257.

Mutagenicity of Nonylphenol and Octylphenol Using Salmonella Mutation Assay.

Year 2007, Volume: 24 Issue: 3, 299 - 302, 01.09.2007

Meltem Boyacıoğlu Özlem Çakal Arslan Hatice Parlak Muhammet Ali Karaaslan

Abstract

Nonilfenol ve Oktifenol’ün Salmonella mutasyon testi ile mutajenitesinin belirlenmesi. Bu çalışmada, yüzey suyunda, denizde, yeraltı sularında ve sucul sedimentte yüksek seviyelerde bulunan, endüstri ve bazı evsel ürünlerde yoğun olarak kullanılan Nonilfenol (NP) ve Oktilfenol (OP)’ ün mutajenik aktivitesi test edilmiştir. NP ve OP’nin toksisite ve östrojenik etkisine ait çok sayıda veri bulunmasına rağmen, bu kimyasalların mutajenik etkisi ile ilgi literatür az sayıdadır. Mutajenik etkinin belirlenmesi amacı ile NP 0.937- 4.685 µg/L aralığın da 6 farklı konsantrasyonda, OP ise 10- 160 µg/L aralığında 5 farklı konsantrasyonda test sistemi olarak seçilen Salmonella thyphimirium TA98 ve TA 100 suşları üzerinde (metabolik aktivasyonsuz) test edilmiştir. Sonuçlar revertant koloni sayılarına göre değerlendirildiğinde, tüm NP konsantrasyonlarının toksik olduğu buna rağmen mutajenik etkisinin olmadığı gözlenmiştir. Buna ek olarak OP’ün Salmonella thyphimirium TA98 suşu ile yapılan testlerde 40 μg /L ve Salmonella thyphimirium TA100 suşu ile yapılan testlerde ise 20 μg/L konsantrasyonları mutajenik bulunmuştur. Bu bulgular ışığında yapmış olduğumuz çalışma çevresel konsantrasyonlarda ki NP’ nin toksik, OP’ nin ise mutajenik etkiye sahip olması ile çevresel etkilerinin önemini vurgulamaktadır

Keywords

Alkilfenol ethoksilat nonyilfenol oktilfenol Salmonella thyphimirium mutajenisite

References

  • Ahel, M., W. Giger and M. Koch. 1994. Behavior of alkylphenol polyethoxylate surfactants in the aquatic environment-I. Occurrence and transformation in sewage treatment. Water Res., 28: 1131-1142
  • Ahel, M., J. McEvoy and W. Giger. 1993. Bioaccumulation of the lipophilic metabolites of nonionic surfactants in freshwater organisms. Environ. Pollut., 79: 243-248.
  • Alexander, M. 1981. Biodegradation of chemicals of environmental concern. Sci., 211: 132-138
  • Ames, B.N., J. McCann and E. Yamasaki. 1975. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat. Res., 31: 347 -364
  • APERC. 2004. APE Research Council, Product information. 09.11.2007. http://www.aperc.org/productinfo.htm
  • Arslan Cakal, O. and H. Parlak. 2007. Embryotoxic effects of nonylphenol and octylphenol in sea urchin Arbacia lixula. Ecotox. 16: 439-444.
  • Arslan Cakal, O., H. Parlak, R. Oral and S. Katalay. 2007. The Effects of Nonylphenol and Octylphenol on Embryonic Development of Sea Urchin (Paracentrotus lividus). Arch Environ Contam And Tox. 53: 214-219
  • Bennie, D.T., C.A. Sullivan, H.B. Lee, T.E. Peart and R.J. Maguire. 1997. Occurrence of Alkylphenols and Alkylphenol mono- and di ethoxylates in natural waters of Laurentian Great Lakes basin and the upper St Lawrence River. Sci. Tot. Environ., 193: 263- 275
  • Cerna, N., V. Hajek, E. Stejskalova, L. Dobias, Z. Zudova and P. Rossner. 1991. Environmental genotoxicity monitoring using Salmonella typhimurium strains as indicator system. Sci. Total Environ.1(101): 1-2.
  • Colborn, T., F. Saal and A. Soto. 1993. Developmental effects of endocrine- disrupting chemicals in wildlife and humans. Environ. H. Persp., 101:378- 384
  • Comber, M.H.I., T.D. Williams and K.M. Stewart. 1993. The effects of Nonylphenol on Daphnia magna. Wat. Res. 27: 273-276
  • Cox, C. 1996. Nonyl Phenol And Related Chemicals. J. of Pesticide Ref./ Spring, 16 (1): 15-20. (Corrected 4/2003)
  • Czyż, A., H. Szpilewska, R. Dutkiewiez, W. Kowalska, A. Biniewska- Godlewska and G. Wegrzyn. 2002. Comparison of the Ames test and a enwly developed assay for detection of mutagenic pollution of marine environments. Mutat Res. 519: 67-74.
  • EA. 2005. Environmental Risk Evaluation Report: 4-tert-Octylphenol, April 2005. Environment Agency UK, Published by: Environment Agency, Rio House, Waterside Drive, Aztec West, Almondsbury, Bristol, BS32 4UD. http://www.environment-agency.gov.uk
  • ECB. 2002. 4-nonylphenol (branched) and nonylphenol (CAS Nos: 84852-15- 3 and 25154-52-3 EINECS Nos: 284-325-5 and 246-672-0), European Chemicals Bureau, Summary Risk Assessment Report, UK. http://ecb.jrc.it/DOCUMENTS/Existing- Chemicals/RISK_ASSESSMENT/SUMMARY/4- nonylphenol_nonylphenolsum017.pdf
  • Ekelund, R., A. Bergman, A. Granmo and M. Berggren. 1990. Bioaccumulation of 4- nonylphenol in marine animals-A reevaluation. Environ. Pollut., 64: 107-120.
  • Jobling, S. and Sumpter, J.P. 1993. Detergent components in sewage effluent are weakly estrogenic to fish: an in vitro study using rainbow trout (Oncorhynchus mykiss) hepatocytes. Aqua. Toxicol., 27: 361–372
  • Kataoka, H., T. Hayatsu, G. Hietsch, H. Steinkellner, S. Nishioka, S. Narimatsu, S. Knasmüller and H. Hayatsu. 2000. Identification of mutagenic heterocylic amines(IQ.Trp-P-1 and Aα C) in the water of the Danube River. Mutat. Res., 466: 27-35.
  • Kim, S.K., B. K. Kim, J.H. Shim, J.E. Gil, Y.D. Yoon and J.H. Kim. 2006. Nonylphenol and Octylphenol- Induced Apoptosis in Human Embryonic Stem Cells are related to Fas-Fas Ligand Pathway. Tox. Sci., 94(2): 310- 321.
  • Kotelevtsev, S. V. and I. Ludmilla (1995). Biochemical and Genotoxicological Monitoring of Ecosystems with Special Reference to Lake Baikal and Northern Black Sea. Nato Advanced Study Institute on Molecular Aspects of Oxidative Drug Metabolizing Enzymes: Their Significance in Environmental Toxicology, Chemical Carcinogenesis and Health. 99- 102.
  • Kubo, T., K. Urano and H. Utsumi. 2002. Mutagenicity Characteristics of 255 Environmental Chemicals, J. of H. Sci., 48 (6): 545-554.
  • Kutlu, M., G. Aydogan, F. Susuz and A. Özata. 2004. The Salmonella mutagenicity of water and sediments from the Porsuk River in Turkey. Environ. Tox. and Pharma., 17: 111-116.
  • Maguire, R.J. 1999. Review of Persistence of Nonylphenol and Nonylphenol Ethoxylates in Aquatic Environments. Water Qual. Res. J. Canada., 3437-78
  • Marcomoni, A., B. Pavoni, A. Sfriso and A.A. Orio. 1990. Persistent metabolites of Alkylphenol polyethoxylates in the marine environment. Mar. Chem., 29: 307-323
  • Maron, D.M. and B.N. Ames. 1983. Revised Methods for the Salmonella Mutagenicity Test. Mutat. Res., 113: 173- 215.
  • McCann, J. and B.N. Ames. 1976. Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion. Proc. Natl. Acad. Sci., USA 73: 950- 954.
  • McCann, J., E. Choi, E. Yamasaki and B.N. Ames 1975. Proc. Natl. Acad. Sci., USA 72 5135- 5139.
  • McLeese, D.W., V Zitko, D.B. Sergeant, L. Burridge and C.D. Metcalfe. 1981. Lethality and accumulation of Alkylphenols in aquatic fauna. Chemos., 10: 723-730
  • Mortelmans, K. and E. Zeiger. 2000. The Ames Salmonella/microsome mutagenicity assay. Mutat. Res., 455: 29-60.
  • Naylor, C.G., J.P. Mieure, W.J. Adams, J.A. Weeks, F.J. Castaldi, L.G. Ogle and R.R. Romano. 1992. Alkylphenol ethoxylates in the environment. J. Am. Oil Chem. Soc. 69: 695-703
  • Nimrod, A.C. and W.H. Benson. 1996. Environmental estrogenic effects of alkylphenol ethoxylates. Crit. Rev. Toxicol., 26: 335-364
  • OSPAR. 2006a. Hazardous substance series Number 136, Background document on Nonylphenol. OSPAR Commission (Protection for the Marine Environment of the North-East Atlantic).25.12.2008. http://www.ospar.org/documents/dbase/publications/p00136nonylphenol. pdf>
  • OSPAR. 2006b. Hazardous substance series Number 273, Background document on Octylphenol. OSPAR Commission (Protection for the Marine Environment of the North–east Atlantic). http://www.ospar.org/documents/dbase/publications/p00173_octylphenol .pdf> 25.12.2008.
  • Rasmussen, T.H., T.K. Andreassen, S.N. Pedersen, L.T.M. Van der Ven, P. Bjerregaard and B. Korsgaard. 2002. Effects of waterborne exposure of octylphenol and estrogen on pregnant viviparous eelpout (Zoarces viviparous) and her embryos in ovario. J. Exp. Biol., 205: 3857–3876
  • Schrenk-Bergt, C. and C. Steinberg. 1998. Endokrine Substanzen in der aquatischen Umwelt. In: Steinberg C, Bernhardt H, and Klappner H (Eds), Handbuch Angewandte Limnologie Teil Aquatische Ökotoxikologie. Ecomed, Landsberg, pp 1–55.
  • Snyder, S.A., T.L. Keith, D.A. Verbrugge, E.M. Snyder, T.S. Gross, K. Kanan and J.P. Giesy. 1999. Analytical methods for detection of selected estrogenic compounds in aqueous mixtures. Environ. Sci. and Tec., 33: 2814-2820
  • Soto, A.M., H. Justica, J.W. Wray and C. Sonneschein. 1991. p- Nonylphenol an estrogenic xenobiotic released from “modified” polystyrene. Environ. H. Persp., 92: 167-173
  • TemaNord. 1996. Chemicals with estrogen-like effects. Publication of Nordic Council of ministers. 580 pp
  • Trudeau, V.L., S. Chiu, S.W. Kennedy and R.J. Brooks. 2002. Octylphenol (OP) Alters the Expression of Members of the Amyloid Protein Family in the Hypothalamus of the Snapping Turtle, Chelydra serpentina serpentina Environ. H. Persp., 110 (3): 269-275
  • Vargas, V.M.F., S.B. Migliavacca, A.C. Melo, R.C. Horn, R.H. Guidobono, I.C.F. Sá Fereira and M.H.D. Pestana. 2001. Genotoxicity assessment in aquatic environments under the influence of heavy metals and organic contaminants. Mutat. Res., 490: 141-158.
  • White, R., S. Jobling, S.A. Hoare, J.P. Sumpter and M.G. Parker. 1994. Environmentally persistent Alkylphenolic compounds are estrogenic. Endoc., 135: 175-182
  • Zeytinoglu, H., E. Ergene and B. Tüylü. 2000. Mutagenicity assay in Salmonella for thirteen 2-substitued-1-H-phenanthro imidazoles. Drug Chem. Toxicol., 26: 245-257.
There are 42 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Meltem Boyacıoğlu

Özlem Çakal Arslan

Hatice Parlak

Muhammet Ali Karaaslan

Publication Date September 1, 2007
Submission Date December 7, 2015
Published in Issue Year 2007 Volume: 24 Issue: 3

Cite

APA Boyacıoğlu, M., Arslan, Ö. Ç., Parlak, H., Karaaslan, M. A. (2007). Mutagenicity of Nonylphenol and Octylphenol Using Salmonella Mutation Assay. Ege Journal of Fisheries and Aquatic Sciences, 24(3), 299-302.