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Yıl 2022, Cilt: 4 Sayı: 2, 59 - 66, 29.12.2022

Nuray Denizhan Selehattin Yılmaz Gülşen Sağlıkoğlu Emrah Kılınç Çiğdem Yengin Fatma Gülay Der

https://doi.org/10.51435/turkjac.1132742
Cited By: 1

Öz

Kaynakça

  • [1] The International Olympic Committee (IOC) “Anti-Doping Rules Applicable to the Games of the XXIX Olympiad”, 2008, 3-9.
  • [2] H. Koç, O. Yüksel, Kadınlarda fiziksel ve fizyolojik performansının değerlendirilmesi, Dumlupınar Üniversitesi Sağlık Bilimleri Dergisi, 9, 2007, 1.
  • [3] A.J.P. van Heugtena, W. de Boer, W.S. de Vries, C.M.A. Markesteijn, H. Vromans, Development and validation of a stability-indicating HPLC-UV method for the determination of triamcinolone acetonide and its degradation products in an ointment formulation, J Pharm Biomed Anal, 149, 2018, 149, 265.
  • [4] S. Sudsakorn, L. Kaplan, D.A. Williams, Simultaneous determination of triamcinolone acetonide and oxymetazoline hydrochloride in nasal spray formulations by HPLC, J Pharm Biomed Anal, 40, 2006, 1273.
  • [5] G.M. Fernandes-Cunha, J.B. Saliba, R.C. Siqueira, R. Jorge, A. Silva-Cunha, Determination of triamcinolone acetonide in silicone oil and aqueous humor of vitrectomized rabbits’ eyes: Application for a pharmacokinetic study with intravitreal triamcinolone acetonide injections (Kenalog®40), J Pharm Biomed Anal, 89, 2014, 24.
  • [6] D. De Orsi, M. Pellegrini, S. Pichini, D. Mattioli, E. Marchei, L. Gagliardi, High-performance liquid chromatography–diode array and electrospray-mass spectrometry analysis of non-allowed substances in cosmetic products for preventing hair loss and other hormone-dependent skin diseases, J Pharm Biomed Anal, 48, 2008, 641.
  • [7] S.A. Doppenschmitt, B. Scheidel, F. Harrison, J.P. Surmann, Simultaneous determination of triamcinolone acetonide and hydrocortisone in human plasma by high-performance liquid chromatography, J Chromatogr B: Biomed Sci Appl, 682, 1996, 79.
  • [8] A.M. di Pietra, V. Andrisano, R. Gotti, V. Cavrini, On-line post-column photochemical derivatization in liquid chromatographic-diode-array detection analysis of binary drug mixtures, J Pharm Biomed Anal, 14, 1996, 1191.
  • [9] H. Tokunaga, T. Kimura, J. Kawamura, Gas chromatographic determination of glucocorticoids as trimethylsilyl ether derivatives, Yakugaku Zasshi, 99(8), 1979, 800.
  • [10] D. Agbaba, D. Zivanov-Stakic, S. Vladimirov, K. Zubac, Determination of triamcinolone, triamcinolone acetonide and fluocinonide in dosage forms, Acta Pol Pharm, 47(1-2), 1990, 15-18.
  • [11] E.R.M. Kedor-Hackmann, E.A.S. Gianotto, M.I.R.M. Santoro, Determination of triamcinolone acetonide in ointment by UV derivative spectrophotometry and high performance liquid chromatography, Anal Lett, 30(10), 1997, 1861.
  • [12] Y.S. El-Saharty, N.Y. Hassan, F.H. Metwally, Simultaneous determination of terbinafine HCl and triamcinolone acetonide by UV derivative spectrophotometry and spectrodensitometry, J Pharm Biomed Anal, 28(3-4), 2002, 569.
  • [13] E. Hammam, Determination of triamcinolone acetonide in pharmaceutical formulation and human serum by adsorptive cathodic stripping voltammetry, Chem. Anal. (Warsaw, Pol.), 52, 2007, 43.
  • [14] C. Vedhi, R. Eswar, H.G. Prabu, P. Manisankar, Determination of triamcinolone acetonide steroid on glassy carbon electrode by stripping voltammetric methods, Int J Electrochem Sci, 3, 2008, 509.
  • [15] R.N. Goyal, V.K. Gupta, S. Chatterjee, A sensitive voltammetric sensor for determination of synthetic corticosteroid triamcinolone, abused for doping, Biosens Bioelectron, 24, 2009, 3562.
  • [16] P. Kabasakalian, J. McGlotten, The polarographic reduction of prednisone (17,21-Dihydroxy-l,4-pregnadiene-3,11,20-trione), prednisolone (11,17,21-Trihydroxy-1,4-pregnadiene-3,20-dione) and their precursors, J Am Chem Soc, 78(19), 1956, 5032.
  • [17] P.M. Zagrzewski, K.N. Belikov, I.A. Zinchenko, The study of the electrochemical behavior of triamcinolone acetonide on the carbon paste electrodes for its voltammetric determination, Methods Objects Chem Anal, 13(3), 2018, 136.
  • [18] M.M. Baker, T.S. Belal, M.S. Mahrous, H.M. Ahmed, H.G. Daabees, A validated stability-indicating HPLC-DAD method for simultaneous determination of econazole nitrate, triamcinolone acetonide, benzoic acid and butylated hydroxyanisole in cream dosage form, Analytical Methods, 9, 2016, 2185.
  • [19] M. Sigg, R. Daniels, The effect of alkanediols on the release of triamcinolone acetonide from semisolid dosage forms, Int J Pharm, 605, 2021, 120843.
  • [20] M.M. Sebaiy, S.M. El-Adl, M.M. Baraka, M.S. Mohram, Y.M. Elkady, Stability indicating HPLC method for the simultaneous estimation of triamcinolone acetonide and benzyl alcohol in pure form and Epirelefan® vial, Am J Med Chem, 2(1), 2020, 4.
  • [21] M. Márquez Valls, A. Martínez Labrador, L. Halbaut Bellowa, D. Bravo Torres, P.C. Granda, M. Miñarro Carmona, D. Limón, A.C. Calpena Campmany, Biopharmaceutical Study of Triamcinolone Acetonide Semisolid Formulations for Sublingual and Buccal Administration, Pharmaceutics, 13, 2021, 1080.

Electrochemical and liquid chromatographic analysis of triamcinolone acetonide in pharmaceutical formulations

Yıl 2022, Cilt: 4 Sayı: 2, 59 - 66, 29.12.2022

Nuray Denizhan Selehattin Yılmaz Gülşen Sağlıkoğlu Emrah Kılınç Çiğdem Yengin Fatma Gülay Der

https://doi.org/10.51435/turkjac.1132742
Cited By: 1

Öz

Electrochemical reduction of triamcinolone acetonide on pencil graphite electrode surface was firstly investigated by cyclic voltammetry (CV). The dependence of cathodic peak current and peak potential on different pH medium and scan rate were investigated. The adsorption controlled nature of the peak was achieved. During pH optimization, 0.067 M Phosphate (pH 4.50 to pH 7.50), 0.2 M Acetate (pH 3.50 to 5.50) and 0.04 M Britton Robinson (BR; pH 2.00 to 12.00) buffers were employed as supporting electrolytes. Scan rate optimization was investigated in the range 25-1000 mVs-1 (vs. Ag/AgCl). Maximum peak current was observed in the 0.04 M BR buffer (pH 3.50). Peak current increases and shifts to more cathodic values with the increasing scan rate. Curve of logarithm of peak current (log I) versus logarithm of scan rate (log v) showed linear regression with the equation log(Ip/μA) = 0.8395 log(v/mVs-1)-0.8386 and correlation coefficient (R2: 0.9761). This indicated that slope of the logv-logI curve is close to 1.0 and the cathodic electrode reaction was adsorption controlled, as desirable. The linear range was 1×10-7-5×10-5 M, sensitivity was 1,3347 µA M-1, Limit of detection (LOD) and Limit of quantification (LOQ) were 3.18×10-8 M and 1.00×10-7 M, respectively. HPLC-PDA analysis were performed with H2O:MeOH (28:72, v/v) as mobile phases A and B at a flow rate of 1mL/min at 242nm. Method validation studies were conducted in accordance with ICH Q2(R1) guideline and corresponding results were summarized in tables. HPLC-PDA method displayed linearity in 0.1-50µg/mL (2.3×10-7-1.15×10-4 M) concentration range with LOD and LOQ values as 3.992×10-8 and 1.29×10-7M, respectively.

Anahtar Kelimeler

Triamcinolone acetonide voltammetry HPLC-PDA pencil graphite electrode.

Kaynakça

  • [1] The International Olympic Committee (IOC) “Anti-Doping Rules Applicable to the Games of the XXIX Olympiad”, 2008, 3-9.
  • [2] H. Koç, O. Yüksel, Kadınlarda fiziksel ve fizyolojik performansının değerlendirilmesi, Dumlupınar Üniversitesi Sağlık Bilimleri Dergisi, 9, 2007, 1.
  • [3] A.J.P. van Heugtena, W. de Boer, W.S. de Vries, C.M.A. Markesteijn, H. Vromans, Development and validation of a stability-indicating HPLC-UV method for the determination of triamcinolone acetonide and its degradation products in an ointment formulation, J Pharm Biomed Anal, 149, 2018, 149, 265.
  • [4] S. Sudsakorn, L. Kaplan, D.A. Williams, Simultaneous determination of triamcinolone acetonide and oxymetazoline hydrochloride in nasal spray formulations by HPLC, J Pharm Biomed Anal, 40, 2006, 1273.
  • [5] G.M. Fernandes-Cunha, J.B. Saliba, R.C. Siqueira, R. Jorge, A. Silva-Cunha, Determination of triamcinolone acetonide in silicone oil and aqueous humor of vitrectomized rabbits’ eyes: Application for a pharmacokinetic study with intravitreal triamcinolone acetonide injections (Kenalog®40), J Pharm Biomed Anal, 89, 2014, 24.
  • [6] D. De Orsi, M. Pellegrini, S. Pichini, D. Mattioli, E. Marchei, L. Gagliardi, High-performance liquid chromatography–diode array and electrospray-mass spectrometry analysis of non-allowed substances in cosmetic products for preventing hair loss and other hormone-dependent skin diseases, J Pharm Biomed Anal, 48, 2008, 641.
  • [7] S.A. Doppenschmitt, B. Scheidel, F. Harrison, J.P. Surmann, Simultaneous determination of triamcinolone acetonide and hydrocortisone in human plasma by high-performance liquid chromatography, J Chromatogr B: Biomed Sci Appl, 682, 1996, 79.
  • [8] A.M. di Pietra, V. Andrisano, R. Gotti, V. Cavrini, On-line post-column photochemical derivatization in liquid chromatographic-diode-array detection analysis of binary drug mixtures, J Pharm Biomed Anal, 14, 1996, 1191.
  • [9] H. Tokunaga, T. Kimura, J. Kawamura, Gas chromatographic determination of glucocorticoids as trimethylsilyl ether derivatives, Yakugaku Zasshi, 99(8), 1979, 800.
  • [10] D. Agbaba, D. Zivanov-Stakic, S. Vladimirov, K. Zubac, Determination of triamcinolone, triamcinolone acetonide and fluocinonide in dosage forms, Acta Pol Pharm, 47(1-2), 1990, 15-18.
  • [11] E.R.M. Kedor-Hackmann, E.A.S. Gianotto, M.I.R.M. Santoro, Determination of triamcinolone acetonide in ointment by UV derivative spectrophotometry and high performance liquid chromatography, Anal Lett, 30(10), 1997, 1861.
  • [12] Y.S. El-Saharty, N.Y. Hassan, F.H. Metwally, Simultaneous determination of terbinafine HCl and triamcinolone acetonide by UV derivative spectrophotometry and spectrodensitometry, J Pharm Biomed Anal, 28(3-4), 2002, 569.
  • [13] E. Hammam, Determination of triamcinolone acetonide in pharmaceutical formulation and human serum by adsorptive cathodic stripping voltammetry, Chem. Anal. (Warsaw, Pol.), 52, 2007, 43.
  • [14] C. Vedhi, R. Eswar, H.G. Prabu, P. Manisankar, Determination of triamcinolone acetonide steroid on glassy carbon electrode by stripping voltammetric methods, Int J Electrochem Sci, 3, 2008, 509.
  • [15] R.N. Goyal, V.K. Gupta, S. Chatterjee, A sensitive voltammetric sensor for determination of synthetic corticosteroid triamcinolone, abused for doping, Biosens Bioelectron, 24, 2009, 3562.
  • [16] P. Kabasakalian, J. McGlotten, The polarographic reduction of prednisone (17,21-Dihydroxy-l,4-pregnadiene-3,11,20-trione), prednisolone (11,17,21-Trihydroxy-1,4-pregnadiene-3,20-dione) and their precursors, J Am Chem Soc, 78(19), 1956, 5032.
  • [17] P.M. Zagrzewski, K.N. Belikov, I.A. Zinchenko, The study of the electrochemical behavior of triamcinolone acetonide on the carbon paste electrodes for its voltammetric determination, Methods Objects Chem Anal, 13(3), 2018, 136.
  • [18] M.M. Baker, T.S. Belal, M.S. Mahrous, H.M. Ahmed, H.G. Daabees, A validated stability-indicating HPLC-DAD method for simultaneous determination of econazole nitrate, triamcinolone acetonide, benzoic acid and butylated hydroxyanisole in cream dosage form, Analytical Methods, 9, 2016, 2185.
  • [19] M. Sigg, R. Daniels, The effect of alkanediols on the release of triamcinolone acetonide from semisolid dosage forms, Int J Pharm, 605, 2021, 120843.
  • [20] M.M. Sebaiy, S.M. El-Adl, M.M. Baraka, M.S. Mohram, Y.M. Elkady, Stability indicating HPLC method for the simultaneous estimation of triamcinolone acetonide and benzyl alcohol in pure form and Epirelefan® vial, Am J Med Chem, 2(1), 2020, 4.
  • [21] M. Márquez Valls, A. Martínez Labrador, L. Halbaut Bellowa, D. Bravo Torres, P.C. Granda, M. Miñarro Carmona, D. Limón, A.C. Calpena Campmany, Biopharmaceutical Study of Triamcinolone Acetonide Semisolid Formulations for Sublingual and Buccal Administration, Pharmaceutics, 13, 2021, 1080.
Toplam 21 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Analitik Kimya
Bölüm Research Articles
Yazarlar

Nuray Denizhan 0000-0003-3067-3954

Selehattin Yılmaz 0000-0003-4607-3523

Gülşen Sağlıkoğlu 0000-0002-3407-9787

Emrah Kılınç 0000-0002-4583-8371

Çiğdem Yengin 0000-0002-1353-7355

Fatma Gülay Der Bu kişi benim 0000-0002-2515-8846

Erken Görünüm Tarihi 23 Aralık 2022
Yayımlanma Tarihi 29 Aralık 2022
Gönderilme Tarihi 19 Haziran 2022
Kabul Tarihi 2 Ekim 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 4 Sayı: 2

Kaynak Göster

APA Denizhan, N., Yılmaz, S., Sağlıkoğlu, G., Kılınç, E., vd. (2022). Electrochemical and liquid chromatographic analysis of triamcinolone acetonide in pharmaceutical formulations. Turkish Journal of Analytical Chemistry, 4(2), 59-66. https://doi.org/10.51435/turkjac.1132742
AMA Denizhan N, Yılmaz S, Sağlıkoğlu G, Kılınç E, Yengin Ç, Der FG. Electrochemical and liquid chromatographic analysis of triamcinolone acetonide in pharmaceutical formulations. TurkJAC. Aralık 2022;4(2):59-66. doi:10.51435/turkjac.1132742
Chicago Denizhan, Nuray, Selehattin Yılmaz, Gülşen Sağlıkoğlu, Emrah Kılınç, Çiğdem Yengin, ve Fatma Gülay Der. “Electrochemical and Liquid Chromatographic Analysis of Triamcinolone Acetonide in Pharmaceutical Formulations”. Turkish Journal of Analytical Chemistry 4, sy. 2 (Aralık 2022): 59-66. https://doi.org/10.51435/turkjac.1132742.
EndNote Denizhan N, Yılmaz S, Sağlıkoğlu G, Kılınç E, Yengin Ç, Der FG (01 Aralık 2022) Electrochemical and liquid chromatographic analysis of triamcinolone acetonide in pharmaceutical formulations. Turkish Journal of Analytical Chemistry 4 2 59–66.
IEEE N. Denizhan, S. Yılmaz, G. Sağlıkoğlu, E. Kılınç, Ç. Yengin, ve F. G. Der, “Electrochemical and liquid chromatographic analysis of triamcinolone acetonide in pharmaceutical formulations”, TurkJAC, c. 4, sy. 2, ss. 59–66, 2022, doi: 10.51435/turkjac.1132742.
ISNAD Denizhan, Nuray vd. “Electrochemical and Liquid Chromatographic Analysis of Triamcinolone Acetonide in Pharmaceutical Formulations”. Turkish Journal of Analytical Chemistry 4/2 (Aralık 2022), 59-66. https://doi.org/10.51435/turkjac.1132742.
JAMA Denizhan N, Yılmaz S, Sağlıkoğlu G, Kılınç E, Yengin Ç, Der FG. Electrochemical and liquid chromatographic analysis of triamcinolone acetonide in pharmaceutical formulations. TurkJAC. 2022;4:59–66.
MLA Denizhan, Nuray vd. “Electrochemical and Liquid Chromatographic Analysis of Triamcinolone Acetonide in Pharmaceutical Formulations”. Turkish Journal of Analytical Chemistry, c. 4, sy. 2, 2022, ss. 59-66, doi:10.51435/turkjac.1132742.
Vancouver Denizhan N, Yılmaz S, Sağlıkoğlu G, Kılınç E, Yengin Ç, Der FG. Electrochemical and liquid chromatographic analysis of triamcinolone acetonide in pharmaceutical formulations. TurkJAC. 2022;4(2):59-66.

Cited By

Greens assessment of RP-UPLC method for estimating Triamcinolone Acetonide and its degraded products compared to Box-Behnken and Six Sigma designs
Green Chemistry Letters and Reviews
https://doi.org/10.1080/17518253.2023.2301315
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