Araştırma Makalesi
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Yıl 2021, Cilt: 1 Sayı: 1, 1 - 10, 17.01.2023

Öz

Kaynakça

  • 1. Reynolds EF, In:Martindale-The Extra Pharmacopoeia (31.st ed.) The Royal Pharmaceutical Society, London, 1996, pp. 819-820.
  • 2. European Pharmacopoeia, third ed., Council of Europe, Strasbourg, 2001 supplement, pp. 431-432.
  • 3. Civantos B, Aleixandre A, Blood pressure and -vascular reactivity in hypertensive rats treated with amlodipine and dietary Ca, Europ. J Pharmacol. 2004; 489: 101-110.
  • 4. Khattar RS, Senior R, Swales JD, Lahiri A, Value of ambulatory intra-arterial blood pressure monitoring in the long-term prediction of left ventricular hypertrophy and carotid atherosclerosis in essential hypertension, J. Hum.Hypertens. 1999; 3: 111-116.
  • 5. Resnick LM, Laragh JH, Renin, calcium and the pathophysiologic basis of antihypertensive theraphy, Am. J. Cardiol. 1985; 56: 68-74.
  • 6. Patki RV, Tamhanker CP, Tipnis HP, Simple and rapid high performance liquid chromatographic estimation of amlodipine in pharmaceutical dosage forms, Indian Drugs 1994; 3: 560-565.
  • 7. Sankar SR, Nanjan MJ, Vasudevan M, Shaat N, Suresh B, Simultaneous estimation of atenolol and amlodipine in formulations by reversed phase-HPLC. Indian J. Pharm. Sci. 1997; 59: 171-175.
  • 8. Dhorda VJ, Shetkar NB, Reversed phase liquid chromatographic determination of ramipril and amlodipine in tablets. Indian Drugs 1999; 36: 638-642.
  • 9. Avadhanulu AB, Srinivas JS, Anjaneyulu Y, Reverse phase HPLC determination of Amlodipine besylate in drug and its pharmaceutical dosage forms. Indian Drugs 1996; 33:36-40.
  • 10. Baranda AB, Jimenez RM, Alonso RM, Simultaneous determination of Five 1,4-dihydropyridines in pharmaceutical formulations by high-performance liquid chromatography-amperometric detection. J. Chromatogr. A 2004; 1031: 275-280.
  • 11. Malesuik MD, Cardoso SG, Bajrski L, Lanzanova FA, Determination of Amlodipine in Pharmaceutical Dosage Forms by liquid Chromatography and Ultraviolet Spectrophotometry. J AOAC Inter. 2006; 89: 359-364.
  • 12. Basavaiah K, Chandrashekar U, Nagegowda P, Spectrophotometric and High performance liquid chromatographic determination of amlodipine besylate in pharmaceuticals. Science Asia. 2005; 31: 13-21.
  • 13. Chandrashekhar TG, Rao PSN, Smrita K, Vyas SK, Dutt C, Analysis of amlodipine besylate by HPTLC with fluorimetric detection: a sensitive method for assay of tablets. J Planar Chromatogr Mod. TLC 1994; 7: 458-462.
  • 14. Argekar AP, Powar SG, Simultaneous determination of atenol and amlodipine in tablets by high-performance thin-layer chromatography. J Pharm Biomed Anal. 2000; 21: 1137-42.
  • 15. Gowri N, Vaidhyalingam V, Shantha A, HPTLC method for the simultaneou estimation of amlodipine besylate and Benazepril hydrochloride in tablets. Indian Drugs 2003; 40: 645-648.
  • 16. Altiokka G, Dogrukol-Ak D, Tunçel M, Aboul-Enein HY, Determination of amlodipine in pharmaceutical formulations by differential-pulse voltammetry with a glassy carbon electrode. Archiv der Pharmazie 2002; 335: 104-8.
  • 17. Gazy AAK, Determination of Amlodipine besylate by adsoptive square-wave anodic stripping voltammetry on glassy carbon electrode in tablets and biological fluids. Talanta 2004; 62: 575-82.
  • 18. Basavaiah K, Chandrashekar U, Nagegowda P, Titrimetric and modified spectrophotometric methods for the determination of amlodipine besylate using bromate-bromide mixture and two dyes. Science Asia 2006; 32: 271-278.
  • 19. Prabhakar AH, Giridhar R, A spectrophotometric method for the determination of amlodipine besylate in pure form and in tablets. Indian Drugs. 2002; 39: 204-208.
  • 20. Singhvi I, Chaturvedi SC, Visible spectrophotometric methods for estimation of amlodipine besylate in tablets, Indian J Pharm Sci. 1998; 60: 309-310.
  • 21. Singhvi I, Chaturvedi SC, Spectrophotometric method for determination of amlodipine besylate and benidipine hydrochloride from tablets. Indian J Pharm Sci. 1999; 61: 190- 191.
  • 22. Reddy MN, Rani GT, Rao KVSP, Sankar DG, Sreedhar K, Extractive spectrophotometric determination of amlodipine using erichrome black T and indigocarmine. Indian J Pharm Sci. 1997; 59: 188-9.
  • 23. Çetin G, Sungur S, A spectrophotometric method for the determination of amlodipine in pharmaceutical formulations. Sci Pharm. 1995; 63: 93-8.
  • 24. Lokesh BVS, Reddy MN, Sankar DG, Sreedhar K, Extractive spectrophotometric determination of amlodipine. East Pharm. 1996; 39: 125-6
  • 25. Golcu A, Yuccesoy C, Serin S, The use of charge transfer complexation in the spectrophotometric determination of amlodipine besylate. Sci Pharm. 2000; 68: 225-46.
  • 26. Rahman N, Azmi SN, Spectrophotometric determination of amlodipine besylate by charge transfer complex formation with p-chloranilic acid. Anal Sci. 2000; 16: 1353-56.
  • 27. Rahman N, Hoda MN, Validated spectrophotometric methods for the determination of amlodipine besylate in drug formulations using 2,3-dichloro 5,6-dicyano 1,4-benzoquinone and ascorbic acid. J Pharm Biomed Anal. 2003; 31: 381-92.
  • 28. Sridhar K, Sastry CSP, Reddy MN, Shankar DG, Srinivas KR, Spectrophotometric determination of amlodipine besylate in pure form and tablets. Anal Lett. 1997; 30: 121-133.
  • 29. Meyyanathan SN, Joel J, Scaria S, Sowmya S, Suresh B, Simple spectrophotometric analysis of amlodipine besylate. Indian Drugs 1998; 35: 296-7.
  • 30. Rahman N, Azmi SNH, Spectrophotometric method for the determination of amlodipine besylate with ninhydrin in drug formulations. Il Farmaco. 2001; 56: 731-5.
  • 31. Prasad CVN, Parihar C, Chowdhary TR, Purohit S, Parimoo P, Simultaneous determination of atenolol-amlodipine and haloperidol-trihexaphenidyl in combined tablet preparation by derivative spectroscopy. Pharm Pharmacol Commun. 1998; 4: 325-30.
  • 32. Prasad CVN, Saha RN, Parimoo P, Simultaneous determination of amlodipine-enalapril maleate and amlodipine-lisinopril in combined tablet preparations by derivative spectrophotometry. Pharm Pharmacol Commun. 1999; 5: 383-8.
  • 33. Basavaiah K, Chandrashekar U, Prameela HC, Sensitive spectrophotometric determination of amlodipine and felodipine using iron (III) and ferriciyanide. Il Farmaco. 2003; 58: 141-8.
  • 34. Rahman N, Singh M, Hoda MN, Application of oxidants to the spectrophotometric determination of amlodipine besylate in pharmaceutical formulations. IL Farmaco. 2004; 59: 913-9.
  • 35. Validation of Analytical Procedures, Proceedings of the International Conference on Harmonisation (ICH). Commision of the European Communities, 1996.

Quantitative Determination of Amlodipine Besylate without Derivatized in Pure Form and Tablet Dosage Forms with UV Spectrophotometric Method

Yıl 2021, Cilt: 1 Sayı: 1, 1 - 10, 17.01.2023

Öz

The present work describes the development and validation of UV Spectrophotometric method for direct determination of underivatized amlodipine besylate (ADB) in pure and tablet dosage forms. The validation parameters of linearity, precision, accuracy, recovery, specificity, limit of detection and limit of quantification were studied. The range of quantification for proposed method was 2-17 µg/mL. The precision of method was calculated as the relative standard deviation (RSD) and less than 2 %, and accuracy (relative error) was better than 6 % (n = 6). The developed method was successfully applied for the assay of pharmaceutical dosage forms which do not require any preliminary separation or treatment of the samples. The RSD values for Norlopin® tablet (5 mg) and Norvasc® tablet (5 mg) was found to be less than 2 %. The results obtained from this method were compared with two reference method reported in literature and no significant difference was found statistically (p>0.05).

Kaynakça

  • 1. Reynolds EF, In:Martindale-The Extra Pharmacopoeia (31.st ed.) The Royal Pharmaceutical Society, London, 1996, pp. 819-820.
  • 2. European Pharmacopoeia, third ed., Council of Europe, Strasbourg, 2001 supplement, pp. 431-432.
  • 3. Civantos B, Aleixandre A, Blood pressure and -vascular reactivity in hypertensive rats treated with amlodipine and dietary Ca, Europ. J Pharmacol. 2004; 489: 101-110.
  • 4. Khattar RS, Senior R, Swales JD, Lahiri A, Value of ambulatory intra-arterial blood pressure monitoring in the long-term prediction of left ventricular hypertrophy and carotid atherosclerosis in essential hypertension, J. Hum.Hypertens. 1999; 3: 111-116.
  • 5. Resnick LM, Laragh JH, Renin, calcium and the pathophysiologic basis of antihypertensive theraphy, Am. J. Cardiol. 1985; 56: 68-74.
  • 6. Patki RV, Tamhanker CP, Tipnis HP, Simple and rapid high performance liquid chromatographic estimation of amlodipine in pharmaceutical dosage forms, Indian Drugs 1994; 3: 560-565.
  • 7. Sankar SR, Nanjan MJ, Vasudevan M, Shaat N, Suresh B, Simultaneous estimation of atenolol and amlodipine in formulations by reversed phase-HPLC. Indian J. Pharm. Sci. 1997; 59: 171-175.
  • 8. Dhorda VJ, Shetkar NB, Reversed phase liquid chromatographic determination of ramipril and amlodipine in tablets. Indian Drugs 1999; 36: 638-642.
  • 9. Avadhanulu AB, Srinivas JS, Anjaneyulu Y, Reverse phase HPLC determination of Amlodipine besylate in drug and its pharmaceutical dosage forms. Indian Drugs 1996; 33:36-40.
  • 10. Baranda AB, Jimenez RM, Alonso RM, Simultaneous determination of Five 1,4-dihydropyridines in pharmaceutical formulations by high-performance liquid chromatography-amperometric detection. J. Chromatogr. A 2004; 1031: 275-280.
  • 11. Malesuik MD, Cardoso SG, Bajrski L, Lanzanova FA, Determination of Amlodipine in Pharmaceutical Dosage Forms by liquid Chromatography and Ultraviolet Spectrophotometry. J AOAC Inter. 2006; 89: 359-364.
  • 12. Basavaiah K, Chandrashekar U, Nagegowda P, Spectrophotometric and High performance liquid chromatographic determination of amlodipine besylate in pharmaceuticals. Science Asia. 2005; 31: 13-21.
  • 13. Chandrashekhar TG, Rao PSN, Smrita K, Vyas SK, Dutt C, Analysis of amlodipine besylate by HPTLC with fluorimetric detection: a sensitive method for assay of tablets. J Planar Chromatogr Mod. TLC 1994; 7: 458-462.
  • 14. Argekar AP, Powar SG, Simultaneous determination of atenol and amlodipine in tablets by high-performance thin-layer chromatography. J Pharm Biomed Anal. 2000; 21: 1137-42.
  • 15. Gowri N, Vaidhyalingam V, Shantha A, HPTLC method for the simultaneou estimation of amlodipine besylate and Benazepril hydrochloride in tablets. Indian Drugs 2003; 40: 645-648.
  • 16. Altiokka G, Dogrukol-Ak D, Tunçel M, Aboul-Enein HY, Determination of amlodipine in pharmaceutical formulations by differential-pulse voltammetry with a glassy carbon electrode. Archiv der Pharmazie 2002; 335: 104-8.
  • 17. Gazy AAK, Determination of Amlodipine besylate by adsoptive square-wave anodic stripping voltammetry on glassy carbon electrode in tablets and biological fluids. Talanta 2004; 62: 575-82.
  • 18. Basavaiah K, Chandrashekar U, Nagegowda P, Titrimetric and modified spectrophotometric methods for the determination of amlodipine besylate using bromate-bromide mixture and two dyes. Science Asia 2006; 32: 271-278.
  • 19. Prabhakar AH, Giridhar R, A spectrophotometric method for the determination of amlodipine besylate in pure form and in tablets. Indian Drugs. 2002; 39: 204-208.
  • 20. Singhvi I, Chaturvedi SC, Visible spectrophotometric methods for estimation of amlodipine besylate in tablets, Indian J Pharm Sci. 1998; 60: 309-310.
  • 21. Singhvi I, Chaturvedi SC, Spectrophotometric method for determination of amlodipine besylate and benidipine hydrochloride from tablets. Indian J Pharm Sci. 1999; 61: 190- 191.
  • 22. Reddy MN, Rani GT, Rao KVSP, Sankar DG, Sreedhar K, Extractive spectrophotometric determination of amlodipine using erichrome black T and indigocarmine. Indian J Pharm Sci. 1997; 59: 188-9.
  • 23. Çetin G, Sungur S, A spectrophotometric method for the determination of amlodipine in pharmaceutical formulations. Sci Pharm. 1995; 63: 93-8.
  • 24. Lokesh BVS, Reddy MN, Sankar DG, Sreedhar K, Extractive spectrophotometric determination of amlodipine. East Pharm. 1996; 39: 125-6
  • 25. Golcu A, Yuccesoy C, Serin S, The use of charge transfer complexation in the spectrophotometric determination of amlodipine besylate. Sci Pharm. 2000; 68: 225-46.
  • 26. Rahman N, Azmi SN, Spectrophotometric determination of amlodipine besylate by charge transfer complex formation with p-chloranilic acid. Anal Sci. 2000; 16: 1353-56.
  • 27. Rahman N, Hoda MN, Validated spectrophotometric methods for the determination of amlodipine besylate in drug formulations using 2,3-dichloro 5,6-dicyano 1,4-benzoquinone and ascorbic acid. J Pharm Biomed Anal. 2003; 31: 381-92.
  • 28. Sridhar K, Sastry CSP, Reddy MN, Shankar DG, Srinivas KR, Spectrophotometric determination of amlodipine besylate in pure form and tablets. Anal Lett. 1997; 30: 121-133.
  • 29. Meyyanathan SN, Joel J, Scaria S, Sowmya S, Suresh B, Simple spectrophotometric analysis of amlodipine besylate. Indian Drugs 1998; 35: 296-7.
  • 30. Rahman N, Azmi SNH, Spectrophotometric method for the determination of amlodipine besylate with ninhydrin in drug formulations. Il Farmaco. 2001; 56: 731-5.
  • 31. Prasad CVN, Parihar C, Chowdhary TR, Purohit S, Parimoo P, Simultaneous determination of atenolol-amlodipine and haloperidol-trihexaphenidyl in combined tablet preparation by derivative spectroscopy. Pharm Pharmacol Commun. 1998; 4: 325-30.
  • 32. Prasad CVN, Saha RN, Parimoo P, Simultaneous determination of amlodipine-enalapril maleate and amlodipine-lisinopril in combined tablet preparations by derivative spectrophotometry. Pharm Pharmacol Commun. 1999; 5: 383-8.
  • 33. Basavaiah K, Chandrashekar U, Prameela HC, Sensitive spectrophotometric determination of amlodipine and felodipine using iron (III) and ferriciyanide. Il Farmaco. 2003; 58: 141-8.
  • 34. Rahman N, Singh M, Hoda MN, Application of oxidants to the spectrophotometric determination of amlodipine besylate in pharmaceutical formulations. IL Farmaco. 2004; 59: 913-9.
  • 35. Validation of Analytical Procedures, Proceedings of the International Conference on Harmonisation (ICH). Commision of the European Communities, 1996.
Toplam 35 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık ve İlaç Bilimleri
Bölüm Research Articles
Yazarlar

Murat Öztürk Bu kişi benim 0000-0003-3389-4883

Yücel Kadıoğlu 0000-0001-6590-7306

Yayımlanma Tarihi 17 Ocak 2023
Yayımlandığı Sayı Yıl 2021 Cilt: 1 Sayı: 1

Kaynak Göster

EndNote Öztürk M, Kadıoğlu Y (01 Ocak 2023) Quantitative Determination of Amlodipine Besylate without Derivatized in Pure Form and Tablet Dosage Forms with UV Spectrophotometric Method. International Journal of PharmATA 1 1 1–10.