Öz
Objective: Previous research has suggested
that migraine may be associated with increased vulnerability to oxidative
stress. The purpose of this study was to evaluate serum paraoxonase and
arylesterase activities, thiols levels,
ischemia-modified albumin, the total oxidant status, total antioxidant status,
and oxidative stress index in patients
with migraine without aura.
Material and Methods:
30 patients (5 males and 25 females) and 30 matched healthy controls (8 males
and 22 females) were enrolled. Serum paraoxonase and arylesterase activities,
thiols levels, ischemia-modified albumin, total antioxidant status, total
oxidant status and oxidative stress index were determined by using the
spectrophotometric method. Statistical analysis was conducted using
Mann–Whitney U test and independent samples t-test, and p <0.05 was considered as
statistically significant.
Results:
Paraoxonase and arylesterase levels were
significantly lower in the migraine without aura group compared with the
control group (p <0.05).
Conclusion:
Our findings suggested that the paraoxonase and arylesterase levels might be
associated with migraine without aura. In migraine patients, it is recommended
that oxidative stress markers be investigated with a larger population and
these parameters are taken into consideration.
Anahtar Kelimeler
Destekleyen Kurum
Scientific Research Projects Coordination Unit of Çanakkale Onsekiz Mart University
Proje Numarası
THD-2018-2509
Teşekkür
This work was supported by Scientific Research Projects Coordination Unit of Çanakkale Onsekiz Mart University. Project Number: THD-2018-2509
Kaynakça
- Geyik S, Altunisik E, Neyal AM, Taysi S. Oxidative stress and DNA damage in patients with migraine. The journal of headache and pain. 2016;17:10.
- Tripathi GM, Kalita J, Misra UK. A study of oxidative stress in migraine with special reference to prophylactic therapy. The International journal of neuroscience. Apr 2018;128(4):318-324.
- Yilmaz N, Aydin O, Yegin A, Tiltak A, Eren E, Aykal G. Impaired oxidative balance and association of blood glucose, insulin and HOMA-IR index in migraine. Biochemia medica. 2011;21(2):145-151.
- Alp R, Selek S, Alp SI, Taskin A, Kocyigit A. Oxidative and antioxidative balance in patients of migraine. European review for medical and pharmacological sciences. Oct 2010;14(10):877-882.
- Borkum JM. Migraine Triggers, Oxidative Stress, and the Thyroid. Headache. Apr 2016;56(4):784-785.
- Brennan KC, Charles A. An update on the blood vessel in migraine. Current opinion in neurology. 2010;23(3):266-274.
- Ferroni P, Barbanti P, Della-Morte D, Palmirotta R, Jirillo E, Guadagni F. Redox Mechanisms in Migraine: Novel Therapeutics and Dietary Interventions. Antioxidants & redox signaling. Apr 20 2018;28(12):1144-1183.
- Hamed SA. The vascular risk associations with migraine: Relation to migraine susceptibility and progression. Atherosclerosis. 2009/07/01/ 2009;205(1):15-22.
- Arngrim N, Schytz HW, Britze J, et al. Migraine induced by hypoxia: an MRI spectroscopy and angiography study. Brain : a journal of neurology. Mar 2016;139(Pt 3):723-737.
- Borkum JM. Migraine Triggers and Oxidative Stress: A Narrative Review and Synthesis. Headache. Jan 2016;56(1):12-35.
- Borkum JM. The Migraine Attack as a Homeostatic, Neuroprotective Response to Brain Oxidative Stress: Preliminary Evidence for a Theory. Headache. Jan 2018;58(1):118-135.
- Khosravi A, Nakhaee A, Ameri Z, Fattahzade Ardalani G, Arefpoor Z. Impaired oxidative-antioxidative balance during migraine attack. Journal of the Neurological Sciences. 2017/10/15/ 2017;381:426.
- Borsook D, Maleki N, Burstein R. Chapter 42 - Migraine. In: Zigmond MJ, Rowland LP, Coyle JT, eds. Neurobiology of Brain Disorders. San Diego: Academic Press; 2015:693-708.
- Gur M, Aslan M, Yildiz A, et al. Paraoxonase and arylesterase activities in coronary artery disease. European journal of clinical investigation. Nov 2006;36(11):779-787.
- Erdem FH, Karatay S, Yildirim K, Kiziltunc A. Evaluation of serum paraoxonase and arylesterase activities in ankylosing spondylitis patients. Clinics (Sao Paulo, Brazil). 2010;65(2):175-179.
- Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clinical biochemistry. Dec 2014;47(18):326-332.
- Fidan F, Alkan BM, Ugurlu FG, et al. Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia. Archives of rheumatology. Jun 2017;32(2):112-117.
- Gaze DC. Ischemia modified albumin: a novel biomarker for the detection of cardiac ischemia. Drug metabolism and pharmacokinetics. 2009;24(4):333-341.
- Sławomir Michalak KO, Alicja Płóciniczak, Waldemar Myszka,Marcin Nowicki, Danuta Węgrzyn, Małgorzata Drzewiecka, Kinga Kapecka,Wojciech Kozubski. Ischemia-modifi ed albumin in migraine patients during interictal period. Journal of Medical Science. 2016;85(4).
- The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia : an international journal of headache. Jul 2013;33(9):629-808.
- Stewart WF, Lipton RB, Dowson AJ, Sawyer J. Development and testing of the Migraine Disability Assessment (MIDAS) Questionnaire to assess headache-related disability. Neurology. 2001;56(6 Suppl 1):S20-28.
- Gumusyayla S, Vural G, Bektas H, Neselioglu S, Deniz O, Erel O. Erratum to: A novel oxidative stress marker in migraine patients: dynamic thiol-disulphide homeostasis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. Aug 2016;37(8):1381.
- Sarikaya S, Ciftci S, Yoldas TK, et al. Plasma total antioxidant status, antioxidant status and oxidative stress and their relationship to migraine disease. Journal of the Neurological Sciences. 2015/10/15/ 2015;357:e169-e170.
- Schürks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T. Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ. 2009;339.
- Silva FA, Rueda-Clausen CF, Silva SY, et al. Endothelial function in patients with migraine during the interictal period. Headache. Jan 2007;47(1):45-51.
- Yigit M, Sogut O, Tataroglu O, et al. Oxidative/antioxidative status, lymphocyte DNA damage, and urotensin-2 receptor level in patients with migraine attacks. Neuropsychiatric disease and treatment. 2018;14:367-374.
- Eren Y, Dirik EB, Neþelioðlu S, Erel Ö. Serum Lipid Profiles, Relationship Between Paraoxonase/Arylesterase Activity and High-density Lipoprotein Levels in Patients with Migraine. Turk J Neurol. 2017;23(3):117-121.
- Yilmaz N, Aydin O, Yegin A, Tiltak A, Eren E. Increased levels of total oxidant status and decreased activity of arylesterase in migraineurs. Clinical biochemistry. Jul 2011;44(10-11):832-837.
Öz
Amaç:
Önceki araştırmalar, migrenin oksidatif strese karşı artan hassasiyet ile
ilişkili olabileceğini ileri sürmüştür. Bu çalışmanın amacı, aurasız migren
hastalarında serum paraoksonaz ve arilesteraz aktiviteleri, tiyol düzeyleri,
iskemi-modifiye albümin, total oksidan durum, total antioksidan durum ve
oksidatif stres indeksini araştırmaktır.
Materyal ve Metot:
Aurasız migrenli 30 hasta (5 erkek ve 25 kadın) ve 30 sağlıklı kontrol (8 erkek
ve 22 kadın) çalışmaya dahil edildi. Spektrofotometrik yöntemle serum paraoksonaz
ve arilesteraz aktiviteleri, tiyol düzeyleri, iskemi-modifiye albümin, total
antioksidan durum, total oksidan durum ve oksidatif stres indeksi belirlendi.
İstatistiksel analiz Mann-Whitney U testi ve bağımsız örneklem t-testi
kullanılarak yapıldı ve p <0.05 istatistiksel olarak anlamlı kabul edildi.
Bulgular:
Paraoksonaz ve arilesteraz düzeyleri kontrol grubuna göre aurasız migren
grubunda anlamlı derecede düşük bulundu (p <0.05).
Sonuçlar: Bulgularımız paraoksonaz ve arilesteraz
düzeylerinin aurasız migren ile ilişkili olabileceğini düşündürmektedir. Migren
hastalarında oksidatif stress belirteçlerinin daha büyük bir popülasyona sahip
ve bu parametreler dikkate alınarak araştırılması önerilir.
Anahtar Kelimeler
Proje Numarası
THD-2018-2509
Kaynakça
- Geyik S, Altunisik E, Neyal AM, Taysi S. Oxidative stress and DNA damage in patients with migraine. The journal of headache and pain. 2016;17:10.
- Tripathi GM, Kalita J, Misra UK. A study of oxidative stress in migraine with special reference to prophylactic therapy. The International journal of neuroscience. Apr 2018;128(4):318-324.
- Yilmaz N, Aydin O, Yegin A, Tiltak A, Eren E, Aykal G. Impaired oxidative balance and association of blood glucose, insulin and HOMA-IR index in migraine. Biochemia medica. 2011;21(2):145-151.
- Alp R, Selek S, Alp SI, Taskin A, Kocyigit A. Oxidative and antioxidative balance in patients of migraine. European review for medical and pharmacological sciences. Oct 2010;14(10):877-882.
- Borkum JM. Migraine Triggers, Oxidative Stress, and the Thyroid. Headache. Apr 2016;56(4):784-785.
- Brennan KC, Charles A. An update on the blood vessel in migraine. Current opinion in neurology. 2010;23(3):266-274.
- Ferroni P, Barbanti P, Della-Morte D, Palmirotta R, Jirillo E, Guadagni F. Redox Mechanisms in Migraine: Novel Therapeutics and Dietary Interventions. Antioxidants & redox signaling. Apr 20 2018;28(12):1144-1183.
- Hamed SA. The vascular risk associations with migraine: Relation to migraine susceptibility and progression. Atherosclerosis. 2009/07/01/ 2009;205(1):15-22.
- Arngrim N, Schytz HW, Britze J, et al. Migraine induced by hypoxia: an MRI spectroscopy and angiography study. Brain : a journal of neurology. Mar 2016;139(Pt 3):723-737.
- Borkum JM. Migraine Triggers and Oxidative Stress: A Narrative Review and Synthesis. Headache. Jan 2016;56(1):12-35.
- Borkum JM. The Migraine Attack as a Homeostatic, Neuroprotective Response to Brain Oxidative Stress: Preliminary Evidence for a Theory. Headache. Jan 2018;58(1):118-135.
- Khosravi A, Nakhaee A, Ameri Z, Fattahzade Ardalani G, Arefpoor Z. Impaired oxidative-antioxidative balance during migraine attack. Journal of the Neurological Sciences. 2017/10/15/ 2017;381:426.
- Borsook D, Maleki N, Burstein R. Chapter 42 - Migraine. In: Zigmond MJ, Rowland LP, Coyle JT, eds. Neurobiology of Brain Disorders. San Diego: Academic Press; 2015:693-708.
- Gur M, Aslan M, Yildiz A, et al. Paraoxonase and arylesterase activities in coronary artery disease. European journal of clinical investigation. Nov 2006;36(11):779-787.
- Erdem FH, Karatay S, Yildirim K, Kiziltunc A. Evaluation of serum paraoxonase and arylesterase activities in ankylosing spondylitis patients. Clinics (Sao Paulo, Brazil). 2010;65(2):175-179.
- Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clinical biochemistry. Dec 2014;47(18):326-332.
- Fidan F, Alkan BM, Ugurlu FG, et al. Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia. Archives of rheumatology. Jun 2017;32(2):112-117.
- Gaze DC. Ischemia modified albumin: a novel biomarker for the detection of cardiac ischemia. Drug metabolism and pharmacokinetics. 2009;24(4):333-341.
- Sławomir Michalak KO, Alicja Płóciniczak, Waldemar Myszka,Marcin Nowicki, Danuta Węgrzyn, Małgorzata Drzewiecka, Kinga Kapecka,Wojciech Kozubski. Ischemia-modifi ed albumin in migraine patients during interictal period. Journal of Medical Science. 2016;85(4).
- The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia : an international journal of headache. Jul 2013;33(9):629-808.
- Stewart WF, Lipton RB, Dowson AJ, Sawyer J. Development and testing of the Migraine Disability Assessment (MIDAS) Questionnaire to assess headache-related disability. Neurology. 2001;56(6 Suppl 1):S20-28.
- Gumusyayla S, Vural G, Bektas H, Neselioglu S, Deniz O, Erel O. Erratum to: A novel oxidative stress marker in migraine patients: dynamic thiol-disulphide homeostasis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. Aug 2016;37(8):1381.
- Sarikaya S, Ciftci S, Yoldas TK, et al. Plasma total antioxidant status, antioxidant status and oxidative stress and their relationship to migraine disease. Journal of the Neurological Sciences. 2015/10/15/ 2015;357:e169-e170.
- Schürks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T. Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ. 2009;339.
- Silva FA, Rueda-Clausen CF, Silva SY, et al. Endothelial function in patients with migraine during the interictal period. Headache. Jan 2007;47(1):45-51.
- Yigit M, Sogut O, Tataroglu O, et al. Oxidative/antioxidative status, lymphocyte DNA damage, and urotensin-2 receptor level in patients with migraine attacks. Neuropsychiatric disease and treatment. 2018;14:367-374.
- Eren Y, Dirik EB, Neþelioðlu S, Erel Ö. Serum Lipid Profiles, Relationship Between Paraoxonase/Arylesterase Activity and High-density Lipoprotein Levels in Patients with Migraine. Turk J Neurol. 2017;23(3):117-121.
- Yilmaz N, Aydin O, Yegin A, Tiltak A, Eren E. Increased levels of total oxidant status and decreased activity of arylesterase in migraineurs. Clinical biochemistry. Jul 2011;44(10-11):832-837.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Klinik Tıp Bilimleri |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Proje Numarası | THD-2018-2509 |
| Yayımlanma Tarihi | 20 Nisan 2020 |
| Yayımlandığı Sayı | Yıl 2020 Cilt: 8 Sayı: 1 |