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Different methods of extraction of bioactive compounds and their effect on biological activity: A review

Yıl 2023, Cilt: 10 Sayı: 4, 469 - 494, 01.12.2023
https://doi.org/10.21448/ijsm.1225936

Öz

As of yet, there isn't a single technique that is accepted as the standard for extracting bioactive chemicals from plants. Methods. The effectiveness of both traditional and unconventional extraction methods largely depends on key input variables, knowledge of the composition of plant matter, bioactive chemical chemistry, and scientific knowledge. Results. The necessity for the most suitable and standardized technology to separate active ingredients for plant matter is highlighted by the utilization of bioactive chemicals in several economic sectors, including the pharmaceutical, food, and chemical industries. This review aimed to discuss there are several extraction methods and their basic mechanisms for the extraction of bioactive substances from medicinal plants.

Kaynakça

  • Adegbola, P., Aderibigbe, I., Hammed, W., & Omotayo, T. (2017). Antioxidant and anti-inflammatory medicinal plants have potential role in the treatment of cardiovascular disease: a review. American journal of Cardiovascular Disease, 7(2), 19.
  • Afroz, R.D., Nurunnabi, A.S.M., Khan, M.I., & Jahan, T. (2015). Effect of wheatgrass (Triticum aestivum) juice on high density lipoprotein (HDL) level in experimentally induced dyslipidaemic male long evans rat. Delta Medical College Journal, 3(1), 18-24. http://dx.doi.org/10.3329/dmcj.v3i1.22235
  • Agarwal, R.B., & Rangari, V.D. (2003). Phytochemical investigation and evaluation of anti-inflammatory and anti-arthritic activities of essential oil of Strobilanthus ixiocephala Benth.
  • Ahmad, T., Masoodi, F., Rather, S.A., Wani, S., & Gull, A. (2019). Supercritical fluid extraction: A review. J. Biol. Chem. Chron, 5(1), 114 122. http://dx.doi.org/10.33980/jbcc.2019.v05i01.019
  • Altemimi, A., Lakhssassi, N., Baharlouei, A., Watson, D.G., & Lightfoot, D.A. (2017). Phytochemicals: Extraction, isolation, and identification of bioactive compounds from plant extracts. Plants, 6(4), 42. https://doi.org/10.3390/plants6040042
  • Álvarez-Muñoz, D., Sáez, M., Lara-Martín, P., Gómez-Parra, A., & González-Mazo, E. (2004). New extraction method for the analysis of linear alkylbenzene sulfonates in marine organisms: Pressurized liquid extraction versus Soxhlet extraction. Journal of Chromatography A, 1052(1-2), 33-38. https://doi.org/10.1016/j.chroma.2004.08.014
  • Annadurai, P. (2021). Extraction and Isolation of bioactive compounds from Lantana camara leaves by column Chromatographic techniques. Research Journal of Pharmacy and Technology, 14(3), 1607-1611. http://dx.doi.org/10.5958/0974-360X.2021.00285.7
  • Azmir, J., Zaidul, I.S.M., Rahman, M.M., Sharif, K., Mohamed, A., Sahena, F., . . . Omar, A. (2013). Techniques for extraction of bioactive compounds from plant materials: A review. Journal of Food Engineering, 117(4), 426 436. https://doi.org/10.1016/j.jfoodeng.2013.01.014
  • Bajpai, V.K., Majumder, R., & Park, J.G. (2016). Isolation and purification of plant secondary metabolites using column-chromatographic technique. Bangladesh Journal of Pharmacology, 11(4), 844-848. https://doi.org/10.3329/bjp.v11i4.28185
  • Barzegar, E., Fouladdel, S., Movahhed, T.K., Atashpour, S., Ghahremani, M.H., Ostad, S.N., & Azizi, E. (2015). Effects of berberine on proliferation, cell cycle distribution and apoptosis of human breast cancer T47D and MCF7 cell lines. Iranian journal of Basic Medical Sciences, 18(4), 334.
  • Bast, F., Rani, P., & Meena, D. (2014). Chloroplast DNA phylogeography of holy basil (Ocimum tenuiflorum) in Indian subcontinent. The Scientific World Journal, 2014. https://doi.org/10.1155/2014/847482
  • Bernhoft, A. (2010). A brief review on bioactive compounds in plants. Bioactive Compounds in Plants-Benefits and Risks for Man And Animals, 50, 11-17.
  • Bhateja, S., & Arora, G. (2012). Therapeutic benefits of holy basil (Tulsi) in general and oral medicine: a review. International Journal of Research in Ayurveda and Pharmacy (IJRAP), 3(6), 761-764. http://dx.doi.org/10.7897/2277-4343.03611
  • Biswas, N., & Biswas, A. (2005). Evaluation of some leaf dusts as grain protectant against rice weevil Sitophilus oryzae (Linn.). Environment and Ecology, 23(3), 485.
  • Bitwell, C., Sen, I.S., Luke, C., & Kakoma, M.K. (2023). A review of modern and conventional extraction techniques and their applications for extracting phytochemicals from plants. Scientific African, e01585. https://doi.org/10.1016/j.sciaf.2023.e01585
  • Brusotti, G., Cesari, I., Dentamaro, A., Caccialanza, G., & Massolini, G. (2014). Isolation and characterization of bioactive compounds from plant resources: the role of analysis in the ethnopharmacological approach. Journal of pharmaceutical and Biomedical Analysis, 87, 218-228. https://doi.org/10.1016/j.jpba.2013.03.007
  • Carroll, K.C., Taylor, R., Gray, E., & Brusseau, M.L. (2009). The impact of composition on the physical properties and evaporative mass transfer of a PCE–diesel immiscible liquid. Journal of Hazardous Materials, 164(2 3), 1074 1081. https://doi.org/10.1016/j.jhazmat.2008.09.003
  • Chemat, F., Tomao, V., & Virot, M. (2008). Ultrasound-assisted extraction in food analysis. Handbook of Food Analysis Instruments, 85-103.
  • Chhipa, A.S., & Sisodia, S. (2019). Indian medicinal plants with antidiabetic potential. Journal of Drug Delivery and Therapeutics, 9(1), 257-265. https://doi.org/10.22270/jddt.v9i1.2282
  • Chiremba, C., Rooney, L.W., & Beta, T. (2012). Microwave-assisted extraction of bound phenolic acids in bran and flour fractions from sorghum and maize cultivars varying in hardness. Journal of Agricultural and Food Chemistry, 60(18), 4735-4742. https://doi.org/10.1021/jf300279t
  • Cohen, M.M. (2014). Tulsi-Ocimum sanctum: A herb for all reasons. Journal of Ayurveda and Integrative Medicine, 5(4), 251. https://doi.org/10.4103%2F0975-9476.146554
  • Concha, J., Soto, C., Chamy, R., & Zuniga, M. (2004). Enzymatic pretreatment on rose-hip oil extraction: hydrolysis and pressing conditions. Journal of the American Oil Chemists' Society, 81(6), 549-552. https://doi.org/10.1007/s11746-006-0939-y
  • Croteau, R., Kutchan, T.M., & Lewis, N.G. (2000). Natural products (secondary metabolites). Biochemistry and molecular biology of plants, 24, 1250-1319.
  • Dar, N.G., Hussain, A., Paracha, G.M., & Akhter, S. (2015). Evaluation of different techniques for extraction of antioxidants as bioactive compounds from citrus peels (industrial by products). American-Eurasian Journal of Agricultural and Environmental Sciences, 15(4), 676-682. https://doi.org/10.5829/idosi.aejaes.2015.15.4.12604
  • Dhobi, M., Mandal, V., & Hemalatha, S. (2009). Optimization of microwave assisted extraction of bioactive flavonolignan-silybinin. Journal of chemical metrology, 3(1), 13.
  • Donn, P., Prieto, M.A., Mejuto, J.C., Cao, H., & Simal-Gandara, J. (2022). Functional foods based on the recovery of bioactive ingredients from food and algae by-products by emerging extraction technologies and 3D printing. Food Bioscience, 49, 101853. https://doi.org/10.1016/j.fbio.2022.101853
  • Dudareva, N., & Pichersky, E. (2000). Biochemical and molecular genetic aspects of floral scents. Plant physiology, 122(3), 627-634. https://doi.org/10.1104/pp.122.3.627
  • Dunford, N. (2008). Oil and oilseed processing II. Retrieved from
  • Erb, M., & Kliebenstein, D.J. (2020). Plant secondary metabolites as defenses, regulators, and primary metabolites: the blurred functional trichotomy. Plant physiology, 184(1), 39-52. https://doi.org/10.1104/pp.20.00433
  • Fabricant, D.S., & Farnsworth, N.R. (2001). The value of plants used in traditional medicine for drug discovery. Environmental health perspectives, 109(suppl 1), 69-75.
  • Fotsing Yannick Stéphane, F., Kezetas Jean Jules, B., El-Saber Batiha, G., Ali, I., & Ndjakou Bruno, L. (2022). Extraction of Bioactive Compounds from Medicinal Plants and Herbs. IntechOpen. https://doi.org/10.5772/intechopen.98602
  • Francis, G., Kerem, Z., Makkar, H.P., & Becker, K. (2002). The biological action of saponins in animal systems: a review. British journal of Nutrition, 88(6), 587-605. https://doi.org/10.1079/BJN2002725
  • García-Risco, M.R., Mouhid, L., Salas-Pérez, L., López-Padilla, A., Santoyo, S., Jaime, L., . . . Fornari, T. (2017). Biological activities of Asteraceae (Achillea millefolium and Calendula officinalis) and Lamiaceae (Melissa officinalis and Origanum majorana) plant extracts. Plant Foods for Human Nutrition, 72(1), 96-102. https://doi.org/10.1007/s11130-016-0596-8
  • Gaur, R., Sharma, A., Khare, S., & Gupta, M.N. (2007). A novel process for extraction of edible oils: Enzyme assisted three phase partitioning (EATPP). Bioresource Technology, 98(3), 696-699. https://doi.org/10.1016/j.biortech.2006.01.023
  • George, A., Thankamma, A., Devi, V.R., & Fernandez, A. (2007). Phytochemical investigation of Insulin plant (Costus pictus). Asian Journal of Chemistry, 19(5), 3427.
  • Ghafoor, K., Park, J., & Choi, Y.-H. (2010). Optimization of supercritical fluid extraction of bioactive compounds from grape (Vitis labrusca B.) peel by using response surface methodology. Innovative Food Science & Emerging Technologies, 11(3), 485-490. https://doi.org/10.1016/j.ifset.2010.01.013
  • Ghandahari Yazdi, A.P., Barzegar, M., Sahari, M.A., & Ahmadi Gavlighi, H. (2019). Optimization of the enzyme‐assisted aqueous extraction of phenolic compounds from pistachio green hull. Food Science & Nutrition, 7(1), 356 366. https://doi.org/10.1002/fsn3.900
  • Gholamhoseinian, A., Shahouzehi, B., Joukar, S., & Iranpoor, M. (2012). Effect of Quercus infectoria and Rosa damascena on lipid profile and atherosclerotic plaque formation in rabbit model of hyperlipidemia. Pakistan Journal of Biological Sciences, 15(1), 27-33. https://doi.org/10.3923/pjbs.2012.27.33
  • Gholap, S., & Kar, A. (2003). Effects of Inula racemosa root and Gymnema sylvestre leaf extracts in the regulation of corticosteroid induced diabetes mellitus: involvement of thyroid hormones. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 58(6), 413-415.
  • Giannuzzo, A.N., Boggetti, H.J., Nazareno, M.A., & Mishima, H.T. (2003). Supercritical fluid extraction of naringin from the peel of Citrus paradisi. Phytochemical Analysis, 14(4), 221-223.
  • Guaadaoui, A., Benaicha, S., Elmajdoub, N., Bellaoui, M., & Hamal, A. (2014). What is a bioactive compound? A combined definition for a preliminary consensus. International Journal of Nutrition and Food Sciences, 3(3), 174 179. https://doi.org/10.11648/j.ijnfs.20140303.16
  • Gülçin, İ., Mshvildadze, V., Gepdiremen, A., & Elias, R. (2004). Antioxidant activity of saponins isolated from ivy: α-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F. Planta medica, 70(06), 561-563. https://doi.org/10.1055/s-2004-827158
  • Hegde, P.K., Rao, H.A., & Rao, P.N. (2014). A review on Insulin plant (Costus igneus Nak). Pharmacognosy Reviews, 8(15), 67. https://doi.org/10.4103%2F0973-7847.125536
  • Hemmami, H., Ben Seghir, B., Ben Ali, M., Rebiai, A., Zeghoud, S., & Brahmia, F. (2020). Phenolic profile and antioxidant activity of bee pollen extracts from different regions of Algeria. Ovidius Univ. Ann. Chem, 31, 93-98. https://doi.org/10.2478/auoc-2020-0017
  • Hemmami, H., Seghir, B.B., Rebiai, A., Khelef, A., & Soumeia, Z. (2020). Comparative Study on Polyphenols Content and Antioxid ant Activity of Three Sweet Peppers Varieties (Capsicum annuum L.). Current Chemical Biology, 14(4), 250-261. https://doi.org/10.2174/2212796814999200907162105
  • Hernández, Y., Lobo, M.G., & González, M. (2009). Factors affecting sample extraction in the liquid chromatographic determination of organic acids in papaya and pineapple. Food Chemistry, 114(2), 734-741. https://doi.org/10.1016/j.foodchem.2008.10.021
  • Herrera, M., & De Castro, M.L. (2005). Ultrasound-assisted extraction of phenolic compounds from strawberries prior to liquid chromatographic separation and photodiode array ultraviolet detection. Journal of Chromatography A, 1100(1), 1 7. https://doi.org/10.1016/j.chroma.2005.09.021
  • Herrera, M., & Luque de Castro, M. (2004). Ultrasound-assisted extraction for the analysis of phenolic compounds in strawberries. Analytical and Bioanalytical Chemistry, 379(7), 1106-1112. https://doi.org/10.1007/s00216-004-2684-0
  • Hewavitharana, G.G., Perera, D.N., Navaratne, S., & Wickramasinghe, I. (2020). Extraction methods of fat from food samples and preparation of fatty acid methyl esters for gas chromatography: A review. Arabian Journal of Chemistry, 13(8), 6865-6875. https://doi.org/10.1016/j.arabjc.2020.06.039
  • Howard, L., & Pandjaitan, N. (2008). Pressurized liquid extraction of flavonoids from spinach. Journal of Food Science, 73(3), C151-C157. https://doi.org/10.1111/j.1750-3841.2007.00658.x
  • Howes, M.J.R., Perry, N.S., & Houghton, P.J. (2003). Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 17(1), 1-18. https://doi.org/10.1002/ptr.1280
  • Huie, C.W. (2002). A review of modern sample-preparation techniques for the extraction and analysis of medicinal plants. Analytical and Bioanalytical Chemistry, 373(1), 23-30. https://doi.org/10.1007/s00216-002-1265-3
  • Ibañez, E., Herrero, M., Mendiola, J.A., & Castro-Puyana, M. (2012). Extraction and Characterization of Bioactive Compounds with Health Benefits from Marine Resources: Macro and Micro Algae, Cyanobacteria, and Invertebrates. In: Hayes, M. (eds) Marine Bioactive Compounds. Springer. https://doi.org/10.1007/978-1-4614-1247-2_2
  • Iqbal, J., Abbasi, B.A., Mahmood, T., Kanwal, S., Ali, B., Shah, S.A., & Khalil, A.T. (2017). Plant-derived anticancer agents: A green anticancer approach. Asian Pacific Journal of Tropical Biomedicine, 7(12), 1129-1150. https://doi.org/10.1016/j.apjtb.2017.10.016
  • Jamshidi, N., & Cohen, M.M. (2017). The clinical efficacy and safety of Tulsi in humans: a systematic review of the literature. Evidence-Based Complementary and Alternative Medicine, 2017. https://doi.org/10.1155/2017/9217567
  • Jha, A.K., & Sit, N. (2022). Extraction of bioactive compounds from plant materials using combination of various novel methods: A review. Trends in Food Science & Technology, 119, 579-591. https://doi.org/10.1016/j.tifs.2021.11.019
  • Jila, A., Bernd, O., & Mohsen, M. (2011). Extraction of bioactive chemical compounds from the medicinal Asian plants by microwave irradiation. Journal of Medicinal Plants Research, 5(4), 495-506.
  • Kalidas, C., & Mohan, V. (2010). Genetic diversity of velvet bean, Mucuna pruriens (L.) DC from Southern Western Ghats, India. Int J Biol Tech, 1, 31-37.
  • Kaufmann, B., & Christen, P. (2002). Recent extraction techniques for natural products: microwave‐assisted extraction and pressurised solvent extraction. Phytochemical Analysis: An International Journal of Plant Chemical and Biochemical Techniques, 13(2), 105-113. https://doi.org/10.1002/pca.631
  • Khennouf, S., Benabdallah, H., Gharzouli, K., Amira, S., Ito, H., Kim, T.-H., . . . Gharzouli, A. (2003). Effect of tannins from Quercus suber and Quercus coccifera leaves on ethanol-induced gastric lesions in mice. Journal of Agricultural and Food Chemistry, 51(5), 1469-1473. https://doi.org/10.1021/jf020808y
  • Kumar, A., Sreedharan, S., Kashyap, A.K., Singh, P., & Ramchiary, N. (2021). A review on bioactive phytochemicals and ethnopharmacological potential of purslane (Portulaca oleracea L.). Heliyon, e08669. https://doi.org/10.1016/j.heliyon.2021.e08669
  • Kumar, B.S., Swamy, B.V., Archana, S., & Anitha, M. (2010). A review on natural diuretics. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 1(4), 615-634.
  • Lakkakula, N.R., Lima, M., & Walker, T. (2004). Rice bran stabilization and rice bran oil extraction using ohmic heating. Bioresource Technology, 92(2), 157-161. https://doi.org/10.1016/j.biortech.2003.08.010
  • Landbo, A.-K., & Meyer, A.S. (2001). Enzyme-assisted extraction of antioxidative phenols from black currant juice press residues (Ribes nigrum). Journal of Agricultural and Food Chemistry, 49(7), 3169-3177. https://doi.org/10.1021/jf001443p
  • Latif, S., & Anwar, F. (2009). Physicochemical studies of hemp (Cannabis sativa) seed oil using enzyme‐assisted cold‐pressing. European Journal of Lipid Science and Technology, 111(10), 1042-1048. https://doi.org/10.1002/ejlt.200900008
  • Lee, J., Cho, J.-Y., & Kim, W.-K. (2014). Anti-inflammation effect of Exercise and Korean red ginseng in aging model rats with diet-induced atherosclerosis. Nutrition Research and Practice, 8(3), 284-291. https://doi.org/10.4162/nrp.2014.8.3.284
  • Li, B., Smith, B., & Hossain, M.M. (2006). Extraction of phenolics from citrus peels: II. Enzyme-assisted extraction method. Separation and Purification Technology, 48(2), 189-196. https://doi.org/10.1016/j.seppur.2005.07.019
  • Li, H., Chen, B., & Yao, S. (2005). Application of ultrasonic technique for extracting chlorogenic acid from Eucommia ulmodies Oliv.(E. ulmodies). Ultrasonics Sonochemistry, 12(4), 295-300. https://doi.org/10.1016/j.ultsonch.2004.01.033
  • Liu, D., Zhen, W., Yang, Z., Carter, J.D., Si, H., & Reynolds, K.A. (2006). Genistein acutely stimulates insulin secretion in pancreatic β-cells through a cAMP-dependent protein kinase pathway. Diabetes, 55(4), 1043-1050. https://doi.org/10.2337/diabetes.55.04.06.db05-1089
  • Liu, J., Li, Y., Shi, H., Wang, T., Wu, X., Sun, X., & Yu, L.L. (2016). Components characterization of total tetraploid jiaogulan (Gynostemma pentaphyllum) saponin and its cholesterol-lowering properties. Journal of Functional Foods, 23, 542-555. https://doi.org/10.1016/j.jff.2016.03.013
  • Liu, S., Gallo, D.J., Green, A.M., Williams, D.L., Gong, X., Shapiro, R.A., . . . Billiar, T.R. (2002). Role of toll-like receptors in changes in gene expression and NF-κB activation in mouse hepatocytes stimulated with lipopolysaccharide. Infection and Immunity, 70(7), 3433-3442. https://doi.org/10.1128/iai.70.7.3433-3442.2002
  • Łubek-Nguyen, A., Ziemichód, W., & Olech, M. (2022). Application of Enzyme-Assisted Extraction for the Recovery of Natural Bioactive Compounds for Nutraceutical and Pharmaceutical Applications. Applied Sciences, 12(7), 3232. https://doi.org/10.3390/app12073232
  • Luthria, D.L. (2008). Influence of experimental conditions on the extraction of phenolic compounds from parsley (Petroselinum crispum) flakes using a pressurized liquid extractor. Food Chemistry, 107(2), 745-752. https://doi.org/10.1016/j.foodchem.2007.08.074
  • Lyons, G., Carmichael, E., McRoberts, C., Aubry, A., Thomson, A., & Reynolds, C.K. (2018). Prediction of Lignin Content in Ruminant Diets and Fecal Samples Using Rapid Analytical Techniques. Journal of Agricultural and Food Chemistry, 66(49), 13031-13040. https://doi.org/10.1021/acs.jafc.8b03808
  • Mallikharjuna, P., Rajanna, L., Seetharam, Y., & Sharanabasappa, G. (2007). Phytochemical studies of Strychnos potatorum Lf-A medicinal plant. E-journal of Chemistry, 4(4), 510-518. https://doi.org/10.1155/2007/687859
  • Manthey, J.A., & Guthrie, N. (2002). Antiproliferative activities of citrus flavonoids against six human cancer cell lines. Journal of Agricultural and Food Chemistry, 50(21), 5837-5843. https://doi.org/10.1021/jf020121d
  • Martins, P.M., Lanchote, A.D., Thorat, B.N., & Freitas, L.A. (2017). Turbo-extraction of glycosides from Stevia rebaudiana using a fractional factorial design. Revista Brasileira de Farmacognosia, 27, 510-518. https://doi.org/10.1016/j.bjp.2017.02.007
  • Medina‐Remón, A., Casas, R., Tressserra‐Rimbau, A., Ros, E., Martínez‐González, M.A., Fitó, M., . . . Estruch, R. (2017). Polyphenol intake from a Mediterranean diet decreases inflammatory biomarkers related to atherosclerosis: a substudy of the PREDIMED trial. British Journal of Clinical Pharmacology, 83(1), 114 128. https://doi.org/10.1111/bcp.12986
  • Meini, M.-R., Cabezudo, I., Boschetti, C.E., & Romanini, D. (2019). Recovery of phenolic antioxidants from Syrah grape pomace through the optimization of an enzymatic extraction process. Food Chemistry, 283, 257-264. https://doi.org/10.1016/j.foodchem.2019.01.037
  • Meyers, C.D., Kamanna, V. S., & Kashyap, M. L. (2004). Niacin therapy in atherosclerosis. Current Opinion in Lipidology, 15(6), 659-665.
  • Moldoveanu, S.C., & David, V. (2002). Sample preparation in chromatography. Elsevier.
  • Mroczek, T., & Mazurek, J. (2009). Pressurized liquid extraction and anticholinesterase activity-based thin-layer chromatography with bioautography of Amaryllidaceae alkaloids. Analytica Chimica Acta, 633(2), 188-196. https://doi.org/10.1016/j.aca.2008.11.053
  • Mukherjee, S., & Patra, C. R. (2016). Therapeutic application of anti-angiogenic nanomaterials in cancers. Nanoscale, 8(25), 12444-12470. https://doi.org/10.1039/C5NR07887C
  • Niranjan, K., & Hanmoungjai, P. (2004). Enzyme-aided aquous extraction. In book: Nutritionally Enhanced Edible Oil Processing. AOCS Publishing. http://dx.doi.org/10.1201/9781439822272.ch5
  • Nitiéma, M., Ilboudo, S., Belemnaba, L., Ouédraogo, G., Ouédraogo, S., Ouédraogo, N., . . . Guissou, I. (2018). Acute and sub-acute toxicity studies of aqueous decoction of the trunk barks from Lannea microcarpa Engl. and K. Krause (anacardiaceae) in rodents. World Journal of Pharmacy and Pharmaceutical Sciences, 7(9), 30 42. http://dx.doi.org/10.20959/wjpps20189-12185
  • Palma, M., & Barroso, C. G. (2002). Ultrasound-assisted extraction and determination of tartaric and malic acids from grapes and winemaking by-products. Analytica Chimica Acta, 458(1), 119-130. https://doi.org/10.1016/S0003-2670(01)01527-6
  • Pan, X., Niu, G., & Liu, H. (2003). Microwave-assisted extraction of tea polyphenols and tea caffeine from green tea leaves. Chemical Engineering and Processing: Process Intensification, 42(2), 129-133. https://doi.org/10.1016/S0255-2701(02)00037-5
  • Pandey, G., & Madhuri, S. (2010). Pharmacological activities of Ocimum sanctum (tulsi): a review. Int J Pharm Sci Rev Res, 5(1), 61-66.
  • Patel, D., Kumar, R., Prasad, S., Sairam, K., & Hemalatha, S. (2011). Antidiabetic and in vitro antioxidant potential of Hybanthus enneaspermus (Linn) F. Muell in streptozotocin–induced diabetic rats. Asian Pacific Journal of Tropical Biomedicine, 1(4), 316-322. https://doi.org/10.1016/S2221-1691(11)60051-8
  • Paulsen, B.S. (2010). Highlights through the history of plant medicine. Bioactive compounds in plants-benefits and risks for man and animals, 50.
  • Prakash, P., & Gupta, N. (2005). Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: a short review. Indian Journal of Physiology and Pharmacology, 49(2), 125.
  • Puri, H.S. (2002). Rasayana: Ayurvedic herbs for longevity and rejuvenation. CRC press.
  • Puri, M., Sharma, D., & Barrow, C.J. (2012). Enzyme-assisted extraction of bioactives from plants. Trends in biotechnology, 30(1), 37-44. https://doi.org/10.1016/j.tibtech.2011.06.014
  • Rasul, M.G. (2018). Conventional extraction methods use in medicinal plants, their advantages and disadvantages. Int. J. Basic Sci. Appl. Comput, 2, 10-14.
  • Rostagno, M.A., Palma, M., & Barroso, C.G. (2003). Ultrasound-assisted extraction of soy isoflavones. Journal of Chromatography A, 1012(2), 119 128. https://doi.org/10.1016/S0021-9673(03)01184-1
  • Sarkar, A., Bhattacharjee, S., & Mandal, D.P. (2015). Induction of apoptosis by eugenol and capsaicin in human gastric cancer AGS cells-elucidating the role of p53. Asian Pacific Journal of Cancer Prevention, 16(15), 6753-6759.
  • Sasidharan, S., Chen, Y., Saravanan, D., Sundram, K., & Latha, L.Y. (2011). Extraction, isolation and characterization of bioactive compounds from plants’ extracts. African Journal of Traditional, Complementary and Alternative Medicines, 8(1), 1 10. https://doi.org/10.4314/ajtcam.v8i1.60483
  • Sharma, A., Khare, S., & Gupta, M. (2002). Enzyme‐assisted aqueous extraction of peanut oil. Journal of the American Oil Chemists' Society, 79(3), 215 218. https://doi.org/10.1007/s11746-002-0463-0
  • Shen, J., & Shao, X. (2005). A comparison of accelerated solvent extraction, Soxhlet extraction, and ultrasonic-assisted extraction for analysis of terpenoids and sterols in tobacco. Analytical and Bioanalytical Chemistry, 383(6), 1003-1008. https://doi.org/10.1007/s00216-005-0078-6
  • Shiny, C., Saxena, A., & Gupta, S.P. (2013). Phytochemical investigation of the insulin plant “Costus pictus” D. Don. Int J Pharm Biomed Res, 4(2), 97-104.
  • Shrinet, K., Singh, R.K., Chaurasia, A.K., Tripathi, A., & Kumar, A. (2021). Bioactive compounds and their future therapeutic applications Natural Bioactive Compounds (pp. 337-362). Elsevier. https://doi.org/10.1016/B978-0-12-820655-3.00017-3
  • Smith, R.M. (2003). Before the injection—modern methods of sample preparation for separation techniques. Journal of Chromatography A, 1000(1 2), 3 27. https://doi.org/10.1016/S0021-9673(03)00511-9
  • Sohgaura, A., Bigoniya, P., & Shrivastava, B. (2018). Diuretic potential of Cynodon dactylon, Emblica officinalis, Kalanchoe pinnata and Bambusa nutans. Journal of Pharmacognosy and Phytochemistry, 7(3), 2895-2900.
  • Sy, G., Cissé, A., Nongonierma, R., Sarr, M., Mbodj, N., & Faye, B. (2005). Hypoglycaemic and antidiabetic activity of acetonic extract of Vernonia colorata leaves in normoglycaemic and alloxan-induced diabetic rats. Journal of Ethnopharmacology, 98(1-2), 171-175. https://doi.org/10.1016/j.jep.2005.01.024
  • Taiz, L., & Zeiger, E. (2006). Secondary metabolites and plant defense. Plant physiology, 4, 315-344.
  • Teng, H., Ghafoor, K., & Choi, Y.H. (2009). Optimization of microwave-assisted extraction of active components from Chinese quince using response surface methodology. Journal of the Korean Society for Applied Biological Chemistry, 52(6), 694 701. https://doi.org/10.3839/jksabc.2009.115
  • Toepfl, S., Mathys, A., Heinz, V., & Knorr, D. (2006). Potential of high hydrostatic pressure and pulsed electric fields for energy efficient and environmentally friendly food processing. Food Reviews International, 22(4), 405-423. https://doi.org/10.1080/87559120600865164
  • Tripathi, A. (2018). Immunomodulatory commotion of HMGB 1 in Urethane primed Hepatocarcinogenesis.
  • Triveni, K., Lakshmi, V., Shashidhara, S., & Anitha, S. (2012). Gymnema Sylvestre: a comprehensive review. Pharma Science Monitor, 3(4).
  • Tzanova, M., Atanasov, V., Yaneva, Z., Ivanova, D., & Dinev, T. (2020). Selectivity of current extraction techniques for flavonoids from plant materials. Processes, 8(10), 1222. https://doi.org/10.3390/pr8101222
  • Uwineza, P.A., & Waśkiewicz, A. (2020). Recent advances in supercritical fluid extraction of natural bioactive compounds from natural plant materials. Molecules, 25(17), 3847. https://doi.org/10.3390/molecules25173847
  • Vaidya, S. (2011). Review on gymnema: an herbal medicine for diabetes management. Pharmacia, 1(2), 37-42.
  • Verma, A., Hartonen, K., & Riekkola, M.L. (2008). Optimisation of supercritical fluid extraction of indole alkaloids from Catharanthus roseus using experimental design methodology-comparison with other extraction techniques. Phytochemical Analysis: An International Journal of Plant Chemical and Biochemical Techniques, 19(1), 52-63. https://doi.org/10.1002/pca.1015
  • Vinatoru, M. (2001). An overview of the ultrasonically assisted extraction of bioactive principles from herbs. Ultrasonics Sonochemistry, 8(3), 303 313. https://doi.org/10.1016/S1350-4177(01)00071-2
  • Wang, L., & Weller, C.L. (2006). Recent advances in extraction of nutraceuticals from plants. Trends in Food Science & Technology, 17(6), 300 312. https://doi.org/10.1016/j.tifs.2005.12.004
  • Wani, M., Sarvar, F.A., Agrawal, J., Deshpande, J., Mathew, S., & Khetmalas, M. (2012). Qualitative phytochemical analysis and antimicrobial activity studies of Gymnema sylvestre R. Br. Acta Biologica Indica, 1(1), 121-124.
  • Weaver, B.A. (2014). How Taxol/paclitaxel kills cancer cells. Molecular biology of the cell, 25(18), 2677-2681. https://doi.org/10.1091/mbc.e14-04-0916
  • Yang, Y., & Zhang, F. (2008). Ultrasound-assisted extraction of rutin and quercetin from Euonymus alatus (Thunb.) Sieb. Ultrasonics Sonochemistry, 15(4), 308-313. https://doi.org/10.1016/j.ultsonch.2007.05.001
  • Zeghoud, S., Seghir, B.B., Kouadri, I., Hemmami, H., Amor, I.B., Tliba, A., . . . Rebiai, A. (2023). Classification of plants medicine species from Algerian regions using UV spectroscopy, HPLC chromatography, and chemometrics analysis. Malaysian Journal of Chemistry, 25(1), 126-142.
  • Zghaibi, N., Omar, R., Mustapa Kamal, S.M., Awang Biak, D.R., & Harun, R. (2019). Microwave-assisted brine extraction for enhancement of the quantity and quality of lipid production from microalgae Nannochloropsis sp. Molecules, 24(19), 3581. https://doi.org/10.3390/molecules24193581
  • Zhang, Q.-W., Lin, L.-G., & Ye, W.-C. (2018). Techniques for extraction and isolation of natural products: A comprehensive review. Chinese Medicine, 13(1), 1-26. https://doi.org/10.1186/s13020-018-0177-x

Different methods of extraction of bioactive compounds and their effect on biological activity: A review

Yıl 2023, Cilt: 10 Sayı: 4, 469 - 494, 01.12.2023
https://doi.org/10.21448/ijsm.1225936

Öz

As of yet, there isn't a single technique that is accepted as the standard for extracting bioactive chemicals from plants. Methods. The effectiveness of both traditional and unconventional extraction methods largely depends on key input variables, knowledge of the composition of plant matter, bioactive chemical chemistry, and scientific knowledge. Results. The necessity for the most suitable and standardized technology to separate active ingredients for plant matter is highlighted by the utilization of bioactive chemicals in several economic sectors, including the pharmaceutical, food, and chemical industries. This review aimed to discuss there are several extraction methods and their basic mechanisms for the extraction of bioactive substances from medicinal plants.

Kaynakça

  • Adegbola, P., Aderibigbe, I., Hammed, W., & Omotayo, T. (2017). Antioxidant and anti-inflammatory medicinal plants have potential role in the treatment of cardiovascular disease: a review. American journal of Cardiovascular Disease, 7(2), 19.
  • Afroz, R.D., Nurunnabi, A.S.M., Khan, M.I., & Jahan, T. (2015). Effect of wheatgrass (Triticum aestivum) juice on high density lipoprotein (HDL) level in experimentally induced dyslipidaemic male long evans rat. Delta Medical College Journal, 3(1), 18-24. http://dx.doi.org/10.3329/dmcj.v3i1.22235
  • Agarwal, R.B., & Rangari, V.D. (2003). Phytochemical investigation and evaluation of anti-inflammatory and anti-arthritic activities of essential oil of Strobilanthus ixiocephala Benth.
  • Ahmad, T., Masoodi, F., Rather, S.A., Wani, S., & Gull, A. (2019). Supercritical fluid extraction: A review. J. Biol. Chem. Chron, 5(1), 114 122. http://dx.doi.org/10.33980/jbcc.2019.v05i01.019
  • Altemimi, A., Lakhssassi, N., Baharlouei, A., Watson, D.G., & Lightfoot, D.A. (2017). Phytochemicals: Extraction, isolation, and identification of bioactive compounds from plant extracts. Plants, 6(4), 42. https://doi.org/10.3390/plants6040042
  • Álvarez-Muñoz, D., Sáez, M., Lara-Martín, P., Gómez-Parra, A., & González-Mazo, E. (2004). New extraction method for the analysis of linear alkylbenzene sulfonates in marine organisms: Pressurized liquid extraction versus Soxhlet extraction. Journal of Chromatography A, 1052(1-2), 33-38. https://doi.org/10.1016/j.chroma.2004.08.014
  • Annadurai, P. (2021). Extraction and Isolation of bioactive compounds from Lantana camara leaves by column Chromatographic techniques. Research Journal of Pharmacy and Technology, 14(3), 1607-1611. http://dx.doi.org/10.5958/0974-360X.2021.00285.7
  • Azmir, J., Zaidul, I.S.M., Rahman, M.M., Sharif, K., Mohamed, A., Sahena, F., . . . Omar, A. (2013). Techniques for extraction of bioactive compounds from plant materials: A review. Journal of Food Engineering, 117(4), 426 436. https://doi.org/10.1016/j.jfoodeng.2013.01.014
  • Bajpai, V.K., Majumder, R., & Park, J.G. (2016). Isolation and purification of plant secondary metabolites using column-chromatographic technique. Bangladesh Journal of Pharmacology, 11(4), 844-848. https://doi.org/10.3329/bjp.v11i4.28185
  • Barzegar, E., Fouladdel, S., Movahhed, T.K., Atashpour, S., Ghahremani, M.H., Ostad, S.N., & Azizi, E. (2015). Effects of berberine on proliferation, cell cycle distribution and apoptosis of human breast cancer T47D and MCF7 cell lines. Iranian journal of Basic Medical Sciences, 18(4), 334.
  • Bast, F., Rani, P., & Meena, D. (2014). Chloroplast DNA phylogeography of holy basil (Ocimum tenuiflorum) in Indian subcontinent. The Scientific World Journal, 2014. https://doi.org/10.1155/2014/847482
  • Bernhoft, A. (2010). A brief review on bioactive compounds in plants. Bioactive Compounds in Plants-Benefits and Risks for Man And Animals, 50, 11-17.
  • Bhateja, S., & Arora, G. (2012). Therapeutic benefits of holy basil (Tulsi) in general and oral medicine: a review. International Journal of Research in Ayurveda and Pharmacy (IJRAP), 3(6), 761-764. http://dx.doi.org/10.7897/2277-4343.03611
  • Biswas, N., & Biswas, A. (2005). Evaluation of some leaf dusts as grain protectant against rice weevil Sitophilus oryzae (Linn.). Environment and Ecology, 23(3), 485.
  • Bitwell, C., Sen, I.S., Luke, C., & Kakoma, M.K. (2023). A review of modern and conventional extraction techniques and their applications for extracting phytochemicals from plants. Scientific African, e01585. https://doi.org/10.1016/j.sciaf.2023.e01585
  • Brusotti, G., Cesari, I., Dentamaro, A., Caccialanza, G., & Massolini, G. (2014). Isolation and characterization of bioactive compounds from plant resources: the role of analysis in the ethnopharmacological approach. Journal of pharmaceutical and Biomedical Analysis, 87, 218-228. https://doi.org/10.1016/j.jpba.2013.03.007
  • Carroll, K.C., Taylor, R., Gray, E., & Brusseau, M.L. (2009). The impact of composition on the physical properties and evaporative mass transfer of a PCE–diesel immiscible liquid. Journal of Hazardous Materials, 164(2 3), 1074 1081. https://doi.org/10.1016/j.jhazmat.2008.09.003
  • Chemat, F., Tomao, V., & Virot, M. (2008). Ultrasound-assisted extraction in food analysis. Handbook of Food Analysis Instruments, 85-103.
  • Chhipa, A.S., & Sisodia, S. (2019). Indian medicinal plants with antidiabetic potential. Journal of Drug Delivery and Therapeutics, 9(1), 257-265. https://doi.org/10.22270/jddt.v9i1.2282
  • Chiremba, C., Rooney, L.W., & Beta, T. (2012). Microwave-assisted extraction of bound phenolic acids in bran and flour fractions from sorghum and maize cultivars varying in hardness. Journal of Agricultural and Food Chemistry, 60(18), 4735-4742. https://doi.org/10.1021/jf300279t
  • Cohen, M.M. (2014). Tulsi-Ocimum sanctum: A herb for all reasons. Journal of Ayurveda and Integrative Medicine, 5(4), 251. https://doi.org/10.4103%2F0975-9476.146554
  • Concha, J., Soto, C., Chamy, R., & Zuniga, M. (2004). Enzymatic pretreatment on rose-hip oil extraction: hydrolysis and pressing conditions. Journal of the American Oil Chemists' Society, 81(6), 549-552. https://doi.org/10.1007/s11746-006-0939-y
  • Croteau, R., Kutchan, T.M., & Lewis, N.G. (2000). Natural products (secondary metabolites). Biochemistry and molecular biology of plants, 24, 1250-1319.
  • Dar, N.G., Hussain, A., Paracha, G.M., & Akhter, S. (2015). Evaluation of different techniques for extraction of antioxidants as bioactive compounds from citrus peels (industrial by products). American-Eurasian Journal of Agricultural and Environmental Sciences, 15(4), 676-682. https://doi.org/10.5829/idosi.aejaes.2015.15.4.12604
  • Dhobi, M., Mandal, V., & Hemalatha, S. (2009). Optimization of microwave assisted extraction of bioactive flavonolignan-silybinin. Journal of chemical metrology, 3(1), 13.
  • Donn, P., Prieto, M.A., Mejuto, J.C., Cao, H., & Simal-Gandara, J. (2022). Functional foods based on the recovery of bioactive ingredients from food and algae by-products by emerging extraction technologies and 3D printing. Food Bioscience, 49, 101853. https://doi.org/10.1016/j.fbio.2022.101853
  • Dudareva, N., & Pichersky, E. (2000). Biochemical and molecular genetic aspects of floral scents. Plant physiology, 122(3), 627-634. https://doi.org/10.1104/pp.122.3.627
  • Dunford, N. (2008). Oil and oilseed processing II. Retrieved from
  • Erb, M., & Kliebenstein, D.J. (2020). Plant secondary metabolites as defenses, regulators, and primary metabolites: the blurred functional trichotomy. Plant physiology, 184(1), 39-52. https://doi.org/10.1104/pp.20.00433
  • Fabricant, D.S., & Farnsworth, N.R. (2001). The value of plants used in traditional medicine for drug discovery. Environmental health perspectives, 109(suppl 1), 69-75.
  • Fotsing Yannick Stéphane, F., Kezetas Jean Jules, B., El-Saber Batiha, G., Ali, I., & Ndjakou Bruno, L. (2022). Extraction of Bioactive Compounds from Medicinal Plants and Herbs. IntechOpen. https://doi.org/10.5772/intechopen.98602
  • Francis, G., Kerem, Z., Makkar, H.P., & Becker, K. (2002). The biological action of saponins in animal systems: a review. British journal of Nutrition, 88(6), 587-605. https://doi.org/10.1079/BJN2002725
  • García-Risco, M.R., Mouhid, L., Salas-Pérez, L., López-Padilla, A., Santoyo, S., Jaime, L., . . . Fornari, T. (2017). Biological activities of Asteraceae (Achillea millefolium and Calendula officinalis) and Lamiaceae (Melissa officinalis and Origanum majorana) plant extracts. Plant Foods for Human Nutrition, 72(1), 96-102. https://doi.org/10.1007/s11130-016-0596-8
  • Gaur, R., Sharma, A., Khare, S., & Gupta, M.N. (2007). A novel process for extraction of edible oils: Enzyme assisted three phase partitioning (EATPP). Bioresource Technology, 98(3), 696-699. https://doi.org/10.1016/j.biortech.2006.01.023
  • George, A., Thankamma, A., Devi, V.R., & Fernandez, A. (2007). Phytochemical investigation of Insulin plant (Costus pictus). Asian Journal of Chemistry, 19(5), 3427.
  • Ghafoor, K., Park, J., & Choi, Y.-H. (2010). Optimization of supercritical fluid extraction of bioactive compounds from grape (Vitis labrusca B.) peel by using response surface methodology. Innovative Food Science & Emerging Technologies, 11(3), 485-490. https://doi.org/10.1016/j.ifset.2010.01.013
  • Ghandahari Yazdi, A.P., Barzegar, M., Sahari, M.A., & Ahmadi Gavlighi, H. (2019). Optimization of the enzyme‐assisted aqueous extraction of phenolic compounds from pistachio green hull. Food Science & Nutrition, 7(1), 356 366. https://doi.org/10.1002/fsn3.900
  • Gholamhoseinian, A., Shahouzehi, B., Joukar, S., & Iranpoor, M. (2012). Effect of Quercus infectoria and Rosa damascena on lipid profile and atherosclerotic plaque formation in rabbit model of hyperlipidemia. Pakistan Journal of Biological Sciences, 15(1), 27-33. https://doi.org/10.3923/pjbs.2012.27.33
  • Gholap, S., & Kar, A. (2003). Effects of Inula racemosa root and Gymnema sylvestre leaf extracts in the regulation of corticosteroid induced diabetes mellitus: involvement of thyroid hormones. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 58(6), 413-415.
  • Giannuzzo, A.N., Boggetti, H.J., Nazareno, M.A., & Mishima, H.T. (2003). Supercritical fluid extraction of naringin from the peel of Citrus paradisi. Phytochemical Analysis, 14(4), 221-223.
  • Guaadaoui, A., Benaicha, S., Elmajdoub, N., Bellaoui, M., & Hamal, A. (2014). What is a bioactive compound? A combined definition for a preliminary consensus. International Journal of Nutrition and Food Sciences, 3(3), 174 179. https://doi.org/10.11648/j.ijnfs.20140303.16
  • Gülçin, İ., Mshvildadze, V., Gepdiremen, A., & Elias, R. (2004). Antioxidant activity of saponins isolated from ivy: α-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F. Planta medica, 70(06), 561-563. https://doi.org/10.1055/s-2004-827158
  • Hegde, P.K., Rao, H.A., & Rao, P.N. (2014). A review on Insulin plant (Costus igneus Nak). Pharmacognosy Reviews, 8(15), 67. https://doi.org/10.4103%2F0973-7847.125536
  • Hemmami, H., Ben Seghir, B., Ben Ali, M., Rebiai, A., Zeghoud, S., & Brahmia, F. (2020). Phenolic profile and antioxidant activity of bee pollen extracts from different regions of Algeria. Ovidius Univ. Ann. Chem, 31, 93-98. https://doi.org/10.2478/auoc-2020-0017
  • Hemmami, H., Seghir, B.B., Rebiai, A., Khelef, A., & Soumeia, Z. (2020). Comparative Study on Polyphenols Content and Antioxid ant Activity of Three Sweet Peppers Varieties (Capsicum annuum L.). Current Chemical Biology, 14(4), 250-261. https://doi.org/10.2174/2212796814999200907162105
  • Hernández, Y., Lobo, M.G., & González, M. (2009). Factors affecting sample extraction in the liquid chromatographic determination of organic acids in papaya and pineapple. Food Chemistry, 114(2), 734-741. https://doi.org/10.1016/j.foodchem.2008.10.021
  • Herrera, M., & De Castro, M.L. (2005). Ultrasound-assisted extraction of phenolic compounds from strawberries prior to liquid chromatographic separation and photodiode array ultraviolet detection. Journal of Chromatography A, 1100(1), 1 7. https://doi.org/10.1016/j.chroma.2005.09.021
  • Herrera, M., & Luque de Castro, M. (2004). Ultrasound-assisted extraction for the analysis of phenolic compounds in strawberries. Analytical and Bioanalytical Chemistry, 379(7), 1106-1112. https://doi.org/10.1007/s00216-004-2684-0
  • Hewavitharana, G.G., Perera, D.N., Navaratne, S., & Wickramasinghe, I. (2020). Extraction methods of fat from food samples and preparation of fatty acid methyl esters for gas chromatography: A review. Arabian Journal of Chemistry, 13(8), 6865-6875. https://doi.org/10.1016/j.arabjc.2020.06.039
  • Howard, L., & Pandjaitan, N. (2008). Pressurized liquid extraction of flavonoids from spinach. Journal of Food Science, 73(3), C151-C157. https://doi.org/10.1111/j.1750-3841.2007.00658.x
  • Howes, M.J.R., Perry, N.S., & Houghton, P.J. (2003). Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 17(1), 1-18. https://doi.org/10.1002/ptr.1280
  • Huie, C.W. (2002). A review of modern sample-preparation techniques for the extraction and analysis of medicinal plants. Analytical and Bioanalytical Chemistry, 373(1), 23-30. https://doi.org/10.1007/s00216-002-1265-3
  • Ibañez, E., Herrero, M., Mendiola, J.A., & Castro-Puyana, M. (2012). Extraction and Characterization of Bioactive Compounds with Health Benefits from Marine Resources: Macro and Micro Algae, Cyanobacteria, and Invertebrates. In: Hayes, M. (eds) Marine Bioactive Compounds. Springer. https://doi.org/10.1007/978-1-4614-1247-2_2
  • Iqbal, J., Abbasi, B.A., Mahmood, T., Kanwal, S., Ali, B., Shah, S.A., & Khalil, A.T. (2017). Plant-derived anticancer agents: A green anticancer approach. Asian Pacific Journal of Tropical Biomedicine, 7(12), 1129-1150. https://doi.org/10.1016/j.apjtb.2017.10.016
  • Jamshidi, N., & Cohen, M.M. (2017). The clinical efficacy and safety of Tulsi in humans: a systematic review of the literature. Evidence-Based Complementary and Alternative Medicine, 2017. https://doi.org/10.1155/2017/9217567
  • Jha, A.K., & Sit, N. (2022). Extraction of bioactive compounds from plant materials using combination of various novel methods: A review. Trends in Food Science & Technology, 119, 579-591. https://doi.org/10.1016/j.tifs.2021.11.019
  • Jila, A., Bernd, O., & Mohsen, M. (2011). Extraction of bioactive chemical compounds from the medicinal Asian plants by microwave irradiation. Journal of Medicinal Plants Research, 5(4), 495-506.
  • Kalidas, C., & Mohan, V. (2010). Genetic diversity of velvet bean, Mucuna pruriens (L.) DC from Southern Western Ghats, India. Int J Biol Tech, 1, 31-37.
  • Kaufmann, B., & Christen, P. (2002). Recent extraction techniques for natural products: microwave‐assisted extraction and pressurised solvent extraction. Phytochemical Analysis: An International Journal of Plant Chemical and Biochemical Techniques, 13(2), 105-113. https://doi.org/10.1002/pca.631
  • Khennouf, S., Benabdallah, H., Gharzouli, K., Amira, S., Ito, H., Kim, T.-H., . . . Gharzouli, A. (2003). Effect of tannins from Quercus suber and Quercus coccifera leaves on ethanol-induced gastric lesions in mice. Journal of Agricultural and Food Chemistry, 51(5), 1469-1473. https://doi.org/10.1021/jf020808y
  • Kumar, A., Sreedharan, S., Kashyap, A.K., Singh, P., & Ramchiary, N. (2021). A review on bioactive phytochemicals and ethnopharmacological potential of purslane (Portulaca oleracea L.). Heliyon, e08669. https://doi.org/10.1016/j.heliyon.2021.e08669
  • Kumar, B.S., Swamy, B.V., Archana, S., & Anitha, M. (2010). A review on natural diuretics. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 1(4), 615-634.
  • Lakkakula, N.R., Lima, M., & Walker, T. (2004). Rice bran stabilization and rice bran oil extraction using ohmic heating. Bioresource Technology, 92(2), 157-161. https://doi.org/10.1016/j.biortech.2003.08.010
  • Landbo, A.-K., & Meyer, A.S. (2001). Enzyme-assisted extraction of antioxidative phenols from black currant juice press residues (Ribes nigrum). Journal of Agricultural and Food Chemistry, 49(7), 3169-3177. https://doi.org/10.1021/jf001443p
  • Latif, S., & Anwar, F. (2009). Physicochemical studies of hemp (Cannabis sativa) seed oil using enzyme‐assisted cold‐pressing. European Journal of Lipid Science and Technology, 111(10), 1042-1048. https://doi.org/10.1002/ejlt.200900008
  • Lee, J., Cho, J.-Y., & Kim, W.-K. (2014). Anti-inflammation effect of Exercise and Korean red ginseng in aging model rats with diet-induced atherosclerosis. Nutrition Research and Practice, 8(3), 284-291. https://doi.org/10.4162/nrp.2014.8.3.284
  • Li, B., Smith, B., & Hossain, M.M. (2006). Extraction of phenolics from citrus peels: II. Enzyme-assisted extraction method. Separation and Purification Technology, 48(2), 189-196. https://doi.org/10.1016/j.seppur.2005.07.019
  • Li, H., Chen, B., & Yao, S. (2005). Application of ultrasonic technique for extracting chlorogenic acid from Eucommia ulmodies Oliv.(E. ulmodies). Ultrasonics Sonochemistry, 12(4), 295-300. https://doi.org/10.1016/j.ultsonch.2004.01.033
  • Liu, D., Zhen, W., Yang, Z., Carter, J.D., Si, H., & Reynolds, K.A. (2006). Genistein acutely stimulates insulin secretion in pancreatic β-cells through a cAMP-dependent protein kinase pathway. Diabetes, 55(4), 1043-1050. https://doi.org/10.2337/diabetes.55.04.06.db05-1089
  • Liu, J., Li, Y., Shi, H., Wang, T., Wu, X., Sun, X., & Yu, L.L. (2016). Components characterization of total tetraploid jiaogulan (Gynostemma pentaphyllum) saponin and its cholesterol-lowering properties. Journal of Functional Foods, 23, 542-555. https://doi.org/10.1016/j.jff.2016.03.013
  • Liu, S., Gallo, D.J., Green, A.M., Williams, D.L., Gong, X., Shapiro, R.A., . . . Billiar, T.R. (2002). Role of toll-like receptors in changes in gene expression and NF-κB activation in mouse hepatocytes stimulated with lipopolysaccharide. Infection and Immunity, 70(7), 3433-3442. https://doi.org/10.1128/iai.70.7.3433-3442.2002
  • Łubek-Nguyen, A., Ziemichód, W., & Olech, M. (2022). Application of Enzyme-Assisted Extraction for the Recovery of Natural Bioactive Compounds for Nutraceutical and Pharmaceutical Applications. Applied Sciences, 12(7), 3232. https://doi.org/10.3390/app12073232
  • Luthria, D.L. (2008). Influence of experimental conditions on the extraction of phenolic compounds from parsley (Petroselinum crispum) flakes using a pressurized liquid extractor. Food Chemistry, 107(2), 745-752. https://doi.org/10.1016/j.foodchem.2007.08.074
  • Lyons, G., Carmichael, E., McRoberts, C., Aubry, A., Thomson, A., & Reynolds, C.K. (2018). Prediction of Lignin Content in Ruminant Diets and Fecal Samples Using Rapid Analytical Techniques. Journal of Agricultural and Food Chemistry, 66(49), 13031-13040. https://doi.org/10.1021/acs.jafc.8b03808
  • Mallikharjuna, P., Rajanna, L., Seetharam, Y., & Sharanabasappa, G. (2007). Phytochemical studies of Strychnos potatorum Lf-A medicinal plant. E-journal of Chemistry, 4(4), 510-518. https://doi.org/10.1155/2007/687859
  • Manthey, J.A., & Guthrie, N. (2002). Antiproliferative activities of citrus flavonoids against six human cancer cell lines. Journal of Agricultural and Food Chemistry, 50(21), 5837-5843. https://doi.org/10.1021/jf020121d
  • Martins, P.M., Lanchote, A.D., Thorat, B.N., & Freitas, L.A. (2017). Turbo-extraction of glycosides from Stevia rebaudiana using a fractional factorial design. Revista Brasileira de Farmacognosia, 27, 510-518. https://doi.org/10.1016/j.bjp.2017.02.007
  • Medina‐Remón, A., Casas, R., Tressserra‐Rimbau, A., Ros, E., Martínez‐González, M.A., Fitó, M., . . . Estruch, R. (2017). Polyphenol intake from a Mediterranean diet decreases inflammatory biomarkers related to atherosclerosis: a substudy of the PREDIMED trial. British Journal of Clinical Pharmacology, 83(1), 114 128. https://doi.org/10.1111/bcp.12986
  • Meini, M.-R., Cabezudo, I., Boschetti, C.E., & Romanini, D. (2019). Recovery of phenolic antioxidants from Syrah grape pomace through the optimization of an enzymatic extraction process. Food Chemistry, 283, 257-264. https://doi.org/10.1016/j.foodchem.2019.01.037
  • Meyers, C.D., Kamanna, V. S., & Kashyap, M. L. (2004). Niacin therapy in atherosclerosis. Current Opinion in Lipidology, 15(6), 659-665.
  • Moldoveanu, S.C., & David, V. (2002). Sample preparation in chromatography. Elsevier.
  • Mroczek, T., & Mazurek, J. (2009). Pressurized liquid extraction and anticholinesterase activity-based thin-layer chromatography with bioautography of Amaryllidaceae alkaloids. Analytica Chimica Acta, 633(2), 188-196. https://doi.org/10.1016/j.aca.2008.11.053
  • Mukherjee, S., & Patra, C. R. (2016). Therapeutic application of anti-angiogenic nanomaterials in cancers. Nanoscale, 8(25), 12444-12470. https://doi.org/10.1039/C5NR07887C
  • Niranjan, K., & Hanmoungjai, P. (2004). Enzyme-aided aquous extraction. In book: Nutritionally Enhanced Edible Oil Processing. AOCS Publishing. http://dx.doi.org/10.1201/9781439822272.ch5
  • Nitiéma, M., Ilboudo, S., Belemnaba, L., Ouédraogo, G., Ouédraogo, S., Ouédraogo, N., . . . Guissou, I. (2018). Acute and sub-acute toxicity studies of aqueous decoction of the trunk barks from Lannea microcarpa Engl. and K. Krause (anacardiaceae) in rodents. World Journal of Pharmacy and Pharmaceutical Sciences, 7(9), 30 42. http://dx.doi.org/10.20959/wjpps20189-12185
  • Palma, M., & Barroso, C. G. (2002). Ultrasound-assisted extraction and determination of tartaric and malic acids from grapes and winemaking by-products. Analytica Chimica Acta, 458(1), 119-130. https://doi.org/10.1016/S0003-2670(01)01527-6
  • Pan, X., Niu, G., & Liu, H. (2003). Microwave-assisted extraction of tea polyphenols and tea caffeine from green tea leaves. Chemical Engineering and Processing: Process Intensification, 42(2), 129-133. https://doi.org/10.1016/S0255-2701(02)00037-5
  • Pandey, G., & Madhuri, S. (2010). Pharmacological activities of Ocimum sanctum (tulsi): a review. Int J Pharm Sci Rev Res, 5(1), 61-66.
  • Patel, D., Kumar, R., Prasad, S., Sairam, K., & Hemalatha, S. (2011). Antidiabetic and in vitro antioxidant potential of Hybanthus enneaspermus (Linn) F. Muell in streptozotocin–induced diabetic rats. Asian Pacific Journal of Tropical Biomedicine, 1(4), 316-322. https://doi.org/10.1016/S2221-1691(11)60051-8
  • Paulsen, B.S. (2010). Highlights through the history of plant medicine. Bioactive compounds in plants-benefits and risks for man and animals, 50.
  • Prakash, P., & Gupta, N. (2005). Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: a short review. Indian Journal of Physiology and Pharmacology, 49(2), 125.
  • Puri, H.S. (2002). Rasayana: Ayurvedic herbs for longevity and rejuvenation. CRC press.
  • Puri, M., Sharma, D., & Barrow, C.J. (2012). Enzyme-assisted extraction of bioactives from plants. Trends in biotechnology, 30(1), 37-44. https://doi.org/10.1016/j.tibtech.2011.06.014
  • Rasul, M.G. (2018). Conventional extraction methods use in medicinal plants, their advantages and disadvantages. Int. J. Basic Sci. Appl. Comput, 2, 10-14.
  • Rostagno, M.A., Palma, M., & Barroso, C.G. (2003). Ultrasound-assisted extraction of soy isoflavones. Journal of Chromatography A, 1012(2), 119 128. https://doi.org/10.1016/S0021-9673(03)01184-1
  • Sarkar, A., Bhattacharjee, S., & Mandal, D.P. (2015). Induction of apoptosis by eugenol and capsaicin in human gastric cancer AGS cells-elucidating the role of p53. Asian Pacific Journal of Cancer Prevention, 16(15), 6753-6759.
  • Sasidharan, S., Chen, Y., Saravanan, D., Sundram, K., & Latha, L.Y. (2011). Extraction, isolation and characterization of bioactive compounds from plants’ extracts. African Journal of Traditional, Complementary and Alternative Medicines, 8(1), 1 10. https://doi.org/10.4314/ajtcam.v8i1.60483
  • Sharma, A., Khare, S., & Gupta, M. (2002). Enzyme‐assisted aqueous extraction of peanut oil. Journal of the American Oil Chemists' Society, 79(3), 215 218. https://doi.org/10.1007/s11746-002-0463-0
  • Shen, J., & Shao, X. (2005). A comparison of accelerated solvent extraction, Soxhlet extraction, and ultrasonic-assisted extraction for analysis of terpenoids and sterols in tobacco. Analytical and Bioanalytical Chemistry, 383(6), 1003-1008. https://doi.org/10.1007/s00216-005-0078-6
  • Shiny, C., Saxena, A., & Gupta, S.P. (2013). Phytochemical investigation of the insulin plant “Costus pictus” D. Don. Int J Pharm Biomed Res, 4(2), 97-104.
  • Shrinet, K., Singh, R.K., Chaurasia, A.K., Tripathi, A., & Kumar, A. (2021). Bioactive compounds and their future therapeutic applications Natural Bioactive Compounds (pp. 337-362). Elsevier. https://doi.org/10.1016/B978-0-12-820655-3.00017-3
  • Smith, R.M. (2003). Before the injection—modern methods of sample preparation for separation techniques. Journal of Chromatography A, 1000(1 2), 3 27. https://doi.org/10.1016/S0021-9673(03)00511-9
  • Sohgaura, A., Bigoniya, P., & Shrivastava, B. (2018). Diuretic potential of Cynodon dactylon, Emblica officinalis, Kalanchoe pinnata and Bambusa nutans. Journal of Pharmacognosy and Phytochemistry, 7(3), 2895-2900.
  • Sy, G., Cissé, A., Nongonierma, R., Sarr, M., Mbodj, N., & Faye, B. (2005). Hypoglycaemic and antidiabetic activity of acetonic extract of Vernonia colorata leaves in normoglycaemic and alloxan-induced diabetic rats. Journal of Ethnopharmacology, 98(1-2), 171-175. https://doi.org/10.1016/j.jep.2005.01.024
  • Taiz, L., & Zeiger, E. (2006). Secondary metabolites and plant defense. Plant physiology, 4, 315-344.
  • Teng, H., Ghafoor, K., & Choi, Y.H. (2009). Optimization of microwave-assisted extraction of active components from Chinese quince using response surface methodology. Journal of the Korean Society for Applied Biological Chemistry, 52(6), 694 701. https://doi.org/10.3839/jksabc.2009.115
  • Toepfl, S., Mathys, A., Heinz, V., & Knorr, D. (2006). Potential of high hydrostatic pressure and pulsed electric fields for energy efficient and environmentally friendly food processing. Food Reviews International, 22(4), 405-423. https://doi.org/10.1080/87559120600865164
  • Tripathi, A. (2018). Immunomodulatory commotion of HMGB 1 in Urethane primed Hepatocarcinogenesis.
  • Triveni, K., Lakshmi, V., Shashidhara, S., & Anitha, S. (2012). Gymnema Sylvestre: a comprehensive review. Pharma Science Monitor, 3(4).
  • Tzanova, M., Atanasov, V., Yaneva, Z., Ivanova, D., & Dinev, T. (2020). Selectivity of current extraction techniques for flavonoids from plant materials. Processes, 8(10), 1222. https://doi.org/10.3390/pr8101222
  • Uwineza, P.A., & Waśkiewicz, A. (2020). Recent advances in supercritical fluid extraction of natural bioactive compounds from natural plant materials. Molecules, 25(17), 3847. https://doi.org/10.3390/molecules25173847
  • Vaidya, S. (2011). Review on gymnema: an herbal medicine for diabetes management. Pharmacia, 1(2), 37-42.
  • Verma, A., Hartonen, K., & Riekkola, M.L. (2008). Optimisation of supercritical fluid extraction of indole alkaloids from Catharanthus roseus using experimental design methodology-comparison with other extraction techniques. Phytochemical Analysis: An International Journal of Plant Chemical and Biochemical Techniques, 19(1), 52-63. https://doi.org/10.1002/pca.1015
  • Vinatoru, M. (2001). An overview of the ultrasonically assisted extraction of bioactive principles from herbs. Ultrasonics Sonochemistry, 8(3), 303 313. https://doi.org/10.1016/S1350-4177(01)00071-2
  • Wang, L., & Weller, C.L. (2006). Recent advances in extraction of nutraceuticals from plants. Trends in Food Science & Technology, 17(6), 300 312. https://doi.org/10.1016/j.tifs.2005.12.004
  • Wani, M., Sarvar, F.A., Agrawal, J., Deshpande, J., Mathew, S., & Khetmalas, M. (2012). Qualitative phytochemical analysis and antimicrobial activity studies of Gymnema sylvestre R. Br. Acta Biologica Indica, 1(1), 121-124.
  • Weaver, B.A. (2014). How Taxol/paclitaxel kills cancer cells. Molecular biology of the cell, 25(18), 2677-2681. https://doi.org/10.1091/mbc.e14-04-0916
  • Yang, Y., & Zhang, F. (2008). Ultrasound-assisted extraction of rutin and quercetin from Euonymus alatus (Thunb.) Sieb. Ultrasonics Sonochemistry, 15(4), 308-313. https://doi.org/10.1016/j.ultsonch.2007.05.001
  • Zeghoud, S., Seghir, B.B., Kouadri, I., Hemmami, H., Amor, I.B., Tliba, A., . . . Rebiai, A. (2023). Classification of plants medicine species from Algerian regions using UV spectroscopy, HPLC chromatography, and chemometrics analysis. Malaysian Journal of Chemistry, 25(1), 126-142.
  • Zghaibi, N., Omar, R., Mustapa Kamal, S.M., Awang Biak, D.R., & Harun, R. (2019). Microwave-assisted brine extraction for enhancement of the quantity and quality of lipid production from microalgae Nannochloropsis sp. Molecules, 24(19), 3581. https://doi.org/10.3390/molecules24193581
  • Zhang, Q.-W., Lin, L.-G., & Ye, W.-C. (2018). Techniques for extraction and isolation of natural products: A comprehensive review. Chinese Medicine, 13(1), 1-26. https://doi.org/10.1186/s13020-018-0177-x
Toplam 121 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Yapısal Biyoloji
Bölüm Makaleler
Yazarlar

Imane Ghenabzia Bu kişi benim 0009-0005-4945-7989

Hadia Hemmami Bu kişi benim 0000-0002-5205-9325

Ilham Ben Amor 0000-0003-4850-485X

Soumeia Zeghoud Bu kişi benim 0000-0002-3342-0840

Bachir Ben Seghir Bu kişi benim 0000-0003-1201-0567

Rokaia Hammoudi Bu kişi benim 0000-0002-3188-9653

Erken Görünüm Tarihi 11 Kasım 2023
Yayımlanma Tarihi 1 Aralık 2023
Gönderilme Tarihi 29 Aralık 2022
Yayımlandığı Sayı Yıl 2023 Cilt: 10 Sayı: 4

Kaynak Göster

APA Ghenabzia, I., Hemmami, H., Ben Amor, I., Zeghoud, S., vd. (2023). Different methods of extraction of bioactive compounds and their effect on biological activity: A review. International Journal of Secondary Metabolite, 10(4), 469-494. https://doi.org/10.21448/ijsm.1225936
International Journal of Secondary Metabolite
e-ISSN: 2148-6905