Araştırma Makalesi
Antidiabetic and antioxidant effect of Origanum minutiflorum O. Schwarz & P. H. Davis in streptozotocin-induced diabetic rats
Öz
In this study, the antidiabetic potential of aqueous extract of Origanum minutiflorum was tested using streptozotocin induced diabetic rats. Changes in body weight, blood glucose level, biochemical parameters, antioxidant enzyme activities and histopathological examination of kidney were evaluated. The administration of aqueous extract and carvacrol to diabetic group rats caused significant decrease in blood glucose, biochemical parameters of serum and significantly increased the concentration of high density lipoprotein cholesterol. The administration of aqueous extract and carvacrol significantly increased the antioxidant enzyme activity and reduced the MDA level. The histopathological analysis of kidney showed that aqueous extract and carvacrol had possible ameliorative effect against kidney damage. Aqueous extract is also showed α-amylase and α-glucosidase inhibitor activity with high antioxidant activity. These scientific results confirm the use of O. minutiflorum as adjuvant antidiabetic therapy.
Anahtar Kelimeler
Antidiabetic activity Antioxidant activity Carvacrol Origanum minutiflorum.
Destekleyen Kurum
Research Fund of the Erciyes University
Proje Numarası
FDK-2016-6703
Kaynakça
- A.M. Vincent, J.W. Russell, P. Low, E.L. Feldman, Oxidative stress in the pathogenesis of diabetic neuropathy, Endocr. Rev., 25 (2004) 612-628.
- Z.G. Li, W. Zhang, G. Grunberger, A.A.F. Sima, Hipocampal Neuronal Apoptosis in Type1 Diabetes, Brain Res., 946 (2002) 221–231.
- Z. Çambay, Investigation of the effects of Pomegranate (Punica granatum) flower on aspartate aminotransferase and alanine aminotransferase levels in diabetic rats serum, Ecol. Life Sci., 6 (2011) 124–133.
- A. Yönem, M. Özata, Diabetes Mellitus: Diagnosis, Classification, Clinical Features, Istanbul Medical Publishing, 2006.
- I. Satman, T. Yilmaz, A. Sengul, S. Salman, F. Salman, S. Uygur, I. Bastar, Y. Tutuncu, M. Sargin, N. Dinccag, K. Karsidag, S. Kalaca, C. Ozcan, H. King, Population-based study of diabetes and risk characteristics in Turkey: results of the Turkish Diabetes Epidemiology Study (TURDEP), Diabetes Care, 25 (2002) 1551–1556.
- M.P. Kahkonen, A.I. Hopia, H.J. Vuorela, J.P. Rauha, K. Pihlaja, T.S. Kujala, M. Heinonen, Antioxidant activity of plant extracts containing phenolic compounds, J. Agric. Food Chem., 47 (1999) 3954–3962.
- S. Oksana, B. Marian, R. Mahendra, S.H. Bo, Plant phenolic compounds for food, pharmaceutical and cosmetiсs production, J. Med. Plants Res., 6 (2012) 2526–2539.
- D.M. Pereira, P. Valentão, J.A. Pereira, P.B. Andrade, Phenolics: From Chemistry to Biology, Molecules, 14 (2009) 2202–2211.
- M.J. Balunas, A.D. Kinghorn, Drug discovery from medicinal plants, Life Sci., 78 (2005) 431–441.
- J. Anita, S.S. Katewa, P.K. Galav, N. Ambika, Unrecorded Ethnomedicinal Uses of Biodiversity from Tadgarh-Raoli Wildlife Sanctuary, Rajasthan, India, Acta Bot. Yunnanica, 29 (2007) 337–344.
- S. Albayrak, A. Aksoy, Phenolic contents and biological activity of endemic Origanum minutiflorum grown in Turkey, Indian J. Pharm. Educ. Res., 53 (2019) 160–169.
- A. Lemhadri, N.A. Zeggwagh, M. Maghrani, H. Jouad, M. Eddouks, Anti-hyperglycaemic activity of the aqueous extract of Origanum vulgare growing wild in Tafilalet region, J. Ethnopharmacol., 92 (2004) 251–256.
- S. Albayrak, A. Aksoy, O. Sagdic, E. Hamzaoglu, Compositions, antioxidant and antimicrobial activities of Helichrysum (Asteraceae) species collected from Turkey, Food Chem., 119 (2010) 114–122.
- G. Zengin, C. Sarikurkcu, A. Aktumsek, R. Ceylan, O. Ceylan, A comprehensive study on phytochemical characterization of Haplophyllum myrtifolium Boiss endemic to Turkey and its inhibitory potential against key enzymes involved in Alzheimer, skin diseases and type II diabetes, Ind. Crops Prod., 53 (2014) 244–251.
- R. Yazdanparast, A. Ardestani, S. Jamshidi, Experimental diabetes treated with Achillea santolina: effect on pancreatic oxidative parameters, J. Ethnopharmacol., 112 (2007) 13–18.
- L.S. Wan, C.P. Chen, Z.Q. Xiao, Y.L. Wang, Q.X. Min, Y. Yue, J. Chen, In vitro and in vivo anti-diabetic activity of Swertia kouitchensis extract, J. Ethnopharmacol., 147 (2013) 622–630.
- H. Carvalho, I.V.F. Santos, C.F. Rocha, A. Barros, B. Souza, I. Ferreira, R. Bezerra, C. Lima, A. Castro, J.T. Carvalho, Effect of the treatment of Copaifera duckei oleoresin (copaiba) in streptozotocin-induced diabetic rats, J. Rev. Bras. Farmacogn., 28 (2018) 724–731.
- A. Çarlıoğlu, D. Akdeniz, R. Alkan, E. Uz, H. Haltaş, F. Turgut, S. Uysal, The Effect of Zofenopril on Pancreas, Kidney and Liver of Diabetic Rats, Turkish Nephrol. Dial. Transplant. J., 23 (2014) 118–124.
- I. Gulcin, V. Mshvildadze, A. Gepdiremen, R. Elias, The antioxidant activity of a triterpenoid glycoside isolated from the berries of Hedera colchica: 3-O-(beta-D-glucopyranosyl)-hederagenin, Phyther. Res., 20 (2006) 130–134.
- R. Apak, K. Guclu, M. Ozyurek, E. Karademir, E. Ercag, The cupric ion reducing antioxidant capacity and polyphenolic content of some herbal teas, Int. J. Food Sci. Nutr., 57 (2006) 292–304.
- F. Oke, B. Aslim, Biological potentials and cytotoxicity of various extracts from endemic Origanum minutiflorum O Schwarz & PH Davis, Food Chem. Toxicol., 48 (2010) 1728–1733.
- C. Sarikurkcu, G. Zengin, M. Oskay, S. Uysal, R. Ceylan, A. Aktumsek, Composition, antioxidant, antimicrobial and enzyme inhibition activities of two Origanum vulgare subspecies (subsp vulgare and subsp hirtum) essential oils, Ind. Crops Prod., 70 (2015) 178–184.
- M. Eidi, A. Eidi, H. Zamanizadeh, Effect of Salvia officinalis L leaves on serum glucose and insulin in healthy and streptozotocin-induced diabetic rats, J. Ethnopharmacol., 100 (2005) 310–313.
- K. Umasankar, D.R. Ramya, N. Balwin, Antioxidant potential of carvacrol studied in high-fat -fed and low-dose streptozotocin-induced experimental diabetic rats, Der Pharm. Lett., 7 (2015) 124–131.
- S. Kadan, B. Saad, Y. Sasson, H. Zaid, In vitro evaluation of anti-diabetic activity and cytotoxicity of chemically analysed Ocimum basilicum extracts, Food Chem., 196 (2016) 1066–1074.
- A.A. Elberry, F.M. Harraz, S.A. Ghareib, S.A. Gabr, A.A. Nagy, E. Abdel-Sattar, Methanolic extract of Marrubium vulgare ameliorates hyperglycemia and dyslipidemia in streptozotocin-induced diabetic rats, Int. J. Diabetes Mellit., 3 (2015) 37–44.
- M.A. Esmaeili, R. Yazdanparast, Hypoglycaemic effect of Teucrium polium: studies with rat pancreatic islets, J. Ethnopharmacol., 95 (2004) 27–30.
- D. Kumar, S. Kumar, S. Kohli, R. Arya, J. Gupta, Antidiabetic activity of methanolic bark extract of Albizia odoratissima Benth in alloxan induced diabetic albino mice, Asian Pac. J. Trop. Med., 4 (2011) 900–903.
- N. Sendoğdu, M. Aslan, D. Deliorman, F. Ergun, E. Yeşilada, Antidiabetic and antioxidant effects of Vitis vinifera L leaves in streptozotocin-diabetic rats, Turkish J. Pharm. Sci., 3 (2006) 7–18.
- G. Bayramoglu, H. Senturk, A. Bayramoglu, M. Uyanoglu, S. Colak, A. Ozmen, D. Kolankaya, Carvacrol partially reverses symptoms of diabetes in STZ-induced diabetic rats, Cytotechnology, 66 (2014) 251–257.
Yıl 2023,
Cilt: 51 Sayı: 3, 259 - 270, 16.07.2023
Öz
Anahtar Kelimeler
Antidiabetic activity Antioxidant activity Carvacrol Origanum minutiflorum.
Proje Numarası
FDK-2016-6703
Kaynakça
- A.M. Vincent, J.W. Russell, P. Low, E.L. Feldman, Oxidative stress in the pathogenesis of diabetic neuropathy, Endocr. Rev., 25 (2004) 612-628.
- Z.G. Li, W. Zhang, G. Grunberger, A.A.F. Sima, Hipocampal Neuronal Apoptosis in Type1 Diabetes, Brain Res., 946 (2002) 221–231.
- Z. Çambay, Investigation of the effects of Pomegranate (Punica granatum) flower on aspartate aminotransferase and alanine aminotransferase levels in diabetic rats serum, Ecol. Life Sci., 6 (2011) 124–133.
- A. Yönem, M. Özata, Diabetes Mellitus: Diagnosis, Classification, Clinical Features, Istanbul Medical Publishing, 2006.
- I. Satman, T. Yilmaz, A. Sengul, S. Salman, F. Salman, S. Uygur, I. Bastar, Y. Tutuncu, M. Sargin, N. Dinccag, K. Karsidag, S. Kalaca, C. Ozcan, H. King, Population-based study of diabetes and risk characteristics in Turkey: results of the Turkish Diabetes Epidemiology Study (TURDEP), Diabetes Care, 25 (2002) 1551–1556.
- M.P. Kahkonen, A.I. Hopia, H.J. Vuorela, J.P. Rauha, K. Pihlaja, T.S. Kujala, M. Heinonen, Antioxidant activity of plant extracts containing phenolic compounds, J. Agric. Food Chem., 47 (1999) 3954–3962.
- S. Oksana, B. Marian, R. Mahendra, S.H. Bo, Plant phenolic compounds for food, pharmaceutical and cosmetiсs production, J. Med. Plants Res., 6 (2012) 2526–2539.
- D.M. Pereira, P. Valentão, J.A. Pereira, P.B. Andrade, Phenolics: From Chemistry to Biology, Molecules, 14 (2009) 2202–2211.
- M.J. Balunas, A.D. Kinghorn, Drug discovery from medicinal plants, Life Sci., 78 (2005) 431–441.
- J. Anita, S.S. Katewa, P.K. Galav, N. Ambika, Unrecorded Ethnomedicinal Uses of Biodiversity from Tadgarh-Raoli Wildlife Sanctuary, Rajasthan, India, Acta Bot. Yunnanica, 29 (2007) 337–344.
- S. Albayrak, A. Aksoy, Phenolic contents and biological activity of endemic Origanum minutiflorum grown in Turkey, Indian J. Pharm. Educ. Res., 53 (2019) 160–169.
- A. Lemhadri, N.A. Zeggwagh, M. Maghrani, H. Jouad, M. Eddouks, Anti-hyperglycaemic activity of the aqueous extract of Origanum vulgare growing wild in Tafilalet region, J. Ethnopharmacol., 92 (2004) 251–256.
- S. Albayrak, A. Aksoy, O. Sagdic, E. Hamzaoglu, Compositions, antioxidant and antimicrobial activities of Helichrysum (Asteraceae) species collected from Turkey, Food Chem., 119 (2010) 114–122.
- G. Zengin, C. Sarikurkcu, A. Aktumsek, R. Ceylan, O. Ceylan, A comprehensive study on phytochemical characterization of Haplophyllum myrtifolium Boiss endemic to Turkey and its inhibitory potential against key enzymes involved in Alzheimer, skin diseases and type II diabetes, Ind. Crops Prod., 53 (2014) 244–251.
- R. Yazdanparast, A. Ardestani, S. Jamshidi, Experimental diabetes treated with Achillea santolina: effect on pancreatic oxidative parameters, J. Ethnopharmacol., 112 (2007) 13–18.
- L.S. Wan, C.P. Chen, Z.Q. Xiao, Y.L. Wang, Q.X. Min, Y. Yue, J. Chen, In vitro and in vivo anti-diabetic activity of Swertia kouitchensis extract, J. Ethnopharmacol., 147 (2013) 622–630.
- H. Carvalho, I.V.F. Santos, C.F. Rocha, A. Barros, B. Souza, I. Ferreira, R. Bezerra, C. Lima, A. Castro, J.T. Carvalho, Effect of the treatment of Copaifera duckei oleoresin (copaiba) in streptozotocin-induced diabetic rats, J. Rev. Bras. Farmacogn., 28 (2018) 724–731.
- A. Çarlıoğlu, D. Akdeniz, R. Alkan, E. Uz, H. Haltaş, F. Turgut, S. Uysal, The Effect of Zofenopril on Pancreas, Kidney and Liver of Diabetic Rats, Turkish Nephrol. Dial. Transplant. J., 23 (2014) 118–124.
- I. Gulcin, V. Mshvildadze, A. Gepdiremen, R. Elias, The antioxidant activity of a triterpenoid glycoside isolated from the berries of Hedera colchica: 3-O-(beta-D-glucopyranosyl)-hederagenin, Phyther. Res., 20 (2006) 130–134.
- R. Apak, K. Guclu, M. Ozyurek, E. Karademir, E. Ercag, The cupric ion reducing antioxidant capacity and polyphenolic content of some herbal teas, Int. J. Food Sci. Nutr., 57 (2006) 292–304.
- F. Oke, B. Aslim, Biological potentials and cytotoxicity of various extracts from endemic Origanum minutiflorum O Schwarz & PH Davis, Food Chem. Toxicol., 48 (2010) 1728–1733.
- C. Sarikurkcu, G. Zengin, M. Oskay, S. Uysal, R. Ceylan, A. Aktumsek, Composition, antioxidant, antimicrobial and enzyme inhibition activities of two Origanum vulgare subspecies (subsp vulgare and subsp hirtum) essential oils, Ind. Crops Prod., 70 (2015) 178–184.
- M. Eidi, A. Eidi, H. Zamanizadeh, Effect of Salvia officinalis L leaves on serum glucose and insulin in healthy and streptozotocin-induced diabetic rats, J. Ethnopharmacol., 100 (2005) 310–313.
- K. Umasankar, D.R. Ramya, N. Balwin, Antioxidant potential of carvacrol studied in high-fat -fed and low-dose streptozotocin-induced experimental diabetic rats, Der Pharm. Lett., 7 (2015) 124–131.
- S. Kadan, B. Saad, Y. Sasson, H. Zaid, In vitro evaluation of anti-diabetic activity and cytotoxicity of chemically analysed Ocimum basilicum extracts, Food Chem., 196 (2016) 1066–1074.
- A.A. Elberry, F.M. Harraz, S.A. Ghareib, S.A. Gabr, A.A. Nagy, E. Abdel-Sattar, Methanolic extract of Marrubium vulgare ameliorates hyperglycemia and dyslipidemia in streptozotocin-induced diabetic rats, Int. J. Diabetes Mellit., 3 (2015) 37–44.
- M.A. Esmaeili, R. Yazdanparast, Hypoglycaemic effect of Teucrium polium: studies with rat pancreatic islets, J. Ethnopharmacol., 95 (2004) 27–30.
- D. Kumar, S. Kumar, S. Kohli, R. Arya, J. Gupta, Antidiabetic activity of methanolic bark extract of Albizia odoratissima Benth in alloxan induced diabetic albino mice, Asian Pac. J. Trop. Med., 4 (2011) 900–903.
- N. Sendoğdu, M. Aslan, D. Deliorman, F. Ergun, E. Yeşilada, Antidiabetic and antioxidant effects of Vitis vinifera L leaves in streptozotocin-diabetic rats, Turkish J. Pharm. Sci., 3 (2006) 7–18.
- G. Bayramoglu, H. Senturk, A. Bayramoglu, M. Uyanoglu, S. Colak, A. Ozmen, D. Kolankaya, Carvacrol partially reverses symptoms of diabetes in STZ-induced diabetic rats, Cytotechnology, 66 (2014) 251–257.
Toplam 30 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Mühendislik |
| Bölüm | Articles |
| Yazarlar | |
| Proje Numarası | FDK-2016-6703 |
| Erken Görünüm Tarihi | 14 Temmuz 2023 |
| Yayımlanma Tarihi | 16 Temmuz 2023 |
| Kabul Tarihi | 10 Nisan 2023 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 51 Sayı: 3 |
Kaynak Göster
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