Objectives:
The aim of the
study was to evaluate the oxidative stress level in patients, diagnosed with Helicobacter pylori infection, using a
novel marker (thiol/disulphide homeostasis) and to compare the level in infected
individuals with that in healthy volunteers.
Methods: A total of 60 patients diagnosed with gastritis, erosive gastritis or ulcer by endoscopy were included and biopsied.
The 30 patients diagnosed with H. pylori and 30 healthy individuals were enrolled. Medical histories, physical examination results, body mass index (BMI), hemogram, free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating
hormone (TSH), urea, creatinin, aspartate aminotransferase (AST), alanine
aminotransferase (ALT), albumin, total cholesterol, triglycerides, high density lipoprotein (HDL), low density lipoprotein) LDL and thiol/disulphide levels obtained in the study groups were
compared.
Results: There was no significant difference between
the total thiol, native thiol,
disulphide/native thiol and dissulphide/total thiol ratios of the patient and
control group. When the H. pylori patients were stratified by
endoscopic evaluation as having mild (superficial gastritis or normal
appearance) or severe (ulcer or erosive areas)
symptoms, there were significant differences in disulphide, disulphide/native thiol, disulphide/total thiol and native thiol/total
thiol levels. We also observed BMI and the total, native thiol levels of H. pylori patients were inversely
related.( r: 0.562, p = 0.001; r: 0.0552,
p = 0.002).
Conclusions: Thiol/disulphide homeostasis is likely to differ with
both duration and severity of H. pylori
infection. Further investigations are needed to investigate the effect of H. pylori on oxidative stress.
Birincil Dil | İngilizce |
---|---|
Konular | Biyokimya ve Hücre Biyolojisi (Diğer), Endokrinoloji, Gastroenteroloji ve Hepatoloji, İç Hastalıkları |
Bölüm | Original Article |
Yazarlar | |
Yayımlanma Tarihi | 4 Kasım 2019 |
Gönderilme Tarihi | 13 Temmuz 2018 |
Kabul Tarihi | 23 Ocak 2019 |
Yayımlandığı Sayı | Yıl 2019 Cilt: 5 Sayı: 6 |