Investigation on the effectiveness of mastitis vaccine (Startvac®) in sheep and goat gangrenous mastitis cases caused by Staphylococcus aureus
Öz
Mastitis is the inflammatory reaction of the udder to bacterial, chemical, thermal and mechanical effects. It causes significant production losses. The purpose of this study is to determine the effectiveness of Startvac® (Hipra), vaccine in sheep and goats with gangrenous mastitis caused by Staphylococcus aureus. The research sample consisted of eight sheep and four goats. The sheep and goats were divided into two groups. The first group was administered classical treatment procedure (parenteral and intramammary antibiotics with nonsteroidal anti-inflammatory drug). In the second group, 1 ml Startvac® vaccine was used with classical treatment procedure. Patients returned to normal in the first group after 48 hours, although lactation ceased on day six and hardness was detected in the udder tissue. On day 10 of treatment, the clinical findings of the animals returned to normal, although the milk yield was much lower when compared to the other treatment group. The clinical appearance of in Group 2 returned to normal after 48 hours, and the animals recovered on Day 6 of treatment. On Day 10, the clinical symptoms disappeared and milk yield increased significantly compared to Group 1. It was concluded that Startvac® mastitis vaccine could increase treatment success in gangrenous mastitis cases in sheep and goats when administered in addition to the classical clinical treatment.
Anahtar Kelimeler
Kaynakça
- 1. Alaçam E. (1990). Mastitis. in: Koyun-Keçi hastalıkları ve Yetiştiriciliği. Tüm Vet. Hayvancılık Hizmetleri Yayını. Teknografik Matbaası, İstanbul, pp.375-388.
- 2. Baştan A. (2013). İneklerde Meme Sağlığı ve Sorunları. 2. Baskı, Kardelen ofset ve matbaacılık, Ankara.
- 3. Pir Yağcı İ. (2005). Koyunlarda Mastitisin Etiyopatogenezi ve Tanısı. Veteriner Hekimler Derneği Dergisi, 76(3-4),30-34.
- 4. Tel OY, Aslantaş Ö, Keskin O et al. (2011). Investigation of Toxin Genes of Staphylococcus Aureus Strains Isolated from Gangrenous Mastitis in Ewes. Kafkas Univ Vet Fak Derg. 17(5):869-871.
- 5. Büyükpamukçu M. (1980). Veteriner Patoloji. 3. Cilt, Ankara Üniversitesi Basımevi, Ankara, pp.174-191.
- 6. Belschner AP, Hallberg JW, Nickerson SC et al. (1996). Staphylococcus aureus mastitis therapy revisited. Proceedings, National Mastitis Council Annual Meeting, Madison, Wisconsin, 116-122.
- 7. Watson DL. (1988). Vaccination against experimental staphylococcal mastitis in ewes. Res Vet Sci. 45(1):16-21.
- 8. Pereira UP, Oliveira DGS, Mesquita LR et al. (2011). Efficacy of Staphylococcus aureus vaccines for bovine mastitis: A systematic review. Vet Microbiol. 148(2–4): 117-124.
- 9. Anonymous. (2014). What is Starvac®? Access Url: www.startvac.com Date of access: 8.12.2014.
- 10. Quinn PJ, Carter ME, Markey BK et al. (1994). Clinical Veterinary Microbiology. Mosby-Year Book Europe Limited, Lynton House, London, 209-236.
- 11. Sambrook J, Russell W (2002). Molecular cloning: a laboratory manual (3rd ed.), Cold Spring Harbor Press, New York, NY.
- 12. Riffon RS. (2001). Development of a Rapid and Sensitive Test for identification of major pathogens in bovine mastitis by PCR. J Clin Microbiol. 39(7): 2584–2589.
- 13. Bauer AU, Kirby WM, Sherris JC et al. (1966). Antibiotic susceptibility testing by a standardized single disc method. J Clin Pathol. 45:493-494.
- 14. CLSI. (2012). Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Second Informational Supplement. CLSI document M100-S22. Wayne, PA: Clinical and Laboratory Standards Institute.
- 15. Foster N, Berndt A, Lalmanach AC et al. (2012). Emergency and therapeutic vaccination is stimulating innate immunity an option? Res Vet Sci. 93(1):7–12.
- 16. Diker KS. (1998). İmmunoloji. Medisan Yayınevi Ltd. Şti. 1. Baskı, Ankara.
- 17. França CA, Peixoto RM, Cavalcante MB et al. (2012). Antimicrobial resistance of Staphylococcus spp. from small ruminant mastitis in Brazil. Chirles Pesq Vet Bras. 32(8):747-753.
- 18. Kunz F, Corti S, Giezendanner N et al. (2011). Antimicrobial resistance of Staphylococcus aureus and coagulase negative staphylococci isolated from mastitis milk samples from sheep and goats. Schweiz Arch Tierheilkd. 153(2):63-69.
- 19. Virdis S, Scarano C, Cossu F et al. (2010). Antibiotic resistance in staphylococcus aureus and coagulase negative staphylococci İsolated from goats with subclinical mastitis. Vet Med Int. Article ID 517060, 6 pages doi:10.4061/2010/517060.
- 20. Tel OY, Aslantaş O, Keskin O et al. (2012). Investigation of the antibiotic resistance and biofilm formation of Staphylococcus aureus strains isolated from gangrenous mastitis of ewes. Acta Vet Hung. 60(2):189-197.
Koyun ve keçilerde Staphylococcus aureus kaynaklı gangrenli mastitis olgularında mastitis aşısının (Startvac®) etkinliğinin araştırılması
Öz
Mastitis;
memenin bakteriyel, kimyasal, termal ve mekanik etkilere verdiği yangısal
reaksiyondur. Önemli üretim kaybına neden olur. Bu çalışmanın amacı; Staphylococcus
aureus kaynaklı kangrenli
mastitisli koyun ve keçilerde Startvac® (Hipra) aşısının etkinliğini
belirlemektir. Araştırma materyalini sekiz koyun ve dört keçi oluşturmaktadır.
Koyun ve keçiler iki gruba ayrıldı. İlk gruba klasik tedavi prosedürü
(parenteral ve meme içi antibiyotik tedavisi ile birlikte nonsteroidal
antienflamatuar ilaç), ikinci grupta klasik tedavi ile birlikte 1 ml Startvac®
aşısı uygulandı. İlk grupta her ne kadar 6. günde laktasyon durmuş ve meme
lobunda sertlik oluşmuşsa da hastalar 48 saat sonrasında normale döndü.
Tedavinin 10. gününde süt verimi diğer tedavi grubuna göre daha az olmasının
yanı sıra hayvanların klinik bulguları normale döndü. Grup 2 de klinik görünüm
48. saatte normale döndü ve tedavinin 6. gününde iyileştiler. Onuncu günde klinik
semptomlar yok oldu ve süt verimi Grup 1’e göre önemli düzeyde arttı. Koyun ve
keçilerde kangrenli mastitis olgularında klasik tedaviye ek olarak uygulanan
Startvac® mastitis aşısının tedavi başarısını arttırabileceği
sonucuna varılmıştır.
Anahtar Kelimeler
Kaynakça
- 1. Alaçam E. (1990). Mastitis. in: Koyun-Keçi hastalıkları ve Yetiştiriciliği. Tüm Vet. Hayvancılık Hizmetleri Yayını. Teknografik Matbaası, İstanbul, pp.375-388.
- 2. Baştan A. (2013). İneklerde Meme Sağlığı ve Sorunları. 2. Baskı, Kardelen ofset ve matbaacılık, Ankara.
- 3. Pir Yağcı İ. (2005). Koyunlarda Mastitisin Etiyopatogenezi ve Tanısı. Veteriner Hekimler Derneği Dergisi, 76(3-4),30-34.
- 4. Tel OY, Aslantaş Ö, Keskin O et al. (2011). Investigation of Toxin Genes of Staphylococcus Aureus Strains Isolated from Gangrenous Mastitis in Ewes. Kafkas Univ Vet Fak Derg. 17(5):869-871.
- 5. Büyükpamukçu M. (1980). Veteriner Patoloji. 3. Cilt, Ankara Üniversitesi Basımevi, Ankara, pp.174-191.
- 6. Belschner AP, Hallberg JW, Nickerson SC et al. (1996). Staphylococcus aureus mastitis therapy revisited. Proceedings, National Mastitis Council Annual Meeting, Madison, Wisconsin, 116-122.
- 7. Watson DL. (1988). Vaccination against experimental staphylococcal mastitis in ewes. Res Vet Sci. 45(1):16-21.
- 8. Pereira UP, Oliveira DGS, Mesquita LR et al. (2011). Efficacy of Staphylococcus aureus vaccines for bovine mastitis: A systematic review. Vet Microbiol. 148(2–4): 117-124.
- 9. Anonymous. (2014). What is Starvac®? Access Url: www.startvac.com Date of access: 8.12.2014.
- 10. Quinn PJ, Carter ME, Markey BK et al. (1994). Clinical Veterinary Microbiology. Mosby-Year Book Europe Limited, Lynton House, London, 209-236.
- 11. Sambrook J, Russell W (2002). Molecular cloning: a laboratory manual (3rd ed.), Cold Spring Harbor Press, New York, NY.
- 12. Riffon RS. (2001). Development of a Rapid and Sensitive Test for identification of major pathogens in bovine mastitis by PCR. J Clin Microbiol. 39(7): 2584–2589.
- 13. Bauer AU, Kirby WM, Sherris JC et al. (1966). Antibiotic susceptibility testing by a standardized single disc method. J Clin Pathol. 45:493-494.
- 14. CLSI. (2012). Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Second Informational Supplement. CLSI document M100-S22. Wayne, PA: Clinical and Laboratory Standards Institute.
- 15. Foster N, Berndt A, Lalmanach AC et al. (2012). Emergency and therapeutic vaccination is stimulating innate immunity an option? Res Vet Sci. 93(1):7–12.
- 16. Diker KS. (1998). İmmunoloji. Medisan Yayınevi Ltd. Şti. 1. Baskı, Ankara.
- 17. França CA, Peixoto RM, Cavalcante MB et al. (2012). Antimicrobial resistance of Staphylococcus spp. from small ruminant mastitis in Brazil. Chirles Pesq Vet Bras. 32(8):747-753.
- 18. Kunz F, Corti S, Giezendanner N et al. (2011). Antimicrobial resistance of Staphylococcus aureus and coagulase negative staphylococci isolated from mastitis milk samples from sheep and goats. Schweiz Arch Tierheilkd. 153(2):63-69.
- 19. Virdis S, Scarano C, Cossu F et al. (2010). Antibiotic resistance in staphylococcus aureus and coagulase negative staphylococci İsolated from goats with subclinical mastitis. Vet Med Int. Article ID 517060, 6 pages doi:10.4061/2010/517060.
- 20. Tel OY, Aslantaş O, Keskin O et al. (2012). Investigation of the antibiotic resistance and biofilm formation of Staphylococcus aureus strains isolated from gangrenous mastitis of ewes. Acta Vet Hung. 60(2):189-197.
Ayrıntılar
| Bölüm | Araştıma |
|---|---|
| Yazarlar | |
| Yayımlanma Tarihi | 25 Aralık 2017 |
| Kabul Tarihi | 6 Ocak 2017 |
| Yayımlandığı Sayı | Yıl 2017 Cilt: 10 Sayı: 2 |
