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Odontojenik Keratokistlerde Farklı Tedavi Yaklaşımları ve Takip Sonuçlarının Retrospektif Olarak Değerlendirilmesi

Year 2024, Volume: 3 Issue: 1, 308 - 316, 10.05.2024

Kübra Uğurlu Nilüfer Özkan Emel Bulut

https://doi.org/10.58711/turkishjdentres.vi.1463641

Abstract

Amaç: Odontojenik keratokistler (OKK); lokal agresif özellikleri ve yüksek nüks etme oranları ile karakterize
odontojenik kistlerdir. Bu çalışmada; OKK’lerin demografik özellikleri, tedavi sonuçları ve nüks oranlarının incelenmesi hedeflenmektedir.
Gereç ve Yöntem: Bu çalışma; Ondokuz Mayıs Üniversitesi Diş Hekimliği Fakültesi Ağız, Diş ve Çene Cerrahisi Anabilim Dalı’nda yürütülmüştür. Çalışmaya OKK tanısı konulan 19 hasta dahil edilmiştir. Hastaların; yaş, cinsiyet, lezyonun lokalizasyonu, uygulanan cerrahi tedavi yöntemleri, nüks varlığı ve takip süreleri retrospektif olarak incelenmiştir.
Bulgular: İncelenen hastaların yaş aralığı 8-79 yıl aralığında olup ortalama yaşları 38,7’dir. 19 hastanın 14’ü
kadın, 5’i ise erkektir. İncelenen 20 lezyondan 11’i multiloküler, 9’u ise uniloküler radyografik görünümdedir. Lezyonların 18’i mandibular posterior bölgede tespit edilmiştir. Tedavi yöntemleri olarak enükleasyon ve küretaj öne çıkmış, bazı vakalarda ise lezyon boyutlarının küçültülmesi amacıyla dekompresyon tedavisine başvurulmuştur. Tedavisi tamamlanan 16 hastanın 3’ünde nüks geliştiği tespit edilmiştir. Takip süreleri 5 ila 120 ay arasında değişkenlik göstermektedir.
Sonuç: Odontojenik keratokistlerin tedavisinde kullanılan yöntemlerin dikkatle seçilmesi ve hastaların uzun süreli klinik ve radyografik olarak takip edilmesi, tedavi başarısı üzerinde önemli bir etkiye sahiptir.

Keywords

Odontojenik kistler Odontojenik keratokist Retrospektif değerlendirme

Ethical Statement

Bu araştırma, Ondokuz Mayıs Üniversitesi Klinik Araştırmalar Etik Kurulu tarafından 05.03.2024 tarihli 2024/92 karar numarası ile etik onayı almış ve Helsinki Deklarasyonu Prensipleri’ne uygun olarak yapılmıştır.

References

  • Stoelinga P. The odontogenic keratocyst revisited. International Journal of Oral and Maxillofacial Surgery. 2022;51(11):1420-3.
  • Reichart PA, Philipsen HP, Sciubba JJ. The new classification of head and neck tumours (WHO)—any changes? Oral oncology. 2006;8(42):757-8.
  • Kaczmarzyk T, Stypułkowska J, Tomaszewska R. Update of the WHO classification of odontogenic and maxillofacial bone tumours. Journal of Stomatology. 2017;70(5):484- 506.
  • Soluk-Tekkesin M, Wright JM. The World Health Organization classification of odontogenic lesions: a summary of the changes of the 2022 (5th) edition. Turkish Journal of Pathology. 2022;38(2):168.
  • Pitak-Arnnop P, Chaine A, Oprean N, Dhanuthai K, Bertrand J-C, Bertolus C. Management of odontogenic keratocysts of the jaws: a ten-year experience with 120 consecutive lesions. Journal of Cranio-Maxillofacial Surgery. 2010;38(5):358-64.
  • Chirapathomsakul D, Sastravaha P, Jansisyanont P. A review of odontogenic keratocysts and the behavior of recurrences. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontology. 2006;101(1):5-9.
  • Habibi A, Saghravanian N, Habibi M, Mellati E, Habibi M. Keratocystic odontogenic tumor: a 10-year retrospective study of 83 cases in an Iranian population. Journal of oral science. 2007;49(3):229-35.
  • Myoung H, Hong S-P, Hong S-D, Lee J-I, Lim C-Y, Choung P-H, et al. Odontogenic keratocyst: review of 256 cases for recurrence and clinicopathologic parameters. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2001;91(3):328-33.
  • Pogrel M. The keratocystic odontogenic tumor. Oral and Maxillofacial Surgery Clinics. 2013;25(1):21-30.
  • Titinchi F, Nortje CJ. Keratocystic odontogenic tumor: a recurrence analysis of clinical and radiographic parameters. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2012;114(1):136-42.
  • Morgan TA, Burton CC, Qian F. A retrospective review of treatment of the odontogenic keratocyst. Journal of oral and maxillofacial surgery. 2005;63(5):635-9.
  • Mendes RA, Carvalho JF, van der Waal I. Biological pathways involved in the aggressive behavior of the keratocystic odontogenic tumor and possible implications for molecular oriented treatment–an overview. Oral oncology. 2010;46(1):19-24.
  • Singh AK, Khanal N, Chaulagain R, Bhujel N, Singh RP. How effective is 5-Fluorouracil as an adjuvant in the management of odontogenic keratocyst? A systematic review and meta-analysis. British Journal of Oral and Maxillofacial Surgery. 2022;60(6):746-54.
  • Madras J, Lapointe H. Keratocystic odontogenic tumour: reclassification of the odontogenic keratocyst from cyst to tumour. Journal of the Canadian Dental Association. 2008;74(2).
  • Roopak B, Singh M, Shah A, Patel G. Keratocystic odontogenic tumor: treatment modalities: study of 3 cases. Nigerian Journal of Clinical Practice. 2014;17(3):378-83.
  • Brannon RB. The odontogenic keratocyst: A clinicopathologic study of 312 cases. Part I. Clinical features. Oral Surgery, Oral Medicine, Oral Pathology. 1976;42(1):54-72.
  • Kinard BE, Chuang S-K, August M, Dodson TB. How well do we manage the odontogenic keratocyst? Journal of Oral and Maxillofacial Surgery. 2013;71(8):1353-8.
  • Kocakahyaoğlu B, Çetiner S. Odontojenik keratokistlerin tanı ve tedavisinde güncel yaklaşımlar. Gazi Üniversitesi Diş Hekimliği Fakültesi Dergisi. 2007;24(2):119-23.
  • Gang T-I, Huh K-H, Yi W-J, Heo M-S, Lee S-S, Kim J-H, et al. Diagnostic ability of differential diagnosis in ameloblastoma and odontogenic keratocyst by imaging modalities and observers. Imaging Science in Dentistry. 2006;36(4):177-82.
  • Boffano P, Ruga E, Gallesio C. Keratocystic odontogenic tumor (odontogenic keratocyst): preliminary retrospective review of epidemiologic, clinical, and radiologic features of 261 lesions from University of Turin. Journal of oral and maxillofacial surgery. 2010;68(12):2994-9.
  • Jung H-D, Lim J-H, Kim HJ, Nam W, Cha I-H. Appropriate follow-up period for odontogenic keratocyst: a retrospective study. Maxillofacial plastic and reconstructive surgery. 2021;43:1-6.
  • Blanchard SB. Odontogenic keratocysts: review of the literature and report of a case. Journal of periodontology. 1997;68(3):306-11.
  • Abdullah WA. Surgical treatment of keratocystic odontogenic tumour: A review article. The Saudi dental journal. 2011;23(2):61-5.
  • Zhao Y-F, Wei J-X, Wang S-P. Treatment of odontogenic keratocysts: a follow-up of 255 Chinese patients. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2002;94(2):151-6.
  • El-Hajj G, Anneroth G. Odontogenic keratocysts—a retrospective clinical and histologic study. International journal of oral and maxillofacial surgery. 1996;25(2):124-9.
  • Chuong R, Donoff RB, Guralnick W. The odontogenic keratocyst. Journal of Oral and Maxillofacial Surgery. 1982;40(12):797-802.
  • Pogrel MA. Treatment of keratocysts: the case for decompression and marsupialization. Journal of oral and maxillofacial surgery. 2005;63(11):1667-73.
  • Tolstunov L, Treasure T. Surgical treatment algorithm for odontogenic keratocyst: combined treatment of odontogenic keratocyst and mandibular defect with marsupialization, enucleation, iliac crest bone graft, and dental implants. Journal of Oral and maxillofacial Surgery. 2008;66(5):1025-36.
  • Brøndum N, Jensen VJ. Recurrence of keratocysts and decompression treatment: a long-term follow-up of fortyfour cases. Oral surgery, oral medicine, oral pathology. 1991;72(3):265-9.
  • Marker P, Brøndum N, Pr P, Bastian HL. Treatment of large odontogenic keratocysts by decompression and later cystectomy: a long-term follow-up and a histologic study of 23 cases. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 1996;82(2):122-31.
  • Pogrel MA, Jordan R. Marsupialization as a definitive treatment for the odontogenic keratocyst. Journal of oral and maxillofacial surgery. 2004;62(6):651-5.
  • Maurette PE, Jorge J, de Moraes M. Conservative treatment protocol of odontogenic keratocyst: a preliminary study. Journal of oral and maxillofacial surgery. 2006;64(3):379- 83.
  • Loescher A, Robinson P. The effect of surgical medicaments on peripheral nerve function. British Journal of Oral and Maxillofacial Surgery. 1998;36(5):327-32.
  • Hellstein J, Hopkins T, Morgan T. The history and mystery of Carnoy solution: an assessment of the need for chloroform. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology. 2007;4(103):e24.
  • Janas-Naze A, Zhang W, Szuta M. Modified Carnoy’s Versus Carnoy’s Solution in the Management of Odontogenic Keratocysts—A Single Center Experience. Journal of Clinical Medicine. 2023;12(3):1133.
  • Dashow JE, McHugh JB, Braun TM, Edwards SP, Helman JI, Ward BB. Significantly decreased recurrence rates in keratocystic odontogenic tumor with simple enucleation and curettage using Carnoy’s versus modified Carnoy’s solution. Journal of Oral and Maxillofacial Surgery. 2015;73(11):2132-5.
  • Longley DB, Harkin DP, Johnston PG. 5-fluorouracil: mechanisms of action and clinical strategies. Nature reviews cancer. 2003;3(5):330-8.
  • Ledderhof NJ, Caminiti MF, Bradley G, Lam DK. Topical 5-fluorouracil is a novel targeted therapy for the keratocystic odontogenic tumor. Journal of Oral and Maxillofacial Surgery. 2017;75(3):514-24.
  • Melean LP, Guerrero LM, Lopez L. 5-fluorouacil in the treatment of odontogenic keratocysts—incidence of recurrence and inferior alveolar nerve paresthesia: a systematic review. Oral and Maxillofacial Surgery. 2023;27(3):489-96.
  • Emmings F, Neiders M, Greene Jr G, Koepf S, Gage A. Freezing the mandible without excision. Journal of oral surgery (American Dental Association: 1965). 1966;24(2):145-55.
  • Schmidt BL. The use of liquid nitrogen cryotherapy in the management of the odontogenic keratocyst. Oral and Maxillofacial Surgery Clinics. 2003;15(3):393-405.
  • Zhou J, Jiao S, Chen X, Wang Y. Treatment of recurrent odontogenic keratocyst with enucleation and cryosurgery: a retrospective study of 10 cases. Shanghai kou Qiang yi xue= Shanghai Journal of Stomatology. 2005;14(5):476-8.
  • Pogrel MA. The use of liquid nitrogen cryotherapy in the management of locally aggressive bone lesions. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons. 1993;51(3):269-73.
  • Blanas N, Freund B, Schwartz M, Furst IM. Systematic review of the treatment and prognosis of the odontogenic keratocyst. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2000;90(5):553-8.
  • Al-Moraissi EA, Dahan AA, Alwadeai MS, Oginni FO, Al-Jamali JM, Alkhutari AS, et al. What surgical treatment has the lowest recurrence rate following the management f keratocystic odontogenic tumor?: A large systematic review and meta-analysis. Journal of Cranio-Maxillofacial Surgery. 2017;45(1):131-44.
  • Ortakoğlu K, Köymen R, Karasu H, Doğan N. Gorlin Goltz sendromu (Bazal hücreli nevus sendromu)(İki olgu nedeniyle). T Klin Diş Hek Bil. 2000;6:168-73.
  • Timoçin N, Doğan Ö. Gorlin-Goltz Sendromu Olgu Bildirisi. İstanbul Üniversitesi Diş Hekimliği Fakültesi Dergisi. 1994;28(1):53-6.
  • González-Alva P, Tanaka A, Oku Y, Yoshizawa D, Itoh S, Sakashita H, et al. Keratocystic odontogenic tumor: a retrospective study of 183 cases. Journal of oral science. 2008;50(2):205-12.
  • Crowley TE, Kaugars GE, Gunsolley JC. Odontogenic keratocysts: a clinical and histologic comparison of the parakeratin and orthokeratin variants. Journal of Oral and Maxillofacial Surgery. 1992;50(1):22-6.
  • Lam K, L. Chan AC. Odontogenic keratocysts: a clinicopathological study in Hong Kong Chinese. The Laryngoscope. 2000;110(8):1328-32.

Retrospective Evaluation of Different Treatment Approaches and Follow-up Outcomes in Odontogenic Keratocysts

Year 2024, Volume: 3 Issue: 1, 308 - 316, 10.05.2024

Kübra Uğurlu Nilüfer Özkan Emel Bulut

https://doi.org/10.58711/turkishjdentres.vi.1463641

Abstract

Aim: Odontogenic keratocysts (OCCs) are odontogenic cysts characterised by locally aggressive features and high recurrence rates. The aim of this study is to investigate the demographic characteristics, treatment results and recurrence rates of OCCs.
Material and Method: This study was conducted in the Department of Oral and Maxillofacial Surgery at Ondokuz Mayıs University Faculty of Dentistry. The study included nineteen patients diagnosed with OCCs. Age, gender, localization of the lesion, surgical treatment methods, presence of recurrence and follow-up periods of the patients were retrospectively analysed.
Results: The age range of the patients was 8-79 years with a mean age of 38.7 years. 14 of 19 patients were female and 5 were male. Of the 20 lesions, 11 were multilocular and 9 were unilocular radiographically. The mandibular posterior region revealed 18 of the lesions. Enucleation and curettage
were the most common treatment modalities, and in some cases decompression therapy was used to reduce the size of the lesions. Recurrence was detected in 3 of 16 patients whose treatment was completed. Follow-up periods varied between 5 and 120 months.
Conclusion: Careful selection of the methods used in the treatment of odontogenic keratocysts and long-term clinical and radiographic follow-up of patients have a significant effect on treatment success.

Keywords

Odontogenic cysts; Odontogenic keratocyst; Retrospective analysis

References

  • Stoelinga P. The odontogenic keratocyst revisited. International Journal of Oral and Maxillofacial Surgery. 2022;51(11):1420-3.
  • Reichart PA, Philipsen HP, Sciubba JJ. The new classification of head and neck tumours (WHO)—any changes? Oral oncology. 2006;8(42):757-8.
  • Kaczmarzyk T, Stypułkowska J, Tomaszewska R. Update of the WHO classification of odontogenic and maxillofacial bone tumours. Journal of Stomatology. 2017;70(5):484- 506.
  • Soluk-Tekkesin M, Wright JM. The World Health Organization classification of odontogenic lesions: a summary of the changes of the 2022 (5th) edition. Turkish Journal of Pathology. 2022;38(2):168.
  • Pitak-Arnnop P, Chaine A, Oprean N, Dhanuthai K, Bertrand J-C, Bertolus C. Management of odontogenic keratocysts of the jaws: a ten-year experience with 120 consecutive lesions. Journal of Cranio-Maxillofacial Surgery. 2010;38(5):358-64.
  • Chirapathomsakul D, Sastravaha P, Jansisyanont P. A review of odontogenic keratocysts and the behavior of recurrences. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontology. 2006;101(1):5-9.
  • Habibi A, Saghravanian N, Habibi M, Mellati E, Habibi M. Keratocystic odontogenic tumor: a 10-year retrospective study of 83 cases in an Iranian population. Journal of oral science. 2007;49(3):229-35.
  • Myoung H, Hong S-P, Hong S-D, Lee J-I, Lim C-Y, Choung P-H, et al. Odontogenic keratocyst: review of 256 cases for recurrence and clinicopathologic parameters. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2001;91(3):328-33.
  • Pogrel M. The keratocystic odontogenic tumor. Oral and Maxillofacial Surgery Clinics. 2013;25(1):21-30.
  • Titinchi F, Nortje CJ. Keratocystic odontogenic tumor: a recurrence analysis of clinical and radiographic parameters. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2012;114(1):136-42.
  • Morgan TA, Burton CC, Qian F. A retrospective review of treatment of the odontogenic keratocyst. Journal of oral and maxillofacial surgery. 2005;63(5):635-9.
  • Mendes RA, Carvalho JF, van der Waal I. Biological pathways involved in the aggressive behavior of the keratocystic odontogenic tumor and possible implications for molecular oriented treatment–an overview. Oral oncology. 2010;46(1):19-24.
  • Singh AK, Khanal N, Chaulagain R, Bhujel N, Singh RP. How effective is 5-Fluorouracil as an adjuvant in the management of odontogenic keratocyst? A systematic review and meta-analysis. British Journal of Oral and Maxillofacial Surgery. 2022;60(6):746-54.
  • Madras J, Lapointe H. Keratocystic odontogenic tumour: reclassification of the odontogenic keratocyst from cyst to tumour. Journal of the Canadian Dental Association. 2008;74(2).
  • Roopak B, Singh M, Shah A, Patel G. Keratocystic odontogenic tumor: treatment modalities: study of 3 cases. Nigerian Journal of Clinical Practice. 2014;17(3):378-83.
  • Brannon RB. The odontogenic keratocyst: A clinicopathologic study of 312 cases. Part I. Clinical features. Oral Surgery, Oral Medicine, Oral Pathology. 1976;42(1):54-72.
  • Kinard BE, Chuang S-K, August M, Dodson TB. How well do we manage the odontogenic keratocyst? Journal of Oral and Maxillofacial Surgery. 2013;71(8):1353-8.
  • Kocakahyaoğlu B, Çetiner S. Odontojenik keratokistlerin tanı ve tedavisinde güncel yaklaşımlar. Gazi Üniversitesi Diş Hekimliği Fakültesi Dergisi. 2007;24(2):119-23.
  • Gang T-I, Huh K-H, Yi W-J, Heo M-S, Lee S-S, Kim J-H, et al. Diagnostic ability of differential diagnosis in ameloblastoma and odontogenic keratocyst by imaging modalities and observers. Imaging Science in Dentistry. 2006;36(4):177-82.
  • Boffano P, Ruga E, Gallesio C. Keratocystic odontogenic tumor (odontogenic keratocyst): preliminary retrospective review of epidemiologic, clinical, and radiologic features of 261 lesions from University of Turin. Journal of oral and maxillofacial surgery. 2010;68(12):2994-9.
  • Jung H-D, Lim J-H, Kim HJ, Nam W, Cha I-H. Appropriate follow-up period for odontogenic keratocyst: a retrospective study. Maxillofacial plastic and reconstructive surgery. 2021;43:1-6.
  • Blanchard SB. Odontogenic keratocysts: review of the literature and report of a case. Journal of periodontology. 1997;68(3):306-11.
  • Abdullah WA. Surgical treatment of keratocystic odontogenic tumour: A review article. The Saudi dental journal. 2011;23(2):61-5.
  • Zhao Y-F, Wei J-X, Wang S-P. Treatment of odontogenic keratocysts: a follow-up of 255 Chinese patients. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2002;94(2):151-6.
  • El-Hajj G, Anneroth G. Odontogenic keratocysts—a retrospective clinical and histologic study. International journal of oral and maxillofacial surgery. 1996;25(2):124-9.
  • Chuong R, Donoff RB, Guralnick W. The odontogenic keratocyst. Journal of Oral and Maxillofacial Surgery. 1982;40(12):797-802.
  • Pogrel MA. Treatment of keratocysts: the case for decompression and marsupialization. Journal of oral and maxillofacial surgery. 2005;63(11):1667-73.
  • Tolstunov L, Treasure T. Surgical treatment algorithm for odontogenic keratocyst: combined treatment of odontogenic keratocyst and mandibular defect with marsupialization, enucleation, iliac crest bone graft, and dental implants. Journal of Oral and maxillofacial Surgery. 2008;66(5):1025-36.
  • Brøndum N, Jensen VJ. Recurrence of keratocysts and decompression treatment: a long-term follow-up of fortyfour cases. Oral surgery, oral medicine, oral pathology. 1991;72(3):265-9.
  • Marker P, Brøndum N, Pr P, Bastian HL. Treatment of large odontogenic keratocysts by decompression and later cystectomy: a long-term follow-up and a histologic study of 23 cases. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 1996;82(2):122-31.
  • Pogrel MA, Jordan R. Marsupialization as a definitive treatment for the odontogenic keratocyst. Journal of oral and maxillofacial surgery. 2004;62(6):651-5.
  • Maurette PE, Jorge J, de Moraes M. Conservative treatment protocol of odontogenic keratocyst: a preliminary study. Journal of oral and maxillofacial surgery. 2006;64(3):379- 83.
  • Loescher A, Robinson P. The effect of surgical medicaments on peripheral nerve function. British Journal of Oral and Maxillofacial Surgery. 1998;36(5):327-32.
  • Hellstein J, Hopkins T, Morgan T. The history and mystery of Carnoy solution: an assessment of the need for chloroform. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology. 2007;4(103):e24.
  • Janas-Naze A, Zhang W, Szuta M. Modified Carnoy’s Versus Carnoy’s Solution in the Management of Odontogenic Keratocysts—A Single Center Experience. Journal of Clinical Medicine. 2023;12(3):1133.
  • Dashow JE, McHugh JB, Braun TM, Edwards SP, Helman JI, Ward BB. Significantly decreased recurrence rates in keratocystic odontogenic tumor with simple enucleation and curettage using Carnoy’s versus modified Carnoy’s solution. Journal of Oral and Maxillofacial Surgery. 2015;73(11):2132-5.
  • Longley DB, Harkin DP, Johnston PG. 5-fluorouracil: mechanisms of action and clinical strategies. Nature reviews cancer. 2003;3(5):330-8.
  • Ledderhof NJ, Caminiti MF, Bradley G, Lam DK. Topical 5-fluorouracil is a novel targeted therapy for the keratocystic odontogenic tumor. Journal of Oral and Maxillofacial Surgery. 2017;75(3):514-24.
  • Melean LP, Guerrero LM, Lopez L. 5-fluorouacil in the treatment of odontogenic keratocysts—incidence of recurrence and inferior alveolar nerve paresthesia: a systematic review. Oral and Maxillofacial Surgery. 2023;27(3):489-96.
  • Emmings F, Neiders M, Greene Jr G, Koepf S, Gage A. Freezing the mandible without excision. Journal of oral surgery (American Dental Association: 1965). 1966;24(2):145-55.
  • Schmidt BL. The use of liquid nitrogen cryotherapy in the management of the odontogenic keratocyst. Oral and Maxillofacial Surgery Clinics. 2003;15(3):393-405.
  • Zhou J, Jiao S, Chen X, Wang Y. Treatment of recurrent odontogenic keratocyst with enucleation and cryosurgery: a retrospective study of 10 cases. Shanghai kou Qiang yi xue= Shanghai Journal of Stomatology. 2005;14(5):476-8.
  • Pogrel MA. The use of liquid nitrogen cryotherapy in the management of locally aggressive bone lesions. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons. 1993;51(3):269-73.
  • Blanas N, Freund B, Schwartz M, Furst IM. Systematic review of the treatment and prognosis of the odontogenic keratocyst. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2000;90(5):553-8.
  • Al-Moraissi EA, Dahan AA, Alwadeai MS, Oginni FO, Al-Jamali JM, Alkhutari AS, et al. What surgical treatment has the lowest recurrence rate following the management f keratocystic odontogenic tumor?: A large systematic review and meta-analysis. Journal of Cranio-Maxillofacial Surgery. 2017;45(1):131-44.
  • Ortakoğlu K, Köymen R, Karasu H, Doğan N. Gorlin Goltz sendromu (Bazal hücreli nevus sendromu)(İki olgu nedeniyle). T Klin Diş Hek Bil. 2000;6:168-73.
  • Timoçin N, Doğan Ö. Gorlin-Goltz Sendromu Olgu Bildirisi. İstanbul Üniversitesi Diş Hekimliği Fakültesi Dergisi. 1994;28(1):53-6.
  • González-Alva P, Tanaka A, Oku Y, Yoshizawa D, Itoh S, Sakashita H, et al. Keratocystic odontogenic tumor: a retrospective study of 183 cases. Journal of oral science. 2008;50(2):205-12.
  • Crowley TE, Kaugars GE, Gunsolley JC. Odontogenic keratocysts: a clinical and histologic comparison of the parakeratin and orthokeratin variants. Journal of Oral and Maxillofacial Surgery. 1992;50(1):22-6.
  • Lam K, L. Chan AC. Odontogenic keratocysts: a clinicopathological study in Hong Kong Chinese. The Laryngoscope. 2000;110(8):1328-32.
There are 50 citations in total.

Details

Primary Language Turkish
Subjects Oral and Maxillofacial Surgery
Journal Section Research Articles
Authors

Kübra Uğurlu 0000-0001-9659-9844

Nilüfer Özkan 0000-0002-0034-5733

Emel Bulut 0000-0002-3907-2234

Publication Date May 10, 2024
Submission Date April 2, 2024
Acceptance Date May 6, 2024
Published in Issue Year 2024 Volume: 3 Issue: 1

Cite

Vancouver Uğurlu K, Özkan N, Bulut E. Odontojenik Keratokistlerde Farklı Tedavi Yaklaşımları ve Takip Sonuçlarının Retrospektif Olarak Değerlendirilmesi. J Turkish Dent Res. 2024;3(1):308-16.
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