Research Article
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Year 2021, Volume: 4 Issue: 2, 70 - 76, 31.08.2021

Abstract

References

  • 1. Priya G. Management of prediabetes. J Pak Med Assoc. 2018;68(4):669-671.
  • 2. Tabák AG, Herder C, Rathmann W, et al. Prediabetes: a high-risk state for diabetes development. Lancet. 2012; 379(9833):2279-90.
  • 3. American Diabetes Association. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2021. Diabetes Care. 2021;44(Suppl 1):S15-S33.
  • 4. Zand A, Ibrahim K, Patham B. Prediabetes: Why Should We Care? Methodist Debakey Cardiovasc J. 2018;14(4):289-297.
  • 5. Cirulli V, Yebra M. Netrins: beyond the brain. Nat Rev Mol Cell Biol. 2007; 8(4):296-306.
  • 6. Rajasekharan S, Kennedy TE. The netrin protein family. Genome Biol. 2009;10(9):239.
  • 7. Hedgecock EM, Culotti JG, Hall DH. The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron. 1990; 4(1):61-85.
  • 8. Ishii N, Wadsworth WG, Stern BD, et al. UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans. Neuron. 1992;9(5):873-81.
  • 9. Serafini T, Colamarino SA, Leonardo ED, et al. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell. 1996; 87(6):1001-14.
  • 10. Mehlen P, Furne C. Netrin-1: when a neuronal guidance cue turns out to be a regulator of tumorigenesis. Cell Mol Life Sci. 2005; 62(22):2599-616.
  • 11. Kefeli U, Ucuncu Kefeli A, Cabuk D, et al. Netrin-1 in cancer: Potential biomarker and therapeutic target? Tumour Biol. 2017;39(4):1010428317698388.
  • 12. Ramesh G, Berg A, Jayakumar C. Plasma netrin-1 is a diagnostic biomarker of human cancers. Biomarkers. 2011;16(2):172-80.
  • 13. Layne K, Ferro A, Passacquale G. Netrin-1 as a novel therapeutic target in cardiovascular disease: to activate or inhibit? Cardiovasc Res. 2015;107(4):410-9.
  • 14. Ramesh G, Kwon O, Ahn K. Netrin-1: a novel universal biomarker of human kidney injury. Transplant Proc. 2010;42(5):1519-22.
  • 15. Mehlen P, Guenebeaud C. Netrin-1 and its dependence receptors as original targets for cancer therapy. Curr Opin Oncol. 2010;22(1):46-54.
  • 16. Yim J, Kim G, Lee BW, et al. Relationship Between Circulating Netrin-1 Concentration, Impaired Fasting Glucose, and Newly Diagnosed Type 2 Diabetes. Front Endocrinol (Lausanne). 2018; 23(9):691.
  • 17. Liu C, Ke X, Wang Y, et al. The level of netrin-1 is decreased in newly diagnosed type 2 diabetes mellitus patients. BMC Endocr Disord. 2016;16(1):33.
  • 18. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care. 1999; 22(9):1462-70.
  • 19. Moore KJ, Fisher EA. Macrophages, atherosclerosis and the potential of netrin-1 as a novel target for future therapeutic intervention.Future Cardiol. 2012;8(3):349-52.
  • 20. Park KW, Crouse D, Lee M, et al. The axonal attractant Netrin-1 is an angiogenic factor. Proc Natl Acad Sci USA. 2004;101(46):16210-5.
  • 21. Ly NP, Komatsuzaki K, Fraser IP, et al. Netrin-1 inhibits leukocyte migration in vitro and in vivo. Proc Natl Acad Sci USA. 2005;102(41):14729-34.
  • 22. Mao X, Xing H, Mao A, et al. Netrin-1 attenuates cardiac ischemia reperfusion injury and generates alternatively activated macrophages. Inflammation. 2014; 37(2):573-80.
  • 23. Ranganathan PV, Jayakumar C, Ramesh G. Netrin-1-treated macrophages protect the kidney against ischemia-reperfusion injury and suppress inflammation by inducing M2 polarization. Am J Physiol Renal Physiol. 2013;304(7):F948-57.
  • 24. Yimer EM, Zewdie KA, Hishe HZ. Netrin as a Novel Biomarker and Its Therapeutic Implications in Diabetes Mellitus and Diabetes-Associated Complications. J Diabetes Res. 2018; 2018:8250521.
  • 25. Nedeva I, Gateva A, Assyov Y, et al. Relationship between circulating netrin-1 levels, obesity, prediabetes and newly diagnosed type 2 diabetes. Arch Physiol Biochem. 2020; 1-6. https://doi.org/10.1080/13813455.2020.1780453
  • 26. Ay E, Marakoglu K, Kizmaz M, et al. Evaluation of Netrin-1 Levels and Albuminuria in Patients With Diabetes. J Clin Lab Anal. 2016;30:972–7.
  • 27. Mandrekar JN. Receiver operating characteristic curve in diagnostic test assessment. J Thorac Oncol. 2010;5(9):1315-6.

EVALUATION OF SERUM LEVELS OF NETRIN-1 AS A POTENTIAL BIOMARKER FOR EARLY PREDICTION OF PREDIABETES

Year 2021, Volume: 4 Issue: 2, 70 - 76, 31.08.2021

Abstract

Objectives: Prediabetes is a candidate status for Type 2 diabetes, typically identified glycemic values range above normal but below diabetes thresholds. Early and accurate diagnosis of this period would be helpful to prevent the diabetes and its consequences. Netrin-1 is a potential metabolic biomarker that has been associated with diabetes. Previous studies are scarce and have yielded contrasting results on serum netrin-1 levels in diabetes. The aim of this study was to investigate the correlation between serum netrin-1 levels and prediabetes.
Methods: Sixty nine participants with prediabetes and 35 healthy controls were included in this study. Serum netrin-1 levels were determined using the Enzyme Linked Immunosorbent Assay (ELISA) method. Correlation analysis were done to assess the relationship between serum netrin-1 levels and biochemical parameters.
Results: Serum netrin-1 levels were significantly decreased in the prediabetes group compared to the healthy control group (P<0.0001). A significant negative correlation was observed between serum netrin-1 levels and age, hemoglobin A1c (HbA1c), sedimantation, fasting blood glucose (FBG) and C-reactive protein (CRP) (r = -0.2738, 0.2886, r = -0.3180; P<0.01, r = -0.3439 and r = -0.3987; P<0.01, respectively.
Conclusion: Serum netrin-1 significantly negative-correlated with prediabetes and also with FBG and HbA1c. These results suggested that netrin-1 could be used as a biomarker for the early detection or screening of prediabetes.

References

  • 1. Priya G. Management of prediabetes. J Pak Med Assoc. 2018;68(4):669-671.
  • 2. Tabák AG, Herder C, Rathmann W, et al. Prediabetes: a high-risk state for diabetes development. Lancet. 2012; 379(9833):2279-90.
  • 3. American Diabetes Association. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2021. Diabetes Care. 2021;44(Suppl 1):S15-S33.
  • 4. Zand A, Ibrahim K, Patham B. Prediabetes: Why Should We Care? Methodist Debakey Cardiovasc J. 2018;14(4):289-297.
  • 5. Cirulli V, Yebra M. Netrins: beyond the brain. Nat Rev Mol Cell Biol. 2007; 8(4):296-306.
  • 6. Rajasekharan S, Kennedy TE. The netrin protein family. Genome Biol. 2009;10(9):239.
  • 7. Hedgecock EM, Culotti JG, Hall DH. The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron. 1990; 4(1):61-85.
  • 8. Ishii N, Wadsworth WG, Stern BD, et al. UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans. Neuron. 1992;9(5):873-81.
  • 9. Serafini T, Colamarino SA, Leonardo ED, et al. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell. 1996; 87(6):1001-14.
  • 10. Mehlen P, Furne C. Netrin-1: when a neuronal guidance cue turns out to be a regulator of tumorigenesis. Cell Mol Life Sci. 2005; 62(22):2599-616.
  • 11. Kefeli U, Ucuncu Kefeli A, Cabuk D, et al. Netrin-1 in cancer: Potential biomarker and therapeutic target? Tumour Biol. 2017;39(4):1010428317698388.
  • 12. Ramesh G, Berg A, Jayakumar C. Plasma netrin-1 is a diagnostic biomarker of human cancers. Biomarkers. 2011;16(2):172-80.
  • 13. Layne K, Ferro A, Passacquale G. Netrin-1 as a novel therapeutic target in cardiovascular disease: to activate or inhibit? Cardiovasc Res. 2015;107(4):410-9.
  • 14. Ramesh G, Kwon O, Ahn K. Netrin-1: a novel universal biomarker of human kidney injury. Transplant Proc. 2010;42(5):1519-22.
  • 15. Mehlen P, Guenebeaud C. Netrin-1 and its dependence receptors as original targets for cancer therapy. Curr Opin Oncol. 2010;22(1):46-54.
  • 16. Yim J, Kim G, Lee BW, et al. Relationship Between Circulating Netrin-1 Concentration, Impaired Fasting Glucose, and Newly Diagnosed Type 2 Diabetes. Front Endocrinol (Lausanne). 2018; 23(9):691.
  • 17. Liu C, Ke X, Wang Y, et al. The level of netrin-1 is decreased in newly diagnosed type 2 diabetes mellitus patients. BMC Endocr Disord. 2016;16(1):33.
  • 18. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care. 1999; 22(9):1462-70.
  • 19. Moore KJ, Fisher EA. Macrophages, atherosclerosis and the potential of netrin-1 as a novel target for future therapeutic intervention.Future Cardiol. 2012;8(3):349-52.
  • 20. Park KW, Crouse D, Lee M, et al. The axonal attractant Netrin-1 is an angiogenic factor. Proc Natl Acad Sci USA. 2004;101(46):16210-5.
  • 21. Ly NP, Komatsuzaki K, Fraser IP, et al. Netrin-1 inhibits leukocyte migration in vitro and in vivo. Proc Natl Acad Sci USA. 2005;102(41):14729-34.
  • 22. Mao X, Xing H, Mao A, et al. Netrin-1 attenuates cardiac ischemia reperfusion injury and generates alternatively activated macrophages. Inflammation. 2014; 37(2):573-80.
  • 23. Ranganathan PV, Jayakumar C, Ramesh G. Netrin-1-treated macrophages protect the kidney against ischemia-reperfusion injury and suppress inflammation by inducing M2 polarization. Am J Physiol Renal Physiol. 2013;304(7):F948-57.
  • 24. Yimer EM, Zewdie KA, Hishe HZ. Netrin as a Novel Biomarker and Its Therapeutic Implications in Diabetes Mellitus and Diabetes-Associated Complications. J Diabetes Res. 2018; 2018:8250521.
  • 25. Nedeva I, Gateva A, Assyov Y, et al. Relationship between circulating netrin-1 levels, obesity, prediabetes and newly diagnosed type 2 diabetes. Arch Physiol Biochem. 2020; 1-6. https://doi.org/10.1080/13813455.2020.1780453
  • 26. Ay E, Marakoglu K, Kizmaz M, et al. Evaluation of Netrin-1 Levels and Albuminuria in Patients With Diabetes. J Clin Lab Anal. 2016;30:972–7.
  • 27. Mandrekar JN. Receiver operating characteristic curve in diagnostic test assessment. J Thorac Oncol. 2010;5(9):1315-6.
There are 27 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Çiğdem Aydın Acar 0000-0002-1311-2314

Suray Pehlivanoğlu 0000-0001-7422-2974

Mehmet Kök This is me 0000-0002-5285-4513

Gizem Yılmaz 0000-0001-6183-5771

Publication Date August 31, 2021
Published in Issue Year 2021 Volume: 4 Issue: 2

Cite

APA Aydın Acar, Ç., Pehlivanoğlu, S., Kök, M., Yılmaz, G. (2021). EVALUATION OF SERUM LEVELS OF NETRIN-1 AS A POTENTIAL BIOMARKER FOR EARLY PREDICTION OF PREDIABETES. Turkish Journal of Health Science and Life, 4(2), 70-76.