Evaluation of Cognitive Functions in Hypertensive Patients and Its Relationship with Serum Midkine Levels
Abstract
Objective: Hypertension (HT) is one of the risk factors associated with dementia. Our aim was to research cognitive functions in patients with HT and its relationship to midkine levels in serum.
Material and Methods: This study examined 45 patients who were over 60 years of age, had at least five years of education, and had an essential HT diagnosis. We also had 30 healthy control subjects. The Mini Mental State Examination (MMSE) was applied to the patients. Scores of 24 and lower from the MMSE indicated a cognitive disorder. In relation serum levels of midkine were also evaluated.
Results: The MMSE scores of the HT patients were compared to the control group and were significantly lower (p<0.01). Midkine levels in the HT patients (25.10 ±8.16 ng/mL) compared to the control group (19.59±7.53 ng/mL) and were significantly higher (p< 0.01). Midkine levels were also higher in HT patients with cognitive impairment compared to HT patients without any cognitive impairment (p<0.05). A significant negative correlation was observed between midkine levels and MMSE scores, (r = 0.558, p<0.01).
Conclusion: This study has demonstrated an important relationship between increased serum midkine levels and cognitive decline in HT patients.
References
- 1. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age specifi c relevance of usual blood pressure to vascular mortality. A metaanalysis of individual data for an million adult in 61 prospective studies. Lancet 2002; 360: 1903–913.
- 2. Ruitenberg A, Skoog I, Ott A, Aevarsson O, Witteman JC, Lernfelt B et al. Blood pressure and risk of dementia: result from the Rotterdam study and the Gothenberg H-70 study. Dement Geriatric Cogn Disord 2001; 12: 33–9.
Hipertansif Hastalarda Kognitif Fonksiyonların Değerlendirilmesi ve Serum Midkine Düzeyleriyle İlişkisi
Abstract
Amaç:Hipertansiyon (HT) demans ile ilişkili risk faktörlerinden biridir. Çalışmanın amacı, HT’lu hastalarda kognitif fonksiyonlar ve serum midkine düzeyleri ile ilişkisini araştırmaktır.
Gereç ve Yöntem: Bu çalışmada, 60 yaşın üstünde, en az beş yıllık eğitim alan ve HT tanısı almış 45 hasta ve 30 sağlıklı kontrol incelendi. Hastalara Mini Mental Durum Değerlendirme (MMDD) testi uygulanmıştır. MMDD skoru 24 ve daha düşük olanlar kognitif bozukluk olarak tanımlandı. Bu gruplarda serum midkine seviyeleri değerlendirildi.
Bulgular: HT’lu hastalarının MMDD skorları kontrol grubuyla karşılaştırıldı ve anlamlı olarak düşük bulundu (p <0.01). HT’lu hastalarda midkine düzeyleri (25.10 ± 8.16 ng/mL) kontrol grubuyla (19.59 ± 7.53 ng/mL) kıyaslandığında belirgin olarak yüksekti (p <0.01). HT hasta grubunda kognitif bozukluğu olanlar ve olmayanlar arasında Midkine düzeyleri karşılaştıldı. Kognitif bozukluğu olan HT hastalarında Midkine belirgin olarak daha yüksekti (p <0.05). Ayrıca Midkine düzeyleri ile MMDD skorları arasında anlamlı bir negatif korelasyon gözlendi (r = 0.558, p <0.01).
Sonuç: Bu çalışma, HT’lu hastalarda artan serum midkine düzeyleri ile kognitif fonksiyon azalması arasında önemli bir ilişki olduğunu göstermiştir.
References
- 1. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age specifi c relevance of usual blood pressure to vascular mortality. A metaanalysis of individual data for an million adult in 61 prospective studies. Lancet 2002; 360: 1903–913.
- 2. Ruitenberg A, Skoog I, Ott A, Aevarsson O, Witteman JC, Lernfelt B et al. Blood pressure and risk of dementia: result from the Rotterdam study and the Gothenberg H-70 study. Dement Geriatric Cogn Disord 2001; 12: 33–9.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Articles |
| Authors | |
| Publication Date | April 12, 2017 |
| Submission Date | March 1, 2017 |
| Published in Issue | Year 2017 Volume: 7 Issue: 1 |
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