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The Use of Phystostrogen in Vasomotor Symptoms During the Menopause Period

Year 2022, Volume: 5 Issue: 3, 476 - 484, 05.12.2022
https://doi.org/10.38108/ouhcd.1010358

Abstract

Various problems (physical, hormonal and emotional) related to estrogen deficiency are observed in women in the menopausal period. These problems are accompanied by vasomotor changes such as hot flashes, sweating, palpitations, headache, sleep disturbances, muscle and joint pain, depressed mood, distraction, frequent forgetting, decreased libido, vaginal atrophy and urinary problems, osteoporosis, cardiovascular diseases, urogenital changes and includes cancers. Vasomotor symptoms affect 60-90% of women in menopause and cause serious physical symptoms. Hormone replacement therapy is the most widely used and considered to be the most effective treatment method for menopausal complaints. Despite this, it has been determined that women tend to use herbal treatments, which they consider more natural and safer than hormones. In the literature, it is stated that women in menopause prefer to receive complementary or alternative treatment methods and phytoestrogens through nutritional supplements to alleviate the vasomotor symptoms seen in this period. However, in the menopausal period, which is one of the most important stages of a woman's life, incorrect and erroneous use of complementary or alternative treatment methods to alleviate symptoms may also cause undesirable negative results. The purpose of this review is to examine the effects of phytoestrogens on vasomotor symptoms in menopause.

References

  • Abdali K, Khajehei M, Tabatabaee HR. (2010). Effect of St John's wort on severity, frequency, and duration of hot flashes in premenopausal, perimenopausal and postmenopausal women: a randomized, double-blind, placebo-controlled study. Menopause, 17, 326-331.
  • Abbaspoor Z, Hajikhani NA, Afshari P. (2011). Effect of Vitex agnus-castus on menopausal early symptoms in postmenopausal women: a randomized, double blind, placebo-controlled study. British Journal of Medicine & Medical Research,1, 132-140.
  • Aghamiri V. (2016). Hop un (Humulus lupulus L.) erken menopoz semptomları ve sıcak basması üzerine etkisi: Randomize plasebo kontrollü bir çalışma. Klinik Uygulamada Tamamlayıcı Tedaviler, 23, 130-135.
  • Alpaslan M. (2018). Menopoz semptomlarının günlük yaşam aktivitelerine etkisi. Ordu Üniversitesi Sağlık Bilimleri Enstitüsü. Ordu.
  • Antmeni ŞE, Ögenler O. (2018). İnsan sağlığında fitoöstrojenlerin önemi. Lokman Hekim Dergisi, 8, 185-190.
  • Bawar S, Sadaf F, Rahim R, Faiz NR. (2013). Comparison of vasomotor symptoms in postmenopausal women with different socio-economic status. Gomal Journal of Medical Sciences,11, 195-198.
  • Bolanos-Diaz R, Zavala-Gonzales J, Mezones-Holguin E, Francia-Romero J. (2011). Soy extract versus hormone therapy for reduction of menopausal hot flushes: indirect comparison. Menopause, 18, 825-829.
  • Canat HL, Kadıoğlu, A. (2019). Genito-üriner hastalıklarda fitoterapinin yeri. TÜD/Türk Üroloji Akademisi Yayını, s. 19-25.
  • Cederroth CR, Zimmermann C, Nef S. (2012). Soy, phytoestrogens and their impact on reproductive health. Molecular Cellular Endocrinology, 355, 192-200.
  • Chang VC, Cotterchio M, Boucher BA, Jenkins D, Mirea L, McCann SE, et al. (2019). Postmenopausal women: a randomized controlled ıntervention trial. Nutrition Cancer, 71, 385-398.
  • Colli MC, Bracht A, Soares AA, de Oliveira AL, Bôer CG, de Souza CG. et al. (2012). Evaluation of the efficacy of flaxseed meal and flaxseed extract in reducing menopausal symptoms. Journal of Medicinal Food, 9, 840-845.
  • Coon JT, Pittler MH, Ernst E. (2007). Trifolium pratense isoflavones in the treatment of menopausal hot flushes: a systematic review and meta-analysis. Phytomedicine, 2, 153-9. 34.
  • Chantal NM. (2017). Oral acute toxicity and estrogenic-like effects of the aqueous extract of anthocleista schweinfurthii gilg (loganiaceae). Pharmacologia, 8, 9-17.
  • Chung DJ, Kim HY, Park KH, Jeong KA, Lee SK, Lee YI, et al. (2007). Black cohosh and St. John's wort (GYNO-Plus) for climacteric symptoms. Yonsei Medical Journal, 48, 289-294.
  • Daily JW, Ko BS, Ryuk J, Liu M, Zhang W, Park S. (2019). Equol decreases hot flashes in postmenopausal women: a systematic review and meta-analysis of randomized clinical trials. Journal Medicine Food, 22, 127-139.
  • Dew TP, Williamson G. (2013). Controlled flax interventions for the improvement of menopausal symptoms and postmenopausal bone health: a systematic review. Menopause, 20, 1207-1215.
  • Drewe J, Zimmermann C, Zahner C. (2013). The effect of a Cimicifuga racemosa extracts Ze 450 in the treatment of climacteric complaints-an observational study. Phytomedicine, 20(8-9), 659-666.
  • Dündar T, Aksu H. (2021). Klimakterik dönemdeki kadınların menopozal semptom ve tutumları. Dokuz Eylül Üniversitesi Hemşirelik Fakültesi Elektronik Dergisi, 2, 134-140.
  • Enseleit F, Sudano I, Périat D, Winnik S, Wolfrum M, Flammer AJ. et al. (2012). Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo controlled, cross-over study. European Heart Journal, 33, 1589–1597.
  • Erbaş N, Demirel G. (2017). Klimakterik dönemdeki kadınların menopoza ilişkin yakınmalarının ve menopozal tutumlarının cinsel yaşam kalitesi üzerine etkisinin değerlendirilmesi. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, 4, 220–225.
  • Ertem G. (2010). Kadınların Menopoz sonrası yaşam kalitelerinin incelenmesi. Uluslararası İnsan Bilimleri Dergisi, 7, 469-483.
  • Franco OH, Chowdhury R, Troup J, Voortman T, Kunutsor S, Kavousi M, et al. (2016). Use of plant-based therapies and menopausal symptoms: a systematic review and meta-analysis. The Latest Medical Research, Reviews, and Guidelines, 315, 2554-2563.
  • Ghazanfarpour M, Sadeghi R, Latifnejad Roudsari R, Khadivzadeh T, Khorsand I, Afiat M, et al. (2016). Effects of flaxseed and Hypericum perforatum on hot flash, vaginal atrophy and estrogen-dependent cancers in menopausal women: a systematic review and meta-analysis. Avicenna Journal of Phytomedicine, 6, 273- 283.
  • Gözüyeşil E, Başer M. (2016). Menopozal dönemde yaşanan vazomotor yakınmaların günlük yaşam aktiviteleri üzerine etkisi. Anadolu Hemşirelik ve Sağlık Bilimleri Dergisi, 19, 261-264.
  • Guo PP, Li P, Zhang XH, Liu N, Wang J, Chen DD, et al (2019). Complementary and alternative medicine for natural and treatment-induced vasomotor symptoms: An overview of systematic reviews and meta-analyses. Complementary Therapies Clinical Practice, 36, 181-194.
  • Gün Ç, Demirci N. (2015). Menopozda bitkisel tedavi kullanımı. Arşiv Kaynak Tarama Dergisi, 24, 520-530. Hall E, Frey BN, Soares CN.(2011). Non-hormonal treatment strategies for vasomotor symptoms. Drugs, 71, 287-304.
  • Heyerick A, Vervarcke S, Depypere H, Bracke M, De Keukeleire D. (2006). A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts. Maturitas, 54, 164–75.
  • Holloway D. (2011). An overview of the menopause: assessment and management. Nursing Standard, 25, 47-57.
  • Höbek R, Kuş B. (2017). Menopozal sıcak basması kontrolünde kullanılan nonfarmakolojik yöntemler. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi, 6, 104 –112.
  • Jack-Ide I, Emelifeonwu E, Adika A. (2014). Psychological effects and experiences of menopausal women in a rural community in Niger Delta region of Nigeria. International Journal of Nursing and Midwifery, 6, 74-79.
  • Jenabi E, Shobeiri F, Hazavehei SM, Roshanaei G. (2018). Kediotu'nın sıcak basmaların şiddeti ve sıklığı üzerindeki etkisi: Üçlü kör randomize klinik çalışma. Kadın Sağlığı, 58, 297-304.
  • Kışlak P, Genç F. (2019). Osteoporoz ve Tedavisi. Lectio Scientific Journal of Health and Natural Sciences, 3, 1-18.
  • Kilci Ş, Gül E. (2019). Menopozda semptom yönetiminde kullanılan kanıta dayalı uygulamalar. Sakarya Üniversitesi Holistik Sağlık Dergisi, 2, 36-54.
  • Kohama T, Negami M. (2013). Effect of low-dose French maritime pine bark extract on climacteric syndrome in 170 perimenopausal women. Journal Reproductive Medicine, 58, 39-46.
  • Kocaadam B, Akdevelioğlu Y. (2018). Fitoöstrojenler ve üreme sağlığı. Beslenme Diyetetik Dergisi, 46, 84-89.
  • Laakmann E, Grajecki D, Doege K, Zu Eulenburg C, Buhling KJ. (2012). Efficacy of Cimicifuga racemosa, Hypericum perforatum and Agnus castus in the treatment of climacteric complaints: a systematic review. Gynecology Endocrinology, 28, 703–709.
  • Lethaby A, Marjoribanks J, Kronenberg F, Roberts H, Eden J, Brown J. (2013). Phytoestrogens for menopausal vasomotor symptoms. Cochrane Database of Systematic Reviews, 12-13.
  • Myers SP, Vigar V. (2017). Effects of a standardized extract of Trifolium pratense (Promensil) at a dosage of 80 mg in the treatment of menopausal hot flushes: A systematic review and meta-analysis. Phytomedicine, 15(24), 141-147.
  • Monsefi M, Nadi A, Alinejad Z. (2017). The effects of Salvia officinalis L. on granulosa cells and in vitro maturation of oocytes in mice. International Journal of Reproductive Biomedicine, 15, 649-660.
  • Özcan H, Oskay Ü. (2013) Menopoz döneminde semptom yönetiminde kanıta dayalı uygulamalar. Göztepe Tıp Dergisi, 28, 157-163.
  • Poluzzi E, Piccinni C, Raschi E, Rampa A, Recanatini M, De Ponti F. (2014). Phytoestrogens in postmenopause: the state of the art from a chemical, pharmacological and regulatory perspective. Current Medicine Chemical, 21, 417-436.
  • Rad, SK (2016). The effect of salvia officinalis tablet on hot flushes, night sweating, and estradiol hormone in postmenopausal women. International Journal of Medical Research & Health Science, 5, 257-263.
  • Rodríguez-García C, Sánchez-Quesada C, Toledo E, Delgado-Rodríguez M, Gaforio JJ. (2019). Naturally lignan-rich foods: a dietary tool for health promotion?. Molecules, 24, 917.
  • Sarri G, Pedder H, Dias S, Guo Y, Lumsden MA. (2017). Vasomotor symptoms resulting from natural menopause: a systematic review and network meta-analysis of treatment effects from the National Institute for Health and Care Excellence guideline on menopause. British Journal of Obstetrics and Gynaecology, 10, 1514-152.
  • Shams T, Firwana B, Habib F, Alshahrani A, AlNouh B, Murad MH, et al. (2013). SSRIs for Hot flashes: A Systematic Review and Meta-analysis of Randomized Trials. Journal Genetic International Medicine, 29, 204-213.
  • Shaygannia E, Bahmani M, Zamanzad B, Rafieian-Kopaei M. (2016). A review study on Punica granatum L. Journal Evid Based Complementary Alternative Medicine, 21, 221-227.
  • Soldamli RV, Arslanoglu SF. (2019). Fitoöstrojenik bitkiler; ne kadar tüketilmeli?. International Journal of Life Sciences and Biotechnology, 2, 183- 204.
  • Sourinejad H, Raisi Dehkordi Z, Beigi M, Adibmoghaddam E, Hadian M. (2019). Journal of Midwifery and Reproductive Health, 7, 1691-1711.
  • Štulíková K. (2018). Therapeutic perspectives of 8-prenylnaringenin, a potent phytoestrogen from hops. Molecules, 23, 660-661.
  • North American Menopause Society (NAMS) (2011). The role of soy isoflavones in menopausal health: report of the North American Menopause Society/Wulf H. Utian Translational Science Symposium in Chicago. Menopause, 18, 732-753.
  • Wobser RW, Takov V. (2020). Karayılan otu (Actaea Racemosa, Siyah Bugbane, Kara Yılan, Peri Mum) Stat Pearls Yayınları. 1-8.
  • Yılmaz MS, Atak N. (2014). Meme kanseri riskinin beslenme ile ilişkili faktörler açısından değerlendirilmesi. Turkish Journal Public Health, 12, 51-60.

Menopoz Döneminde Vazomotor Semptomlarda Fitoöstrojen Kullanımı

Year 2022, Volume: 5 Issue: 3, 476 - 484, 05.12.2022
https://doi.org/10.38108/ouhcd.1010358

Abstract

Menopoz dönemindeki kadınlarda östrojen eksikliğine bağlı, çeşitli sorunlar (fiziksel, hormonal ve duygusal) görülmektedir. Bu sorunlar sıcak basması, terleme, çarpıntı, baş ağrısı, uyku bozukluğu gibi vazomotor değişikliklerle birlikte kas ve eklem ağrıları, depresif ruh hali, dikkat dağınıklığı, sık unutma, libido azalması, vajinal atrofi ve üriner sorunlar, osteoporoz, kardiyovasküler hastalıklar, ürogenital değişiklikler ve kanserleri kapsamaktadır. Vazomotor semptomlar menopoz dönemindeki kadınların %60-90’ını etkilemekte ve ciddi fiziksel semptomlara neden olmaktadır. Menopoz şikâyetleri için en çok kullanılan ve en etkili olduğu düşünülen tedavi yöntemi hormon replasman tedavisidir. Buna rağmen, kadınların hormonlardan daha doğal ve güvenli gördükleri bitkisel tedavilere yöneldikleri belirlenmiştir. Literatürde, menopozdaki kadınların bu dönemde görülen vazomotor semptomları hafifletmek için tamamlayıcı veya alternatif tedavi yöntemlerini ve fitoöstrojenleri besin desteği yoluyla almayı tercih ettikleri belirtilmektedir. Bununla birlikte, kadın hayatının en önemli evrelerinden biri olan menopozal dönemde, kadınların semptomları hafifletmek için tamamlayıcı veya alternatif tedavi yöntemlerini yanlış ve hatalı kullanmaları istenmeyen olumsuz sonuçlara da neden olabilmektedir. Bu derlemenin amacı menopoz döneminde yaşanan vazomotor semptomlar üzerinde fitoöstrojenlerin etkilerini incelemektir.

References

  • Abdali K, Khajehei M, Tabatabaee HR. (2010). Effect of St John's wort on severity, frequency, and duration of hot flashes in premenopausal, perimenopausal and postmenopausal women: a randomized, double-blind, placebo-controlled study. Menopause, 17, 326-331.
  • Abbaspoor Z, Hajikhani NA, Afshari P. (2011). Effect of Vitex agnus-castus on menopausal early symptoms in postmenopausal women: a randomized, double blind, placebo-controlled study. British Journal of Medicine & Medical Research,1, 132-140.
  • Aghamiri V. (2016). Hop un (Humulus lupulus L.) erken menopoz semptomları ve sıcak basması üzerine etkisi: Randomize plasebo kontrollü bir çalışma. Klinik Uygulamada Tamamlayıcı Tedaviler, 23, 130-135.
  • Alpaslan M. (2018). Menopoz semptomlarının günlük yaşam aktivitelerine etkisi. Ordu Üniversitesi Sağlık Bilimleri Enstitüsü. Ordu.
  • Antmeni ŞE, Ögenler O. (2018). İnsan sağlığında fitoöstrojenlerin önemi. Lokman Hekim Dergisi, 8, 185-190.
  • Bawar S, Sadaf F, Rahim R, Faiz NR. (2013). Comparison of vasomotor symptoms in postmenopausal women with different socio-economic status. Gomal Journal of Medical Sciences,11, 195-198.
  • Bolanos-Diaz R, Zavala-Gonzales J, Mezones-Holguin E, Francia-Romero J. (2011). Soy extract versus hormone therapy for reduction of menopausal hot flushes: indirect comparison. Menopause, 18, 825-829.
  • Canat HL, Kadıoğlu, A. (2019). Genito-üriner hastalıklarda fitoterapinin yeri. TÜD/Türk Üroloji Akademisi Yayını, s. 19-25.
  • Cederroth CR, Zimmermann C, Nef S. (2012). Soy, phytoestrogens and their impact on reproductive health. Molecular Cellular Endocrinology, 355, 192-200.
  • Chang VC, Cotterchio M, Boucher BA, Jenkins D, Mirea L, McCann SE, et al. (2019). Postmenopausal women: a randomized controlled ıntervention trial. Nutrition Cancer, 71, 385-398.
  • Colli MC, Bracht A, Soares AA, de Oliveira AL, Bôer CG, de Souza CG. et al. (2012). Evaluation of the efficacy of flaxseed meal and flaxseed extract in reducing menopausal symptoms. Journal of Medicinal Food, 9, 840-845.
  • Coon JT, Pittler MH, Ernst E. (2007). Trifolium pratense isoflavones in the treatment of menopausal hot flushes: a systematic review and meta-analysis. Phytomedicine, 2, 153-9. 34.
  • Chantal NM. (2017). Oral acute toxicity and estrogenic-like effects of the aqueous extract of anthocleista schweinfurthii gilg (loganiaceae). Pharmacologia, 8, 9-17.
  • Chung DJ, Kim HY, Park KH, Jeong KA, Lee SK, Lee YI, et al. (2007). Black cohosh and St. John's wort (GYNO-Plus) for climacteric symptoms. Yonsei Medical Journal, 48, 289-294.
  • Daily JW, Ko BS, Ryuk J, Liu M, Zhang W, Park S. (2019). Equol decreases hot flashes in postmenopausal women: a systematic review and meta-analysis of randomized clinical trials. Journal Medicine Food, 22, 127-139.
  • Dew TP, Williamson G. (2013). Controlled flax interventions for the improvement of menopausal symptoms and postmenopausal bone health: a systematic review. Menopause, 20, 1207-1215.
  • Drewe J, Zimmermann C, Zahner C. (2013). The effect of a Cimicifuga racemosa extracts Ze 450 in the treatment of climacteric complaints-an observational study. Phytomedicine, 20(8-9), 659-666.
  • Dündar T, Aksu H. (2021). Klimakterik dönemdeki kadınların menopozal semptom ve tutumları. Dokuz Eylül Üniversitesi Hemşirelik Fakültesi Elektronik Dergisi, 2, 134-140.
  • Enseleit F, Sudano I, Périat D, Winnik S, Wolfrum M, Flammer AJ. et al. (2012). Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo controlled, cross-over study. European Heart Journal, 33, 1589–1597.
  • Erbaş N, Demirel G. (2017). Klimakterik dönemdeki kadınların menopoza ilişkin yakınmalarının ve menopozal tutumlarının cinsel yaşam kalitesi üzerine etkisinin değerlendirilmesi. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, 4, 220–225.
  • Ertem G. (2010). Kadınların Menopoz sonrası yaşam kalitelerinin incelenmesi. Uluslararası İnsan Bilimleri Dergisi, 7, 469-483.
  • Franco OH, Chowdhury R, Troup J, Voortman T, Kunutsor S, Kavousi M, et al. (2016). Use of plant-based therapies and menopausal symptoms: a systematic review and meta-analysis. The Latest Medical Research, Reviews, and Guidelines, 315, 2554-2563.
  • Ghazanfarpour M, Sadeghi R, Latifnejad Roudsari R, Khadivzadeh T, Khorsand I, Afiat M, et al. (2016). Effects of flaxseed and Hypericum perforatum on hot flash, vaginal atrophy and estrogen-dependent cancers in menopausal women: a systematic review and meta-analysis. Avicenna Journal of Phytomedicine, 6, 273- 283.
  • Gözüyeşil E, Başer M. (2016). Menopozal dönemde yaşanan vazomotor yakınmaların günlük yaşam aktiviteleri üzerine etkisi. Anadolu Hemşirelik ve Sağlık Bilimleri Dergisi, 19, 261-264.
  • Guo PP, Li P, Zhang XH, Liu N, Wang J, Chen DD, et al (2019). Complementary and alternative medicine for natural and treatment-induced vasomotor symptoms: An overview of systematic reviews and meta-analyses. Complementary Therapies Clinical Practice, 36, 181-194.
  • Gün Ç, Demirci N. (2015). Menopozda bitkisel tedavi kullanımı. Arşiv Kaynak Tarama Dergisi, 24, 520-530. Hall E, Frey BN, Soares CN.(2011). Non-hormonal treatment strategies for vasomotor symptoms. Drugs, 71, 287-304.
  • Heyerick A, Vervarcke S, Depypere H, Bracke M, De Keukeleire D. (2006). A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts. Maturitas, 54, 164–75.
  • Holloway D. (2011). An overview of the menopause: assessment and management. Nursing Standard, 25, 47-57.
  • Höbek R, Kuş B. (2017). Menopozal sıcak basması kontrolünde kullanılan nonfarmakolojik yöntemler. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi, 6, 104 –112.
  • Jack-Ide I, Emelifeonwu E, Adika A. (2014). Psychological effects and experiences of menopausal women in a rural community in Niger Delta region of Nigeria. International Journal of Nursing and Midwifery, 6, 74-79.
  • Jenabi E, Shobeiri F, Hazavehei SM, Roshanaei G. (2018). Kediotu'nın sıcak basmaların şiddeti ve sıklığı üzerindeki etkisi: Üçlü kör randomize klinik çalışma. Kadın Sağlığı, 58, 297-304.
  • Kışlak P, Genç F. (2019). Osteoporoz ve Tedavisi. Lectio Scientific Journal of Health and Natural Sciences, 3, 1-18.
  • Kilci Ş, Gül E. (2019). Menopozda semptom yönetiminde kullanılan kanıta dayalı uygulamalar. Sakarya Üniversitesi Holistik Sağlık Dergisi, 2, 36-54.
  • Kohama T, Negami M. (2013). Effect of low-dose French maritime pine bark extract on climacteric syndrome in 170 perimenopausal women. Journal Reproductive Medicine, 58, 39-46.
  • Kocaadam B, Akdevelioğlu Y. (2018). Fitoöstrojenler ve üreme sağlığı. Beslenme Diyetetik Dergisi, 46, 84-89.
  • Laakmann E, Grajecki D, Doege K, Zu Eulenburg C, Buhling KJ. (2012). Efficacy of Cimicifuga racemosa, Hypericum perforatum and Agnus castus in the treatment of climacteric complaints: a systematic review. Gynecology Endocrinology, 28, 703–709.
  • Lethaby A, Marjoribanks J, Kronenberg F, Roberts H, Eden J, Brown J. (2013). Phytoestrogens for menopausal vasomotor symptoms. Cochrane Database of Systematic Reviews, 12-13.
  • Myers SP, Vigar V. (2017). Effects of a standardized extract of Trifolium pratense (Promensil) at a dosage of 80 mg in the treatment of menopausal hot flushes: A systematic review and meta-analysis. Phytomedicine, 15(24), 141-147.
  • Monsefi M, Nadi A, Alinejad Z. (2017). The effects of Salvia officinalis L. on granulosa cells and in vitro maturation of oocytes in mice. International Journal of Reproductive Biomedicine, 15, 649-660.
  • Özcan H, Oskay Ü. (2013) Menopoz döneminde semptom yönetiminde kanıta dayalı uygulamalar. Göztepe Tıp Dergisi, 28, 157-163.
  • Poluzzi E, Piccinni C, Raschi E, Rampa A, Recanatini M, De Ponti F. (2014). Phytoestrogens in postmenopause: the state of the art from a chemical, pharmacological and regulatory perspective. Current Medicine Chemical, 21, 417-436.
  • Rad, SK (2016). The effect of salvia officinalis tablet on hot flushes, night sweating, and estradiol hormone in postmenopausal women. International Journal of Medical Research & Health Science, 5, 257-263.
  • Rodríguez-García C, Sánchez-Quesada C, Toledo E, Delgado-Rodríguez M, Gaforio JJ. (2019). Naturally lignan-rich foods: a dietary tool for health promotion?. Molecules, 24, 917.
  • Sarri G, Pedder H, Dias S, Guo Y, Lumsden MA. (2017). Vasomotor symptoms resulting from natural menopause: a systematic review and network meta-analysis of treatment effects from the National Institute for Health and Care Excellence guideline on menopause. British Journal of Obstetrics and Gynaecology, 10, 1514-152.
  • Shams T, Firwana B, Habib F, Alshahrani A, AlNouh B, Murad MH, et al. (2013). SSRIs for Hot flashes: A Systematic Review and Meta-analysis of Randomized Trials. Journal Genetic International Medicine, 29, 204-213.
  • Shaygannia E, Bahmani M, Zamanzad B, Rafieian-Kopaei M. (2016). A review study on Punica granatum L. Journal Evid Based Complementary Alternative Medicine, 21, 221-227.
  • Soldamli RV, Arslanoglu SF. (2019). Fitoöstrojenik bitkiler; ne kadar tüketilmeli?. International Journal of Life Sciences and Biotechnology, 2, 183- 204.
  • Sourinejad H, Raisi Dehkordi Z, Beigi M, Adibmoghaddam E, Hadian M. (2019). Journal of Midwifery and Reproductive Health, 7, 1691-1711.
  • Štulíková K. (2018). Therapeutic perspectives of 8-prenylnaringenin, a potent phytoestrogen from hops. Molecules, 23, 660-661.
  • North American Menopause Society (NAMS) (2011). The role of soy isoflavones in menopausal health: report of the North American Menopause Society/Wulf H. Utian Translational Science Symposium in Chicago. Menopause, 18, 732-753.
  • Wobser RW, Takov V. (2020). Karayılan otu (Actaea Racemosa, Siyah Bugbane, Kara Yılan, Peri Mum) Stat Pearls Yayınları. 1-8.
  • Yılmaz MS, Atak N. (2014). Meme kanseri riskinin beslenme ile ilişkili faktörler açısından değerlendirilmesi. Turkish Journal Public Health, 12, 51-60.
There are 52 citations in total.

Details

Primary Language Turkish
Subjects Nursing
Journal Section Review
Authors

Özlem Çakır 0000-0003-2063-5321

Nevin Akdolun Balkaya 0000-0003-2374-1541

Sevgül Dönmez 0000-0003-2420-8167

Early Pub Date December 5, 2022
Publication Date December 5, 2022
Submission Date October 15, 2021
Published in Issue Year 2022 Volume: 5 Issue: 3

Cite

APA Çakır, Ö., Balkaya, N. A., & Dönmez, S. (2022). Menopoz Döneminde Vazomotor Semptomlarda Fitoöstrojen Kullanımı. Ordu Üniversitesi Hemşirelik Çalışmaları Dergisi, 5(3), 476-484. https://doi.org/10.38108/ouhcd.1010358