Research Article
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Year 2019, Volume: 36 Issue: 2, 35 - 42, 25.12.2019

Abstract

References

  • References:1.Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-TieulentJemal A. Global Cancerstatistics. CA Cancer J Clin 2015;65(2):87-108. 2. Hoory T, Monie A, Gravitt P, Wu TC. Molecular epidemiology of human papillomavirus. J Formos Med Assoc 2008;107(3):198-217.3. Munoz N, Franceschi S, Bosetti C, Moreno V, Herrero R, Smith JS, et al. Role of parity and human papillomavirus in cervical cancer: the IARC multicentric case-control study. Lancet 2002;359:1093-101.4. Milutin Gasperov N, Sabol I, Matovina M, Spaventi S, Grce M. Detection and typing of human papillomaviruses combining different methods: polymerase chain reaction, restriction fragment length polymorphism, line probe assay and sequencing. Pathol Oncol Res 2008;14(4):355-63.5. Türkiye Kanser İstatistikleri 2015. http://www.kanser.gov.tr/ Dosya/ca_istatistik/ANA_rapor_2012 sooonn.pdf (Erişim tarihi:25.12.2015)6. Cervical Cytology Screening. ACOG Practice Bulletin No 109. American College of Obstetricians and Gynecologists. Obstet Gynecol. 2009; 114: 1409-20 7. Jennifer E. Frank. The Colposcopic Examination. J Midwifery Womens Health. 2008; 53: 447-528. Eroğlu C, Keşli R, Eryılmaz MA, Ünlü Y, Gönenç O, Çelik Ç. Serviks kanseri için riski olan kadınlarda HPV tiplendirmesi ve HPV sıklığının risk faktörleri ve servikal smearle ilişkisi. Nobel Med 2011;7:72–7.9. Dönmez AG. Şişli Etfal Eğitim ve Araştırma Hastanesi’nde çalışan kadın sağlık personelinin serviks kanserine ilişkin bilgi düzeyinin ve farkındalığının araştırılması. Tıpta uzmanlık tezi. S.B. Şişli Etfal Eğitim ve Araştırma Hastanesi, Aile Hekimliği Kliniği, İstanbul, 2007. 10. Can H, Öztürk Y.K, Güçlü Y.A, Öztürk F, Demir Ş. Kadın Sağlık Çalışanlarının Serviks Kanseri Farkındalığı. Tepecik Eğit Hast Derg 2010;20(2):77-84.
  • 11.Akhan SE. Ülkemizde servikal kanser epidemiyolojisi ve HPV serotipleri. ANKEM Derg 2007; 21(2):96-98. 12. T. C. Sağlık Bakanlığı Sağlık İstatistikleri Yıllığı 2015. Yayın No:1054. Ankara: Sistem Ofset Basım Yayın; 2016. ss.36–713. Munoz N, Bosch FX, de Sanjose S, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Eng J Med 2003; 348: 518-527.
  • 14. Özcelik B, Serin IS, Gökahmetoğlu S, Başbuğ M, Erez R. Human papillomavirus frequency of women at low risk of developing cervical cancer: a preliminary study from a Turkish University. Eur J Gynaecol Oncol 2003; 24: 157-159.15. Aktepe O, Altındiş M, Aktepe F, Yılmazer M, Fenkçi V. Risk altındaki kadınların servikal örneklerinde human papilloma virus araştırılması. Osmangazi Tıp Dergisi 2007; 29: 131–135.16. Ergünay K, Mısırlıoglu M, Fırat P, ve ark. Sitolojik olarak anomali saptanan serviks örneklerinde insan papilloma virus DNA’sının araştırılması ve virusun tiplendirilmesi. Mikrobiyol Bült 2007; 41: 219-226.17. Sapmaz E, Şimşek M, Çelik H, Kumru S, Doymaz MZ. Bölgemizdeki servikal intraepitelyal neoplazi vakalarında HPV 16 ve 18 genomlarının PCR yöntemi ile araştırılması. Türkiye Klinikleri J Gynecol Obst 2003;13: 58-61.18. M. Kyrgiou, I. Tsoumpou, T. Vrekoussis et al. The up-to-date evidence on colposcopy practice and treatment of cervical intraepithelial neoplasia: The cochrane colposcopy &cervical cytopathology collaborative group (C5 group) approach. Cancer Treatment Reviews. 2006; 32:516-2319. Mitchell MF, Schottenfeld D, Tortolero-Luna G, Cantor SB, Richards-Kortum R. Colposcopy for the diagnosis of squamous intraepithelial lesions: a meta-analysis. Obstet Gynecol. 1998; 91: 626-3120. Pretorius RG, Peterson P, Azizi F. Subsequent risk and presentation of cervical intraepithelial neoplasia(CIN) 3 or cancer after a colposcopic diagnosis of CIN 1 or less. Am J Obstet Gynecol. 2006; 195: 1260-521. Ergeneli MH, Duran EH, Ergin T, Demirhan B, Erdogan M. Atypical squamous cells of undetermined significance. Clinical experience in a Turkish university hospital. Eur J Obstet Gynecol Reprod Biol 2001; 96: 108-110.22. Bozkurt TT. 2000-2005 yılları arasında İstanbul Eğitim ve Araştırma Hastanesi servikal smear tarama sonuçlarımız. Uzmanlık Tezi. İstanbul: Sağlık Bakanlığı İstanbul Eğitim ve Araştırma Hastanesi, Aile Hekimliği Bölümü, 2007.23.Özdamar ŞO, Bektaş S, Barut F, ve ark. Zonguldak Karaelmas Üniversitesi Tıp Fakültesi Hastanesi’nin 2003-2005 yılları sitoloji deneyimi. Türk Patoloji Dergisi 2006; 22: 92-95.24. Thomas C. Wrigt Jr., L. Stewart Massad, Charles J. Dunton et al. 2006 Consencus Guidelines for the Management of Women with Abnormal Cervical Screening Tests. Journal of Lower Genital Tract Disease. Volume 11, Number 4, 2007; 201-22225. Wright TC, Cox JT, Massad LS, Wilkinson EJ. 2001 Consensus guidelines fort he management of women with cervical cytological abnormalities. JAMA. 2002; 287:2120-926. M. Kyrgiou, I. Tsoumpou, T. Vrekoussis et al. The up-to-date evidence on colposcopy practice and treatment of cervical intraepithelial neoplasia: The cochrane colposcopy &cervical cytopathology collaborative group (C5 group) approach. Cancer Treatment Reviews. 2006; 32:516-2327. Arbyn M, Paraskevaidis E, Martin-Hirsch P, Prendiville W, Dillner J. Clinical utility of HPV-DNA detection: triage of minor cervical lesions, follow-up of women treated for high-grade CIN: an update of pooled evidence. Gynecol Oncol. 2005; 99 (3 Supply 1): S7-S1128. Syrjanen SM, Syrjanen KJ . New concepts on the role of human papillomavirus in cell cycle regulation. Ann. Med. 1999 Jun;31(3):175–87.29. Schneider A, Hoyer H, Lotz B et al. Screening for high-grade cervical intra-epithelial neoplasia and cancer by testing for high-risk HPV, routine cytology or colposcopy. Int J Cancer. 2000;89:529-34.30. Manos MM, Kinney WK, Hurley LB. et al. Identifying women with cervical neoplasia: using human papillomavirus DNA testing for equivocal Papanicolaou results. KAİSER study. JAMA. 1999;281:1605-1031. Guido R, Schiffman M, Solomon D. Et al. ASCUS LSIL Triage Study (ALTS) Group. Postcolposcopy management strategies for women referred with low-grade squamous intraepithelial lesions or human papillomavirus DNA-positive atypical squamous cells of undetermined significance: a two-year prospective study. Am J Obstet Gynecol. 2003;188:1401-5.

Evaluation of colposcopy results for patients who are HPV DNA positive in KETEM

Year 2019, Volume: 36 Issue: 2, 35 - 42, 25.12.2019

Abstract

We evaluated colposcopy and postoperative biopsy results in cases referred to our oncology center from the Cancer Early Diagnosis and Treatment Center (KETEM) due to Human Papilloma Virus (HPV) positivity and/or cervical pre- malignant lesion (CPL). A total of 1230 female patients who were admitted to our Oncology outpatient clinic between January 2016 and December 2017 with positive HPV DNA screening tests from KETEM regardless of whether they had cervical premalignant lesion or not as a result of Papanicolaou smear (PAP smear) were included in the study. Colposcopy was performed in all cases and cervical biopsy was performed in patients who had suspicious lesions. Nosignificant relationship was found between smoking status, educational status and financial status and HPV DNA screening test results (p = 0.123, p = 0.201, p = 0.244, respectively). The sensitivity of colposcopy to detect cervical pre- malignant lesions was 99.2% and positive predictive value (PPD) was 74.1%. In determining the cervical premalignant lesions, the sensitivity of smear was41.3% and its specificity was 66.5%, PPV (positive predictive value) was 78.1%and NPV (negative predictive value) was 28.2%. In our study, the sensitivity of the HPV test to determine cervical premalignant lesions was 93.1%, PPV was74%, specificity 86% and NPV was 30%. The accuracy of HPV types in deter-mining CPLs was found to be (530 + 17)/776=71.4%. Positivity on the HPV DNA screening test is the leading risk factor for cervical cancer development. As a result, the first step in family medicine and KETEM activities is to reducethe frequency of these cancers and the complications related to the disease by increasing information and screening examination applications.

References

  • References:1.Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-TieulentJemal A. Global Cancerstatistics. CA Cancer J Clin 2015;65(2):87-108. 2. Hoory T, Monie A, Gravitt P, Wu TC. Molecular epidemiology of human papillomavirus. J Formos Med Assoc 2008;107(3):198-217.3. Munoz N, Franceschi S, Bosetti C, Moreno V, Herrero R, Smith JS, et al. Role of parity and human papillomavirus in cervical cancer: the IARC multicentric case-control study. Lancet 2002;359:1093-101.4. Milutin Gasperov N, Sabol I, Matovina M, Spaventi S, Grce M. Detection and typing of human papillomaviruses combining different methods: polymerase chain reaction, restriction fragment length polymorphism, line probe assay and sequencing. Pathol Oncol Res 2008;14(4):355-63.5. Türkiye Kanser İstatistikleri 2015. http://www.kanser.gov.tr/ Dosya/ca_istatistik/ANA_rapor_2012 sooonn.pdf (Erişim tarihi:25.12.2015)6. Cervical Cytology Screening. ACOG Practice Bulletin No 109. American College of Obstetricians and Gynecologists. Obstet Gynecol. 2009; 114: 1409-20 7. Jennifer E. Frank. The Colposcopic Examination. J Midwifery Womens Health. 2008; 53: 447-528. Eroğlu C, Keşli R, Eryılmaz MA, Ünlü Y, Gönenç O, Çelik Ç. Serviks kanseri için riski olan kadınlarda HPV tiplendirmesi ve HPV sıklığının risk faktörleri ve servikal smearle ilişkisi. Nobel Med 2011;7:72–7.9. Dönmez AG. Şişli Etfal Eğitim ve Araştırma Hastanesi’nde çalışan kadın sağlık personelinin serviks kanserine ilişkin bilgi düzeyinin ve farkındalığının araştırılması. Tıpta uzmanlık tezi. S.B. Şişli Etfal Eğitim ve Araştırma Hastanesi, Aile Hekimliği Kliniği, İstanbul, 2007. 10. Can H, Öztürk Y.K, Güçlü Y.A, Öztürk F, Demir Ş. Kadın Sağlık Çalışanlarının Serviks Kanseri Farkındalığı. Tepecik Eğit Hast Derg 2010;20(2):77-84.
  • 11.Akhan SE. Ülkemizde servikal kanser epidemiyolojisi ve HPV serotipleri. ANKEM Derg 2007; 21(2):96-98. 12. T. C. Sağlık Bakanlığı Sağlık İstatistikleri Yıllığı 2015. Yayın No:1054. Ankara: Sistem Ofset Basım Yayın; 2016. ss.36–713. Munoz N, Bosch FX, de Sanjose S, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Eng J Med 2003; 348: 518-527.
  • 14. Özcelik B, Serin IS, Gökahmetoğlu S, Başbuğ M, Erez R. Human papillomavirus frequency of women at low risk of developing cervical cancer: a preliminary study from a Turkish University. Eur J Gynaecol Oncol 2003; 24: 157-159.15. Aktepe O, Altındiş M, Aktepe F, Yılmazer M, Fenkçi V. Risk altındaki kadınların servikal örneklerinde human papilloma virus araştırılması. Osmangazi Tıp Dergisi 2007; 29: 131–135.16. Ergünay K, Mısırlıoglu M, Fırat P, ve ark. Sitolojik olarak anomali saptanan serviks örneklerinde insan papilloma virus DNA’sının araştırılması ve virusun tiplendirilmesi. Mikrobiyol Bült 2007; 41: 219-226.17. Sapmaz E, Şimşek M, Çelik H, Kumru S, Doymaz MZ. Bölgemizdeki servikal intraepitelyal neoplazi vakalarında HPV 16 ve 18 genomlarının PCR yöntemi ile araştırılması. Türkiye Klinikleri J Gynecol Obst 2003;13: 58-61.18. M. Kyrgiou, I. Tsoumpou, T. Vrekoussis et al. The up-to-date evidence on colposcopy practice and treatment of cervical intraepithelial neoplasia: The cochrane colposcopy &cervical cytopathology collaborative group (C5 group) approach. Cancer Treatment Reviews. 2006; 32:516-2319. Mitchell MF, Schottenfeld D, Tortolero-Luna G, Cantor SB, Richards-Kortum R. Colposcopy for the diagnosis of squamous intraepithelial lesions: a meta-analysis. Obstet Gynecol. 1998; 91: 626-3120. Pretorius RG, Peterson P, Azizi F. Subsequent risk and presentation of cervical intraepithelial neoplasia(CIN) 3 or cancer after a colposcopic diagnosis of CIN 1 or less. Am J Obstet Gynecol. 2006; 195: 1260-521. Ergeneli MH, Duran EH, Ergin T, Demirhan B, Erdogan M. Atypical squamous cells of undetermined significance. Clinical experience in a Turkish university hospital. Eur J Obstet Gynecol Reprod Biol 2001; 96: 108-110.22. Bozkurt TT. 2000-2005 yılları arasında İstanbul Eğitim ve Araştırma Hastanesi servikal smear tarama sonuçlarımız. Uzmanlık Tezi. İstanbul: Sağlık Bakanlığı İstanbul Eğitim ve Araştırma Hastanesi, Aile Hekimliği Bölümü, 2007.23.Özdamar ŞO, Bektaş S, Barut F, ve ark. Zonguldak Karaelmas Üniversitesi Tıp Fakültesi Hastanesi’nin 2003-2005 yılları sitoloji deneyimi. Türk Patoloji Dergisi 2006; 22: 92-95.24. Thomas C. Wrigt Jr., L. Stewart Massad, Charles J. Dunton et al. 2006 Consencus Guidelines for the Management of Women with Abnormal Cervical Screening Tests. Journal of Lower Genital Tract Disease. Volume 11, Number 4, 2007; 201-22225. Wright TC, Cox JT, Massad LS, Wilkinson EJ. 2001 Consensus guidelines fort he management of women with cervical cytological abnormalities. JAMA. 2002; 287:2120-926. M. Kyrgiou, I. Tsoumpou, T. Vrekoussis et al. The up-to-date evidence on colposcopy practice and treatment of cervical intraepithelial neoplasia: The cochrane colposcopy &cervical cytopathology collaborative group (C5 group) approach. Cancer Treatment Reviews. 2006; 32:516-2327. Arbyn M, Paraskevaidis E, Martin-Hirsch P, Prendiville W, Dillner J. Clinical utility of HPV-DNA detection: triage of minor cervical lesions, follow-up of women treated for high-grade CIN: an update of pooled evidence. Gynecol Oncol. 2005; 99 (3 Supply 1): S7-S1128. Syrjanen SM, Syrjanen KJ . New concepts on the role of human papillomavirus in cell cycle regulation. Ann. Med. 1999 Jun;31(3):175–87.29. Schneider A, Hoyer H, Lotz B et al. Screening for high-grade cervical intra-epithelial neoplasia and cancer by testing for high-risk HPV, routine cytology or colposcopy. Int J Cancer. 2000;89:529-34.30. Manos MM, Kinney WK, Hurley LB. et al. Identifying women with cervical neoplasia: using human papillomavirus DNA testing for equivocal Papanicolaou results. KAİSER study. JAMA. 1999;281:1605-1031. Guido R, Schiffman M, Solomon D. Et al. ASCUS LSIL Triage Study (ALTS) Group. Postcolposcopy management strategies for women referred with low-grade squamous intraepithelial lesions or human papillomavirus DNA-positive atypical squamous cells of undetermined significance: a two-year prospective study. Am J Obstet Gynecol. 2003;188:1401-5.
There are 3 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Clinical Research
Authors

Murat Alan

Muhammet Ali Oruc This is me

Mustafa Kurt This is me

Yasemin Alan This is me

Muzaffer Sanci This is me

Publication Date December 25, 2019
Submission Date February 28, 2019
Acceptance Date October 31, 2019
Published in Issue Year 2019 Volume: 36 Issue: 2

Cite

APA Alan, M., Oruc, M. A., Kurt, M., Alan, Y., et al. (2019). Evaluation of colposcopy results for patients who are HPV DNA positive in KETEM. Journal of Experimental and Clinical Medicine, 36(2), 35-42.
AMA Alan M, Oruc MA, Kurt M, Alan Y, Sanci M. Evaluation of colposcopy results for patients who are HPV DNA positive in KETEM. J. Exp. Clin. Med. December 2019;36(2):35-42.
Chicago Alan, Murat, Muhammet Ali Oruc, Mustafa Kurt, Yasemin Alan, and Muzaffer Sanci. “Evaluation of Colposcopy Results for Patients Who Are HPV DNA Positive in KETEM”. Journal of Experimental and Clinical Medicine 36, no. 2 (December 2019): 35-42.
EndNote Alan M, Oruc MA, Kurt M, Alan Y, Sanci M (December 1, 2019) Evaluation of colposcopy results for patients who are HPV DNA positive in KETEM. Journal of Experimental and Clinical Medicine 36 2 35–42.
IEEE M. Alan, M. A. Oruc, M. Kurt, Y. Alan, and M. Sanci, “Evaluation of colposcopy results for patients who are HPV DNA positive in KETEM”, J. Exp. Clin. Med., vol. 36, no. 2, pp. 35–42, 2019.
ISNAD Alan, Murat et al. “Evaluation of Colposcopy Results for Patients Who Are HPV DNA Positive in KETEM”. Journal of Experimental and Clinical Medicine 36/2 (December 2019), 35-42.
JAMA Alan M, Oruc MA, Kurt M, Alan Y, Sanci M. Evaluation of colposcopy results for patients who are HPV DNA positive in KETEM. J. Exp. Clin. Med. 2019;36:35–42.
MLA Alan, Murat et al. “Evaluation of Colposcopy Results for Patients Who Are HPV DNA Positive in KETEM”. Journal of Experimental and Clinical Medicine, vol. 36, no. 2, 2019, pp. 35-42.
Vancouver Alan M, Oruc MA, Kurt M, Alan Y, Sanci M. Evaluation of colposcopy results for patients who are HPV DNA positive in KETEM. J. Exp. Clin. Med. 2019;36(2):35-42.