Research Article
BibTex RIS Cite

Bazı İlaç Kalıntılarının US ve US/H2O2 Prosesleri ile Giderimi

Year 2017, Volume:6 ICOCEE Special Issue, 371 - 379, 27.12.2017
https://doi.org/10.17100/nevbiltek.322699

Abstract

Klasik
atıksu arıtma tesisleri ilaçların tam ve etkin bir şekilde giderilmesi için
tasarlanmamıştır. Bu nedenle bazı ilaç kalıntıları su ortamlarına deşarj
edilebilir. İleri oksidasyon prosesleri bu kalıntıların giderilmesi için en çok
kullanılan yöntemlerdir. Bu çalışmanın amacı, ultrases (US) ve ultrases-H2O2
(US- H2O2) proseslerinin
Karbamazepin, (CBZ), Kafein(CAF) ve Parasetamol(PAR)
ilaç kalıntılarının giderimin deki performanslarını değerlendirmektir. US-H2O2
prosesi farklı H2O2 konsantrasyonların da uygulanmıştır. Stok
H2O2 çözeltisi ultrasonik su banyosuna ilaç çözeltileri
yerleştirilmeden önce ilave edilmiştir. US-H2O2 prosesinde
1, 3, 5 ve 7 mg/L H2O2 konsantrasyonlarında
çalışılmıştır. Bu uygulamada amaç US-H2O2 prosesi için
optimum H2O2 konsantrasyonun belirlenmesidir. Tüm
çalışmalar 53 kHz frekansında ve 90W elektriksel güçteki ultrasonik su
banyosunda gerçekleştirilmiştir. Proses süresi 60 dakikadır. Her bir ilaç için
giriş ve çıkış konsantrasyonları LC-MS/MS ile ölçülmüştür. Elde edilen deneysel
sonuçlar göstermiştir ki ultrases tek başına kullanıldığında, CBZ, CAF ve PAR
ilaç kalıntılarının giderimin de yeterli olamamıştır. Ancak,  US-H2O2 prosesi 7 mg/L
H2O2 konsantrasyonunda, 60 dakikalık proses süresi
sonunda sırasıyla CBZ için 33%, CAF için 25%, PAR için 31% giderim sağlamıştır.
US-H2O2 prosesin de H2O2 konsantrasyonundaki
artış tüm ilaç giderimlerini olumlu yönde etkilemiştir ve bu çalışma
göstermiştir ki H2O2 konsantrasyonu bu proses için önemli
bir işletme koşuludur.

References

  • Kümmerer K., Al-Ahmad, A., “Biodegradability of the anti-tumour agents 5-fluorouracil, cytarabine and gemcitabine: impact of the chemical structure and synergistic toxicity with hospital effluent” Acta Hydrochimica et Hydrobiologica, 25, 166-172, 1999
  • Kümmerer K., “Drugs in the environment: emmisions of drugs, diagnostic aids and disinfectans into wastewater by hospitals in relation to other sources: A review” Chemosphere, 45, 957-969, 2001
  • Roefer P., Synder S., Zegers R.E., Rexing D.J., Frank, J.L., “Endocrine –Disrupting Chemicals in a Source Water” Journal of AWWA, 92(8), 52-58, 2000
  • USEPA, (U.S. Environmental Protection Agency). “Endocrine disrupter screening and testing advisory committee (EDSTAC) final report” 1998
  • Loraine, G.A. ve Glaze, W.H., “Destruction of vapour phase halogenated methanes by means of ultraviolet photolysis” 47th. Purdue Industrial Waste Conference Proceedings, Lewis Publishers, Inc. Chelsea, Michigan, 367-376, USA, 1992
  • Zepp R.G., Hoigne J., Bader H., “Nitrate-Induced Photooxidation of Trace Organic Chemicals in Water” Environ. Sci. Technol., 21, 443-450,1987
  • Gogate P. R., Pandit A.B., “A Rewiev of Imperative Technologies for Wastewater Treatment I: Oxidation Technologies at Ambient Conditions” Advances in Environmental Research, 8, 501-551, 2004
  • Thompson L.H., Doraiswamy L.K., “Sonochemistry: Science and Engineering. Industrial and Engineering Chemistry Research” 38, 1215-1249, 1999
  • Heberer T., “Tracking persistent pharmaceutical residues from municipal sewage to drinking water” Journal of Hydrology, 266, 175–189, 2002
  • Viglino L., Aboulfadl K., Daneshvar Mahvelat A., Prévost M., Sauvé, S., “On-line solid phase extraction and liquid chromatography/tandem mass spectrometry to quantify pharmaceuticals, pesticides and some metabolites in wastewaters, drinking, and surface waters” Journal of Environmental Monitoring, 10, 482–489, 2008
  • Conkle J.L., White J.R., Metcalfe, C.D., “Reduction of pharmaceutically active compounds by a lagoon wetland wastewater treatment system in Southeast Louisiana” Chemosphere, 73, 1741–1748, 2009
  • Tang-Liu D.D., William R.L., Riegelman, S., “Disposition of Caffeine and its metabolites in man. Journal of Pharmacology and Experimental Therapeutics” 224, 180–185, 1983
  • Buerge I.J., Poiger T., Müller, M.D., Buser, H.R., “Caffeine, an anthropogenic marker for wastewater contamination of surface waters” Environmental Science and Technology, 37, 691–700, 2003
  • De Luna M.D.G., Veciana M.L., Su C-C., Lu M-C., “Acetaminophen degradation by electro-Fenton and photoelectro-Fenton using a double cathode electrochemical cell” Journal of Hazardous Materials, 217–218, 200–207, 2012
  • IsariebelQ.O., Carine J.L., Ulises-Javier J.H., Anne-Marine W., Henri D., “Sonolysis of levodopa and paracetamol in aqueous solutions,” Ultrason. Sonochem., 16, 610-616, 2009
  • Arredondo Valdez H.C., García Jiménez G., Gutiérrez Granados S., Ponce de León C., “Degradation of paracetamol by advance oxidation processes using modified reticulated vitreous carbon electrodes with TiO2 and CuO/TiO2/Al2O3” Chemosphere, 89, 1195–1201, 2012
  • Bedner M., Maccrehan W., “Transformation of acetaminophen by chlorination produces the toxicants 1,4-benzoquinone and N-acetly-p-benzoquinone imine” Environ. Sci. Technol., 40, 516-522, 2006
  • Tran N., Patrick D., Zaviska F., Brar S.K., “Sonochemical deradation of the persistent pharmaceutical carbamazepine” Journal of Environmental Management, 131,25-32, 2013
  • Naddeo V., Meriç S., Kassnos D., Belgiorno V., Guida M., “Fate of pharmaceuticals in contaminated urban waste water effluent under ultrasonic irradiation” Science Direct, 43, 4019-4027, 2009
  • Villaroel E., Silva-Agredo J., Petrier J., Taborda G., Torres-Palma R.A., “ Ultrasonic degradation of acetaminophen in water: Effect of sonochemical parameters and water matrix” Ultrasonics Sonochemistry, 21, 1763-1769,2014
  • Méndez-Arriaga F., Torres-Palma R.A., Peitrier C., Espulgas S., Gimenez J., Pulgarin, C., “Ultrasonic treatment of water contaminated with ibuprofen” Water Res., 42, 4243-4248, 2008

Removal of Some Pharmaceutical Residues by US and US/H2O2 Processes

Year 2017, Volume:6 ICOCEE Special Issue, 371 - 379, 27.12.2017
https://doi.org/10.17100/nevbiltek.322699

Abstract

Conventional sewage
treatment plants are not specifically designed for the efficient and complete
removal of pharmaceuticals. Eventually, some pharmaceutical residues may
discharge into the aquatic environment. Advanced oxidation processes are the
most commonly used methods for the removal of these residues. The aim of this
study was to evaluate the performance of ultrasonic(US) and ultrasonic-H2O2
processes on the removal of Carbamazepine(CBZ), Caffeine(CAF) and
Paracetamol(PAR). The US-H2O2 process was applied at
different H2O2 concentrations. The H2O2
stock solution was added to the pharmaceutical solutions before being placed in
the ultrasonic sound bath. The US/H2O2 process was
studied at 1, 3, 5 and 7 mg/L H2O2 concentrations. This
application is aimed to determine the optimal H2O2 concentration
for US-H2O2 process. All studies were carried out in
ultrasonic water bath which was operated at fixed 53 kHz frequency and 90 W
electrical power. The process time was set to 60 minutes. The inlet and outlet
concentrations for each pharmaceutical were measured by LC-MS/MS instrument. The
finding of experimental results show that US is not sufficiently effective for
the removal of CBZ, CAF and PAR residues. On the other hand, the US-H2O2
process was investigated. Approximately 33%, 25% and 31% removal
efficiencies were observed with 7 mg/L H2O2 concentration
for CBZ, CAF and PAR at the end of 60 minutes, respectively. The increase in
concentration of H2O2 affects positively the removal for
each pharmaceutical residue in US-H2O2 process. This
study has shown that H2O2 concentration is an important
operating condition for this process.

References

  • Kümmerer K., Al-Ahmad, A., “Biodegradability of the anti-tumour agents 5-fluorouracil, cytarabine and gemcitabine: impact of the chemical structure and synergistic toxicity with hospital effluent” Acta Hydrochimica et Hydrobiologica, 25, 166-172, 1999
  • Kümmerer K., “Drugs in the environment: emmisions of drugs, diagnostic aids and disinfectans into wastewater by hospitals in relation to other sources: A review” Chemosphere, 45, 957-969, 2001
  • Roefer P., Synder S., Zegers R.E., Rexing D.J., Frank, J.L., “Endocrine –Disrupting Chemicals in a Source Water” Journal of AWWA, 92(8), 52-58, 2000
  • USEPA, (U.S. Environmental Protection Agency). “Endocrine disrupter screening and testing advisory committee (EDSTAC) final report” 1998
  • Loraine, G.A. ve Glaze, W.H., “Destruction of vapour phase halogenated methanes by means of ultraviolet photolysis” 47th. Purdue Industrial Waste Conference Proceedings, Lewis Publishers, Inc. Chelsea, Michigan, 367-376, USA, 1992
  • Zepp R.G., Hoigne J., Bader H., “Nitrate-Induced Photooxidation of Trace Organic Chemicals in Water” Environ. Sci. Technol., 21, 443-450,1987
  • Gogate P. R., Pandit A.B., “A Rewiev of Imperative Technologies for Wastewater Treatment I: Oxidation Technologies at Ambient Conditions” Advances in Environmental Research, 8, 501-551, 2004
  • Thompson L.H., Doraiswamy L.K., “Sonochemistry: Science and Engineering. Industrial and Engineering Chemistry Research” 38, 1215-1249, 1999
  • Heberer T., “Tracking persistent pharmaceutical residues from municipal sewage to drinking water” Journal of Hydrology, 266, 175–189, 2002
  • Viglino L., Aboulfadl K., Daneshvar Mahvelat A., Prévost M., Sauvé, S., “On-line solid phase extraction and liquid chromatography/tandem mass spectrometry to quantify pharmaceuticals, pesticides and some metabolites in wastewaters, drinking, and surface waters” Journal of Environmental Monitoring, 10, 482–489, 2008
  • Conkle J.L., White J.R., Metcalfe, C.D., “Reduction of pharmaceutically active compounds by a lagoon wetland wastewater treatment system in Southeast Louisiana” Chemosphere, 73, 1741–1748, 2009
  • Tang-Liu D.D., William R.L., Riegelman, S., “Disposition of Caffeine and its metabolites in man. Journal of Pharmacology and Experimental Therapeutics” 224, 180–185, 1983
  • Buerge I.J., Poiger T., Müller, M.D., Buser, H.R., “Caffeine, an anthropogenic marker for wastewater contamination of surface waters” Environmental Science and Technology, 37, 691–700, 2003
  • De Luna M.D.G., Veciana M.L., Su C-C., Lu M-C., “Acetaminophen degradation by electro-Fenton and photoelectro-Fenton using a double cathode electrochemical cell” Journal of Hazardous Materials, 217–218, 200–207, 2012
  • IsariebelQ.O., Carine J.L., Ulises-Javier J.H., Anne-Marine W., Henri D., “Sonolysis of levodopa and paracetamol in aqueous solutions,” Ultrason. Sonochem., 16, 610-616, 2009
  • Arredondo Valdez H.C., García Jiménez G., Gutiérrez Granados S., Ponce de León C., “Degradation of paracetamol by advance oxidation processes using modified reticulated vitreous carbon electrodes with TiO2 and CuO/TiO2/Al2O3” Chemosphere, 89, 1195–1201, 2012
  • Bedner M., Maccrehan W., “Transformation of acetaminophen by chlorination produces the toxicants 1,4-benzoquinone and N-acetly-p-benzoquinone imine” Environ. Sci. Technol., 40, 516-522, 2006
  • Tran N., Patrick D., Zaviska F., Brar S.K., “Sonochemical deradation of the persistent pharmaceutical carbamazepine” Journal of Environmental Management, 131,25-32, 2013
  • Naddeo V., Meriç S., Kassnos D., Belgiorno V., Guida M., “Fate of pharmaceuticals in contaminated urban waste water effluent under ultrasonic irradiation” Science Direct, 43, 4019-4027, 2009
  • Villaroel E., Silva-Agredo J., Petrier J., Taborda G., Torres-Palma R.A., “ Ultrasonic degradation of acetaminophen in water: Effect of sonochemical parameters and water matrix” Ultrasonics Sonochemistry, 21, 1763-1769,2014
  • Méndez-Arriaga F., Torres-Palma R.A., Peitrier C., Espulgas S., Gimenez J., Pulgarin, C., “Ultrasonic treatment of water contaminated with ibuprofen” Water Res., 42, 4243-4248, 2008
There are 21 citations in total.

Details

Subjects Engineering
Journal Section ICOCEE 2017 (International Conference on Civil and Environmental Engineering) Özel Sayısı
Authors

Gamze Sönmez

Mustafa Işık

Publication Date December 27, 2017
Acceptance Date November 10, 2017
Published in Issue Year 2017 Volume:6 ICOCEE Special Issue

Cite

APA Sönmez, G., & Işık, M. (2017). Bazı İlaç Kalıntılarının US ve US/H2O2 Prosesleri ile Giderimi. Nevşehir Bilim Ve Teknoloji Dergisi, 6, 371-379. https://doi.org/10.17100/nevbiltek.322699
AMA Sönmez G, Işık M. Bazı İlaç Kalıntılarının US ve US/H2O2 Prosesleri ile Giderimi. Nevşehir Bilim ve Teknoloji Dergisi. December 2017;6:371-379. doi:10.17100/nevbiltek.322699
Chicago Sönmez, Gamze, and Mustafa Işık. “Bazı İlaç Kalıntılarının US Ve US/H2O2 Prosesleri Ile Giderimi”. Nevşehir Bilim Ve Teknoloji Dergisi 6, December (December 2017): 371-79. https://doi.org/10.17100/nevbiltek.322699.
EndNote Sönmez G, Işık M (December 1, 2017) Bazı İlaç Kalıntılarının US ve US/H2O2 Prosesleri ile Giderimi. Nevşehir Bilim ve Teknoloji Dergisi 6 371–379.
IEEE G. Sönmez and M. Işık, “Bazı İlaç Kalıntılarının US ve US/H2O2 Prosesleri ile Giderimi”, Nevşehir Bilim ve Teknoloji Dergisi, vol. 6, pp. 371–379, 2017, doi: 10.17100/nevbiltek.322699.
ISNAD Sönmez, Gamze - Işık, Mustafa. “Bazı İlaç Kalıntılarının US Ve US/H2O2 Prosesleri Ile Giderimi”. Nevşehir Bilim ve Teknoloji Dergisi 6 (December 2017), 371-379. https://doi.org/10.17100/nevbiltek.322699.
JAMA Sönmez G, Işık M. Bazı İlaç Kalıntılarının US ve US/H2O2 Prosesleri ile Giderimi. Nevşehir Bilim ve Teknoloji Dergisi. 2017;6:371–379.
MLA Sönmez, Gamze and Mustafa Işık. “Bazı İlaç Kalıntılarının US Ve US/H2O2 Prosesleri Ile Giderimi”. Nevşehir Bilim Ve Teknoloji Dergisi, vol. 6, 2017, pp. 371-9, doi:10.17100/nevbiltek.322699.
Vancouver Sönmez G, Işık M. Bazı İlaç Kalıntılarının US ve US/H2O2 Prosesleri ile Giderimi. Nevşehir Bilim ve Teknoloji Dergisi. 2017;6:371-9.

Dergimizin tarandığı indeksler


12300          20980     2097822081