Abstract
Transcranial Magnetic Stimulation (rTMS) non-invasively modulates brain networks via stimulating relevant brain regions responsible for motor and cognitive functions. However, replicating human and animal data suggests the therapeutic role of repetitive transcranial magnetic stimulation (rTMS) in many neurological diseases. In this letter, we evaluate the role of rTMS on the network neuroplasticity and neuroprotective pathways, including especially the Brain-Derived Neurotrophic Factor (BDNF), which mediates the pro-cognitive and neuroprotective effects of rTMs, suggesting that rTMS is a potential neuroprotective and pro-cognitive therapy.
Keywords
Transcranial Magnetic Stimulation Neuroprotection Neurological Diseases Neuroplasticity BDNF Alzheimer’Disease Parkinson’s Disease
References
- 1-Eschweiler G.W. (2003) Entwicklung der transkraniellen Magnetstimulation (TMS). In: Eschweiler G.W., Wild B., Bartels M. (eds) Elektromagnetische Therapien in der Psychiatrie. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57370-5_16
- 2- Yulug B. Neuroprotective treatment strategies for poststroke mood disorders: A minireview on atypical neuroleptic drugs and selective serotonin re-uptake inhibitors. Brain Res Bull. 2009 Sep 28;80(3):95-9. doi: 10.1016/j.brainresbull.2009.06.013. Epub 2009 Jul 1. PMID: 19576272.
- 3- Caglayan B, Kilic E, Dalay A, et al. Allyl isothiocyanate attenuates oxidative stress and inflammation by modulating Nrf2/HO-1 and NF-κB pathways in traumatic brain injury in mice. Mol Biol Rep. 2019;46(1):241-250. doi:10.1007/s11033-018-4465-4
- 4-Lapchak, Paul A., and John H. Zhang, eds. Neuroprotective therapy for stroke and ischemic disease. Switzerland: Springer International Publishing, 2017. doi:10.1007/978-3-319-45345-3
- 5- Hanoglu L, Velioglu HA, Hanoglu T, Yulug B. Neuroimaging-Guided Transcranial Magnetic and Direct Current Stimulation in MCI: Toward an Individual, Effective and Disease-Modifying Treatment [published online ahead of print, 2021 Nov 9]. Clin EEG Neurosci. 2021;15500594211052815. doi:10.1177/15500594211052815
- 6- Yulug B, Hanoglu L, Tavli AM, Yılmaz NH, Kılıc E. The Brain Protective Effect of rTMS (Repetitive Transcranial Magnetic Stimulation) in Depression: A Mini-Review in Animal Studies. Med Chem. 2016;12(6):500-505. doi:10.2174/1573406411666151005110321
- 7-Yuluğ B, Ozan E, Kilic E. Brain-derived neurotrophic factor polymorphism as a genetic risk for depression? A short review of the literature. J Neuropsychiatry Clin Neurosci. 2010 Winter;22(1):123.E5-6. doi: 10.1176/jnp.2010.22.1.123.e5
- 8- Yulug B, Hanoglu L, Khanmammadov E, et al. Beyond The Therapeutic Effect of rTMS in Alzheimer's Disease: A Possible Neuroprotective Role of Hippocampal BDNF? : A Minireview. Mini Rev Med Chem. 2018;18(17):1479-1485. doi:10.2174/1389557517666170927162537
- 9. Velioglu HA, Hanoglu L, Bayraktaroglu Z, et al. Left lateral parietal rTMS improves cognition and modulates resting brain connectivity in patients with Alzheimer's disease: Possible role of BDNF and oxidative stress. Neurobiol Learn Mem. 2021;180:107410. doi:10.1016/j.nlm.2021.107410
- 10. Saricaoglu M, Hanoglu L, Toprak G, Yilmaz NH, Yulug B. The Multifactorial Role of Pre-supplementary Motor Area Stimulation in the Freezing of Gait: An Alternative Strategy to the Classical Drug-Target Approach [published online ahead of print, 2021 Oct 14]. Endocr Metab Immune Disord Drug Targets. 2021;10.2174/1871530321666211014170107. doi:10.2174/1871530321666211014170107
Abstract
Transkraniyal Manyetik Stimülasyon (rTMS), motor ve bilişsel işlevlerden sorumlu ilgili beyin bölgelerini uyararak beyin ağlarını non-invaziv olarak modüle eder. Bununla birlikte, insan ve hayvan verilerinin kopyalanması, birçok nörolojik hastalıkta tekrarlayan transkraniyal manyetik stimülasyonun (rTMS) terapötik rolünü ortaya koymaktadır. Bu yazıda, özellikle rTM'lerin bilişsel ve nöroprotektif etkilerine aracılık eden Beyinden Türetilmiş Nörotrofik Faktör (BDNF) dahil olmak üzere, rTMS'nin ağ nöroplastisitesi ve nöroprotektif yolaklar üzerindeki rolünü gözden geçirdik. BDNF rTM'lerin bilişsel ve nöroprotektif etkileri, rTMS'nin potansiyel bir nöroprotektif ve pro-bilişsel terapi olduğunu düşündürmektedir.
Keywords
Transkraniyal Manyetik Uyarım Nöroproteksiyon; Nörolojik Hastalıklar Nöroplastisite; BDNF Alzheimer hastalığı Parkinson hastalığı
References
- 1-Eschweiler G.W. (2003) Entwicklung der transkraniellen Magnetstimulation (TMS). In: Eschweiler G.W., Wild B., Bartels M. (eds) Elektromagnetische Therapien in der Psychiatrie. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57370-5_16
- 2- Yulug B. Neuroprotective treatment strategies for poststroke mood disorders: A minireview on atypical neuroleptic drugs and selective serotonin re-uptake inhibitors. Brain Res Bull. 2009 Sep 28;80(3):95-9. doi: 10.1016/j.brainresbull.2009.06.013. Epub 2009 Jul 1. PMID: 19576272.
- 3- Caglayan B, Kilic E, Dalay A, et al. Allyl isothiocyanate attenuates oxidative stress and inflammation by modulating Nrf2/HO-1 and NF-κB pathways in traumatic brain injury in mice. Mol Biol Rep. 2019;46(1):241-250. doi:10.1007/s11033-018-4465-4
- 4-Lapchak, Paul A., and John H. Zhang, eds. Neuroprotective therapy for stroke and ischemic disease. Switzerland: Springer International Publishing, 2017. doi:10.1007/978-3-319-45345-3
- 5- Hanoglu L, Velioglu HA, Hanoglu T, Yulug B. Neuroimaging-Guided Transcranial Magnetic and Direct Current Stimulation in MCI: Toward an Individual, Effective and Disease-Modifying Treatment [published online ahead of print, 2021 Nov 9]. Clin EEG Neurosci. 2021;15500594211052815. doi:10.1177/15500594211052815
- 6- Yulug B, Hanoglu L, Tavli AM, Yılmaz NH, Kılıc E. The Brain Protective Effect of rTMS (Repetitive Transcranial Magnetic Stimulation) in Depression: A Mini-Review in Animal Studies. Med Chem. 2016;12(6):500-505. doi:10.2174/1573406411666151005110321
- 7-Yuluğ B, Ozan E, Kilic E. Brain-derived neurotrophic factor polymorphism as a genetic risk for depression? A short review of the literature. J Neuropsychiatry Clin Neurosci. 2010 Winter;22(1):123.E5-6. doi: 10.1176/jnp.2010.22.1.123.e5
- 8- Yulug B, Hanoglu L, Khanmammadov E, et al. Beyond The Therapeutic Effect of rTMS in Alzheimer's Disease: A Possible Neuroprotective Role of Hippocampal BDNF? : A Minireview. Mini Rev Med Chem. 2018;18(17):1479-1485. doi:10.2174/1389557517666170927162537
- 9. Velioglu HA, Hanoglu L, Bayraktaroglu Z, et al. Left lateral parietal rTMS improves cognition and modulates resting brain connectivity in patients with Alzheimer's disease: Possible role of BDNF and oxidative stress. Neurobiol Learn Mem. 2021;180:107410. doi:10.1016/j.nlm.2021.107410
- 10. Saricaoglu M, Hanoglu L, Toprak G, Yilmaz NH, Yulug B. The Multifactorial Role of Pre-supplementary Motor Area Stimulation in the Freezing of Gait: An Alternative Strategy to the Classical Drug-Target Approach [published online ahead of print, 2021 Oct 14]. Endocr Metab Immune Disord Drug Targets. 2021;10.2174/1871530321666211014170107. doi:10.2174/1871530321666211014170107
Details
| Primary Language | English |
|---|---|
| Subjects | Internal Diseases |
| Journal Section | Editorial |
| Authors | |
| Publication Date | December 31, 2021 |
| Submission Date | December 12, 2021 |
| Acceptance Date | December 18, 2021 |
| Published in Issue | Year 2021 Volume: 5 Issue: 3 |
This Journal is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.