Dokuz Eylül Üniversitesi Bilimsel Araştırmalar Koordinatörlüğü
2020.KB.SAG.039
Standard treatment for colorectal cancer includes surgery, radiotherapy, and chemotherapy. Conventional chemotherapeutic agents used in colorectal cancer such as 5-fluorouracil, capecitabine which is oral form of 5-fluorouracil, irinotecan, and oxaliplatin. One of the major challenges in chemotherapy considered as drug resistance. Drug resistance occurs in many different mechanisms such as alteration in tumor microenvironment, growth kinetics, genetic variations, and tumor heterogeneity. These cytotoxic agents are used in combination form to overcome drug resistance on colorectal cancer. They can also be used in combination with cytotoxic agents as bevacizumab and cetuximab. Combination therapy depends on tumor burden, type, stage, and molecular characteristics. It is crucial to choose the combination therapy to be applied by taking these factors into consideration. In this review, current drug resistance mechanisms were discussed and then mechanisms of conventional chemotherapy related resistance were explained.
2020.KB.SAG.039
Primary Language | English |
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Subjects | Health Care Administration |
Journal Section | Reviews |
Authors | |
Project Number | 2020.KB.SAG.039 |
Publication Date | February 26, 2021 |
Submission Date | January 7, 2021 |
Published in Issue | Year 2021 Volume: 5 Issue: 1 |