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Effects of Phytotheraphy in Diabetes Mellitus

Year 2023, Volume: 8 Issue: 3, 265 - 272, 30.09.2023
https://doi.org/10.35229/jaes.1284154

Abstract

Diabetes mellitus (DM) is a chronic disease characterized by a persistent increase in blood glucose levels, causing various metabolic disorders. There are 2 main types of diabetes: Diabetes Mellitus Type 1 (insulin-dependent) and Diabetes Mellitus Type 2 (insulin-independent). Type 1 DM results from the inability to produce insulin as a result of epigenetic (autoimmunity / mutation) or acquired destruction of the β cells of the pancreas. T2DM is characterized by a prolonged increase in blood glucose levels due to a defect in insulin secretion or the insulin receptor. If diabetes is not treated well, it can affect various organs such as the heart, blood vessels, kidneys, brain and eyes, leading to various life-threatening complications and even death. Since there is no complete treatment for the disease, the applications are aimed at keeping blood glucose levels under control. However, the drugs applied may have different side effects. With this situation, medicinal plants with antihypoglycemic and antidiabetic potential have been used as supplements in diabetes. The aim of supportive treatment is to increase the effect of medical treatment, to reduce the effects of complications due to DM, and to increase the living standards of patients. The aim of this review is to compile the mechanisms of action of phytotherapeutic agents obtained from various medicinal plants on experimental animals and cell lines for which diabetes models were created.

References

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Diyabetes Mellitusta Fitoterapinin Etkisi

Year 2023, Volume: 8 Issue: 3, 265 - 272, 30.09.2023
https://doi.org/10.35229/jaes.1284154

Abstract

Diabetes mellitus (DM), kan glukoz seviyesinde kalıcı bir artışla karakterize, çeşitli metabolik bozukluğa neden olan kronik bir hastalıktır. Diyabetes Mellitus Tip 1(insüline bağımlı) ve Diyabetes Mellitus Tip 2 (insülinden bağımsız) olmak üzere 2 ana diyabet tipi bulunmaktadır. Tip 1 DM, pankreasın β hücrelerinin epigenetik (otoimmünite / mutasyon) veya edinsel olarak yok olması sonucunda insülin üretilememesinden kaynaklanmaktadır. T2DM, insülin sekresyonundaki veya insülin reseptöründeki defekt nedeniyle kan şekeri seviyesinde uzun süreli artış ile karakterizedir. Diyabet iyi tedavi edilmezse kalp, damar, böbrek, beyin, göz gibi çeşitli organları etkileyerek yaşamı tehdit eden çeşitli komplikasyonlara hatta ölüme yol açabilmektedir. Hastalığın tam bir tedavisi bulunmamakla yapılan uygulamalar kan glukoz seviyesini kontrol altında tutmaya yöneliktir. Ancak uygulanan ilaçların farklı yan etkileri bulunabilmektedir. Bu durumla beraber antihipoglisemik ve antidiyabetik potansiyeli olan medikal bitkiler diyabette destekleyici olarak kullanılmaya başlanmıştır. Destekleyici tedavinin amacı ise uygulanan medikal tedavinin etkisini artırmak, DM’ye bağlı oluşan komplikasyonların etkisini azaltmak ve hastaların yaşam standartlarını yükseltmektir. Bu derlemenin amacı, çeşitli medikal bitkilerden elde edilen fitoterapik ajanların diyabet modeli oluşturulan deney hayvanları ve hücre hatları üzerinde etki mekanizmalarının derlenmesidir.

References

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  • Adeniyi, A., Asase, A., Ekpe, P., Asitoakor, B. K., Adu- Gyamfi, A., Avekor, P. Y. (2018). Ethnobotanical study of medicinal plants from Ghana; confirmation of ethnobotanical uses, and review of biological and toxicological studies on medicinal plants used in Apra Hills Sacred Grove. Journal of Herbal Medicine. DOI: 10.1016/j.hermed.2018.02.001
  • Afshari, A.T., Shirpoor, A., Farshid, A., Saadatian, R., Rasmi, Y., Saboory, E., Ilkhanizadeh, B. & Allameh, A. (2007). The effect of ginger on diabetic nephropathy, plasma antioxidant capacity and lipid peroxidation in rats. Food Chemistry, 101(1), 148-153. DOI: 10.1016/j.foodchem.2006.01.013
  • Aniszewski, T. (2015). Alkaloids: Chemistry, Biology, Ecology, and Applications: Second Edition.
  • Arruda, D.C., Miguel, D.C., Yokoyama-Yasunaka, J.K.U., Katzin, A.M., Uliana, S.R.B. (2009). Inhibitory activity of limonene against Leishmania parasites in vitro and in vivo. Biomedicine & pharmacotherapy, 63(9), 643- 649. DOI: 10.1016/j.biopha.2009.02.004
  • Atkinson, M.A., Eisenbarth, G.S. & Michels, A.W. (2014). Type 1 diabetes. The Lancet, 383(9911), 69-82.
  • Bacanlı, M., Aydın, S., Anlar, H., Çal Doğan, T., Ari, N., Bucurgat, Ü., Başaran, A., Basaran, N.(2018). Can ursolic acid be beneficial against diabetes in rats? Turkish Journal of Biochemistry, 43. DO: 10.1515/tjb-2017-0289
  • Bharti, S., Rani, N., Krishnamurthy, B. & Arya, D.S. (2014). Preclinical evidence for the pharmacological actions of naringin: a review. Planta Med, 80(6), 437-451. DOI: 10.1055/s- 0034-1368351
  • Bishayee, A., Barnes, K.F., Bhatia, D., Darvesh, A.S. & Carroll, R.T. (2010). Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis. Cancer Prev Res (Phila), 3(6), 753-763. DOI: 10.1158/1940-6207.Capr-09- 0171
  • Chang, W., Li, K., Guan, F., Yao, F., Yu, Y., Zhang, M. & Hatch, G.M., Chen, L. (2016). Berberine Pretreatment Confers Cardioprotection Against Ischemia-Reperfusion Injury in a Rat Model of Type 2 Diabetes. J Cardiovasc Pharmacol Ther, 21(5), 486-494. DOI: 10.1177/1074248415627873
  • Chawla, A., Chawla, R. & Jaggi, S. (2016). Microvasular and macrovascular complications in diabetes mellitus: Distinct or continuum? Indian J Endocrinol Metab, 20(4), 546-551. DOI: 10.4103/2230-8210.183480
  • Dar, A., Faizi, S., Naqvi, S., Roome, T., Zikr-ur- Rehman, S., Ali, M., Firdous, S. & Moin, S.T. (2005). Analgesic and antioxidant activity of mangiferin and its derivatives: the structure activity relationship. Biol Pharm Bull, 28(4), 596- 600. DOI: 10.1248/bpb.28.596
  • Del Toro-Arreola, S., Flores-Torales, E., Torres- Lozano, C., Del Toro-Arreola, A., Tostado- Pelayo, K., Guadalupe Ramirez-Dueñas, M. & Daneri-Navarro, A. (2005). Effect of D- limonene on immune response in BALB/c mice with lymphoma. Int Immunopharmacol, 5(5), 829-838. DOI: 10.1016/j.intimp.2004.12.012
  • Dong, Y., Chen, Y.T., Yang, Y.X., Zhou, X.J., Dai, S.J., Tong, J.F., Shou, D. & Li, C. (2016). Metabolomics Study of Type 2 Diabetes Mellitus and the AntiDiabetic Effect of Berberine in Zucker Diabetic Fatty Rats Using Uplc-ESI- Hdms. Phytother Res, 30(5), 823-828. DOI: 10.1002/ptr.5587
  • Duraisami, R., Srinivasan, D. & Ramaswamy, S. (2009). Anticonvulsant activity of bioflavonoid gossypin. Bangladesh Journal of Pharmacology, 4. DOI: 10.3329/bjp.v4i1.1081
  • Ekar, T., Kreft, S. (2019). Common risks of adulterated and mislabeled herbal preparations. Food Chem Toxicol, 123, 288-297. DOI: 10.1016/j.fct.2018.10.043
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Details

Primary Language Turkish
Journal Section Articles
Authors

Muhammed Taha Kaya 0000-0003-2744-4763

Tolga Güvenç 0000-0003-1468-3415

Early Pub Date September 15, 2023
Publication Date September 30, 2023
Submission Date April 16, 2023
Acceptance Date July 28, 2023
Published in Issue Year 2023 Volume: 8 Issue: 3

Cite

APA Kaya, M. T., & Güvenç, T. (2023). Diyabetes Mellitusta Fitoterapinin Etkisi. Journal of Anatolian Environmental and Animal Sciences, 8(3), 265-272. https://doi.org/10.35229/jaes.1284154


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