Research Article
Year 2017,
Volume: 4 Issue: 3, Special Issue 2, 512 - 516, 20.12.2017
Abstract
Natural products derived from plants play a significant role in drug discovery due to the revealing a large variety of pharmaceutical effects. Kickxia spuriawas collected from Bingol, Turkey. Aerial parts of the plant were boiled in water for 2 h then extracted with ethyl acetate. After evaporation of the solvent by rotary evaporator, the extract was subjected to column chromatography to yield the compound identified as 6,7-dimethoxy-5-hydroxyflavone by spectroscopic method including 1D-, 2D-NMR, LC-TOF/MS. Antiproliferative activity of isolated compound was tested against HeLa (human cervix carcinoma) cell lines by xCELLigence assay, and found out that the compound exhibited excellent activity.
Keywords
References
- Jhanwar, Y.S., & Divgi, C. (2005). Current status of therapy of solid tumors. Journal of Nuclear Medicine, 46(1): 141S-50S.
- Patel, D., Shukla, S., & Gupta, S. (2007). Apigenin and cancer chemoprevention: progress, potential and promise. International Journal of Oncology, 30(1): 233-45.
- Newman, D.J., Cragg, G.M., & Snader, K.M. (2003). Natural products as sources of new drugs over the period 1981-2002. Journal of Natural Products, 66(7): 1022-37.
- Newman, D.J., & Cragg, G.M. (2007). Natural products as sources of new drugs over the last 25 years. Journal of Natural Products, 70(3): 461-77.
- Davis, P.H. Flora of Turkey and The East Aegean Islands. University Press, Edinburgh (1978).
- Khan, I., & Aqil, M. (1993). Isolation and identification of pectolinarin and mannitol from Kickxia ramosissima (Wall). Chemical and Environmental Research, 2(3): 287-89.
- Amin, A., Tuenter, E., Foubert, K., Iqbal, J., Cos, P., Maes, L., et al. (2017). In vitro and in silico antidiabetic and antimicrobial evaluation of constituents from Kickxia ramosissima (Nanorrhinum ramosissimum). Frontiers in Pharmacology, 8: 1-12.
- Singh, M., & Prakash, L. (1987). A New Flavone Glycoside and Other Chemical-Constituents from Kickxia Ramosissima Wall - (Scrophulariaceae). Pharmazie, 42(7): 490-91.
- Al-Rehaily, A.J., Abdel-Kader, M.S., Ahmad, M.S., & Mossa, J.S. (2006). Iridoid glucosides from Kickxia abhaica D.A Sutton from Scrophulariaceae. Phytochemistry, 67(5): 429-32.
- Ghani, N.A., Ahmat, N., Ismail, N.H., & Zakaria, I. (2011). Flavonoid constituents from the stem bark of polyalthia cauliflora var. Cauliflora. Australian Journal of Basic and Applied Sciences, 5(8): 154-58.
- Erenler, R., Meral, B., Sen, O., Elmastas, M., Aydin, A., Eminagaoglu, O., et al. (2017). Bioassay-guided isolation, identification of compounds from Origanum rotundifolium and investigation of their antiproliferative and antioxidant activities. Pharmaceutical Biology, 55(1): 1646-53.
- Erenler, R., Sen, O., Aksit, H., Demirtas, I., Yaglioglu, A.S., Elmastas, M., et al. (2016). Isolation and identification of chemical constituents from Origanum majorana and investigation of antiproliferative and antioxidant activities. Journal of the Science of Food and Agriculture, 96(3): 822-36.
- Demirtas, I., Erenler, R., Elmastas, M., & Goktasoglu, A. (2013). Studies on the antioxidant potential of flavones of Allium vineale isolated from its water-soluble fraction. Food Chemistry, 136(1): 34-40.
- Elmastas, M., Erenler, R., Isnac, B., Aksit, H., Sen, O., Genc, N., et al. (2016). Isolation and identification of a new neo-clerodane diterpenoid from Teucrium chamaedrys L. Natural Product Research, 30(3): 299-304.
- Erenler, R., Yilmaz, S., Aksit, H., Sen, O., Genc, N., Elmastas, M., et al. (2014). Antioxidant Activities of Chemical Constituents Isolated from Echinops orientalis Trauv. Records of Natural Products, 8(1): 32-36.
- Erenler, R., Telci, I., Ulutas, M., Demirtas, I., Gul, F., Elmastas, M., et al. (2015). Chemical Constituents, Quantitative Analysis and Antioxidant Activities of Echinacea purpurea (L.) Moench and Echinacea pallida (Nutt.) Nutt. Journal of Food Biochemistry, 39(5): 622-30.
- Harborne, J.B., & Williams, C.A. (2000). Advances in flavonoid research since 1992. Phytochemistry, 55(6): 481-504.
- Harborne, J.B., & Williams, C.A. (1995). Anthocyanins and Other Flavonoids. Natural Product Reports, 12(6): 639-57.
- Nicolaou, K.C., Hepworth, D., King, N.P., & Finlay, M.R.V. (1999). Chemistry, biology and medicine of selected tubulin polymerizing agents. Pure and Applied Chemistry, 71(6): 989-97.
Year 2017,
Volume: 4 Issue: 3, Special Issue 2, 512 - 516, 20.12.2017
Abstract
Natural
products derived from plants play a significant role in drug discovery due to
the revealing a large variety of pharmaceutical effects. Kickxia spuriawas collected from Bingol, Turkey. Aerial parts of
the plant were boiled in water for 2 h then extracted with ethyl acetate. After
evaporation of the solvent by rotary evaporator, the extract was subjected to
column chromatography to yield the compound identified as 6,7-dimethoxy-5-hydroxyflavone by
spectroscopic method including 1D-, 2D-NMR, LC-TOF/MS. Antiproliferative
activity of isolated compound was tested against HeLa (human cervix carcinoma)
cell lines by xCELLigence assay, and found out that the compound exhibited
excellent activity.
Keywords
References
- Jhanwar, Y.S., & Divgi, C. (2005). Current status of therapy of solid tumors. Journal of Nuclear Medicine, 46(1): 141S-50S.
- Patel, D., Shukla, S., & Gupta, S. (2007). Apigenin and cancer chemoprevention: progress, potential and promise. International Journal of Oncology, 30(1): 233-45.
- Newman, D.J., Cragg, G.M., & Snader, K.M. (2003). Natural products as sources of new drugs over the period 1981-2002. Journal of Natural Products, 66(7): 1022-37.
- Newman, D.J., & Cragg, G.M. (2007). Natural products as sources of new drugs over the last 25 years. Journal of Natural Products, 70(3): 461-77.
- Davis, P.H. Flora of Turkey and The East Aegean Islands. University Press, Edinburgh (1978).
- Khan, I., & Aqil, M. (1993). Isolation and identification of pectolinarin and mannitol from Kickxia ramosissima (Wall). Chemical and Environmental Research, 2(3): 287-89.
- Amin, A., Tuenter, E., Foubert, K., Iqbal, J., Cos, P., Maes, L., et al. (2017). In vitro and in silico antidiabetic and antimicrobial evaluation of constituents from Kickxia ramosissima (Nanorrhinum ramosissimum). Frontiers in Pharmacology, 8: 1-12.
- Singh, M., & Prakash, L. (1987). A New Flavone Glycoside and Other Chemical-Constituents from Kickxia Ramosissima Wall - (Scrophulariaceae). Pharmazie, 42(7): 490-91.
- Al-Rehaily, A.J., Abdel-Kader, M.S., Ahmad, M.S., & Mossa, J.S. (2006). Iridoid glucosides from Kickxia abhaica D.A Sutton from Scrophulariaceae. Phytochemistry, 67(5): 429-32.
- Ghani, N.A., Ahmat, N., Ismail, N.H., & Zakaria, I. (2011). Flavonoid constituents from the stem bark of polyalthia cauliflora var. Cauliflora. Australian Journal of Basic and Applied Sciences, 5(8): 154-58.
- Erenler, R., Meral, B., Sen, O., Elmastas, M., Aydin, A., Eminagaoglu, O., et al. (2017). Bioassay-guided isolation, identification of compounds from Origanum rotundifolium and investigation of their antiproliferative and antioxidant activities. Pharmaceutical Biology, 55(1): 1646-53.
- Erenler, R., Sen, O., Aksit, H., Demirtas, I., Yaglioglu, A.S., Elmastas, M., et al. (2016). Isolation and identification of chemical constituents from Origanum majorana and investigation of antiproliferative and antioxidant activities. Journal of the Science of Food and Agriculture, 96(3): 822-36.
- Demirtas, I., Erenler, R., Elmastas, M., & Goktasoglu, A. (2013). Studies on the antioxidant potential of flavones of Allium vineale isolated from its water-soluble fraction. Food Chemistry, 136(1): 34-40.
- Elmastas, M., Erenler, R., Isnac, B., Aksit, H., Sen, O., Genc, N., et al. (2016). Isolation and identification of a new neo-clerodane diterpenoid from Teucrium chamaedrys L. Natural Product Research, 30(3): 299-304.
- Erenler, R., Yilmaz, S., Aksit, H., Sen, O., Genc, N., Elmastas, M., et al. (2014). Antioxidant Activities of Chemical Constituents Isolated from Echinops orientalis Trauv. Records of Natural Products, 8(1): 32-36.
- Erenler, R., Telci, I., Ulutas, M., Demirtas, I., Gul, F., Elmastas, M., et al. (2015). Chemical Constituents, Quantitative Analysis and Antioxidant Activities of Echinacea purpurea (L.) Moench and Echinacea pallida (Nutt.) Nutt. Journal of Food Biochemistry, 39(5): 622-30.
- Harborne, J.B., & Williams, C.A. (2000). Advances in flavonoid research since 1992. Phytochemistry, 55(6): 481-504.
- Harborne, J.B., & Williams, C.A. (1995). Anthocyanins and Other Flavonoids. Natural Product Reports, 12(6): 639-57.
- Nicolaou, K.C., Hepworth, D., King, N.P., & Finlay, M.R.V. (1999). Chemistry, biology and medicine of selected tubulin polymerizing agents. Pure and Applied Chemistry, 71(6): 989-97.
There are 19 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Structural Biology |
| Journal Section | Articles |
| Authors | |
| Publication Date | December 20, 2017 |
| Submission Date | May 4, 2017 |
| Published in Issue | Year 2017 Volume: 4 Issue: 3, Special Issue 2 |
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