Research Article
BibTex RIS Cite

Year 2022, Volume: 6 Issue: 2, 142 - 146, 31.12.2022

Ramazan Erenler Esma Nur Geçer Büşra Moran Bozer

https://doi.org/10.32571/ijct.1187754

Abstract

References

  • 1. Topçu, G.; Erenler, R.; Çakmak, O.; Johansson, C. B.; Çelik, C.; Chai, H.-B.; Pezzuto, J. M. Phytochemistry 1999, 50 (7), 1195-1199.
  • 2. Elmastas, M.; Ozturk, L.; Gokce, I.; Erenler, R.; Aboul-Enein, H. Y. Anal. Lett. 2004, 37 (9), 1859-1869.
  • 3. Demirtas, I.; Erenler, R.; Elmastas, M.; Goktasoglu, A. Food Chem. 2013, 136 (1), 34-40.
  • 4. Erenler, R.; Yilmaz, S.; Aksit, H.; Sen, O.; Genc, N.; Elmastas, M.; Demirtas, I. Rec. Nat. Prod. 2014, 8 (1), 32-36.
  • 5. Kaya, G.; Karakaya, R.; Tilgel, E.; Sandikci, M.; Yucel, E.; Cicek, G.; Kayir, O.; Aksit, H.; Telci, I.; Guzel, A. J. New Results Sci. 2014, 7 (7), 1-6.
  • 6. Türkmen, N.; Öz, A.; Sönmez, A.; Erol, T.; Gülümser, D.; Yurdakul, B.; Kayır, Ö.; Elmastas, M.; Erenler, R. J. New Results Sci. 2014, 6 (6), 27-31.
  • 7. Saidi, A.; Hambaba, L.; Kucuk, B.; Cacan, E.; Erenler, R. Curr. Bioact. Compd. 2022, 18 (3), 72-83.
  • 8. Koysu, P.; Genc, N.; Elmastas, M.; Aksit, H.; Erenler, R. Nat. Prod. Res. 2019, 33 (24), 3592-3595.
  • 9. Erenler, R.; Telci, I.; Ulutas, M.; Demirtas, I.; Gul, F.; Elmastas, M.; Kayir, O. J. Food Biochem. 2015, 39 (5), 622-630.
  • 10. Dede, E.; Genc, N.; Elmastas, M.; Aksit, H.; Erenler, R. Nat. Prod. J. 2019, 9 (3), 238-243.
  • 11. Erenler, R.; Nusret, G.; Elmastaş, M.; Eminağaoğlu, Ö. Turk. J. Biodiv. 2019, 2 (1), 13-17.
  • 12. Nusret, G.; Elmastas, M.; Telci, I.; Erenler, R. Int. J. Chem. Technol. 2020, 4 (2), 179-184.
  • 13. Aydin, A.; Erenler, R.; Yılmaz, B.; Tekin, Ş. J. Turk. Chem. Soc., Sec A: Chem 2016, 3 (3), 217-228.
  • 14. Elmastas, M.; Erenler, R.; Isnac, B.; Aksit, H.; Sen, O.; Genc, N.; Demirtas, I. Nat. Prod. Res. 2016, 30 (3), 299-304.
  • 15. Gecer, E. N. J. Inorg. Organomet. Polym. Mater. 2021, 31 (11), 4402-4409.
  • 16. Gecer, E. N.; Erenler, R.; Temiz, C.; Genc, N.; Yildiz, I. Particul. Sci. Technol. 2021, 40 (1), 50-57.
  • 17. Genc, N. Particul. Sci. Technol. 2021, 39 (5), 562-568.
  • 18. Genc, N.; Yildiz, I.; Chaoui, R.; Erenler, R.; Temiz, C.; Elmastas, M. Inorg. Nano-Met. Chem. 2021, 51 (3), 411-419.
  • 19. Burlacu, E.; Tanase, C.; Coman, N.-A.; Berta, L. Molecules 2019, 24 (23), 4354.
  • 20. de Souza, T. A. J.; Souza, L. R. R.; Franchi, L. P. Ecotox. Environ. Safe. 2019, 171, 691-700.
  • 21. El-Seedi, H. R.; El-Shabasy, R. M.; Khalifa, S. A.; Saeed, A.; Shah, A.; Shah, R.; Iftikhar, F. J.; Abdel-Daim, M. M.; Omri, A.; Hajrahand, N. H. RSC Adv. 2019, 9 (42), 24539-24559.
  • 22. Faraz, A.; Faizan, M.; Sami, F.; Siddiqui, H.; Pichtel, J.; Hayat, S. IET Nanobiotech. 2019, 13 (4), 345-352.
  • 23. Ökten, S.; Çakmak, O.; Erenler, R.; Yüce, Ö.; Tekin, S. Turk. J. Chem. 2013, 37 (6), 896-908.
  • 24. G Ravelo, A.; Estévez-Braun, A.; Chávez-Orellana, H.; Pérez-Sacau, E.; Mesa-Siverio, D. Curr. Top. Med. Chem. 2004, 4 (2), 241-265.
  • 25. Erenler, R.; Meral, B.; Sen, O.; Elmastas, M.; Aydin, A.; Eminagaoglu, O.; Topcu, G. Pharm. Biol. 2017, 55 (1), 1646-1653.
  • 26. Elmastas, M.; Celik, S. M.; Genc, N.; Aksit, H.; Erenler, R.; Gulcin, İ. Int. J. Food Prop. 2018, 21 (1), 374-384.
  • 27. Erenler, R.; Demirtas, I.; Karan, T.; Gul, F.; Kayir, O.; Karakoc, O. C. Trends Phytochem. Res. 2018, 2 (2), 91-96.
  • 28. Karan, T.; Simsek, S.; Yildiz, I.; Erenler, R. Int. J. Sec. Metabol. 2018, 5 (2), 87-93.
  • 29. Erenler, R.; Sen, O.; Aksit, H.; Demirtas, I.; Yaglioglu, A. S.; Elmastas, M.; Telci, İ. J. Sci. Food Agr. 2016, 96 (3), 822-836.
  • 30. Erenler, R.; Dag, B. Inorg. Nano-Met. Chem. 2022, 52 (4), 485-492.
  • 31. Sahin Yaglioglu, A.; Akdulum, B.; Erenler, R.; Demirtas, I.; Telci, I.; Tekin, S. Med. Chem. Res. 2013, 22 (6), 2946-2953.
  • 32. Erenler, R.; Pabuccu, K.; Yaglioglu, A. S.; Demirtas, I.; Gul, F. Z. Naturforsch. C 2016, 71 (3-4), 87-92.
  • 33. Erenler, R.; Sen, O.; Yaglioglu, A. S.; Demirtas, I. Comb. Chem. High. T. Scr. 2016, 19 (1), 66-72.
  • 34. Erenler, R.; Sen, O.; Yildiz, I.; Aydın, A. Rec. Nat. Prod. 2016, 10 (6), 766-770.
  • 35. Karan, T.; Erenler, R.; Bozer, B. M. Z. Naturforsch. C 2022.
  • 36. Hu, W.; Kavanagh, J. J. Lancet Oncol. 2003, 4 (12), 721-729.

Cytotoxic, apoptotic, and necrotic effects of silver nanoparticles biosynthesized using Origanum majorana extract

Year 2022, Volume: 6 Issue: 2, 142 - 146, 31.12.2022

Ramazan Erenler Esma Nur Geçer Büşra Moran Bozer

https://doi.org/10.32571/ijct.1187754

Abstract

application. Anticancer activity of Origanum majorana extract and silver nanoparticles was investigated by MTT assay using human pancreatic adenocarcinoma cell lines (Capan-1), mouse normal fibroblast cell lines (L929), and human colon adenocarcinoma cell line (Caco-2). AgNPs@Om exhibited the excellent cytotoxic effect on Capan-1 cell lines with the cell viability of 29.17% and 25.70%, 22.49%, 21.16% at 1.0, 0.5, 0.25, 0.125 μg/mL respectively. However, the extract was determined to show moderate activity. A considerable fall in the viable cell number in Caco-2 cell lines was observed after the treatment of AgNPs@Om. The viable cells of Caco-2 cell lines were detected as 32.0% at 1.0 μg/mL with the treatment of nanoparticles. Yet, the viable Caco-2 cells were determined as 48.2% with the treatment of O. majorana extract. Both extract and nanoparticles had no impact on the viability of non-tumor cells (L929). Moreover, nanoparticles induced apoptosis. Consequently, AgNPs@Om may be a promising anticancer drug candidate.

Keywords

Silver nanoparticles natural products Origanum majorana anticancer activity.

References

  • 1. Topçu, G.; Erenler, R.; Çakmak, O.; Johansson, C. B.; Çelik, C.; Chai, H.-B.; Pezzuto, J. M. Phytochemistry 1999, 50 (7), 1195-1199.
  • 2. Elmastas, M.; Ozturk, L.; Gokce, I.; Erenler, R.; Aboul-Enein, H. Y. Anal. Lett. 2004, 37 (9), 1859-1869.
  • 3. Demirtas, I.; Erenler, R.; Elmastas, M.; Goktasoglu, A. Food Chem. 2013, 136 (1), 34-40.
  • 4. Erenler, R.; Yilmaz, S.; Aksit, H.; Sen, O.; Genc, N.; Elmastas, M.; Demirtas, I. Rec. Nat. Prod. 2014, 8 (1), 32-36.
  • 5. Kaya, G.; Karakaya, R.; Tilgel, E.; Sandikci, M.; Yucel, E.; Cicek, G.; Kayir, O.; Aksit, H.; Telci, I.; Guzel, A. J. New Results Sci. 2014, 7 (7), 1-6.
  • 6. Türkmen, N.; Öz, A.; Sönmez, A.; Erol, T.; Gülümser, D.; Yurdakul, B.; Kayır, Ö.; Elmastas, M.; Erenler, R. J. New Results Sci. 2014, 6 (6), 27-31.
  • 7. Saidi, A.; Hambaba, L.; Kucuk, B.; Cacan, E.; Erenler, R. Curr. Bioact. Compd. 2022, 18 (3), 72-83.
  • 8. Koysu, P.; Genc, N.; Elmastas, M.; Aksit, H.; Erenler, R. Nat. Prod. Res. 2019, 33 (24), 3592-3595.
  • 9. Erenler, R.; Telci, I.; Ulutas, M.; Demirtas, I.; Gul, F.; Elmastas, M.; Kayir, O. J. Food Biochem. 2015, 39 (5), 622-630.
  • 10. Dede, E.; Genc, N.; Elmastas, M.; Aksit, H.; Erenler, R. Nat. Prod. J. 2019, 9 (3), 238-243.
  • 11. Erenler, R.; Nusret, G.; Elmastaş, M.; Eminağaoğlu, Ö. Turk. J. Biodiv. 2019, 2 (1), 13-17.
  • 12. Nusret, G.; Elmastas, M.; Telci, I.; Erenler, R. Int. J. Chem. Technol. 2020, 4 (2), 179-184.
  • 13. Aydin, A.; Erenler, R.; Yılmaz, B.; Tekin, Ş. J. Turk. Chem. Soc., Sec A: Chem 2016, 3 (3), 217-228.
  • 14. Elmastas, M.; Erenler, R.; Isnac, B.; Aksit, H.; Sen, O.; Genc, N.; Demirtas, I. Nat. Prod. Res. 2016, 30 (3), 299-304.
  • 15. Gecer, E. N. J. Inorg. Organomet. Polym. Mater. 2021, 31 (11), 4402-4409.
  • 16. Gecer, E. N.; Erenler, R.; Temiz, C.; Genc, N.; Yildiz, I. Particul. Sci. Technol. 2021, 40 (1), 50-57.
  • 17. Genc, N. Particul. Sci. Technol. 2021, 39 (5), 562-568.
  • 18. Genc, N.; Yildiz, I.; Chaoui, R.; Erenler, R.; Temiz, C.; Elmastas, M. Inorg. Nano-Met. Chem. 2021, 51 (3), 411-419.
  • 19. Burlacu, E.; Tanase, C.; Coman, N.-A.; Berta, L. Molecules 2019, 24 (23), 4354.
  • 20. de Souza, T. A. J.; Souza, L. R. R.; Franchi, L. P. Ecotox. Environ. Safe. 2019, 171, 691-700.
  • 21. El-Seedi, H. R.; El-Shabasy, R. M.; Khalifa, S. A.; Saeed, A.; Shah, A.; Shah, R.; Iftikhar, F. J.; Abdel-Daim, M. M.; Omri, A.; Hajrahand, N. H. RSC Adv. 2019, 9 (42), 24539-24559.
  • 22. Faraz, A.; Faizan, M.; Sami, F.; Siddiqui, H.; Pichtel, J.; Hayat, S. IET Nanobiotech. 2019, 13 (4), 345-352.
  • 23. Ökten, S.; Çakmak, O.; Erenler, R.; Yüce, Ö.; Tekin, S. Turk. J. Chem. 2013, 37 (6), 896-908.
  • 24. G Ravelo, A.; Estévez-Braun, A.; Chávez-Orellana, H.; Pérez-Sacau, E.; Mesa-Siverio, D. Curr. Top. Med. Chem. 2004, 4 (2), 241-265.
  • 25. Erenler, R.; Meral, B.; Sen, O.; Elmastas, M.; Aydin, A.; Eminagaoglu, O.; Topcu, G. Pharm. Biol. 2017, 55 (1), 1646-1653.
  • 26. Elmastas, M.; Celik, S. M.; Genc, N.; Aksit, H.; Erenler, R.; Gulcin, İ. Int. J. Food Prop. 2018, 21 (1), 374-384.
  • 27. Erenler, R.; Demirtas, I.; Karan, T.; Gul, F.; Kayir, O.; Karakoc, O. C. Trends Phytochem. Res. 2018, 2 (2), 91-96.
  • 28. Karan, T.; Simsek, S.; Yildiz, I.; Erenler, R. Int. J. Sec. Metabol. 2018, 5 (2), 87-93.
  • 29. Erenler, R.; Sen, O.; Aksit, H.; Demirtas, I.; Yaglioglu, A. S.; Elmastas, M.; Telci, İ. J. Sci. Food Agr. 2016, 96 (3), 822-836.
  • 30. Erenler, R.; Dag, B. Inorg. Nano-Met. Chem. 2022, 52 (4), 485-492.
  • 31. Sahin Yaglioglu, A.; Akdulum, B.; Erenler, R.; Demirtas, I.; Telci, I.; Tekin, S. Med. Chem. Res. 2013, 22 (6), 2946-2953.
  • 32. Erenler, R.; Pabuccu, K.; Yaglioglu, A. S.; Demirtas, I.; Gul, F. Z. Naturforsch. C 2016, 71 (3-4), 87-92.
  • 33. Erenler, R.; Sen, O.; Yaglioglu, A. S.; Demirtas, I. Comb. Chem. High. T. Scr. 2016, 19 (1), 66-72.
  • 34. Erenler, R.; Sen, O.; Yildiz, I.; Aydın, A. Rec. Nat. Prod. 2016, 10 (6), 766-770.
  • 35. Karan, T.; Erenler, R.; Bozer, B. M. Z. Naturforsch. C 2022.
  • 36. Hu, W.; Kavanagh, J. J. Lancet Oncol. 2003, 4 (12), 721-729.
There are 36 citations in total.

Details

Primary Language English
Subjects Chemical Engineering
Journal Section Research Articles
Authors

Ramazan Erenler 0000-0002-0505-3190

Esma Nur Geçer 0000-0002-0095-079X

Büşra Moran Bozer 0000-0002-7280-4417

Publication Date December 31, 2022
Published in Issue Year 2022 Volume: 6 Issue: 2

Cite

APA Erenler, R., Geçer, E. N., & Moran Bozer, B. (2022). Cytotoxic, apoptotic, and necrotic effects of silver nanoparticles biosynthesized using Origanum majorana extract. International Journal of Chemistry and Technology, 6(2), 142-146. https://doi.org/10.32571/ijct.1187754
AMA Erenler R, Geçer EN, Moran Bozer B. Cytotoxic, apoptotic, and necrotic effects of silver nanoparticles biosynthesized using Origanum majorana extract. Int. J. Chem. Technol. December 2022;6(2):142-146. doi:10.32571/ijct.1187754
Chicago Erenler, Ramazan, Esma Nur Geçer, and Büşra Moran Bozer. “Cytotoxic, Apoptotic, and Necrotic Effects of Silver Nanoparticles Biosynthesized Using Origanum Majorana Extract”. International Journal of Chemistry and Technology 6, no. 2 (December 2022): 142-46. https://doi.org/10.32571/ijct.1187754.
EndNote Erenler R, Geçer EN, Moran Bozer B (December 1, 2022) Cytotoxic, apoptotic, and necrotic effects of silver nanoparticles biosynthesized using Origanum majorana extract. International Journal of Chemistry and Technology 6 2 142–146.
IEEE R. Erenler, E. N. Geçer, and B. Moran Bozer, “Cytotoxic, apoptotic, and necrotic effects of silver nanoparticles biosynthesized using Origanum majorana extract”, Int. J. Chem. Technol., vol. 6, no. 2, pp. 142–146, 2022, doi: 10.32571/ijct.1187754.
ISNAD Erenler, Ramazan et al. “Cytotoxic, Apoptotic, and Necrotic Effects of Silver Nanoparticles Biosynthesized Using Origanum Majorana Extract”. International Journal of Chemistry and Technology 6/2 (December 2022), 142-146. https://doi.org/10.32571/ijct.1187754.
JAMA Erenler R, Geçer EN, Moran Bozer B. Cytotoxic, apoptotic, and necrotic effects of silver nanoparticles biosynthesized using Origanum majorana extract. Int. J. Chem. Technol. 2022;6:142–146.
MLA Erenler, Ramazan et al. “Cytotoxic, Apoptotic, and Necrotic Effects of Silver Nanoparticles Biosynthesized Using Origanum Majorana Extract”. International Journal of Chemistry and Technology, vol. 6, no. 2, 2022, pp. 142-6, doi:10.32571/ijct.1187754.
Vancouver Erenler R, Geçer EN, Moran Bozer B. Cytotoxic, apoptotic, and necrotic effects of silver nanoparticles biosynthesized using Origanum majorana extract. Int. J. Chem. Technol. 2022;6(2):142-6.
 Download Cover Image

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.