Research Article
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Year 2017, Volume: 1 Issue: 1, 7 - 13, 17.10.2017
https://doi.org/10.32571/ijct.335934

Abstract

References

  • 1. Nordberg, A.; Svensson, A.L. Drug Saf. 1998, 19(6), 465-480.
  • 2. Thompson, P.A.; Wright, D.E.; Counsell, C.E.; Zajicek, J. Int. Psychogeriatr. 2012, 24(5), 689-697.
  • 3. Demiralay, E.C.; Alsancak, G.; Ozkan, S.A. J. Sep. Sci. 2009, 32, 2928 - 2936.
  • 4. Yılmaz, H.; Demiralay,E.C. J. Liq. Chromatogr. Relat. Technol. 2015, 38(1), 97-103.
  • 5. Babič, S.; Horvat, A.J.M.; Pavlović, D.; Kaštelan Macan, M. Trends Analyt. Chem. 2007, 26(11), 1043-1061.
  • 6. Talay, A.; Demiralay, E.C.; Daldal, Y.D.; Üstün, Z.J. Mol. Liq. 2015, 208, 286-290.
  • 7. Tam, K.Y.; Hadley, M.; Patterson, W. Talanta 1999, 49, 539-546.
  • 8. Tam, K.Y.; Takács-Novák, K. Anal. Chim. Acta 2001, 434, 157-167.
  • 9. Sanli, S.; Altun, Y.; Guven, G. J. Chem. Eng. Data 2014, 59, 4015-4020.
  • 10. Daldal, Y.D.; Çakır, C.; Yılmaz, H.; Demiralay, E.C.; Özkan, S.A.; Alsancak, G. Curr. Drug. Ther. 2014, 9, 277-284.
  • 11. Sun, N.; Avdeef, A. J. Pharm. Biomed. Anal. 2011, 56, 173-182.
  • 12. Narasimham, L.; Dnyandeo Barhate, V. Eur. J. Chem, 2011, 2 (1), 36-46.
  • 13. Sanli, N.; Sanli, S.; Sızır, U.; Gumustas, M., Ozkan, S.A. Chromatographia 2011, 73(11-12), 1171-1176.
  • 14. Canbay, H.S.; Demiralay, E.C.; Alsancak, G.; Ozkan, S.A. J. Chem. Eng. Data 2011, 56(5), 2071-2076.
  • 15. Yasuda, M. Bull. Chem. Soc. Jpn. 1959, 32, 429-432.
  • 16. Shedlovsky, T. Electrolytes, in: B. Peasce (Ed.), Pergamon Press, New York, 1962.
  • 17. Marvin Sketch program, Chemaxon, http://www.chemaxon.com, (accessed 2016).
  • 18. Rondinini, S.; Mussini, P.R.; Mussini, T. Pure Appl. Chem. 1987, 59, 1549-1560.
  • 19. Beltran, J.L.; Codony, R.; Prat, M.D. Anal. Chim. Acta 1993, 276, 441-454.
  • 20. Daldal, Y.D.; Demiralay, E.C.; Ozkan, S.A. J. Braz. Chem. Soc. 2016, 27(3), 493-499.
  • 21. NLREG Version 4.0. P.H. Sherrod. http://www.sandh.com/Sherrod, (accessed 1991).
  • 22. Uysal, R.; Daldal, Y.D.; Üstün, Z.; Demiralay, E.C. Eurasian J. Anal. Chem. 2017, 12(1), 23-43.
  • 23. Meloun, M.; Bordovská, S.; Galla, L. SRX Pharmacol. 2010, 2010, 1-14.
  • 24. Hsieh, Y.H.; Yang, Y.H.; Yeh, H.H.; Lin, P.C.; Chen, S.H. Electrophoresis 2009, 30(4), 644-653.
  • 25. Luan, F.; Ma, W.; Zhang, H.; Zhang, X.; Liu, M.; Hu, Z.; Fan, B. Pharm. Res. 2005, 22, 1454-1460.
  • 26. Ishihama, Y.; Nakamura, M.; Miwa, T.; Kajima, T; Asakawa, N. J. Pharm. Sci. 2002, 91(4), 933-942.

Determination of spectrophotometric protonation constant of cholinesterase inhibitors

Year 2017, Volume: 1 Issue: 1, 7 - 13, 17.10.2017
https://doi.org/10.32571/ijct.335934

Abstract

The protonation constant (pKa) of rivastigmine, galantamine and
donepezil which are cholinesterase inhibitors used in cure
of Alzheimer's disease in acetonitrile-water binary
mixtures were determined at 25 oC in ionic strength by
spectrophotometric method. Spectra of the drugs were recorded with 1 nm
resolution over the 200 to 400 nm interval. Data assessment was carried
out with the STAR software program to calculate molar
absorbances and stability constants of the compounds studied. A
queous protonation constant of these compounds were calculated from
determined through linear  relationship between the mole fraction of
acetonitrile and the 
pKvalues and the Yasuda-Shedlovsky equality. The pKa values
of inhibitors at 25°C were converted to values at 37°C, without extra
estimation. The predicted and calculated pKa
 values were compared with literature values.

References

  • 1. Nordberg, A.; Svensson, A.L. Drug Saf. 1998, 19(6), 465-480.
  • 2. Thompson, P.A.; Wright, D.E.; Counsell, C.E.; Zajicek, J. Int. Psychogeriatr. 2012, 24(5), 689-697.
  • 3. Demiralay, E.C.; Alsancak, G.; Ozkan, S.A. J. Sep. Sci. 2009, 32, 2928 - 2936.
  • 4. Yılmaz, H.; Demiralay,E.C. J. Liq. Chromatogr. Relat. Technol. 2015, 38(1), 97-103.
  • 5. Babič, S.; Horvat, A.J.M.; Pavlović, D.; Kaštelan Macan, M. Trends Analyt. Chem. 2007, 26(11), 1043-1061.
  • 6. Talay, A.; Demiralay, E.C.; Daldal, Y.D.; Üstün, Z.J. Mol. Liq. 2015, 208, 286-290.
  • 7. Tam, K.Y.; Hadley, M.; Patterson, W. Talanta 1999, 49, 539-546.
  • 8. Tam, K.Y.; Takács-Novák, K. Anal. Chim. Acta 2001, 434, 157-167.
  • 9. Sanli, S.; Altun, Y.; Guven, G. J. Chem. Eng. Data 2014, 59, 4015-4020.
  • 10. Daldal, Y.D.; Çakır, C.; Yılmaz, H.; Demiralay, E.C.; Özkan, S.A.; Alsancak, G. Curr. Drug. Ther. 2014, 9, 277-284.
  • 11. Sun, N.; Avdeef, A. J. Pharm. Biomed. Anal. 2011, 56, 173-182.
  • 12. Narasimham, L.; Dnyandeo Barhate, V. Eur. J. Chem, 2011, 2 (1), 36-46.
  • 13. Sanli, N.; Sanli, S.; Sızır, U.; Gumustas, M., Ozkan, S.A. Chromatographia 2011, 73(11-12), 1171-1176.
  • 14. Canbay, H.S.; Demiralay, E.C.; Alsancak, G.; Ozkan, S.A. J. Chem. Eng. Data 2011, 56(5), 2071-2076.
  • 15. Yasuda, M. Bull. Chem. Soc. Jpn. 1959, 32, 429-432.
  • 16. Shedlovsky, T. Electrolytes, in: B. Peasce (Ed.), Pergamon Press, New York, 1962.
  • 17. Marvin Sketch program, Chemaxon, http://www.chemaxon.com, (accessed 2016).
  • 18. Rondinini, S.; Mussini, P.R.; Mussini, T. Pure Appl. Chem. 1987, 59, 1549-1560.
  • 19. Beltran, J.L.; Codony, R.; Prat, M.D. Anal. Chim. Acta 1993, 276, 441-454.
  • 20. Daldal, Y.D.; Demiralay, E.C.; Ozkan, S.A. J. Braz. Chem. Soc. 2016, 27(3), 493-499.
  • 21. NLREG Version 4.0. P.H. Sherrod. http://www.sandh.com/Sherrod, (accessed 1991).
  • 22. Uysal, R.; Daldal, Y.D.; Üstün, Z.; Demiralay, E.C. Eurasian J. Anal. Chem. 2017, 12(1), 23-43.
  • 23. Meloun, M.; Bordovská, S.; Galla, L. SRX Pharmacol. 2010, 2010, 1-14.
  • 24. Hsieh, Y.H.; Yang, Y.H.; Yeh, H.H.; Lin, P.C.; Chen, S.H. Electrophoresis 2009, 30(4), 644-653.
  • 25. Luan, F.; Ma, W.; Zhang, H.; Zhang, X.; Liu, M.; Hu, Z.; Fan, B. Pharm. Res. 2005, 22, 1454-1460.
  • 26. Ishihama, Y.; Nakamura, M.; Miwa, T.; Kajima, T; Asakawa, N. J. Pharm. Sci. 2002, 91(4), 933-942.
There are 26 citations in total.

Details

Subjects Chemical Engineering
Journal Section Research Articles
Authors

Yaşar Doğan Daldal 0000-0003-1211-2686

Ebru Çubuk Demiralay 0000-0002-6270-7509

Güleren Alsancak 0000-0001-5889-1537

Publication Date October 17, 2017
Published in Issue Year 2017 Volume: 1 Issue: 1

Cite

APA Daldal, Y. D., Çubuk Demiralay, E., & Alsancak, G. (2017). Determination of spectrophotometric protonation constant of cholinesterase inhibitors. International Journal of Chemistry and Technology, 1(1), 7-13. https://doi.org/10.32571/ijct.335934
AMA Daldal YD, Çubuk Demiralay E, Alsancak G. Determination of spectrophotometric protonation constant of cholinesterase inhibitors. Int. J. Chem. Technol. December 2017;1(1):7-13. doi:10.32571/ijct.335934
Chicago Daldal, Yaşar Doğan, Ebru Çubuk Demiralay, and Güleren Alsancak. “Determination of Spectrophotometric Protonation Constant of Cholinesterase Inhibitors”. International Journal of Chemistry and Technology 1, no. 1 (December 2017): 7-13. https://doi.org/10.32571/ijct.335934.
EndNote Daldal YD, Çubuk Demiralay E, Alsancak G (December 1, 2017) Determination of spectrophotometric protonation constant of cholinesterase inhibitors. International Journal of Chemistry and Technology 1 1 7–13.
IEEE Y. D. Daldal, E. Çubuk Demiralay, and G. Alsancak, “Determination of spectrophotometric protonation constant of cholinesterase inhibitors”, Int. J. Chem. Technol., vol. 1, no. 1, pp. 7–13, 2017, doi: 10.32571/ijct.335934.
ISNAD Daldal, Yaşar Doğan et al. “Determination of Spectrophotometric Protonation Constant of Cholinesterase Inhibitors”. International Journal of Chemistry and Technology 1/1 (December 2017), 7-13. https://doi.org/10.32571/ijct.335934.
JAMA Daldal YD, Çubuk Demiralay E, Alsancak G. Determination of spectrophotometric protonation constant of cholinesterase inhibitors. Int. J. Chem. Technol. 2017;1:7–13.
MLA Daldal, Yaşar Doğan et al. “Determination of Spectrophotometric Protonation Constant of Cholinesterase Inhibitors”. International Journal of Chemistry and Technology, vol. 1, no. 1, 2017, pp. 7-13, doi:10.32571/ijct.335934.
Vancouver Daldal YD, Çubuk Demiralay E, Alsancak G. Determination of spectrophotometric protonation constant of cholinesterase inhibitors. Int. J. Chem. Technol. 2017;1(1):7-13.