Research Article
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Year 2022, Volume: 8 Issue: 5, 659 - 669, 04.09.2022
https://doi.org/10.18621/eurj.1123564

Abstract

References

  • 1. Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 2018;39:119-77.
  • 2. Neumann F-J, Sousa-Uva M, Ahlsson A, Alfonso F, Banning AP, Benedetto U, et al. 2018 ESC/EACTS Guidelines on myocardial revascularization. Eur Heart J 2019;40:87-165.
  • 3. Toma M, Buller C, Westerhout C, Fu Y, O'Neill W, Holmes D Jr, et al. APEX-AMI Investigators: non-culprit coronary artery percutaneous coronary intervention during acute ST-segment elevation myocardial infarction: Insights from the APEX-AMI trial. Eur Heart J 2010;31:1701-7.
  • 4. Généreux P, Palmerini T, Caixeta A, Rosner G, Green P, Dressler O, et al. Quantification and impact of untreated coronary artery disease after percutaneous coronary intervention: the residual SYNTAX (Synergy Between PCI with Taxus and Cardiac Surgery) score. J Am Coll Cardiol 2012;59:2165-74.
  • 5. Burgess SN, French JK, Nguyen TL, Leung M, Richards DA, et al. The impact of incomplete revascularization on early and late outcomes in ST-elevation myocardial infarction. Am Heart J 2018;205:31-41.
  • 6. Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, et al. Antiinflammatory therapy with canakinumab for atherosclerotic disease. N Engl J Med 2017;377:1119-31.
  • 7. Nording HM, Seizer P, Langer HF. Platelets in inflammation and atherogenesis. Front Immunol 2015;6:98.
  • 8. Celik T, Kaya MG, Akpek M, Gunebakmaz O, Balta S, Sarli B, et al. Predictive value of admission platelet volume indices for in-hospital major adverse cardiovascular events in acute ST-segment elevation myocardial infarction. Angiology 2015;66:155-62.
  • 9. Tsiara S, Elisaf M, Jagroop IA, Mikhailidis DP. Platelets as predictors of vascular risk: is there a practical index of platelet activity? Clin Appl Thromb Hemost 2003;9:177-90.
  • 10. Chen X, Shao M, Zhang T, Zhang W, Meng Y, Zhang H, et al. Prognostic value of the combination of GRACE risk score and mean platelet volume to lymphocyte count ratio in patients with ST-segment elevation myocardial infarction after percutaneous coronary intervention. Exp Ther Med 2020;19:3664-74.
  • 11. Huczek Z, Kochman J, Filipiak KJ, Horszczaruk GJ, Grabowski M, Piatkowski R, et al. Mean platelet volume on admission predicts impaired reperfusion and long-term mortality in acute myocardial infarction treated with primary percutaneous coronary intervention. J Am Coll Cardiol 2005;46:284-90.
  • 12. Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 2010;14:28-32.
  • 13. Bekler A, Ozkan MTA, Tenekecioglu E, Gazi E, Yener AU, Temiz A, et al. Increased platelet distribution width is associated with severity of coronary artery disease in patients with acute coronary syndrome. Angiology 2015;66:638-43.
  • 14. Aslan S, Demir AR, Demir Y, Taşbulak Ö, Altunova M, Karakayalı M, et al. Usefulness of plateletcrit in the prediction of major adverse cardiac and cerebrovascular events in patients with carotid artery stenosis. Vascular 2019;27:479-86.
  • 15. Fuentes QE, Fuentes QF, Andrés V, Pello OM, de Mora JF, Palomo GI. Role of platelets as mediators that link inflammation and thrombosis in atherosclerosis. Platelets 2013;24:255-62.
  • 16. Sage AP, Mallat Z. Multiple potential roles for B cells in atherosclerosis. Ann Med 2014;46:297-303.
  • 17. Basem A, Neeraj S, Meredith A. Mcginn Joseph T. Value of platelet/lymphocyte ratio as a predictor of all-cause mortality after non-ST-elevation myocardial infarction. J Thromb Thrombolysis 2012;34:326-34.
  • 18. Yilmaz E, Aydin E. Prognostic value of the combination of TIMI risk score and mean platelet volume to lymphocyte count ratio in patients with acute coronary syndrome. Cor Vasa 2021;63:652-60.
  • 19. Toma M, Buller CE, Westerhout CM, Fu Y, O'Neill WW, Holmes Jr DR, et al. Non-culprit coronary artery percutaneous coronary intervention during acute ST-segment elevation myocardial infarction: insights from the APEX-AMI trial. Eur Heart J 2010;31:1701-7.
  • 20. Kaplan ZS, Jackson SP. The role of platelets in atherothrombosis. Hematology Am Soc Hematol Educ Program 2011;2011:51-61.
  • 21. Thompson CB, Eaton KA, Princiotta SM, Rushin CA, Valeri CR. Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and function. Br J Haematol 1982;50:509-19.
  • 22. Kırış T, Yazici S, Günaydin ZY, Akyüz Ş, Güzelburç Ö, Atmaca H, et al. The prognostic impact of in-hospital change in mean platelet volume in patients with non-ST-segment elevation myocardial infarction. Angiology 2016;67:690-6.
  • 23. Núñez J, Miñana G, Bodí V, Núñez E, Sanchis J, Husser O, et al. Low lymphocyte count and cardiovascular diseases. Curr Med Chem 2011;18:3226-33.
  • 24. Blum A, Sclarovsky S, Rehavia E, Shohat B. Levels of T-lymphocyte subpopulations, interleukin-1β, and soluble interleukin-2 receptor in acute myocardial infarction. Am Heart J 1994;127:1226-30.
  • 25. Rs H, Karl I. The pathophysiology and treatment of sepsis. N Engl J Med 2003;348:138-50.
  • 26. Horne BD, Anderson JL, John JM, Weaver A, Bair TL, Jensen KR, et al. Which white blood cell subtypes predict increased cardiovascular risk? J Am Coll Cardiol 2005;45:1638-43.
  • 27. Kurtul A, Acikgoz SK. Usefulness of mean platelet volume-to-lymphocyte ratio for predicting angiographic no-reflow and short-term prognosis after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction. Am J Cardiol 2017;120:534-41.
  • 28. Hudzik B, Szkodziński J, Lekston A, Gierlotka M, Poloński L, Gąsior M. Mean platelet volume-to-lymphocyte ratio: a novel marker of poor short-and long-term prognosis in patients with diabetes mellitus and acute myocardial infarction. J Diabetes Complicat 2016;30:1097-102.
  • 29. Lee JH, Park HS, Chae SC, Cho Y, Yang DH, Jeong MH, et al. Predictors of six-month major adverse cardiac events in 30-day survivors after acute myocardial infarction (from the Korea Acute Myocardial Infarction Registry). Am J Cardiol 2009;104:182-9.
  • 30. Gaba P, Gersh BJ, Ali ZA, Moses JW, Stone GW. Complete versus incomplete coronary revascularization: definitions, assessment and outcomes. Nat Rev Cardiol 2021;18:155-68.
  • 31. Loutfi M, Ayad S, Sobhy M. Impact of the residual SYNTAX score on outcomes of revascularization in patients with ST-segment elevation myocardial infarction and multivessel disease. Clin Med Insights Cardiol 2016;10:29-35.
  • 32. Braga CG, Cid-Alvarez AB, Diéguez AR, Alvarez BA, Otero DL, Sánchez RO, et al. Prognostic impact of residual SYNTAX score in patients with ST-elevation myocardial infarction and multivessel disease: analysis of an 8-year all-comers registry. Int J Cardiol 2017;243:21-6.
  • 33. Rydén L, Grant PJ, Anker SD, Berne C, Cosentino F, Danchin N, et al. ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD–summary. Diab Vasc Dis Res 2014;11:133-73.
  • 34. Natali A, Vichi S, Landi P, Severi S, L'abbate A, Ferrannini E. Coronary atherosclerosis in Type II diabetes: angiographic findings and clinical outcome. Diabetologia 2000;43:632-41.
  • 35. Kannel WB. Coronary heart disease risk factors in the elderly. Am J Geriatr Cardiol 2002;11:101-7.
  • 36. Squeri A, Gaibazzi N, Reverberi C, Caracciolo MM, Ardissino D, Gherli T. Ejection fraction change and coronary artery disease severity: a vasodilator contrast stress-echocardiography study. J Am Soc Echocardiog 2012;25:454-9.
  • 37. Kahraman S, Agus HZ, Avci Y, Serbest NG, Guner A, Erturk M. The neutrophil to lymphocyte ratio (NLR) is associated with residual syntax score in patients with ST-segment elevation myocardial infarction. Angiology 2021;72:166-73.

The relationship between platelet indices and residual SYNTAX score in patients with ST-segment elevation myocardial infarction

Year 2022, Volume: 8 Issue: 5, 659 - 669, 04.09.2022
https://doi.org/10.18621/eurj.1123564

Abstract

Objectives: Our aim is to investigate the relationship between thrombocyte indices, which have previously been proven to be associated with many cardiovascular diseases and adverse events, and residual SYNTAX (SYNergy between percutaneous coronary interventionwith TAXus and cardiac surgery) score (rSS) in patients with ST-segment elevation myocardial infarction (STEMI).

Methods: Our study included 534 patients who underwent primary percutaneous coronary intervention (PCI) for STEMI between January 2018 and June 2021. In our study, only patients who underwent infarct-related coronary artery revascularization in the index procedure were evaluated. First of all, patients were compared as two groups as low rSS (rSS ≤ 8) and high rSS (rSS > 8). Our definition of platelet indices includes mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (Pct), MPV to platelet ratio (MPVPR), platelet to lymphocyte ratio (PLR), and MPV to lymphocyte ratio (MPVLR).


Results:
The mean age of the study patients was 56.4 ± 10.3 years and 78.8% were male. The high rSS group had higher C-reactive protein, lower lymphocyte count, and significantly higher platelet indices other than PLR and MPV. Among the platelet indices, MPVLR was found to have the best correlation with rSS (r: 0.398, p < 0.001). MPVLR (AUC: 0.820, 95% CI: 0.701-0.899) was determined as the best diagnostic power index with 5.08 cut-off value in predicting high rSS with 88% sensitivity and 76% specificity (Youden index: 0.64). Age, right coronary artery involvement as culprit lesion, ejection fraction, diabetes mellitus and MPVLR (OR: 5.966 [2.489-8.413], p < 0.001) and PDW were identified as independent risk factors for predicting high rSS.

Conclusions: In conclusion, increased MPVLR is associated with high rSS in STEMI patients. There is a significant positive correlation between MPVLR and rSS. MPVLR is an independent predictor of high rSS.

References

  • 1. Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 2018;39:119-77.
  • 2. Neumann F-J, Sousa-Uva M, Ahlsson A, Alfonso F, Banning AP, Benedetto U, et al. 2018 ESC/EACTS Guidelines on myocardial revascularization. Eur Heart J 2019;40:87-165.
  • 3. Toma M, Buller C, Westerhout C, Fu Y, O'Neill W, Holmes D Jr, et al. APEX-AMI Investigators: non-culprit coronary artery percutaneous coronary intervention during acute ST-segment elevation myocardial infarction: Insights from the APEX-AMI trial. Eur Heart J 2010;31:1701-7.
  • 4. Généreux P, Palmerini T, Caixeta A, Rosner G, Green P, Dressler O, et al. Quantification and impact of untreated coronary artery disease after percutaneous coronary intervention: the residual SYNTAX (Synergy Between PCI with Taxus and Cardiac Surgery) score. J Am Coll Cardiol 2012;59:2165-74.
  • 5. Burgess SN, French JK, Nguyen TL, Leung M, Richards DA, et al. The impact of incomplete revascularization on early and late outcomes in ST-elevation myocardial infarction. Am Heart J 2018;205:31-41.
  • 6. Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, et al. Antiinflammatory therapy with canakinumab for atherosclerotic disease. N Engl J Med 2017;377:1119-31.
  • 7. Nording HM, Seizer P, Langer HF. Platelets in inflammation and atherogenesis. Front Immunol 2015;6:98.
  • 8. Celik T, Kaya MG, Akpek M, Gunebakmaz O, Balta S, Sarli B, et al. Predictive value of admission platelet volume indices for in-hospital major adverse cardiovascular events in acute ST-segment elevation myocardial infarction. Angiology 2015;66:155-62.
  • 9. Tsiara S, Elisaf M, Jagroop IA, Mikhailidis DP. Platelets as predictors of vascular risk: is there a practical index of platelet activity? Clin Appl Thromb Hemost 2003;9:177-90.
  • 10. Chen X, Shao M, Zhang T, Zhang W, Meng Y, Zhang H, et al. Prognostic value of the combination of GRACE risk score and mean platelet volume to lymphocyte count ratio in patients with ST-segment elevation myocardial infarction after percutaneous coronary intervention. Exp Ther Med 2020;19:3664-74.
  • 11. Huczek Z, Kochman J, Filipiak KJ, Horszczaruk GJ, Grabowski M, Piatkowski R, et al. Mean platelet volume on admission predicts impaired reperfusion and long-term mortality in acute myocardial infarction treated with primary percutaneous coronary intervention. J Am Coll Cardiol 2005;46:284-90.
  • 12. Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 2010;14:28-32.
  • 13. Bekler A, Ozkan MTA, Tenekecioglu E, Gazi E, Yener AU, Temiz A, et al. Increased platelet distribution width is associated with severity of coronary artery disease in patients with acute coronary syndrome. Angiology 2015;66:638-43.
  • 14. Aslan S, Demir AR, Demir Y, Taşbulak Ö, Altunova M, Karakayalı M, et al. Usefulness of plateletcrit in the prediction of major adverse cardiac and cerebrovascular events in patients with carotid artery stenosis. Vascular 2019;27:479-86.
  • 15. Fuentes QE, Fuentes QF, Andrés V, Pello OM, de Mora JF, Palomo GI. Role of platelets as mediators that link inflammation and thrombosis in atherosclerosis. Platelets 2013;24:255-62.
  • 16. Sage AP, Mallat Z. Multiple potential roles for B cells in atherosclerosis. Ann Med 2014;46:297-303.
  • 17. Basem A, Neeraj S, Meredith A. Mcginn Joseph T. Value of platelet/lymphocyte ratio as a predictor of all-cause mortality after non-ST-elevation myocardial infarction. J Thromb Thrombolysis 2012;34:326-34.
  • 18. Yilmaz E, Aydin E. Prognostic value of the combination of TIMI risk score and mean platelet volume to lymphocyte count ratio in patients with acute coronary syndrome. Cor Vasa 2021;63:652-60.
  • 19. Toma M, Buller CE, Westerhout CM, Fu Y, O'Neill WW, Holmes Jr DR, et al. Non-culprit coronary artery percutaneous coronary intervention during acute ST-segment elevation myocardial infarction: insights from the APEX-AMI trial. Eur Heart J 2010;31:1701-7.
  • 20. Kaplan ZS, Jackson SP. The role of platelets in atherothrombosis. Hematology Am Soc Hematol Educ Program 2011;2011:51-61.
  • 21. Thompson CB, Eaton KA, Princiotta SM, Rushin CA, Valeri CR. Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and function. Br J Haematol 1982;50:509-19.
  • 22. Kırış T, Yazici S, Günaydin ZY, Akyüz Ş, Güzelburç Ö, Atmaca H, et al. The prognostic impact of in-hospital change in mean platelet volume in patients with non-ST-segment elevation myocardial infarction. Angiology 2016;67:690-6.
  • 23. Núñez J, Miñana G, Bodí V, Núñez E, Sanchis J, Husser O, et al. Low lymphocyte count and cardiovascular diseases. Curr Med Chem 2011;18:3226-33.
  • 24. Blum A, Sclarovsky S, Rehavia E, Shohat B. Levels of T-lymphocyte subpopulations, interleukin-1β, and soluble interleukin-2 receptor in acute myocardial infarction. Am Heart J 1994;127:1226-30.
  • 25. Rs H, Karl I. The pathophysiology and treatment of sepsis. N Engl J Med 2003;348:138-50.
  • 26. Horne BD, Anderson JL, John JM, Weaver A, Bair TL, Jensen KR, et al. Which white blood cell subtypes predict increased cardiovascular risk? J Am Coll Cardiol 2005;45:1638-43.
  • 27. Kurtul A, Acikgoz SK. Usefulness of mean platelet volume-to-lymphocyte ratio for predicting angiographic no-reflow and short-term prognosis after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction. Am J Cardiol 2017;120:534-41.
  • 28. Hudzik B, Szkodziński J, Lekston A, Gierlotka M, Poloński L, Gąsior M. Mean platelet volume-to-lymphocyte ratio: a novel marker of poor short-and long-term prognosis in patients with diabetes mellitus and acute myocardial infarction. J Diabetes Complicat 2016;30:1097-102.
  • 29. Lee JH, Park HS, Chae SC, Cho Y, Yang DH, Jeong MH, et al. Predictors of six-month major adverse cardiac events in 30-day survivors after acute myocardial infarction (from the Korea Acute Myocardial Infarction Registry). Am J Cardiol 2009;104:182-9.
  • 30. Gaba P, Gersh BJ, Ali ZA, Moses JW, Stone GW. Complete versus incomplete coronary revascularization: definitions, assessment and outcomes. Nat Rev Cardiol 2021;18:155-68.
  • 31. Loutfi M, Ayad S, Sobhy M. Impact of the residual SYNTAX score on outcomes of revascularization in patients with ST-segment elevation myocardial infarction and multivessel disease. Clin Med Insights Cardiol 2016;10:29-35.
  • 32. Braga CG, Cid-Alvarez AB, Diéguez AR, Alvarez BA, Otero DL, Sánchez RO, et al. Prognostic impact of residual SYNTAX score in patients with ST-elevation myocardial infarction and multivessel disease: analysis of an 8-year all-comers registry. Int J Cardiol 2017;243:21-6.
  • 33. Rydén L, Grant PJ, Anker SD, Berne C, Cosentino F, Danchin N, et al. ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD–summary. Diab Vasc Dis Res 2014;11:133-73.
  • 34. Natali A, Vichi S, Landi P, Severi S, L'abbate A, Ferrannini E. Coronary atherosclerosis in Type II diabetes: angiographic findings and clinical outcome. Diabetologia 2000;43:632-41.
  • 35. Kannel WB. Coronary heart disease risk factors in the elderly. Am J Geriatr Cardiol 2002;11:101-7.
  • 36. Squeri A, Gaibazzi N, Reverberi C, Caracciolo MM, Ardissino D, Gherli T. Ejection fraction change and coronary artery disease severity: a vasodilator contrast stress-echocardiography study. J Am Soc Echocardiog 2012;25:454-9.
  • 37. Kahraman S, Agus HZ, Avci Y, Serbest NG, Guner A, Erturk M. The neutrophil to lymphocyte ratio (NLR) is associated with residual syntax score in patients with ST-segment elevation myocardial infarction. Angiology 2021;72:166-73.
There are 37 citations in total.

Details

Primary Language English
Subjects Cardiovascular Surgery
Journal Section Original Articles
Authors

Emre Yılmaz 0000-0002-1656-3778

Sencer Çamcı 0000-0003-2152-0470

Publication Date September 4, 2022
Submission Date May 31, 2022
Acceptance Date July 7, 2022
Published in Issue Year 2022 Volume: 8 Issue: 5

Cite

AMA Yılmaz E, Çamcı S. The relationship between platelet indices and residual SYNTAX score in patients with ST-segment elevation myocardial infarction. Eur Res J. September 2022;8(5):659-669. doi:10.18621/eurj.1123564

e-ISSN: 2149-3189 


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