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TİP 2 DİYABET, DİZ OSTEOARTRİTİ VE FEMORAL KARTİLAJ KALINLIĞININ ULTRASONOGRAFİK ÖLÇÜMÜ ARASINDAKİ İLİŞKİ

Year 2023, Volume: 4 Issue: 2, 121 - 126, 28.07.2023
https://doi.org/10.48176/esmj.2023.118

Abstract

Giriş: Bu çalışmanın amacı 1- tip 2 diyabet ile femoral kartilaj kalınlığı ve diz osteoartriti arasındaki ilişkiyi belirlemek, 2- bu ilişki üzerine beden kitle indeksi, abdominal bel çevresi, HbA1c gibi faktörlerin etkisini araştırmaktır.
Yöntem: Bu çalışmaya toplam 126 kadın hasta kabul edilerek, hastalar diyabet varlığı (Diyabet grubu) ve yokluğuna (Kontrol grubu) göre iki gruba ayrıldı. Yaş, hbA1c, beden kitle indeksi, abdominal bel çevresi, vizüel analog skala, yürüme hızı, Kısa Form-36, Kellgren Lawrance Skalası ve ultrasonografik distal femoral kartilaj kalınlık ölçümü çalışmanın değişkenleri idi.
Bulgular: İki grup arasında femoral kartilaj kalınlığı arasında bir fark saptanmadı, ne hbA1c ne de vücut kitle indeksi ve bel çevresi değerleri her 2 grupta da femoral kartilaj kalınlığı ile korelasyon göstermedi. Kontrol grubunda hem beden-kitle indeksi(r=0.422) hem de bel çevresi(r=0.423) Kellgren skorları ile korelasyon gösterdi. Diyabet grubunda ise hbA1c(r=0.404) ve beden kitle indeksi(r=0.696) Kellgren-skorları arasında korelasyon saptanmakla birlikte, abdominal bel çevresi (r=0.791) ile Kellgren skorları arasında güçlü bir korelasyon saptandı.
Sonuç: Tip 2 diyabet ve diz osteoartriti arasında güçlü bir ilişki saptanmıştır ancak tip 2 diyabet ile ultrasonografik femoral kartilaj kalınlığı ölçümü arasında bir ilişki saptanmamıştır. Ayrıca tip 2 diyabet ve osteartritin arasındaki ilişkiye, abdominal obezite, hbA1c ve beden kitle indeksinden daha fazla katkı yapıyor görünmektedir.

Supporting Institution

yok

Project Number

yok

References

  • 1. Molsted S, Tribler J, Snorgaard O. Musculoskeletal pain in patients with type 2 diabetes. Diabetes Res Clin Pract 2021;96:135-40.
  • 2. Courties A, Sellam J. Osteoarthritis and type 2 diabetes mellitus: what are the links? Diabetes Res Clin Pract 2016;122:198-206.
  • 3. Neumann J, Hofmann FC, Heilmeier U, et al. Type 2 diabetes patients have accelerated cartilage matrix degeneration compared to diabetes free controls: data from the Osteoarthritis Initiative. Osteoarthr Cartil 2018;26:751-61.
  • 4. Khor A, Ma CA, Hong C, Hui LLY, Leung YY. Diabetes mellitus is not a risk factor for osteoarthritis. RMD open 2020; 6:e001030.
  • 5. Zhu Z, Sheng X, Zhang J, Yao X. Association between type 2 diabetes status and osteoarthritis in adults aged≥ 50 years. J Orthop Sci 2022; 27:486-91.
  • 6. Wirth W, Hunter DJ, Nevitt MC, et al. Predictive and concurrent validity of cartilage thickness change as a marker of knee osteoarthritis progression: data from the Osteoarthritis Initiative. Osteoarthr Cartil 2017; 25:2063-71.
  • 7. GK Reddy. Glucose-mediated in vitro glycation modulates biomechanical integrity of the soft tissues but not hard tissues. J Orthop Res 2003;21:738-43.
  • 8. Umpierrez GE, Zlatev T, Spanheimer RG. Correction of altered collagen metabolism in diabetic animals with insulin therapy. Matrix 1989;9:336-42.
  • 9. Silberberg R, Hirshberg GE, Lesker P. Enzyme studies in the articular cartilage of diabetic rats and of rats bearing transplanted pancreatic islets. Diabetes 1977;26:732-5.
  • 10. Rosa SC, Goncalves J, Judas F, Mobasheri A, Lopes C. Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage Arthritis Res Ther 2009;11:R80.
  • 11. Vasilic-Brasnjevic S, Marinkovic J, Vlajinac H, et al. Association of body mass index and waist circumference with severity of knee osteoarthritis. Acta reumatol port 2016;41:226-31.
  • 12. Janssen I, Mark AE. Separate and combined influence of body mass index and waist circumference on arthritis and knee osteoarthritis. Int J Obes 2006; 30:1223-8.
  • 13. Felson DT. Weight and osteoarthritis. Journal of Rheumatology Supplement 1995;43:7-9.
  • 14. Duclos M. Osteoarthritis, obesity and type 2 diabetes: The weight of waist circumference. Ann Phys Rehabil Med 2016;59:157-60.
  • 15. Berenbaum F. Osteoarthritis: when chondrocytes don’t wake up on time. Arthritis Rheum 2013;65:2233-5.
  • 16. Alissa EM, Alzughaibi LS, Marzouki ZM. Relationship between serum resistin, body fat and inflammatory markers in females with clinical knee osteoarthritis. The Knee 2020;27:45-50.
  • 17. Buchholz AL, Niesen MC, Gausden EB, et al. Metabolic activity of osteoarthritic knees correlates with BMI. The Knee 2010; 17:161-6.
  • 18. Nicholas M, Vlaeyen JW, Rief W, et al. The IASP classification of chronic pain for ICD-11: chronic primary pain. Pain 2019;160:28-37.
  • 19. Gallagher EJ, Liebman M, Bijur PE. Prospective validation of clinically important changes in pain severity measured on a visual analog scale. Ann Emerg Med 2001;38:633–8.
  • 20. Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 2019; 48:16-31.
  • 21. Lean MEJ, Han TS, Seidell JC. Impairment of health and quality of life in people with large waist circumference. Lancet 1998; 351:853–6.
  • 22. Ware SE, Sherbourne CD. The MOS 36-item short form healthy survey (SF-36), Med Care 1992;30: 473-83.
  • 23. Kellgren JH, Lawrence JS. Radiological assessment of osteoarthrosis. Ann Rheum Dis 1957;16:494-502.
  • 24. Yoon CH, Kim HS, Ju JH, Jee WH, Park SH, Kim HY. Validity of the sonographic longitudinal sagittal image for assessment of the cartilage thickness in the knee osteoarthritis. Clin Rheumatol 2008;27: 1507-16.
  • 25. Dubey NK, Ningrum DNA, Dubey R, et al. Correlation between diabetes mellitus and knee osteoarthritis: a dry-to-wet lab approach. Int J Mol Sci 2018;19:3021.
  • 26. Richter M, Trzeciak T, Owecki M, Pucher A, Kaczmarczyk J. The role of adipocytokines in the pathogenesis of knee joint osteoarthritis. Int Orthop 2015;39:1211-7.
  • 27. Bedewi MA, Elsifey AA, Naguib MF, et al. Ultrasonographic measurement of femoral cartilage thickness in type II diabetic patients. Medicine 2020;99:e19455.
  • 28. Davis TM, Bruce DG, Curtis BH, Barraclough H, Davis WA. The relationship between intensification of blood glucose-lowering therapies, health status and quality of life in type 2 diabetes: The Fremantle Diabetes Study Phase II. Diabetes Res Clin Pract 2018;142:294-302.
  • 29. Tew M, Dowsey MM, Choong A, Choong PF, Clarke P. Co-Morbidities and Sex Differences in Long-Term Quality-of-Life Outcomes among Patients with and without Diabetes after Total Knee Replacement: Five-Year Data from Registry Study. J Clin Med 2020;9:19.
  • 30. Naranjo C, Ortega-Jimenez P, Del Reguero L, Moratalla G, Failde I. Relationship between diabetic neuropathic pain and comorbidity. Their impact on pain intensity, diabetes complications and quality of life in patients with type-2 diabetes mellitus. Diabetes Res Clin Pract 2020; 165:108236.

THE RELATION BETWEEN TYPE 2 DIABETES MELLITUS, KNEE OSTEOARTHRITIS AND ULTRASONOGRAPHIC MEASUREMENT OF FEMORAL CARTILAGE THICKNESS

Year 2023, Volume: 4 Issue: 2, 121 - 126, 28.07.2023
https://doi.org/10.48176/esmj.2023.118

Abstract

Aim: The aim of this study is 1-to determine the relation between knee osteoarthritis, ultrasonographic measurement of femoral cartilage thicknesses and type-2 diabetes,2-to investigate the effect of the related factors such as body mass index, abdominal waist circumference, HbA1c on this relationship.
Methods: A total of 126 female patients was enrolled in this study and divided into two groups: according to presence (Diabetes-Group) or absence (Control-Group) of diabetes mellitus. Variables were age, hbA1c, body-mass index, waist circumference, visual analog scale, gait speed, short form-36, Kellgren-Lawrance Scale and ultrasonographic measurements of distal femoral cartilage thicknesses.
Results: There was no significant difference between groups according to ultrasonography parameters which are correlated with nor HbA1c, nor body-mass-index and waist-circumference in both groups. Both body-mass index(r=0.422) and waist circumference(r=0.423) were moderately correlated with Kellgren scores in Control-Group. In Diabetes-group, HbA1c(r=0.404) and body-mass index(r=0.696) were moderately correlated with Kellgren-scores,moreover waist circumference(r=0.791) was strongly correlated with Kellgren-scores.
Conclusion: There was found a strong relation between type-2 diabetes mellitus and knee osteoarthritis, however there was found no relation between type-2 diabetes and ultrasonographic femoral cartilage thicknesses measurement. Furthermore abdominal obesity seems to contribute to this relation between type 2 diabetes and knee osteoarthritis more than HbA1c and body-mass index.

Project Number

yok

References

  • 1. Molsted S, Tribler J, Snorgaard O. Musculoskeletal pain in patients with type 2 diabetes. Diabetes Res Clin Pract 2021;96:135-40.
  • 2. Courties A, Sellam J. Osteoarthritis and type 2 diabetes mellitus: what are the links? Diabetes Res Clin Pract 2016;122:198-206.
  • 3. Neumann J, Hofmann FC, Heilmeier U, et al. Type 2 diabetes patients have accelerated cartilage matrix degeneration compared to diabetes free controls: data from the Osteoarthritis Initiative. Osteoarthr Cartil 2018;26:751-61.
  • 4. Khor A, Ma CA, Hong C, Hui LLY, Leung YY. Diabetes mellitus is not a risk factor for osteoarthritis. RMD open 2020; 6:e001030.
  • 5. Zhu Z, Sheng X, Zhang J, Yao X. Association between type 2 diabetes status and osteoarthritis in adults aged≥ 50 years. J Orthop Sci 2022; 27:486-91.
  • 6. Wirth W, Hunter DJ, Nevitt MC, et al. Predictive and concurrent validity of cartilage thickness change as a marker of knee osteoarthritis progression: data from the Osteoarthritis Initiative. Osteoarthr Cartil 2017; 25:2063-71.
  • 7. GK Reddy. Glucose-mediated in vitro glycation modulates biomechanical integrity of the soft tissues but not hard tissues. J Orthop Res 2003;21:738-43.
  • 8. Umpierrez GE, Zlatev T, Spanheimer RG. Correction of altered collagen metabolism in diabetic animals with insulin therapy. Matrix 1989;9:336-42.
  • 9. Silberberg R, Hirshberg GE, Lesker P. Enzyme studies in the articular cartilage of diabetic rats and of rats bearing transplanted pancreatic islets. Diabetes 1977;26:732-5.
  • 10. Rosa SC, Goncalves J, Judas F, Mobasheri A, Lopes C. Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage Arthritis Res Ther 2009;11:R80.
  • 11. Vasilic-Brasnjevic S, Marinkovic J, Vlajinac H, et al. Association of body mass index and waist circumference with severity of knee osteoarthritis. Acta reumatol port 2016;41:226-31.
  • 12. Janssen I, Mark AE. Separate and combined influence of body mass index and waist circumference on arthritis and knee osteoarthritis. Int J Obes 2006; 30:1223-8.
  • 13. Felson DT. Weight and osteoarthritis. Journal of Rheumatology Supplement 1995;43:7-9.
  • 14. Duclos M. Osteoarthritis, obesity and type 2 diabetes: The weight of waist circumference. Ann Phys Rehabil Med 2016;59:157-60.
  • 15. Berenbaum F. Osteoarthritis: when chondrocytes don’t wake up on time. Arthritis Rheum 2013;65:2233-5.
  • 16. Alissa EM, Alzughaibi LS, Marzouki ZM. Relationship between serum resistin, body fat and inflammatory markers in females with clinical knee osteoarthritis. The Knee 2020;27:45-50.
  • 17. Buchholz AL, Niesen MC, Gausden EB, et al. Metabolic activity of osteoarthritic knees correlates with BMI. The Knee 2010; 17:161-6.
  • 18. Nicholas M, Vlaeyen JW, Rief W, et al. The IASP classification of chronic pain for ICD-11: chronic primary pain. Pain 2019;160:28-37.
  • 19. Gallagher EJ, Liebman M, Bijur PE. Prospective validation of clinically important changes in pain severity measured on a visual analog scale. Ann Emerg Med 2001;38:633–8.
  • 20. Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 2019; 48:16-31.
  • 21. Lean MEJ, Han TS, Seidell JC. Impairment of health and quality of life in people with large waist circumference. Lancet 1998; 351:853–6.
  • 22. Ware SE, Sherbourne CD. The MOS 36-item short form healthy survey (SF-36), Med Care 1992;30: 473-83.
  • 23. Kellgren JH, Lawrence JS. Radiological assessment of osteoarthrosis. Ann Rheum Dis 1957;16:494-502.
  • 24. Yoon CH, Kim HS, Ju JH, Jee WH, Park SH, Kim HY. Validity of the sonographic longitudinal sagittal image for assessment of the cartilage thickness in the knee osteoarthritis. Clin Rheumatol 2008;27: 1507-16.
  • 25. Dubey NK, Ningrum DNA, Dubey R, et al. Correlation between diabetes mellitus and knee osteoarthritis: a dry-to-wet lab approach. Int J Mol Sci 2018;19:3021.
  • 26. Richter M, Trzeciak T, Owecki M, Pucher A, Kaczmarczyk J. The role of adipocytokines in the pathogenesis of knee joint osteoarthritis. Int Orthop 2015;39:1211-7.
  • 27. Bedewi MA, Elsifey AA, Naguib MF, et al. Ultrasonographic measurement of femoral cartilage thickness in type II diabetic patients. Medicine 2020;99:e19455.
  • 28. Davis TM, Bruce DG, Curtis BH, Barraclough H, Davis WA. The relationship between intensification of blood glucose-lowering therapies, health status and quality of life in type 2 diabetes: The Fremantle Diabetes Study Phase II. Diabetes Res Clin Pract 2018;142:294-302.
  • 29. Tew M, Dowsey MM, Choong A, Choong PF, Clarke P. Co-Morbidities and Sex Differences in Long-Term Quality-of-Life Outcomes among Patients with and without Diabetes after Total Knee Replacement: Five-Year Data from Registry Study. J Clin Med 2020;9:19.
  • 30. Naranjo C, Ortega-Jimenez P, Del Reguero L, Moratalla G, Failde I. Relationship between diabetic neuropathic pain and comorbidity. Their impact on pain intensity, diabetes complications and quality of life in patients with type-2 diabetes mellitus. Diabetes Res Clin Pract 2020; 165:108236.
There are 30 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Research Articles
Authors

Fulya Bakılan 0000-0003-2943-4833

Burcu Ortanca 0000-0001-5421-0116

Fezan Mutlu 0000-0002-9339-4031

Bilgen Mehpare Özer 0000-0002-1643-4175

Project Number yok
Early Pub Date July 28, 2023
Publication Date July 28, 2023
Published in Issue Year 2023 Volume: 4 Issue: 2

Cite

APA Bakılan, F., Ortanca, B., Mutlu, F., Özer, B. M. (2023). THE RELATION BETWEEN TYPE 2 DIABETES MELLITUS, KNEE OSTEOARTHRITIS AND ULTRASONOGRAPHIC MEASUREMENT OF FEMORAL CARTILAGE THICKNESS. Eskisehir Medical Journal, 4(2), 121-126. https://doi.org/10.48176/esmj.2023.118
AMA Bakılan F, Ortanca B, Mutlu F, Özer BM. THE RELATION BETWEEN TYPE 2 DIABETES MELLITUS, KNEE OSTEOARTHRITIS AND ULTRASONOGRAPHIC MEASUREMENT OF FEMORAL CARTILAGE THICKNESS. Eskisehir Med J. July 2023;4(2):121-126. doi:10.48176/esmj.2023.118
Chicago Bakılan, Fulya, Burcu Ortanca, Fezan Mutlu, and Bilgen Mehpare Özer. “THE RELATION BETWEEN TYPE 2 DIABETES MELLITUS, KNEE OSTEOARTHRITIS AND ULTRASONOGRAPHIC MEASUREMENT OF FEMORAL CARTILAGE THICKNESS”. Eskisehir Medical Journal 4, no. 2 (July 2023): 121-26. https://doi.org/10.48176/esmj.2023.118.
EndNote Bakılan F, Ortanca B, Mutlu F, Özer BM (July 1, 2023) THE RELATION BETWEEN TYPE 2 DIABETES MELLITUS, KNEE OSTEOARTHRITIS AND ULTRASONOGRAPHIC MEASUREMENT OF FEMORAL CARTILAGE THICKNESS. Eskisehir Medical Journal 4 2 121–126.
IEEE F. Bakılan, B. Ortanca, F. Mutlu, and B. M. Özer, “THE RELATION BETWEEN TYPE 2 DIABETES MELLITUS, KNEE OSTEOARTHRITIS AND ULTRASONOGRAPHIC MEASUREMENT OF FEMORAL CARTILAGE THICKNESS”, Eskisehir Med J, vol. 4, no. 2, pp. 121–126, 2023, doi: 10.48176/esmj.2023.118.
ISNAD Bakılan, Fulya et al. “THE RELATION BETWEEN TYPE 2 DIABETES MELLITUS, KNEE OSTEOARTHRITIS AND ULTRASONOGRAPHIC MEASUREMENT OF FEMORAL CARTILAGE THICKNESS”. Eskisehir Medical Journal 4/2 (July 2023), 121-126. https://doi.org/10.48176/esmj.2023.118.
JAMA Bakılan F, Ortanca B, Mutlu F, Özer BM. THE RELATION BETWEEN TYPE 2 DIABETES MELLITUS, KNEE OSTEOARTHRITIS AND ULTRASONOGRAPHIC MEASUREMENT OF FEMORAL CARTILAGE THICKNESS. Eskisehir Med J. 2023;4:121–126.
MLA Bakılan, Fulya et al. “THE RELATION BETWEEN TYPE 2 DIABETES MELLITUS, KNEE OSTEOARTHRITIS AND ULTRASONOGRAPHIC MEASUREMENT OF FEMORAL CARTILAGE THICKNESS”. Eskisehir Medical Journal, vol. 4, no. 2, 2023, pp. 121-6, doi:10.48176/esmj.2023.118.
Vancouver Bakılan F, Ortanca B, Mutlu F, Özer BM. THE RELATION BETWEEN TYPE 2 DIABETES MELLITUS, KNEE OSTEOARTHRITIS AND ULTRASONOGRAPHIC MEASUREMENT OF FEMORAL CARTILAGE THICKNESS. Eskisehir Med J. 2023;4(2):121-6.