Evaluation of antioxidant and antimutagenic activities of aluminum chloride

Nurdan Saraç; Aysel Uğur; İnci Rana Karaca

Research Article

Year 2019, Volume: 53 Issue: 2, 51 - 55, 31.05.2019

Nurdan Saraç Aysel Uğur İnci Rana Karaca

Abstract

References

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3. Kaur P, Chandel M, Kumar S, Kumar N, Singh B, Kaur S. Modulatory role of alizarin from Rubia cordifolia L. against genotoxicity of mutagens. Food Chem Toxicol 2010;48:320-325. [CrossRef]
4. Ramanathan B, Smerdon MJ. Changes in nuclear protein acetylation in U.V.-damaged human cells. Carcinogenesis 1986;7:1087-1094. [CrossRef]
5. Fraga CG, Martino VS, Ferraro GE, Cousio JD, Boveris A. Flavonoids as antioxidants evaluated by in vitro and in vivo liver chemiluminescense. Biochem Pharmacol 1987;36:717-720. [CrossRef]
6. Hochstein P, Atallah AS. The nature of oxidants and antioxidant systems in the inhibition of mutation and cancer. Mutat Res 1988;202:363-375. [CrossRef]
7. Møller P, Wallin H. Adduct formation, mutagenesis and nucleotide excision repair of DNA damage produced by reactive oxygen speciesand lipid peroxidation product. Mutat Res 1998;410:271-290. [CrossRef]
8. Marnett LJ. Oxyradicals and DNA damage. Carcinogenesis 2000;21:361-370. [CrossRef]
9. Huang P, Feng L, Oldham EA, Keating MJ, Plunkett W. Superoxide dismutase as a target for the selective killing of cancer cells. Nature 2000;407:390-395. [CrossRef]
10. Kim SY, Shon YH, Lee JS, Kim CH, Nam KS. Antimutagenic activity of soybeans fermented with basidiomycetes in Ames/ Salmonella test. Biotechnol Let 2000;22:1197-1202. [CrossRef]
11. Negi PS, Jayaprakash GK, Jena BS. Antioxidant and antimutagenic activities of pomegranate peel extracts. Food Chem 2003;80:393-397. [CrossRef]
12. Zahin M, Aqil F, Ahmad I. Broad spectrum antimutagenic activity of antioxidant active fraction of Punica granatum L. peel extract. Mutat Res 2010;703:99-107. [CrossRef]
13. Nouri S, Sharif MR, Panahi Y, Ghanei M, Jamali B. Efficacy and Safety of Aluminum Chloride in Controlling External Hemorrhage: An Animal Model Study. Iran Red Crescent Med J 2015;7:e19714. [CrossRef]
14. Robinson JK. Surgery of the skin: Procedural dermatology. Philadelphia: Elsevier Mosby, 2005.
15. Howe N, Cherpelis B. Obtaining rapid and effective hemostasis: Part I. Update and review of topical hemostatic agents. J Am Acad Dermatol 2013;69:659.e1-17. [CrossRef]
16. Tannous Z, Torres A, Gonzáles S. In vivo real-time confocal reflectance microscopy: a noninvasive guide for Mohs microscopic surgery facilitated by aluminum chloride, an excellent contrast enhancer. Dermatol Surg 2003;29:839-846. [CrossRef]
17. Csempesz F, Vág J, Fazekas A. In vitro kinetic study of absorbency of retraction cords. J Prosthet Dent 2003;89:45-49. [CrossRef]
18. Clayman MA, Clayman SM, Seagle MB. A review of the surgical and medical treatment of Frey Syndrome. Ann Plast Surg 2006;57:581-584. [CrossRef]
19. Sawchuk WS, Friedman KJ, Manning T, Pinnell SR. Delayed healing in full-thickness wounds treated with aluminum chloride solution. J Am Acad Dermatol 1986;15:982-989. [CrossRef]
20. Mortelmans K, Zeiger E. The Ames Salmonella/microsome mutagenicity assay. Mutat Res 2000;455:29-60. [CrossRef]
21. Yamasaki K, Hashimoto A, Kokusenya Y, Miyamoto T, Sato T. Electrochemical method for estimating the antioxidative effects of methanol extracts of crude drugs. Chem Pharm Bullet 1994;42:1663-1665. [CrossRef]
22. Jayaprakasha GK, Jaganmohan Rao L. Phenolic constituents from lichen Parmotrema stuppeum (Nyl.). Hale and their antioxidant activity. Zeitsch Naturforsch 2000;55C: 1018-1022. [CrossRef]
23. Maron DM, Ames BN. Revised methods for the Salmonella mutagenicity test. Mutat Res 1983;113:173-215. [CrossRef]
24. Sarac N, Sen B. Antioxidant, mutagenic, antimutagenic activities, and phenolic compounds of Liquidambar orientalis Mill. var. orientalis. Ind Crops Prod 2014;53:60-64. [CrossRef]
25. Evandri MG, Battinelli L, Daniele C, Mastrangelo S, Bolle P, Mazzanti G. The antimutagenic activity of Lavandula angustifolia (lavender) essential oil in the bacterial reverse mutation assay. Food Chem Toxicol 2005;43:1381-1387. [CrossRef]
26. Shureiqi I, Reddy P, Brenner DE. Chemoprevention: General perspective. Crit Rev Oncol/Hematol 2000;33:157-167. [CrossRef]
27. Tsao AS, Kim ES, Hong WK. Chemoprevention of Cancer. CA-A Cancer J Clinic 2004;54:150-180. [CrossRef]
28. Khalaf NA, Shakya AK, Al-Othman A, El-Agbar Z, Farah H. Antioxidant Activity of Some Common Plants. Turk J Biol 2008;32:51-55.
29. Shon MY, Choi SD, Kahng GG, Nam SH, Sung NJ. Antimutagenic, antioxidant and free radical scavenging activity of ethyl acetate extracts from white, yellow and red onions. Food Chem Toxicol 2004;42:659-666. [CrossRef]
30. Parton M, Dowsett M, Smith I. Studies of apoptosis in breast cancer. Brit Med J 2001;322:1528-38. [CrossRef]
31. Pelengaris S, Khan M. The Molecular Biology of Cancer, 2 edn, Blackwell Publishing Ltd; 2006.
32. Kao SY, Chen YW, Chang KW, et al. Detection and screening of oral cancer and Pre-cancerous lesions. J Chin Med Assoc 2009;72:227-33. [CrossRef]
33. Sankaranarayanan R, Dinshaw K, Nene BM, et al. Cervical and oral cancer screening in India. J Med Screen 2006;13:35-8.
34. Ghazali R, Abdullah R, Ramli N, Rajab NF, Ahmad-Kamal MS, Yahya NA. Mutagenic and antimutagenic activities of Mitragyna speciosa Korth extract using Ames test. J Med Plants Res 2011;5:1345-1348.

Evaluation of antioxidant and antimutagenic activities of aluminum chloride

Year 2019, Volume: 53 Issue: 2, 51 - 55, 31.05.2019

Nurdan Saraç Aysel Uğur İnci Rana Karaca

Abstract

Purpose Hemostatic agents are used to control hemorrhage and the gingival crevicular fluid for dental applications. In this study; the antimutagenic and antioxidant activities of aluminum chloride (AlCl3), a topical hemostatic agent used especially in the fields of dermatology and dentistry, were determined. To our knowledge, this is the first study that investigates these properties. Materials and Methods The antioxidant activity was determined by DPPH free radical scavenging and β-carotene-linoleic acid bleaching assays. The antimutagenic activity was evaluated with the Ames Salmonella/ microsome mutagenicity test using Salmonella typhimurium TA98 and TA100 strains. Results The total antioxidant activity of AlCl3, determined by β-carotene bleaching assay was found to be 25.59 ± 2.55% and the DPPH scavenging activity of AlCl3 was determined as 17.49 ± 3.07%. AlCl3 showed not any mutagenicity at the tested concentrations by the AMES test used S. typhimurium TA98 and TA100. This drug demonstrated antimutagenic effects at the test concentrations and the strongest antimutagenic activity was observed on 1.25 mg·mL-1/plate concentration of AlCl3. Conclusion AlCl3 showed potent antimutagenic and antioxidant activities and these properties are significant for dentistry and dermatology.

Keywords

ames, hemostatic, DPPH, oxidative stress, AlCl

References

1. Davydov V, Hansen LA, Shackelford DA. Is DNA repair compromised in Alzheimer's disease?. Neurobiol Aging 2003;24:953-968. [CrossRef]
2. Coppedè F, Migliore L. DNA damage and repair in Alzheimer's disease. Curr Alzheimer Res 2009;6:36-47. [CrossRef]
3. Kaur P, Chandel M, Kumar S, Kumar N, Singh B, Kaur S. Modulatory role of alizarin from Rubia cordifolia L. against genotoxicity of mutagens. Food Chem Toxicol 2010;48:320-325. [CrossRef]
4. Ramanathan B, Smerdon MJ. Changes in nuclear protein acetylation in U.V.-damaged human cells. Carcinogenesis 1986;7:1087-1094. [CrossRef]
5. Fraga CG, Martino VS, Ferraro GE, Cousio JD, Boveris A. Flavonoids as antioxidants evaluated by in vitro and in vivo liver chemiluminescense. Biochem Pharmacol 1987;36:717-720. [CrossRef]
6. Hochstein P, Atallah AS. The nature of oxidants and antioxidant systems in the inhibition of mutation and cancer. Mutat Res 1988;202:363-375. [CrossRef]
7. Møller P, Wallin H. Adduct formation, mutagenesis and nucleotide excision repair of DNA damage produced by reactive oxygen speciesand lipid peroxidation product. Mutat Res 1998;410:271-290. [CrossRef]
8. Marnett LJ. Oxyradicals and DNA damage. Carcinogenesis 2000;21:361-370. [CrossRef]
9. Huang P, Feng L, Oldham EA, Keating MJ, Plunkett W. Superoxide dismutase as a target for the selective killing of cancer cells. Nature 2000;407:390-395. [CrossRef]
10. Kim SY, Shon YH, Lee JS, Kim CH, Nam KS. Antimutagenic activity of soybeans fermented with basidiomycetes in Ames/ Salmonella test. Biotechnol Let 2000;22:1197-1202. [CrossRef]
11. Negi PS, Jayaprakash GK, Jena BS. Antioxidant and antimutagenic activities of pomegranate peel extracts. Food Chem 2003;80:393-397. [CrossRef]
12. Zahin M, Aqil F, Ahmad I. Broad spectrum antimutagenic activity of antioxidant active fraction of Punica granatum L. peel extract. Mutat Res 2010;703:99-107. [CrossRef]
13. Nouri S, Sharif MR, Panahi Y, Ghanei M, Jamali B. Efficacy and Safety of Aluminum Chloride in Controlling External Hemorrhage: An Animal Model Study. Iran Red Crescent Med J 2015;7:e19714. [CrossRef]
14. Robinson JK. Surgery of the skin: Procedural dermatology. Philadelphia: Elsevier Mosby, 2005.
15. Howe N, Cherpelis B. Obtaining rapid and effective hemostasis: Part I. Update and review of topical hemostatic agents. J Am Acad Dermatol 2013;69:659.e1-17. [CrossRef]
16. Tannous Z, Torres A, Gonzáles S. In vivo real-time confocal reflectance microscopy: a noninvasive guide for Mohs microscopic surgery facilitated by aluminum chloride, an excellent contrast enhancer. Dermatol Surg 2003;29:839-846. [CrossRef]
17. Csempesz F, Vág J, Fazekas A. In vitro kinetic study of absorbency of retraction cords. J Prosthet Dent 2003;89:45-49. [CrossRef]
18. Clayman MA, Clayman SM, Seagle MB. A review of the surgical and medical treatment of Frey Syndrome. Ann Plast Surg 2006;57:581-584. [CrossRef]
19. Sawchuk WS, Friedman KJ, Manning T, Pinnell SR. Delayed healing in full-thickness wounds treated with aluminum chloride solution. J Am Acad Dermatol 1986;15:982-989. [CrossRef]
20. Mortelmans K, Zeiger E. The Ames Salmonella/microsome mutagenicity assay. Mutat Res 2000;455:29-60. [CrossRef]
21. Yamasaki K, Hashimoto A, Kokusenya Y, Miyamoto T, Sato T. Electrochemical method for estimating the antioxidative effects of methanol extracts of crude drugs. Chem Pharm Bullet 1994;42:1663-1665. [CrossRef]
22. Jayaprakasha GK, Jaganmohan Rao L. Phenolic constituents from lichen Parmotrema stuppeum (Nyl.). Hale and their antioxidant activity. Zeitsch Naturforsch 2000;55C: 1018-1022. [CrossRef]
23. Maron DM, Ames BN. Revised methods for the Salmonella mutagenicity test. Mutat Res 1983;113:173-215. [CrossRef]
24. Sarac N, Sen B. Antioxidant, mutagenic, antimutagenic activities, and phenolic compounds of Liquidambar orientalis Mill. var. orientalis. Ind Crops Prod 2014;53:60-64. [CrossRef]
25. Evandri MG, Battinelli L, Daniele C, Mastrangelo S, Bolle P, Mazzanti G. The antimutagenic activity of Lavandula angustifolia (lavender) essential oil in the bacterial reverse mutation assay. Food Chem Toxicol 2005;43:1381-1387. [CrossRef]
26. Shureiqi I, Reddy P, Brenner DE. Chemoprevention: General perspective. Crit Rev Oncol/Hematol 2000;33:157-167. [CrossRef]
27. Tsao AS, Kim ES, Hong WK. Chemoprevention of Cancer. CA-A Cancer J Clinic 2004;54:150-180. [CrossRef]
28. Khalaf NA, Shakya AK, Al-Othman A, El-Agbar Z, Farah H. Antioxidant Activity of Some Common Plants. Turk J Biol 2008;32:51-55.
29. Shon MY, Choi SD, Kahng GG, Nam SH, Sung NJ. Antimutagenic, antioxidant and free radical scavenging activity of ethyl acetate extracts from white, yellow and red onions. Food Chem Toxicol 2004;42:659-666. [CrossRef]
30. Parton M, Dowsett M, Smith I. Studies of apoptosis in breast cancer. Brit Med J 2001;322:1528-38. [CrossRef]
31. Pelengaris S, Khan M. The Molecular Biology of Cancer, 2 edn, Blackwell Publishing Ltd; 2006.
32. Kao SY, Chen YW, Chang KW, et al. Detection and screening of oral cancer and Pre-cancerous lesions. J Chin Med Assoc 2009;72:227-33. [CrossRef]
33. Sankaranarayanan R, Dinshaw K, Nene BM, et al. Cervical and oral cancer screening in India. J Med Screen 2006;13:35-8.
34. Ghazali R, Abdullah R, Ramli N, Rajab NF, Ahmad-Kamal MS, Yahya NA. Mutagenic and antimutagenic activities of Mitragyna speciosa Korth extract using Ames test. J Med Plants Res 2011;5:1345-1348.

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Details

Primary Language	English
Journal Section	Original Research Articles
Authors	Nurdan Saraç This is me 0000-0001-7676-542X Aysel Uğur This is me 0000-0002-5188-1106 İnci Rana Karaca 0000-0003-1870-2687
Publication Date	May 31, 2019
Submission Date	August 22, 2018
Published in Issue	Year 2019 Volume: 53 Issue: 2

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EndNote	Saraç N, Uğur A, Karaca İR (May 1, 2019) Evaluation of antioxidant and antimutagenic activities of aluminum chloride. European Oral Research 53 2 51–55.

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