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Kronik hastalıklar ekseninde diyette yüksek fruktoz ve doymuş yağ asitlerinin kronik düşük derece inflamasyon üzerine etkisi

Year 2019, Volume: 44 Issue: 2, 685 - 694, 30.06.2019
https://doi.org/10.17826/cumj.482623

Abstract

Son
yıllarda kronik hastalıkların ortaya çıkmasında, kronik düşük derece
inflamasyonun rolü üzerinde durulmaktadır. Kronik düşük derece inflamasyon,
sistemik dolaşım ve çeşitli dokularda inflamatuvar medyatörlerin ve bazı
proinflamatuvar sitokinlerin artışı ile karakterize olan metabolik bir
süreçtir. C reaktif protein (CRP), tümör nekrozis faktör-α (TNF-α),
interlökin-1 (IL-1), interlökin-4 (IL-4), interlökin-6 (IL-6), toll benzeri
reseptör-4 (TLR-4) kronik düşük derece inflamasyonda rol oynayan bazı
proinflamatuvar moleküllerdir.  Güncel
çalışmalarda, hazır ve işlenmiş besinlerin tüketimiyle artan fruktoz ve doymuş
yağ asitleri alımının kronik düşük derece inflamasyon oluşumunda etkileri
olduğu gösterilmektedir. Bu derlemede, diyetle yüksek fruktoz ve doymuş yağ
asitleri alımının, proinflamatuvar medyatörler aracılığıyla kronik düşük derece
inflamasyon oluşumuna etkisi incelenmiştir.

References

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Effects of dietary high fructose and saturated fatty acids on chronic low grade inflammation in the perspective of chronic diseases

Year 2019, Volume: 44 Issue: 2, 685 - 694, 30.06.2019
https://doi.org/10.17826/cumj.482623

Abstract

In
recent years, the role of chronic low grade inflammation in the emergence of
chronic diseases has been emphasized. Chronic low grade inflammation is a
metabolic process characterized by systemic circulation and increased
inflammatory mediators and some proinflammatory cytokines in various tissues.
C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-1
(IL-1), interleukin-4 (IL-4), interleukin-6 (IL-6), toll like receptor-4
(TLR-4) are some proinflammatory molecules that play a role in the chronic low
grade inflammation. Recent studies have shown that fructose and saturated fatty
acids, which are consumed with increased consumption of processed foods in the
current diet, might trigger  chronic low
grade inflammation. In this review, the effects of dietary high fructose and
saturated fatty acids on development of chronic low grade inflammation through
some proinflammatory mediators were examined. 


References

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  • 3. Zaki SM, Abdel Fattah S, Hassan DS. The differential effects of high-fat and high fructose diets on the liver of male albino rat and the proposed underlying mechanisms. Folia Morphol (Warsz). 2018.
  • 4. Zitvogel L, Pietrocola F, Kroemer G. Nutrition, inflammation and cancer. Nat Immunol. 2017;18(8):843-50.
  • 5. Silveira BKS, Oliveira TMS, Andrade PA, Hermsdorff HHM, Rosa COB, Franceschini S. Dietary Pattern and Macronutrients Profile on the Variation of Inflammatory Biomarkers: Scientific Update. Cardiol Res Pract. 2018;2018:4762575.
  • 6. Calder PC, Ahluwalia N, Albers R, Bosco N, Bourdet-Sicard R, Haller D, et al. A consideration of biomarkers to be used for evaluation of inflammation in human nutritional studies. Br J Nutr. 2013;109 Suppl 1:S1-34.
  • 7. Barbaresko J, Koch M, Schulze MB, Nothlings U. Dietary pattern analysis and biomarkers of low-grade inflammation: a systematic literature review. Nutr Rev. 2013;71(8):511-27.
  • 8. Zhang DM, Jiao RQ, Kong LD. High Dietary Fructose: Direct or Indirect Dangerous Factors Disturbing Tissue and Organ Functions. Nutrients. 2017;9(4).
  • 9. Nishida K, Otsu K. Inflammation and metabolic cardiomyopathy. Cardiovasc Res. 2017;113(4):389-98.
  • 10. Kuzma JN, Cromer G, Hagman DK, Breymeyer KL, Roth CL, Foster-Schubert KE, et al. No differential effect of beverages sweetened with fructose, high-fructose corn syrup, or glucose on systemic or adipose tissue inflammation in normal-weight to obese adults: a randomized controlled trial. Am J Clin Nutr. 2016;104(2):306-14.
  • 11. Ruiz-Nunez B, Dijck-Brouwer DA, Muskiet FA. The relation of saturated fatty acids with low-grade inflammation and cardiovascular disease. J Nutr Biochem. 2016;36:1-20.
  • 12. DiNicolantonio JJ, Lucan SC, O'Keefe JH. The Evidence for Saturated Fat and for Sugar Related to Coronary Heart Disease. Prog Cardiovasc Dis. 2016;58(5):464-72.
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  • 14. Calder PC, Ahluwalia N, Brouns F, Buetler T, Clement K, Cunningham K, et al. Dietary factors and low-grade inflammation in relation to overweight and obesity. Br J Nutr. 2011;106 Suppl 3:S5-78.
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  • 22. van Diepen JA, Berbee JF, Havekes LM, Rensen PC. Interactions between inflammation and lipid metabolism: relevance for efficacy of anti-inflammatory drugs in the treatment of atherosclerosis. Atherosclerosis. 2013;228(2):306-15.
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  • 25. Makarem N, Bandera EV, Nicholson JM, Parekh N. Consumption of Sugars, Sugary Foods, and Sugary Beverages in Relation to Cancer Risk: A Systematic Review of Longitudinal Studies. Annu Rev Nutr. 2018.
  • 26. Malik VS, Hu FB. Fructose and Cardiometabolic Health: What the Evidence From Sugar-Sweetened Beverages Tells Us. J Am Coll Cardiol. 2015;66(14):1615-24.
  • 27. Duffey KJ, Popkin BM. High-fructose corn syrup: is this what's for dinner? Am J Clin Nutr. 2008;88(6):1722S-32S.
  • 28. Dekker MJ, Su Q, Baker C, Rutledge AC, Adeli K. Fructose: a highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome. Am J Physiol Endocrinol Metab. 2010;299(5):E685-94.
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  • 30. Hu FB, Malik VS. Sugar-sweetened beverages and risk of obesity and type 2 diabetes: epidemiologic evidence. Physiol Behav. 2010;100(1):47-54.
  • 31. Kisioglu B, Nergiz-Unal R. Potential effect of maternal dietary sucrose or fructose syrup on CD36, leptin, and ghrelin-mediated fetal programming of obesity. Nutr Neurosci. 2018:1-11.
  • 32. Yuruk AA, Nergiz-Unal R. Maternal dietary free or bound fructose diversely influence developmental programming of lipogenesis. Lipids Health Dis. 2017;16(1):226.
  • 33. Choi Y, Abdelmegeed MA, Song BJ. Diet high in fructose promotes liver steatosis and hepatocyte apoptosis in C57BL/6J female mice: Role of disturbed lipid homeostasis and increased oxidative stress. Food Chem Toxicol. 2017;103:111-21.
  • 34. Porto ML, Lirio LM, Dias AT, Batista AT, Campagnaro BP, Mill JG, et al. Increased oxidative stress and apoptosis in peripheral blood mononuclear cells of fructose-fed rats. Toxicol In Vitro. 2015;29(8):1977-81.
  • 35. Sanchez-Lozada LG, Mu W, Roncal C, Sautin YY, Abdelmalek M, Reungjui S, et al. Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver. Eur J Nutr. 2010;49(1):1-9.
  • 36. Baena M, Sanguesa G, Hutter N, Sanchez RM, Roglans N, Laguna JC, et al. Fructose supplementation impairs rat liver autophagy through mTORC activation without inducing endoplasmic reticulum stress. Biochim Biophys Acta. 2015;1851(2):107-16.
  • 37. Cox CL, Stanhope KL, Schwarz JM, Graham JL, Hatcher B, Griffen SC, et al. Circulating concentrations of monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, and soluble leukocyte adhesion molecule-1 in overweight/obese men and women consuming fructose- or glucose-sweetened beverages for 10 weeks. J Clin Endocrinol Metab. 2011;96(12):E2034-8.
  • 38. Johnston RD, Stephenson MC, Crossland H, Cordon SM, Palcidi E, Cox EF, et al. No difference between high-fructose and high-glucose diets on liver triacylglycerol or biochemistry in healthy overweight men. Gastroenterology. 2013;145(5):1016-25 e2.
  • 39. Aeberli I, Gerber PA, Hochuli M, Kohler S, Haile SR, Gouni-Berthold I, et al. Low to moderate sugar-sweetened beverage consumption impairs glucose and lipid metabolism and promotes inflammation in healthy young men: a randomized controlled trial. Am J Clin Nutr. 2011;94(2):479-85.
  • 40. Lee JH. Polyunsaturated Fatty acids in children. Pediatr Gastroenterol Hepatol Nutr. 2013;16(3):153-61.
  • 41. Hacettepe Üniversitesi Beslenme ve Diyetetik Bölümü. Türkiye'ye Özgü Besin ve Beslenme Rehberi. Temmuz 2015.
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  • 43. Fritsche KL. The science of fatty acids and inflammation. Adv Nutr. 2015;6(3):293S-301S.
  • 44. Teeman CS, Kurti SP, Cull BJ, Emerson SR, Haub MD, Rosenkranz SK. Postprandial lipemic and inflammatory responses to high-fat meals: a review of the roles of acute and chronic exercise. Nutr Metab (Lond). 2016;13:80.
  • 45. Nergiz-Unal R. Diyet Yağı ve Yağ Asitleriyle İmmün Sistem Etkileşimi. Turkiye Klinikleri J Nutr Diet. 2016;2(2):32-5.
  • 46. Enos RT, Davis JM, Velazquez KT, McClellan JL, Day SD, Carnevale KA, et al. Influence of dietary saturated fat content on adiposity, macrophage behavior, inflammation, and metabolism: composition matters. J Lipid Res. 2013;54(1):152-63.
  • 47. Enos RT, Velazquez KT, Murphy EA. Insight into the impact of dietary saturated fat on tissue-specific cellular processes underlying obesity-related diseases. J Nutr Biochem. 2014;25(6):600-12.
  • 48. Suganami T, Tanimoto-Koyama K, Nishida J, Itoh M, Yuan X, Mizuarai S, et al. Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler Thromb Vasc Biol. 2007;27(1):84-91.
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There are 67 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Review
Authors

Mahmut Bodur 0000-0002-2105-8485

Reyhan Nergiz Ünal 0000-0002-3143-7710

Publication Date June 30, 2019
Acceptance Date January 13, 2019
Published in Issue Year 2019 Volume: 44 Issue: 2

Cite

MLA Bodur, Mahmut and Reyhan Nergiz Ünal. “Kronik hastalıklar Ekseninde Diyette yüksek Fruktoz Ve Doymuş Yağ Asitlerinin Kronik düşük Derece Inflamasyon üzerine Etkisi”. Cukurova Medical Journal, vol. 44, no. 2, 2019, pp. 685-94, doi:10.17826/cumj.482623.