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Streptozotosin kaynaklı diyabetik sıçanlarda Arum rupicola'nın in vivo antioksidan potansiyeli

Year 2019, Volume: 8 Issue: 3, 866 - 874, 30.09.2019
https://doi.org/10.17798/bitlisfen.547871

Abstract

Diabetes mellitus, dünya popülasyonunun
azımsanmayacak bir kesimini etkileyen metabolik bir hastalıktır. Arum rupicola, Doğu ve Güneydoğu Anadolu’da,
halk hekimliğinde diyabetin tedavisi için kullanılmaktadır. Bu çalışma, Arum rupicola’nın streptozotosin (STZ)
ile oluşturulan diyabetik sıçanlarda toprak üstü kök ve gövde liyoflize
ekstresinin oksidatif stres belirteçleri üzerine etkisini değerlendirmek için
tasarlanmıştır. Çalışmanın deneysel modellemesine göre, toplam 36 adet erkek
sıçan rastgele altı gruba ayrıldı. İlk grup, normal kontrol (NK), ikinci grup
streptozotosin (STZ) deneysel diyabet oluşturuldu (DK). Üçüncü grup, standart
drug- akarboz (DAK) deneme süresince verildi. Dört, beş ve altıncı gruplardaki sıçanlar
STZ ile diyabet oluşturulduktan sonra sırasıyla 100, 200 ve 400 mg/kg (DAR 100,
DAR 200, DAR 400 mg/kg.) doz aralığında Arum
rupicola
liyoflize ekstresi gavaj yolu sıçanlara verildi.



Bu çalışmada Antioksidan savunma sistemi
unsurlarından olan süperoksit dismutaz (SOD), glutatyon peroksidaz (GPx),
katalaz (CAT) aktivitesi ile non-enzimatik antioksidan olan glutatyon (GSH)'un
düzeylerinin ölçümleri gerçekleştirildi. Ayrıca, lipit peroksidasyonun (LPO)
son ürünü malondialdehit (MDA) içeriği ölçüldü. Diyabetik gruplarda, uygulama
dozlarının tümünde SOD, GPx ve CAT ve GSH düzeylerindeki azalışlar normal
kontrol (NK) grubuna göre anlamlı bulundu. Ancak eritrosit ve karaciğer
dokularında lipit peroksidasyonu sonucu oluşan MDA'in düzeyinde görülen azalma
normal kontrol ve diyabetik kontrol gruplarına göre anlamlı bulundu (p≤0.05). Diğer
yandan, beyin dokusu DAR3 grubunda ve böbrek dokusu DAR1, DAR2, DAR3
gruplarında artan MDA düzeyleri istatiksel olarak anlamlı bulunmuştur. Bitki
ekstresi uygulanan diyabetik gruplarda, farklı dokularda belirlenen değişken
SOD, GPx ve CAT aktivite ve GSH’un ölçümleri istatistiksel olarak anlamlı
bulundu (p≤0.05).



Sonuç olarak Arum rupicola, diyabetik sıçanlarda oksidatif strese karşı
uygulanan bitki ekstresinin doz aralığına göre dokudan-dokuya farklılık
gösteren antioksidatif etkiye sahip olduğu söylenebilir.

References

  • Referans1 Jadidoleslami, M., Abbasnejad, M., & Shahraki, M. R. (2010). The survey of Aloe vera aqueous extract and glibenclamid interaction on blood glucose, LFT and lipids diabetic induced male rats by streptozotocin. Journal of Rafsanjan University of Medical sciences, 9(3), 185-194.
  • Referans2 Mokhtari, M., & Mohammadi, J. (2012). The effect of hydroalcoholic extracts of Prangos ferulacea on blood factors of kidney and liver functions in diabetic male wistar rats. Journal of Fasa University of Medical Sciences, 2(3), 174-180.
  • Referans3 Shirali, S., Bathaei, S. Z., Nakhjavani, M., & Ashoori, M. R. (2012). Effects of saffron (Crocus sativus L.) aqueous extract on serum biochemical factors in streptozotocin-induced diabetic rats.
  • Referans4 Bhattacharya, S., Manna, P., Gachhui, R., & Sil, P. C. (2013). D-Saccharic acid 1, 4-lactone protects diabetic rat kidney by ameliorating hyperglycemia- mediated oxidative stress and renal inflammatory cytokines via NF-κB and PKC signaling. Toxicology and applied pharmacology, 267(1), 16-29.
  • Referans5 Brownlee, M., The pathobiology of diabetic complications: a unifying mechanism. Diabetes. 2005, 54(6):1615-25. Doi: 10.2337/ diabetes.54.6.1615.
  • Referans6 Nishikawa, T., Edelstein, D., Du, X.L., Yamagishi, S., Matsu¬mura, T., Kaneda, Y., Yorek, M.A., Beebe, D., Oates, P.J., Hammes, H.P., Giardino, I., and Brownlee, M., Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature. 2000, 404(6779):787-90. Doi: 10.1038/35008121. Referans7 Yamagishi, S.I., Edelstein, D., Du, X.L., and Brownlee, M., Hyperglycemia potentiates collagen-induced platelet activation through mitochondrial superoxide overproduction. Diabetes. 2001, 50(6):1491-4. Doi: 10.2337/ diabetes.50.6.1491.
  • Referans8 Bayani, U., Singh, A.V., Zamboni, P., and Mahajan, R.T., Oxida¬tive Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options. Curr Neurop¬harmacol. 2009, 7(1): 65–74. Doi: 10.2174/157015909787602823.
  • Referans9 Rahimi-Madiseh, M., Heidarian, E., Kheiri, S., & Rafieian-Kopaei, M. (2017). Effect of hydroalcoholic Allium ampeloprasum extract on oxidative stress, diabetes mellitus and dyslipidemia in alloxan-induced diabetic rats. Biomedicine & pharmacotherapy, 86, 363-367.
  • Referans10 Rahimi-Madiseh, M., Gholami-Arjenaki, M., Bahmani, M., Mardani, G., Farzan, M., & Rafieian-Kopaei, M. (2016). Evaluation of minerals, phenolics and anti-radical activity of three species of Iranian berberis fruit. Der Pharma Chemica, 8(2), 191-197.
  • Referans11 Güneş, S., Savran, A., Paksoy, M. Y., & Çakılcıoğlu, U. (2018). Survey of wild food plants for human consumption in Karaisalı (Adana-Turkey).
  • Referans12 Dalar, A. (2018). Plant Taxa Used in the Treatment of Diabetes in Van Province, Turkey. International Journal of Secondary Metabolite, 5(3), 171-185.
  • Referans13 Kaisoon, O., Konczak, I., Siriamornpun, S., 2012. Potential health enhancing properties of edible flowers from Thailand. Food Res. Int. 46 (2), 563–571.
  • Referans14 Ahmad, W., Khan, I., Khan, M. A., Ahmad, M., Subhan, F., & Karim, N. (2014). Evaluation of antidiabetic and antihyperlipidemic activity of Artemisia indica linn (aeriel parts) in Streptozotocin induced diabetic rats. Journal of ethnopharmacology, 151(1), 618-623.
  • Referans15 Hemalatha, S., Wahi, A. K., Singh, P. N., Chansouria, J. P. N., 2004. Hypoglycemic activity of withania coaculants dunal in streptozotocin induced diabetic rats. Journal of Ethnopharmacolgy, 93: 261–264.
  • Referans16 Kanitkar, M., & Bhonde, R. (2004). Existence of islet regenerating factors within the pancreas. The Review of Diabetic Studies, 1(4), 185.
  • Referans17 Xia, E., Rao, G., Remmen, H. V., Heydari, A. R., Richardson, A., 1994. Activities of antioxidant enzymes in various tissues of male fischer 344 rats are altered by food restriction. J. Nutr., 125: 195-201.
  • Referans18 McCord, J. M., & Fridovich, I. (1969). Superoxide dismutase an enzymic function for erythrocuprein (hemocuprein). Journal of Biological chemistry, 244(22), 6049-6055.
  • Referans19 Aebi, H. Catalase in Vitro. In Methods in Enzymology; Academy Press: New York, NY, USA, 1984; pp. 121–126.
  • Referans20 Beutler, E. (1963). Improved method for the determination of blood glutathione. J. lab. clin. Med., 61, 882-888.
  • Referans21 Jain, S. K., McVie, R., Duett, J., & Herbst, J. J. (1989). Erythrocyte membrane lipid peroxidation and glycosylated hemoglobin in diabetes. Diabetes, 38(12), 1539-1543.
  • Referans22 Bondy, S. C. (1992). Ethanol toxicity and oxidative stress. Toxicology letters, 63(3), 231-241.
  • Referans23 Husain, K., Scott, B. R., Reddy, S. K., & Somani, S. M. (2001). Chronic ethanol and nicotine interaction on rat tissue antioxidant defense system. Alcohol, 25(2), 89-97.
  • Referans24 Yang, H. L., Chen, S. C., Chang, N. W., Chang, J. M., Lee, M. L., Tsai, P. C., . & Hseu, Y. C. (2006). Protection from oxidative damage using Bidens pilosa extracts in normal human erythrocytes. Food and Chemical Toxicology, 44(9), 1513-1521
  • Referans25 Jain, S. K. (1989). Hyperglycemia can cause membrane lipid peroxidation and osmotic fragility in human red blood cells. Journal of Biological Chemistry, 264(35), 21340-21345.
  • Referans26 Jangir, R. N., & Jain, G. C. (2017). Evaluation of antidiabetic activity of hydroalcoholic extract of Cassia fistula Linn. pod in streptozotocin-induced diabetic rats. Pharmacognosy Journal, 9(5).
  • Referans27 Almeida, D. A. T. D., Braga, C. P., Novelli, E. L. B., & Fernandes, A. A. H. (2012). Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin. Brazilian Archives of Biology and Technology, 55(4), 527-536
  • Referans28 Taheri, E., Djalali, M., Saedisomeolia, A., Moghadam, A. M., Djazayeri, A., & Qorbani, M. (2012). The relationship between the activates of antioxidant enzymes in red blood cells and body mass index in Iranian type 2 diabetes and healthy subjects. Journal of Diabetes & Metabolic Disorders, 11(1), 3.
  • Referans29 Molehin, O. R., Oloyede, O. I., & Adefegha, S. A. (2018). Streptozotocin-induced diabetes in rats: effects of white butterfly (Clerodendrum volubile) leaves on blood glucose levels, lipid profile and antioxidant status. Toxicology mechanisms and methods, 28(8), 573-586.
  • Referans30 Sies H. Glutathione and its role in cellular functions. Free Radic Biol Med 1999;27:916-21
  • Referans31 Wu, G., Fang, Y. Z., Yang, S., Lupton, J. R., & Turner, N. D. (2004). Glutathione metabolism and its implications for health. The Journal of nutrition, 134(3), 489-492.
  • Referans32 Argano, M., et al., 1997. Dehydroeppiandrosterone administration prevents the oxidative damage induced by acute hyperglycemia in rats. Journal endocrinology, 155, 233–240.
  • Referans33 Tiwari, B. K., Abidi, A. B., Rizvi, S. I., & Pandey, K. B. (2018). Effect of oral supplementation of composite leaf extract of medicinal plants on biomarkers of oxidative stress in induced diabetic Wistar rats. Archives of physiology and biochemistry, 124(4), 361-366.
  • Referans34 Demir, E., Keser, S., & YILMAZ, Ö. (2016). Acı Badem Yağının Streptozotosin Kaynaklı Diyabetik Sıçanların Serum ve Eritrositlerindeki Bazı Biyokimyasal Parametreler Üzerindeki Etkileri. Karaelmas Fen ve Mühendislik Dergisi, 5(2), 61-67.
  • Referans35 Padayatty, S. J., Katz, A., Wang, Y., Eck, P., Kwon, O., Lee, J. H., & Levine, M. (2003). Vitamin C as an antioxidant: evaluation of its role in disease prevention. Journal of the American college of Nutrition, 22(1), 18-35.
  • Referans36 Çomu, F. M., Polat, Y., Özer, A., Erer, D., Kirişçi, M., Dursun, A. D., ... & Arslan, M. (2017). The Effect of Picroside-2 on Erythrocyte Deformability and Lipid Peroxidation in Streptozotocin-Induced Diabetic Rats Subjected to Left Anterior Descending Artery-Ischaemia Reperfusion. Gazi Medical Journal, 28(2)
  • Referans37 Yang, H.L., Chen, S.C., Chang, N.W., et al., Protection from oxidative damage using Bidenspilosa extracts in normal human erythrocytes, Food and Chemical Toxicology, 44, 1513-1521, 2006.
  • Referans38 Gomathi, D., Ravikumar, G., Kalaiselvi, M., Devaki, K., & Uma, C. (2013). Efficacy of Evolvulus alsinoides (L.) L. on insulin and antioxidants activity in pancreas of streptozotocin induced diabetic rats. Journal of Diabetes & Metabolic Disorders, 12(1), 39.
  • Referans39 Liu M, Song X, Zhang J, Zhang C, Gao Z, Li S, et al. Protective effects on liver, kidney and pancreas of enzymatic- and acidic-hydrolysis of polysaccharides by spent mushroom compost (Hypsizigus marmoreus). Sci Rep 2017;7:43212.
  • Referans40 Hassan SK, El-Sammad NM, Mousa AM, Mohammed MH, Farrag AR, Hashim AN, et al . Hypoglycemic and antioxidant activities of Caesalpinia ferrea Martius leaf extract in streptozotocin-induced diabetic rats. Asian Pac J Trop Biomed 2015;5:462-71.
  • Referans41 Jangir RN, Jain GC. Antidiabetic and antioxidant potential of hydroalcoholic extract of Moringa oleifera leaves in streptozotocin-induced diabetic rats. Eur J Pharm Med Res 2016;3:438-50.
Year 2019, Volume: 8 Issue: 3, 866 - 874, 30.09.2019
https://doi.org/10.17798/bitlisfen.547871

Abstract

References

  • Referans1 Jadidoleslami, M., Abbasnejad, M., & Shahraki, M. R. (2010). The survey of Aloe vera aqueous extract and glibenclamid interaction on blood glucose, LFT and lipids diabetic induced male rats by streptozotocin. Journal of Rafsanjan University of Medical sciences, 9(3), 185-194.
  • Referans2 Mokhtari, M., & Mohammadi, J. (2012). The effect of hydroalcoholic extracts of Prangos ferulacea on blood factors of kidney and liver functions in diabetic male wistar rats. Journal of Fasa University of Medical Sciences, 2(3), 174-180.
  • Referans3 Shirali, S., Bathaei, S. Z., Nakhjavani, M., & Ashoori, M. R. (2012). Effects of saffron (Crocus sativus L.) aqueous extract on serum biochemical factors in streptozotocin-induced diabetic rats.
  • Referans4 Bhattacharya, S., Manna, P., Gachhui, R., & Sil, P. C. (2013). D-Saccharic acid 1, 4-lactone protects diabetic rat kidney by ameliorating hyperglycemia- mediated oxidative stress and renal inflammatory cytokines via NF-κB and PKC signaling. Toxicology and applied pharmacology, 267(1), 16-29.
  • Referans5 Brownlee, M., The pathobiology of diabetic complications: a unifying mechanism. Diabetes. 2005, 54(6):1615-25. Doi: 10.2337/ diabetes.54.6.1615.
  • Referans6 Nishikawa, T., Edelstein, D., Du, X.L., Yamagishi, S., Matsu¬mura, T., Kaneda, Y., Yorek, M.A., Beebe, D., Oates, P.J., Hammes, H.P., Giardino, I., and Brownlee, M., Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature. 2000, 404(6779):787-90. Doi: 10.1038/35008121. Referans7 Yamagishi, S.I., Edelstein, D., Du, X.L., and Brownlee, M., Hyperglycemia potentiates collagen-induced platelet activation through mitochondrial superoxide overproduction. Diabetes. 2001, 50(6):1491-4. Doi: 10.2337/ diabetes.50.6.1491.
  • Referans8 Bayani, U., Singh, A.V., Zamboni, P., and Mahajan, R.T., Oxida¬tive Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options. Curr Neurop¬harmacol. 2009, 7(1): 65–74. Doi: 10.2174/157015909787602823.
  • Referans9 Rahimi-Madiseh, M., Heidarian, E., Kheiri, S., & Rafieian-Kopaei, M. (2017). Effect of hydroalcoholic Allium ampeloprasum extract on oxidative stress, diabetes mellitus and dyslipidemia in alloxan-induced diabetic rats. Biomedicine & pharmacotherapy, 86, 363-367.
  • Referans10 Rahimi-Madiseh, M., Gholami-Arjenaki, M., Bahmani, M., Mardani, G., Farzan, M., & Rafieian-Kopaei, M. (2016). Evaluation of minerals, phenolics and anti-radical activity of three species of Iranian berberis fruit. Der Pharma Chemica, 8(2), 191-197.
  • Referans11 Güneş, S., Savran, A., Paksoy, M. Y., & Çakılcıoğlu, U. (2018). Survey of wild food plants for human consumption in Karaisalı (Adana-Turkey).
  • Referans12 Dalar, A. (2018). Plant Taxa Used in the Treatment of Diabetes in Van Province, Turkey. International Journal of Secondary Metabolite, 5(3), 171-185.
  • Referans13 Kaisoon, O., Konczak, I., Siriamornpun, S., 2012. Potential health enhancing properties of edible flowers from Thailand. Food Res. Int. 46 (2), 563–571.
  • Referans14 Ahmad, W., Khan, I., Khan, M. A., Ahmad, M., Subhan, F., & Karim, N. (2014). Evaluation of antidiabetic and antihyperlipidemic activity of Artemisia indica linn (aeriel parts) in Streptozotocin induced diabetic rats. Journal of ethnopharmacology, 151(1), 618-623.
  • Referans15 Hemalatha, S., Wahi, A. K., Singh, P. N., Chansouria, J. P. N., 2004. Hypoglycemic activity of withania coaculants dunal in streptozotocin induced diabetic rats. Journal of Ethnopharmacolgy, 93: 261–264.
  • Referans16 Kanitkar, M., & Bhonde, R. (2004). Existence of islet regenerating factors within the pancreas. The Review of Diabetic Studies, 1(4), 185.
  • Referans17 Xia, E., Rao, G., Remmen, H. V., Heydari, A. R., Richardson, A., 1994. Activities of antioxidant enzymes in various tissues of male fischer 344 rats are altered by food restriction. J. Nutr., 125: 195-201.
  • Referans18 McCord, J. M., & Fridovich, I. (1969). Superoxide dismutase an enzymic function for erythrocuprein (hemocuprein). Journal of Biological chemistry, 244(22), 6049-6055.
  • Referans19 Aebi, H. Catalase in Vitro. In Methods in Enzymology; Academy Press: New York, NY, USA, 1984; pp. 121–126.
  • Referans20 Beutler, E. (1963). Improved method for the determination of blood glutathione. J. lab. clin. Med., 61, 882-888.
  • Referans21 Jain, S. K., McVie, R., Duett, J., & Herbst, J. J. (1989). Erythrocyte membrane lipid peroxidation and glycosylated hemoglobin in diabetes. Diabetes, 38(12), 1539-1543.
  • Referans22 Bondy, S. C. (1992). Ethanol toxicity and oxidative stress. Toxicology letters, 63(3), 231-241.
  • Referans23 Husain, K., Scott, B. R., Reddy, S. K., & Somani, S. M. (2001). Chronic ethanol and nicotine interaction on rat tissue antioxidant defense system. Alcohol, 25(2), 89-97.
  • Referans24 Yang, H. L., Chen, S. C., Chang, N. W., Chang, J. M., Lee, M. L., Tsai, P. C., . & Hseu, Y. C. (2006). Protection from oxidative damage using Bidens pilosa extracts in normal human erythrocytes. Food and Chemical Toxicology, 44(9), 1513-1521
  • Referans25 Jain, S. K. (1989). Hyperglycemia can cause membrane lipid peroxidation and osmotic fragility in human red blood cells. Journal of Biological Chemistry, 264(35), 21340-21345.
  • Referans26 Jangir, R. N., & Jain, G. C. (2017). Evaluation of antidiabetic activity of hydroalcoholic extract of Cassia fistula Linn. pod in streptozotocin-induced diabetic rats. Pharmacognosy Journal, 9(5).
  • Referans27 Almeida, D. A. T. D., Braga, C. P., Novelli, E. L. B., & Fernandes, A. A. H. (2012). Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin. Brazilian Archives of Biology and Technology, 55(4), 527-536
  • Referans28 Taheri, E., Djalali, M., Saedisomeolia, A., Moghadam, A. M., Djazayeri, A., & Qorbani, M. (2012). The relationship between the activates of antioxidant enzymes in red blood cells and body mass index in Iranian type 2 diabetes and healthy subjects. Journal of Diabetes & Metabolic Disorders, 11(1), 3.
  • Referans29 Molehin, O. R., Oloyede, O. I., & Adefegha, S. A. (2018). Streptozotocin-induced diabetes in rats: effects of white butterfly (Clerodendrum volubile) leaves on blood glucose levels, lipid profile and antioxidant status. Toxicology mechanisms and methods, 28(8), 573-586.
  • Referans30 Sies H. Glutathione and its role in cellular functions. Free Radic Biol Med 1999;27:916-21
  • Referans31 Wu, G., Fang, Y. Z., Yang, S., Lupton, J. R., & Turner, N. D. (2004). Glutathione metabolism and its implications for health. The Journal of nutrition, 134(3), 489-492.
  • Referans32 Argano, M., et al., 1997. Dehydroeppiandrosterone administration prevents the oxidative damage induced by acute hyperglycemia in rats. Journal endocrinology, 155, 233–240.
  • Referans33 Tiwari, B. K., Abidi, A. B., Rizvi, S. I., & Pandey, K. B. (2018). Effect of oral supplementation of composite leaf extract of medicinal plants on biomarkers of oxidative stress in induced diabetic Wistar rats. Archives of physiology and biochemistry, 124(4), 361-366.
  • Referans34 Demir, E., Keser, S., & YILMAZ, Ö. (2016). Acı Badem Yağının Streptozotosin Kaynaklı Diyabetik Sıçanların Serum ve Eritrositlerindeki Bazı Biyokimyasal Parametreler Üzerindeki Etkileri. Karaelmas Fen ve Mühendislik Dergisi, 5(2), 61-67.
  • Referans35 Padayatty, S. J., Katz, A., Wang, Y., Eck, P., Kwon, O., Lee, J. H., & Levine, M. (2003). Vitamin C as an antioxidant: evaluation of its role in disease prevention. Journal of the American college of Nutrition, 22(1), 18-35.
  • Referans36 Çomu, F. M., Polat, Y., Özer, A., Erer, D., Kirişçi, M., Dursun, A. D., ... & Arslan, M. (2017). The Effect of Picroside-2 on Erythrocyte Deformability and Lipid Peroxidation in Streptozotocin-Induced Diabetic Rats Subjected to Left Anterior Descending Artery-Ischaemia Reperfusion. Gazi Medical Journal, 28(2)
  • Referans37 Yang, H.L., Chen, S.C., Chang, N.W., et al., Protection from oxidative damage using Bidenspilosa extracts in normal human erythrocytes, Food and Chemical Toxicology, 44, 1513-1521, 2006.
  • Referans38 Gomathi, D., Ravikumar, G., Kalaiselvi, M., Devaki, K., & Uma, C. (2013). Efficacy of Evolvulus alsinoides (L.) L. on insulin and antioxidants activity in pancreas of streptozotocin induced diabetic rats. Journal of Diabetes & Metabolic Disorders, 12(1), 39.
  • Referans39 Liu M, Song X, Zhang J, Zhang C, Gao Z, Li S, et al. Protective effects on liver, kidney and pancreas of enzymatic- and acidic-hydrolysis of polysaccharides by spent mushroom compost (Hypsizigus marmoreus). Sci Rep 2017;7:43212.
  • Referans40 Hassan SK, El-Sammad NM, Mousa AM, Mohammed MH, Farrag AR, Hashim AN, et al . Hypoglycemic and antioxidant activities of Caesalpinia ferrea Martius leaf extract in streptozotocin-induced diabetic rats. Asian Pac J Trop Biomed 2015;5:462-71.
  • Referans41 Jangir RN, Jain GC. Antidiabetic and antioxidant potential of hydroalcoholic extract of Moringa oleifera leaves in streptozotocin-induced diabetic rats. Eur J Pharm Med Res 2016;3:438-50.
There are 40 citations in total.

Details

Primary Language Turkish
Journal Section Araştırma Makalesi
Authors

Necati Özok

İnan Güneş This is me

Publication Date September 30, 2019
Submission Date April 1, 2019
Acceptance Date April 21, 2019
Published in Issue Year 2019 Volume: 8 Issue: 3

Cite

IEEE N. Özok and İ. Güneş, “Streptozotosin kaynaklı diyabetik sıçanlarda Arum rupicola’nın in vivo antioksidan potansiyeli”, Bitlis Eren Üniversitesi Fen Bilimleri Dergisi, vol. 8, no. 3, pp. 866–874, 2019, doi: 10.17798/bitlisfen.547871.

Bitlis Eren University
Journal of Science Editor
Bitlis Eren University Graduate Institute
Bes Minare Mah. Ahmet Eren Bulvari, Merkez Kampus, 13000 BITLIS